Protein Alignment LeuRS-m and LARS1

DIOPT Version :9

• Sequence 1: NP_647932.1
• Gene: LeuRS-m / 38581
• FlyBaseID: FBgn0027085
• Length: 869
• Species: Drosophila melanogaster
• Sequence 2: NP_064502.9
• Gene: LARS1 / 51520
• HGNCID: 6512
• Length: 1176
• Species: Homo sapiens
• Alignment Length: 1088
• Identity: 188/1088 - (17%)
• Similarity: 316/1088 - (29%)
• Gaps: 441/1088 - (40%)

  Fly    38 VKHRIEAHWRE----QLSGGQFNPKDSQDKYYVLSMFPYPSGNLHMGHVRVYTIADSVARFQRMC 98
            ::..|:..|..    :::......:.|:.||:|...:||.:|.||:||....:..:....:||:.
Human    16 IEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLK 80

  Fly    99 GKNVFQPMGWDSFGLPAE----------------------------------------------- 116
            ||....|.|....|:|.:
Human    81 GKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKS 145

  Fly   117 NAANQRGVEPASW--------TEQNIAQMKE--------------QLKRLGCSFDWNHELST--C 157
            .||.:.|.....|        :::.|.:..|              .|||:|...||.....|  .
Human   146 KAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDV 210

  Fly   158 SPKYYKWTQHLFLMLHRH----------------------------------------------- 175
            :|.|..:.:..||.|...
Human   211 NPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPY 275

  Fly   176 -----GLAYQNEALVN--------------WDPVDKTVLADEQVDANGCSWRSGAKVEKKLLRQW 221
                 ||..:|..||.              |...|...:..|.|  ||..:....|..:.:..|.
Human   276 PSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETV--NGDIFICTQKAARNMSYQG 338

  Fly   222 FIRTSA--------YAKQLLDGLEDPTLRDWRDIINLQRHWIGECDGYAFNLLT----SASGLLR 274
            |.:.:.        ..:::|.......|..::.|             |...:||    ..:|::
Human   339 FTKDNGVVPVVKELMGEEILGASLSAPLTSYKVI-------------YVLPMLTIKEDKGTGVV- 389

  Fly   275 VWTTHPEHLKDPHAFL-------VLRSNHHLS-------------KLKGADSLSAANPFAGTTMP 319
              |:.|....|..|.|       .||:.:.:.             ::.|..:|||
Human   390 --TSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSA---------- 442

  Fly   320 VVFSDEVTFPPKSD----------VYL--------AAPSFRGE---------DKDLWDSYGLAFT 357
            |...||:....::|          :||        ....|:|:         .|.:.|: |.|..
Human   443 VTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDA-GDALI 506

  Fly   358 SNGKDEESLSPA-------------------NWEMLRKEVLQ------AATRLNVG---GYRVSS 394
            ....:::.:|.:                   ||:....:.|:      ..||.|..   |:
Human   507 YMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGW---- 567

  Fly   395 KLKDWLISRQRYWGTPIP---------------------IVHCQKCGAVPVPEEQLPVSLPPKDS 438
             |::...||....||.:|                     :.|..:.|.:....|. |:.:.|:..
Human   568 -LQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAES-PLGIRPQQM 630

  Fly   439 PKE----AFLCDCPKCGEKDARRETDTMDTFVDSSWYYLRYLDAQNSERIFDTALTKKFMPVDLY 499
            .||    .|..:.|....:.|:.:.|.:....: .||                       ||||.
Human   631 TKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFE-FWY-----------------------PVDLR 671

  Fly   500 IGGKEHAVLHLYYARFINH---FLHSCGLSPTSEPFSRLLVQGMVMGRSFRVKGSGRYVPETEVE 561
            :.||:....||.|..: ||   :.......||:                  |:.:|.
Human   672 VSGKDLVPNHLSYYLY-NHVAMWPEQSDKWPTA------------------VRANGH-------- 709

  Fly   562 IVNAKKNQAVLKETKEPVVMTWEKMSKSKLNGVEPSDMFNEYGTDTTRLIILADVAPT-SHRNWS 625
                             :::..||||||..|.:..:...:::..|..|| .|||...| ...|:.
Human   710 -----------------LLLNSEKMSKSTGNFLTLTQAIDKFSADGMRL-ALADAGDTVEDANFV 756

  Fly   626 SA-TFPGIL------NWQKRL---WLTLQDFQQAREDQTASDVVPTSEEFLAEDAKLFDARNFYV 680
            .| ...|||      .|.|.:   |    |..::....|.:|.|..||    .:|.:......|.
Human   757 EAMADAGILRLYTWVEWVKEMVANW----DSLRSGPASTFNDRVFASE----LNAGIIKTDQNYE 813

  Fly   681 KGATFNYRHAQQLSVAISKMQGLTNSLRRTPKHVLRHGKQFERALAAQIIMLAPMAPHFASELWS 745
            |   ..::.|  |.....:.|...:..|......: |.:...|.:..|.::|||..||....:|:
Human   814 K---MMFKEA--LKTGFFEFQAAKDKYRELAVEGM-HRELVFRFIEVQTLLLAPFCPHLCEHIWT 872

  Fly   746 KFVAIPGRLNPASQELQWSEDVLAQRWPDIDPAYNLDLSIKVNGFENCVIKVQRTHLDKVTHSDA 810
                :.|:          .:.::...||             |.|..|.|:.....:|.:|||
Human   873 ----LLGK----------PDSIMNASWP-------------VAGPVNEVLIHSSQYLMEVTH--- 907

  Fly   811 LDIAFNTESVTSYLIDKKIRTTNFVLYPGIEAILNIYVDKAKMKQKPP 858
                           |.::|..|::: |.          |.|...|.|
Human   908 ---------------DLRLRLKNYMM-PA----------KGKKTDKQP 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS-m	NP_647932.1	leuS	40..848	CDD:234743	184/1074 (17%)
		LeuRS_core	63..624	CDD:173906	136/813 (17%)
		Anticodon_Ia_like	624..747	CDD:299868	29/132 (22%)
		Anticodon_Ia_like	<723..799	CDD:299868	15/75 (20%)
LARS1	NP_064502.9	tRNA-synt_1g	5..1062	CDD:330949	188/1088 (17%)
		'HIGH' region	53..63		5/9 (56%)
		Editing domain	260..509		44/277 (16%)
		'KMSKS' region	716..720		3/3 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0495
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900