DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LeuRS-m and NAM2

DIOPT Version :9

Sequence 1:	NP_647932.1	Gene:	LeuRS-m / 38581	FlyBaseID:	FBgn0027085	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_013486.3	Gene:	NAM2 / 851098	SGDID:	S000004374	Length:	894	Species:	Saccharomyces cerevisiae

Alignment Length:	897	Identity:	309/897 - (34%)
Similarity:	445/897 - (49%)	Gaps:	149/897 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 WREQLSGGQFNPKD---SQDKYYVLSMFPYPSGNLHMGHVRVYTIADSVARFQRMCGKNVFQPMG 107
            |:::.:.|.  ||.   :....|:|..||||||.||:||:|||.|:||:.||.:..|.||..|||
Yeast    30 WKQKTTRGL--PKQDTLNSGSKYILCQFPYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMG 92

  Fly   108 WDSFGLPAENAANQRGVEPASWTEQNIAQMKEQLKRLGCSFDWNHELSTCSPKYYKWTQHLFLML 172
            ||:|||||||||.:|.:.||.||..|||:||:|::.:..:|||:.|::||.|:|||:||.:||.|
Yeast    93 WDAFGLPAENAAIERSINPAIWTRDNIAKMKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKL 157

  Fly   173 HRHGLAYQNEALVNWDPVDKTVLADEQVDANGCSWRSGAKVEKKLLRQWFIRTSAYAKQLLDGLE 237
            ..:||||:.||.:||||||.||||:|||||.|.||||||.||||.|:|||:..:.:|.:|...|.
Yeast   158 FENGLAYRKEAEINWDPVDMTVLANEQVDAQGRSWRSGAIVEKKQLKQWFLGITKFAPKLKKHLN 222

  Fly   238 DPTLRDW-RDIINLQRHWIGECDG--YAFNLLTSASGLLRVWTTHPEHLKDPHAFLVLRSNHHLS 299
            .  |:|| .::..:|::||||..|  ..|.:.......|.|:||.||.|.... ::.|..:|.:.
Yeast   223 Q--LKDWPSNVKQMQKNWIGESVGAELVFKVADPKFENLIVFTTRPETLFAVQ-YVALALDHPIV 284

  Fly   300 K------------LKGADSL-------------SAANPFAGTTMPVVFSDEV--TFPPKSDVYLA 337
            :            ::.:|.|             .|.||.....:|:..:..|  ::.......:.
Yeast   285 QKYCEEMPDLKEFIQKSDQLPNDTKEGFQLPNIKAVNPLTKEEVPIFAAPYVVSSYGSAPSAVMG 349

  Fly   338 APSFRGEDKDLWDSY------------------------------GLAFTSNGKDEESLSPANWE 372
            .|.....|.:.|.:.                              .:.|||..           .
Yeast   350 CPGHDNRDFEFWQTNCPGEHIKTCIAPFFDDASKVTEQERQRIIDTVPFTSTD-----------G 403

  Fly   373 MLRKE------VLQAATRLNVGGYR---------VSSKLKDWLISRQRYWGTPIPIVHCQKCGAV 422
            :|.||      ||....|.::.|..         |..|::||||||||||||||||:||..||.|
Yeast   404 VLTKECGEHSGVLTVVARKSIMGMLNSEGLSKSVVRYKIRDWLISRQRYWGTPIPIIHCDNCGPV 468

  Fly   423 PVPEEQLPVSLP----------PKDSPKEAFLCDCPKCGEKDARRETDTMDTFVDSSWYYLRYLD 477
            ||||..|||.||          |..:..|.....||.|| ..|:|||||||||:||||||.|:||
Yeast   469 PVPESDLPVKLPELEGLDTKGNPLSTIDEFVNVACPSCG-SPAKRETDTMDTFIDSSWYYFRFLD 532

  Fly   478 AQNSERIFDTALTKKFMPVDLYIGGKEHAVLHLYYARFINHFLHSCGL--SPTS--EPFSRLLVQ 538
            .:|:.:.||..:..|.||||:||||.|||:|||.|:|||..||.|...  .|..  |||.:|:.|
Yeast   533 PKNTSKPFDREIASKNMPVDIYIGGVEHAILHLLYSRFIAKFLGSINAWSDPAGIFEPFKKLVTQ 597

  Fly   539 GMVMGRSFRVKGSGRYVPETEVEIVNAKK--NQAVLKETKEPVVMTWEKMSKSKLNGVEPSDMFN 601
            |||.|:::....||:::...|:..||...  |..::|...:..|:::|||||||.||.:|::...
Yeast   598 GMVQGKTYVDPDSGKFLKPDELTFVNDSPDGNTVIIKSNGKVPVVSYEKMSKSKYNGADPNECIL 662

  Fly   602 EYGTDTTRLIILADVAPTSHRNWSSATFPGILNW-QKRLWLTL------QDFQQAREDQTASDVV 659
            .:|.|.||..||.........||..:...||..| ||.|.||.      :|...:::.:|.:|:
Yeast   663 RHGPDATRAHILFQSPIADALNWDESKIVGIERWLQKVLHLTKNILSLEKDLAISKDYKTPTDL- 726

  Fly   660 PTSEEFLAEDAKLFDARNF--YVKGATFNYRHAQQLSVAISKMQGLTNSLRRTPKHVLRHGKQFE 722
                    .||::....:|  ::|..|.::.....|:..||....|||.|....|......:...
Yeast   727 --------NDAEVKFHNDFQRFLKSITESFEVNLSLNTVISDYMKLTNILESALKKGEVRNEMIV 783

  Fly   723 RALAAQIIMLAPMAPHFASELWSKFVAIPGRLNPASQELQWSEDVLAQRWPDIDPAYN---LDLS 784
            :.|...:.::.|..|..:.|          .....:.:::|::    .|||:::....   ....
Yeast   784 QNLQKLVTVIYPAVPSISEE----------AAEMINSQMEWNQ----YRWPEVERTTESKFKKFQ 834

  Fly   785 IKVNGFENCVIKVQRTHLDKVTHSDALDIAFNTESVTSYLIDKKIRTTNFVL 836
            |.|||....:....:..| |:.....::...|......||::|||:  .||:
Yeast   835 IVVNGRVKFMYTADKNFL-KLGRDAVIETLMNLPEGRMYLMNKKIK--KFVM 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS-m	NP_647932.1	leuS	40..848	CDD:234743	309/897 (34%)
		LeuRS_core	63..624	CDD:173906	257/651 (39%)
		Anticodon_Ia_like	624..747	CDD:299868	29/131 (22%)
		Anticodon_Ia_like	<723..799	CDD:299868	12/78 (15%)
NAM2	NP_013486.3	leuS_bact	21..893	CDD:273057	309/897 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346403
Domainoid	1	1.000	191	1.000	Domainoid score	I632
eggNOG	1	0.900	-	-		E1_COG0495
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6526
Inparanoid	1	1.050	468	1.000	Inparanoid score	I231
Isobase	1	0.950	-	0	Normalized mean entropy	S1418
OMA	1	1.010	-	-		QHG55246
OrthoFinder	1	1.000	-	-		FOG0003811
OrthoInspector	1	1.000	-	-		oto99194
orthoMCL	1	0.900	-	-		OOG6_101393
Panther	1	1.100	-	-	O	PTHR43740
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1448
SonicParanoid	1	1.000	-	-		X2655
TreeFam	1	0.960	-	-
	16	15.740