DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LeuRS-m and EMB2369

DIOPT Version :9

Sequence 1:	NP_647932.1	Gene:	LeuRS-m / 38581	FlyBaseID:	FBgn0027085	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_192344.1	Gene:	EMB2369 / 825755	AraportID:	AT4G04350	Length:	973	Species:	Arabidopsis thaliana

Alignment Length:	931	Identity:	288/931 - (30%)
Similarity:	435/931 - (46%)	Gaps:	165/931 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 HRIEAHWREQLSGGQF--NPKD---SQDKYYVLSMFPYPSG-NLHMGHVRVYTIADSVARFQRMC 98
            |.||..|:......:.  .|.|   |:.|:|||.||||||| .||:||...||..|.:||.:||.
plant    88 HEIEPKWQRYWEDNRIFRTPDDVDTSKPKFYVLDMFPYPSGAGLHVGHPLGYTATDILARLRRMQ 152

  Fly    99 GKNVFQPMGWDSFGLPAENAANQRGVEPASWTEQNIAQMKEQLKRLGCSFDWNHELSTCSPKYYK 163
            |.||..|||||:||||||..|.:.|..|.:.|.:||.:.:.|||.||.|:||:.||||..|.|||
plant   153 GYNVLHPMGWDAFGLPAEQYAIETGTHPKTTTLKNIDRFRLQLKSLGFSYDWDRELSTTEPDYYK 217

  Fly   164 WTQHLFLMLHRHGLAYQNEALVNWDPVDKTVLADEQVDANGCSWRSGAKVEKKLLRQWFIRTSAY 228
            |||.:||.|::.|||||.|..|||.|...||||:|:| .:|.|.|.|..|.:|.:|||.::.:||
plant   218 WTQWIFLQLYKKGLAYQAEVPVNWCPALGTVLANEEV-VDGVSERGGHPVIRKPMRQWMLKITAY 281

  Fly   229 AKQLLDGLEDPTLRDWRDII-NLQRHWIGECDGYAFNL-LTSASGL-----LRVWTTHPEHLKDP 286
            |.:||:.|::   .:|.:.| .:||:|||..:|...|. :....|.     :.|:||.|:.|...
plant   282 ADRLLEDLDE---LEWPESIKEMQRNWIGRSEGAELNFSILDGEGRETDKEITVYTTRPDTLFGA 343

  Fly   287 HAFLVLRSNHHL-----------------------SKLKGAD----------SLSAANPFAGTTM 318
             .::|:...|.|                       |.|:..:          ...|.||..|..:
plant   344 -TYMVVAPEHQLLSYFVTAEQKQQVEEYKDFASRKSDLERTELQKDKTGVFTGCYAKNPANGDAI 407

  Fly   319 PVVFSDEVTFPPKSDVYLAAPSFRGEDKDLWDSY-----------------------GLAFTSNG 360
            |:..:|.|.....:...:|.|:....|.:....|                       ||....|.
plant   408 PIWVADYVLASYGTGAIMAVPAHDTRDNEFALKYNIPIKWVVRNEANSSDDAKQVYPGLGIIENS 472

  Fly   361 KDEESLSPANWEMLRKE----VLQAATRLNVGGYRVSSKLKDWLISRQRYWGTPIPIVHCQKCG- 420
            ...|:....| ::..||    |::.|.|...|..:|:.||:|||.:||||||.||||:...:.|
plant   473 STLETGLDIN-QLSSKEAALKVIEWAERTGNGKKKVNYKLRDWLFARQRYWGEPIPILILDESGE 536

  Fly   421 AVPVPEEQLPVSLP------------PKDSPKEAFLCDCPKCGEKDARRETDTMDTFVDSSWYYL 473
            .:.:.|.:||::||            |..|...:::........|.|:|||.||..:..|.||||
plant   537 TIAISESELPLTLPELNDFTPTGTGEPPLSKAVSWVNTVDPSTGKPAKRETSTMPQWAGSCWYYL 601

  Fly   474 RYLDAQNSERIFDTALTKKFMPVDLYIGGKEHAVLHLYYARFINHFLHSCGLSPTSEPFSRLLVQ 538
            |::|.:|.|.:.|....|.:.|||:|:||.|||||||.|:||.:..|:..|:..|.|||..::.|
plant   602 RFMDPKNPEALVDKEKEKYWSPVDVYVGGAEHAVLHLLYSRFWHKVLYDIGVVSTKEPFKCVINQ 666

  Fly   539 GMVMGR----SFRVKGSGRYVPETEVEIVNAKKNQAVLKETK------------EP---VVMTWE 584
            |:::|.    :::.: .|.||.....|.:| :..|..:.|.|            :|   ::....
plant   667 GIILGEVQYTAWKDQ-EGNYVSADTEERLN-EHQQVTIPEEKVIKSGDHFVLKEDPSIRLIPRVY 729

  Fly   585 KMSKSKLNGVEPSDMFNEYGTDTTRLIILADVAPTSHRNWSSATFPGILNWQKRLWLTLQDFQQA 649
            |||||:.|.|.|.|:..|||.|:.||..:........:.|:::...|:..:..|.|..:....|:
plant   730 KMSKSRGNVVNPDDVVLEYGADSLRLYEMFMGPFRDSKTWNTSGIEGVHRFLARTWRLVIGLPQS 794

  Fly   650 ----REDQTASDVVPTSEEFLAED---AKLFDARNFYVKGATFNYRHAQQLSVAISKMQGLTNSL 707
                ::....:|..||.|:.....   ||:.:.    ::...||        ..||.|....|:
plant   795 DGSFKDGTLVTDDEPTLEQLRTLHKCIAKVTEE----IESTRFN--------TGISGMMEFVNA- 846

  Fly   708 RRTPKHVLRHGKQFERALAAQIIMLAPMAPHFASELWSKFVAIPGRLNPASQELQWSEDVLAQRW 772
                  ..:...|....:...:::|:|.|||.|.||||:.    |..|..:.|          .:
plant   847 ------AYKWNNQPRGIIEPFVLLLSPYAPHMAEELWSRL----GHPNSLAYE----------SF 891

  Fly   773 PDIDPAY----NLDLSIKVNGFENCVIKVQRTHLDKVTHSDALDIAFNTESVTSYLIDKKIRTTN 833
            |..:|.|    .:.|.:::||.....|:|:    :..:..||..:|...:.:..||..:.|:...
plant   892 PKANPDYLKNTTIVLPVQINGKTRGTIEVE----EGCSEDDAFVLASQDDKLRKYLDGQSIKKRI 952

  Fly   834 FVLYPGIEAILNIYVDKAKMK 854
            :|  ||  .|||:.:|:..:|
plant   953 YV--PG--KILNVILDRTNVK 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS-m	NP_647932.1	leuS	40..848	CDD:234743	286/923 (31%)
		LeuRS_core	63..624	CDD:173906	228/660 (35%)
		Anticodon_Ia_like	624..747	CDD:299868	28/129 (22%)
		Anticodon_Ia_like	<723..799	CDD:299868	21/79 (27%)
EMB2369	NP_192344.1	PLN02563	6..970	CDD:178177	288/931 (31%)
		LeuRS_core	116..>307	CDD:173906	100/194 (52%)
		tRNA-synt_1_2	303..498	CDD:290334	36/196 (18%)
		nt_trans	<730..766	CDD:294020	15/35 (43%)
		Anticodon_Ia_Leu_BEm	769..880	CDD:153412	28/129 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	154	1.000	Domainoid score	I1358
eggNOG	1	0.900	-	-		E1_COG0495
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6526
Inparanoid	1	1.050	370	1.000	Inparanoid score	I566
OMA	1	1.010	-	-		QHG55246
OrthoDB	1	1.010	-	-		D375759at2759
OrthoFinder	1	1.000	-	-		FOG0003811
OrthoInspector	1	1.000	-	-		oto3044
orthoMCL	1	0.900	-	-		OOG6_101393
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2655
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.740