Protein Alignment LeuRS-m and ValRS

DIOPT Version :10

• Sequence 1: NP_647932.1
• Gene: LeuRS-m / 38581
• FlyBaseID: FBgn0027085
• Length: 869
• Species: Drosophila melanogaster
• Sequence 2: NP_001260946.1
• Gene: ValRS / 45783
• FlyBaseID: FBgn0027079
• Length: 1055
• Species: Drosophila melanogaster
• Alignment Length: 969
• Identity: 181/969 - (18%)
• Similarity: 301/969 - (31%)
• Gaps: 298/969 - (30%)

  Fly    42 IEAHW-----REQLSGGQFNPK---------DSQDKYYVLSMFPYPSGNLHMGHVRVYTIADSVA 92
            :||.|     :|    |.|.|:         :...|:.::...|..:|:||:||.....|.|::.
  Fly    99 VEAQWYSWWEKE----GFFTPEYGRASIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAIT 159

  Fly    93 RFQRMCGKNVFQPMGWDSFGLPAENAANQRGVEPASWTEQNIA---------------------- 135
            |:.||.|:......|.|..|:     |.|..||...|.::.::
  Fly   160 RYHRMKGRTTLWVPGCDHAGI-----ATQVVVEKLLWRDEKLSRHDLGREKFIERIWDWRREKGG 219

  Fly   136 QMKEQLKRLGCSFDWNHELSTCSPKYYKWTQHLFLMLHRHGLAYQNEALVNWDPVDKTVLADEQV 200
            ::.||||.||.|:||.....|..||..:.....|:.||..|..|::..||||....::.::|.:|
  Fly   220 RIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEV 284

  Fly   201 DANGCSWRSGAKVEKKLLRQWFIRTSAYAKQLLDGLEDPTLRDWRDIINLQRHWIGECDGYAFNL 265
            |          |||  :..:.|:....|.    |.:|                 .|....:|:.:
  Fly   285 D----------KVE--IPGRTFLSIPGYE----DKVE-----------------FGVLIKFAYKV 316

  Fly   266 LTSASGLLRVWTTHPEHLKDPHAFLVLRSNHHLSKLKGADSLSAANPFAGTTMPVVFSDEVTFPP 330
            ..|...:: |.||..|.:....|..|...:.....|.|.   ...:||:...:|:|..:.|....
  Fly   317 EGSDEEII-VATTRIETMLGDTAVAVHPQDDRYKHLHGK---FVVHPFSTRRLPIVCDEFVDMAF 377

  Fly   331 KSDVYLAAPSFRGEDKDLWDSYGLAF--------------------------------------- 356
            .:......|:....|.::.....|.|
  Fly   378 GTGAVKITPAHDPNDYEVGKRCNLPFITIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLY 442

  Fly   357 ------------TSNGKD-EESLSPANWEMLRKEVLQAATRLNVGG-------------YRVSSK 395
                        .|..|| .|.|....|.:...::..:||.....|             |.....
  Fly   443 RETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSDMAASATEAVRSGELKIIPEHHTKTWYHWMDG 507

  Fly   396 LKDWLISRQRYWGTPIPIVH-----------CQKCGAVPVPEEQLPVSLPPKDS---PKEAFLCD 446
            ::||.:|||.:||..||..|           ....|:|...|:...|:....::   ..|.|..|
  Fly   508 IRDWCVSRQLWWGHRIPAYHVSFTDPSLQTGSSAHGSVNDDEQYWIVARSEAEALTKAAERFGVD 572

  Fly   447 CPKCGEKDARRETDTMDTFVDSSWYYLRYLDAQNSERIFDTALTKKFMPVDLYIGGKEHAVLHLY 511
            ..|...|   ::.|.:||:..|..:........:..:...|     |.|..|...|  |.:|..:
  Fly   573 ASKIVLK---QDEDVLDTWFSSGIFPFSVFGWPDQTKDLQT-----FYPTSLLETG--HDILFFW 627

  Fly   512 YARFINHFLHSCGLSPTSEPFSRLLVQGMVMGRSFRVKGSGRYVPETEVEIVNAKKNQAVLKETK 576
            .||.:.......|..|..|.:...:|:          ...||
  Fly   628 VARMVFFGQKLLGKLPFKEVYLHPMVR----------DAHGR----------------------- 659

  Fly   577 EPVVMTWEKMSKSKLNGVEPSDMFN-------------------------------------EYG 604
                    |||||..|.::|.|:..                                     |.|
  Fly   660 --------KMSKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECG 716

  Fly   605 TDTTRLIILADVAPTSHRNWSSATFPGILNWQKRLW-------LTLQDFQQAREDQTASDVVPTS 662
            :|..|..:.|.:......|.......|...:..:||       |.....::...:.:||..:...
  Fly   717 SDALRFALCAYITQARDINLDINRVLGYRFFCNKLWNATKFALLYFTGSEKFDTELSASAAINQM 781

  Fly   663 EEF-LAEDAKLFDARNFYVKGATFNYRHAQQLSVAIS-KMQGLTNSLRRTPKHVLRHGKQFERAL 725
            :.: |:..|...:|.|...:    :|..|...|...: .:..|.:......|.:.:.|.:.::..
  Fly   782 DAWILSRLAAAIEACNTGFE----SYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGSEEQQTA 842

  Fly   726 AAQII---------MLAPMAPHFASELWSKFVAIPGRLNPA--------SQELQWSEDVLAQRWP 773
            |.:.:         :|:|..|....||:.:   :| |.|||        .....|....:.....
  Fly   843 ARRTLYVCLDYGLRLLSPFMPFITEELYQR---LP-RANPAPSICVASYPSNTSWRSTKIESDVE 903

  Fly   774 DIDPA----------YNLDLSIKVNGFENCVIKV-----QRTHLDKVTHSDALDIAFNT 817
            .:..|          |||...:|...:..|...|     :|...|..|.|...::.|::
  Fly   904 FVQKAARIIRSARSDYNLPNKVKTEVYIVCTDSVPSEILKRYASDLATISYCSNVVFDS 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS-m	NP_647932.1	LeuS	40..848	CDD:440261	181/969 (19%)
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	181/969 (19%)