DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LeuRS-m and Lars2

DIOPT Version :9

Sequence 1:	NP_647932.1	Gene:	LeuRS-m / 38581	FlyBaseID:	FBgn0027085	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	XP_006244263.1	Gene:	Lars2 / 363172	RGDID:	1308429	Length:	902	Species:	Rattus norvegicus

Alignment Length:	820	Identity:	350/820 - (42%)
Similarity:	471/820 - (57%)	Gaps:	74/820 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 WRRLLTQSCTRND-------NPELTSDVKHRIEAHWREQL--SGGQFNPKDS-QDKYYVLSMFPY 72
            |.|:: ..|:|:.       ..|.|...:..:|..|.:|:  ...:.:.:|. :.|:|:||||||
  Rat    28 WERII-PGCSRSIYSATGKWTKEYTLQTRKDVEKWWHQQIKVQASKISEEDKLKPKFYLLSMFPY 91

  Fly    73 PSGNLHMGHVRVYTIADSVARFQRMCGKNVFQPMGWDSFGLPAENAANQRGVEPASWTEQNIAQM 137
            |||.||||||||||::|::||||:|.|..|..|||||:|||||||||.:|.:.|.|||:.||..|
  Rat    92 PSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIKHM 156

  Fly   138 KEQLKRLGCSFDWNHELSTCSPKYYKWTQHLFLMLHRHGLAYQNEALVNWDPVDKTVLADEQVDA 202
            ::||.|||..|.|:.|::||.|.||||||:||:.|:..|||||.||||||||||:||||:|||:.
  Rat   157 RKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVNE 221

  Fly   203 NGCSWRSGAKVEKKLLRQWFIRTSAYAKQLLDGLEDPTLRDWRDIINLQRHWIGECDGYAFNLLT 267
            .|||||||||||||.||||||:|:||||.:.|.|.|  |.:|..|..:|.||||:|.|...:...
  Rat   222 YGCSWRSGAKVEKKYLRQWFIKTTAYAKAMQDALAD--LPEWYGIKEMQAHWIGDCVGCHLDFTL 284

  Fly   268 SASG-----LLRVWTTHPE------H--LKDPHAFLVLRSNHHLSKLK---------GADSLS-- 308
            ...|     .|..:|..||      |  :...|..|     |..|.||         |.|.|:
  Rat   285 KVDGQDTGEKLTAYTATPEAIYGISHVAISPSHGLL-----HGCSSLKTALQKALVPGRDCLTPV 344

  Fly   309 -AANPFAGTTMPVVFSDEVTFPPKSDVYLAAPSFRGEDKDLWDSYGLAFTS------NGKDEESL 366
             |.|......:|||...:.......|..:..||...||..|..:.||.::.      :|.:..|.
  Rat   345 MAVNMLTLQEVPVVIMAKPDLEGSLDSKIGIPSTSSEDTRLAQALGLPYSEVIETSPDGTERLSG 409

  Fly   367 SPANWEMLRKEVLQAATR----LNVGGYRVSSKLKDWLISRQRYWGTPIPIVHCQKCGAVPVPEE 427
            |.....|.|::...|.||    :.|||:..|:||||||:|||||||||||||||..||.||||.:
  Rat   410 SAEFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWLVSRQRYWGTPIPIVHCPACGPVPVPLQ 474

  Fly   428 QLPVSLP-----------PKDSPKEAFLCDCPKCGEKDARRETDTMDTFVDSSWYYLRYLDAQNS 481
            .|||:||           |..|..|...|.||:| :..|:||||||||||||:|||.||.|..|:
  Rat   475 DLPVTLPSITSLTGRGGSPLASALEWVNCSCPRC-KGSAKRETDTMDTFVDSAWYYFRYTDPHNT 538

  Fly   482 ERIFDTALTKKFMPVDLYIGGKEHAVLHLYYARFINHFLHSCGLSPTSEPFSRLLVQGMVMGRSF 546
            ...|.:||...:||||||||||||||:||:||||.:||.|...:....|||.:||.||::.|::|
  Rat   539 HSPFSSALADFWMPVDLYIGGKEHAVMHLFYARFFSHFCHRQKMVKHREPFHKLLAQGLIKGQTF 603

  Fly   547 RVKGSGRYVPETEVEIVNAKKNQAVLKETKEPVVMTWEKMSKSKLNGVEPSDMFNEYGTDTTRLI 611
            .:. ||:.:...:::....   ..|..:|||.:.:|||||||||.|||:|.::..:||.||.||.
  Rat   604 HLL-SGQCLKREDIDFTGP---TPVCAKTKERLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLY 664

  Fly   612 ILADVAPTSHRNWSSAT--FPGILNWQKRLWLTLQDFQQAREDQTASDVVPTSEEFLAEDAKLFD 674
            ||....|.....|...|  .||:|.||:|||.....|.:||...||......:.:..|:...|::
  Rat   665 ILFAAPPEKDILWDVKTDALPGVLRWQQRLWSLTTRFIEARTSGTAPQPQLLNNKEKAKARSLWE 729

  Fly   675 ARNFYVKGATFNYRHAQQLSVAISKMQGLTNSLRRTPKHVLRHGKQFERALAAQIIMLAPMAPHF 739
            .:|..:...|.::.....|:..:|::.||:.:|.:..:.::.|..:||.||.|.::|.||:|||.
  Rat   730 YKNAVITQVTTHFTEDFALNSVVSQLMGLSGALSQASQRLVLHSPEFEDALCALLVMAAPLAPHI 794

  Fly   740 ASELWSKFVAIPGRLNPASQELQWSEDVLAQRWPDIDPAY 779
            .||||:....:|.:|   .....|...|:.|.||.:|..:
  Rat   795 TSELWAGLALVPSKL---CDRYAWDAGVMLQAWPTVDSQF 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS-m	NP_647932.1	leuS	40..848	CDD:234743	344/791 (43%)
		LeuRS_core	63..624	CDD:173906	292/606 (48%)
		Anticodon_Ia_like	624..747	CDD:299868	40/124 (32%)
		Anticodon_Ia_like	<723..799	CDD:299868	21/57 (37%)
Lars2	XP_006244263.1	leuS	56..901	CDD:234743	344/791 (43%)
		LeuRS_core	82..677	CDD:173906	292/606 (48%)
		tRNA-synt_1_2	270..429	CDD:290334	42/163 (26%)
		Anticodon_Ia_Leu_BEm	677..802	CDD:153412	40/124 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353490
Domainoid	1	1.000	209	1.000	Domainoid score	I2755
eggNOG	1	0.900	-	-		E1_COG0495
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6526
Inparanoid	1	1.050	629	1.000	Inparanoid score	I811
OMA	1	1.010	-	-		QHG55246
OrthoDB	1	1.010	-	-		D142174at33208
OrthoFinder	1	1.000	-	-		FOG0003811
OrthoInspector	1	1.000	-	-		oto96071
orthoMCL	1	0.900	-	-		OOG6_101393
Panther	1	1.100	-	-	LDO	PTHR43740
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2655
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810