Protein Alignment LeuRS-m and leuS

DIOPT Version :10

• Sequence 1: NP_647932.1
• Gene: LeuRS-m / 38581
• FlyBaseID: FBgn0027085
• Length: 869
• Species: Drosophila melanogaster
• Sequence 2: NP_415175.1
• Gene: leuS / 947497
• ECOCYCID: EG10532
• Length: 860
• Species: Escherichia coli
• Alignment Length: 903
• Identity: 304/903 - (33%)
• Similarity: 430/903 - (47%)
• Gaps: 136/903 - (15%)

  Fly    32 PELTSDVKHRIEAHWREQLSGGQFNPKDSQDKYYVLSMFPYPSGNLHMGHVRVYTIADSVARFQR 96
            ||   :::.:::.||.|:.: .:....:|::|||.|||.|||||.|||||||.|||.|.:||:||
E. coli     7 PE---EIESKVQLHWDEKRT-FEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQR 67

  Fly    97 MCGKNVFQPMGWDSFGLPAENAANQRGVEPASWTEQNIAQMKEQLKRLGCSFDWNHELSTCSPKY 161
            |.||||.||:|||:||||||.||.:....||.||..|||.||.|||.||..:||:.||:||:|:|
E. coli    68 MLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEY 132

  Fly   162 YKWTQHLFLMLHRHGLAYQNEALVNWDPVDKTVLADEQVDANGCSWRSGAKVEKKLLRQWFIRTS 226
            |:|.|..|..|::.||.|:..:.|||.|.|:||||:||| .:||.||...|||:|.:.||||:.:
E. coli   133 YRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQV-IDGCCWRCDTKVERKEIPQWFIKIT 196

  Fly   227 AYAKQLLDGLEDPTLRDWRDII-NLQRHWIGECDG--YAFNLLTSASGLLRVWTTHPEHLKDPHA 288
            |||.:||:.|:  .|..|.|.: .:||:|||..:|  ..|| :......|.|:||.|:.... ..
E. coli   197 AYADELLNDLD--KLDHWPDTVKTMQRNWIGRSEGVEITFN-VNDYDNTLTVYTTRPDTFMG-CT 257

  Fly   289 FLVLRSNHHLS------------------------------KLKGADS-LSAANPFAGTTMPVVF 322
            :|.:.:.|.|:                              :.||.|: ..|.:|..|..:||..
E. coli   258 YLAVAAGHPLAQKAAENNPELAAFIDECRNTKVAEAEMATMEKKGVDTGFKAVHPLTGEEIPVWA 322

  Fly   323 SDEVTFPPKSDVYLAAPSFRGEDKDLWDSYGL--------------------------AFTS--- 358
            ::.|.....:...:|.|.....|.:....|||                          .|.|
E. coli   323 ANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDLSQQALTEKGVLFNSGEF 387

  Fly   359 NGKDEESLSPANWEMLRKEVLQAATRLNVGGYRVSSKLKDWLISRQRYWGTPIPIVHCQKCGAVP 423
            ||.|.|:...|        :....|.:.||..:|:.:|:||.:|||||||.|||:|..:....:|
E. coli   388 NGLDHEAAFNA--------IADKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMP 444

  Fly   424 VPEEQLPVSLPPK------DSPKEAFLCDCPKCGE-----KDARRETDTMDTFVDSSWYYLRYLD 477
            .|::||||.||..      .||.:|    .|:..:     ..|.|||||.|||::|||||.||..
E. coli   445 TPDDQLPVILPEDVVMDGITSPIKA----DPEWAKTTVNGMPALRETDTFDTFMESSWYYARYTC 505

  Fly   478 AQNSERIFDTALTKKFMPVDLYIGGKEHAVLHLYYARFINHFLHSCGLSPTSEPFSRLLVQGMVM 542
            .|..|.:.|:.....::|||:||||.|||::||.|.||.:..:...|:..:.||..:||.||||:
E. coli   506 PQYKEGMLDSEAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVL 570

  Fly   543 GRSFRV---KGSGRYVPETEVEIVNAKKNQAVLKET---KEPVVMTWEKMSKSKLNGVEPSDMFN 601
            ..:|..   .|...:|...:..:...:|.:.|..:.   .|.|.....||||||.||::|..|..
E. coli   571 ADAFYYVGENGERNWVSPVDAIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVE 635

  Fly   602 EYGTDTTRLIILADVAPTSHRNWSSATFPGILNWQKRLWLTLQDFQQAREDQTASDVVPTSEEFL 666
            .||.||.||.::..........|..:...|...:.||:|      :...|.....||...:.:.|
E. coli   636 RYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVW------KLVYEHTAKGDVAALNVDAL 694

  Fly   667 AEDAKLF--DARNFYVKGATFNYRHAQQLSVAISKMQGLTNSLRRTPKHVLRHGKQFERALAAQI 729
            .|:.|..  |......| .|.:....|..:.||:.:..|.|.|.:.|....:.....:.||.|.:
E. coli   695 TENQKALRRDVHKTIAK-VTDDIGRRQTFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVV 758

  Fly   730 IMLAPMAPHFASELWSKFVAIPGRLNPASQELQWSEDVLAQRWPDIDPAYNLDLS----IKVNGF 790
            .||.|..||....||              |||:...|:....||..|....::.|    ::|||.
E. coli   759 RMLNPFTPHICFTLW--------------QELKGEGDIDNAPWPVADEKAMVEDSTLVVVQVNGK 809

  Fly   791 ENCVIKVQRTHLDKVTHSDALDIAFNTESVTSYLIDKKIRTTNFVLYPGIEAILNIYV 848
            ....|.|.   :| .|.....:.|.....|..||....:|...:|  ||  .:||:.|
E. coli   810 VRAKITVP---VD-ATEEQVRERAGQEHLVAKYLDGVTVRKVIYV--PG--KLLNLVV 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS-m	NP_647932.1	LeuS	40..848	CDD:440261	301/893 (34%)
leuS	NP_415175.1	LeuS	1..860	CDD:440261	304/903 (34%)