DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LeuRS-m and MetRS-m

DIOPT Version :9

Sequence 1:	NP_647932.1	Gene:	LeuRS-m / 38581	FlyBaseID:	FBgn0027085	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_001262564.1	Gene:	MetRS-m / 41733	FlyBaseID:	FBgn0027083	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	748	Identity:	135/748 - (18%)
Similarity:	229/748 - (30%)	Gaps:	302/748 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GGQFNPKDSQDKYYVLSMFPYPSGNLHMGHVRVYTIADSVARFQRM--CGKNVFQPMGWDSFGLP 114
            |.::|     ..:||.:...|.:...|:||:....|||:..|:||:  ..::|....|.|..|..
  Fly    13 GTRYN-----SSHYVTTPIFYVNAAPHIGHLYSAVIADAHCRYQRLRYPEQDVRLCTGTDEHGTK 72

  Fly   115 AENAANQRGVEPASWTEQNIAQMKEQLKRLGCSFDWNHELSTCSPKYYKWTQHLFLMLHRHGLAY 179
            .:.||:..||..|.:.: :|:|...::.| ..|...:..:.|...::.:...:.:..||..|..|
  Fly    73 IQQAASLHGVPVAKYCD-DISQRYREVFR-SASIQQDDFIRTTEDRHKRAVANFWRTLHTRGHIY 135

  Fly   180 QNEALVNWDPV-DKTVLADEQV---DANGC--SWRSGAKVEKKLLRQWFIRTSAYAKQLLDGLED 238
             :.|...|..| |:|.|.|.|:   :|.|.  |..||..||      |...|:...:
  Fly   136 -SAAYSGWYCVSDETFLTDSQLRLDEATGTRYSLESGHPVE------WTEETNYMFR-------- 185

  Fly   239 PTLRDWRDIINLQRHWIGECDGYAFNLLTSASGLLRVWTTHPEHLKDPHAFLVLRSNHHLSKLKG 303
              |..::|.:   |||:
  Fly   186 --LSQFQDDV---RHWV------------------------------------------------ 197

  Fly   304 ADSLSAANPFAGTTMPVVFSDEVTFPPKSDVYLAAPSFRGEDKDLWDSYGLAFTSNGKDEESLSP 368
                                                                     |.|..:.|
  Fly   198 ---------------------------------------------------------KTEARVRP 205

  Fly   369 ANWEMLRKEVLQAATRLNVGGYRVSSKLKDWLISRQRYWGTPIPIVHCQKCGAVPVPEEQLPVSL 433
            |.:|.:..:.|             |..|.|..:||      |...||    .|:|||::
  Fly   206 AKFEKILLDTL-------------SEPLPDVSVSR------PSNRVH----WAIPVPDD------ 241

  Fly   434 PPKDSPKEAFLCDCPKCGEKDARRETDTMDTFVDSSWYYLRYLDAQNSERIFDTALTKKFMPVDL 498
                                    ::.|:..::|:...||      :|....|...:..:.|...
  Fly   242 ------------------------DSQTVYVWLDALVNYL------SSVGYPDEKFSAHWPPAQQ 276

  Fly   499 YIGGKEHAVLH-LYYARFINHFLHSCGLSPTSEPF--SRLLVQGMVMGRSFRVKGSGRYVPETEV 560
            .| ||:....| :|:..    ||.:.||.|..:.:  |...|.|
  Fly   277 VI-GKDILKFHGIYWTA----FLLAAGLEPPGQLYVHSHWTVDG--------------------- 315

  Fly   561 EIVNAKKNQAVLKETKEPVVMTWEKMSKSKLNGVEPSDMFNEYGTDTTRLIILADVAPTSHRNWS 625
                                   :||||||.|.|:|.....:|..:..|..:|.:....|..|:|
  Fly   316 -----------------------QKMSKSKHNVVDPLQAAQQYTMEGLRYFLLREGVAHSDGNYS 357

  Fly   626 SATFPGILNWQKRLWLTLQDF--QQAREDQTASDVVPT-SEEFLA------------EDAKL--- 672
            ......|||  ..|..||.:.  :.:.:......:.|: |.|.||            :|:.|
  Fly   358 HVKAQRILN--SELADTLGNLLSRASAKSLNPGQIYPSPSAEHLADLLRSLDVAKRLQDSLLQLS 420

  Fly   673 ------FDARNFYVKGATFNYRHAQQLSVAISKMQGLTNSLRRTPKHVLRHG------KQFERAL 725
                  ::..:|::...|           .::.:....|....:....|:.|      .:.|..:
  Fly   421 ERCESHYECNHFHLVADT-----------TMAALHAANNFFESSKPWTLKAGAPDGNQARLETII 474

  Fly   726 AAQI-------IMLAPMAPHFASELWSKFVAIP 751
            |..:       |:|.|:.|..|:.|..| :::|
  Fly   475 AMTMDALRLSGIVLQPIIPQLANRLLDK-LSVP 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS-m	NP_647932.1	leuS	40..848	CDD:234743	135/748 (18%)
		LeuRS_core	63..624	CDD:173906	103/571 (18%)
		Anticodon_Ia_like	624..747	CDD:299868	27/159 (17%)
		Anticodon_Ia_like	<723..799	CDD:299868	9/36 (25%)
MetRS-m	NP_001262564.1	MetRS_core	20..356	CDD:173907	103/570 (18%)
		PRK11893	21..553	CDD:237012	133/735 (18%)
		Anticodon_Ia_like	365..503	CDD:299868	26/151 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446767
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840