DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LeuRS-m and Lars1

DIOPT Version :9

Sequence 1:	NP_647932.1	Gene:	LeuRS-m / 38581	FlyBaseID:	FBgn0027085	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_001009637.1	Gene:	Lars1 / 291624	RGDID:	1304962	Length:	1178	Species:	Rattus norvegicus

Alignment Length:	1119	Identity:	195/1119 - (17%)
Similarity:	337/1119 - (30%)	Gaps:	403/1119 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ELTSDVKHRIEAHWREQLSGGQF--NPKDSQDKYYVLSMFPYPSGNLHMGHVRVYTIADSVARFQ 95
            ::..:|:.:.||....::|....  ..:.|:.||:|...:||.:|.||:||....:..:....:|
  Rat    15 KIEKEVQQKWEAEKVFEVSASSLEKQKQSSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQ 79

  Fly    96 RMCGKNVFQPMGWDSFGLPAE-------------------------------------------- 116
            |:.||:...|.|....|:|.:
  Rat    80 RLKGKSCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPEEEEEEEESSAKPGDIVMKDKAKG 144

  Fly   117 ---NAANQRGVEPASW--------TEQNIAQMKE--------------QLKRLGCSFDWNHELST 156
               .||.:.|.....|        ::::||:..|              .||::|...||.....|
  Rat   145 KKSKAAAKAGSSKYQWNIMKSLGLSDEDIAKFSEAEHWLDYFPPLAVQDLKKIGLKVDWRRSFIT 209

  Fly   157 --CSPKYYKWTQHLFLMLHRHGLAYQNEALVNWDPVDKTVLAD-EQVDANGCSWRSGAKVEKKLL 218
              .:|.|..:.:..||.|.........:....:.|.|.....| ::....|...:....|:.|:|
  Rat   210 TDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLVKLKVL 274

  Fly   219 RQW------------------------FIRTSAYAKQLLD--GLEDP-------TLRDWRD---- 246
            ..:                        |.:|:.:.:..:.  |.|..       |.|..|:
  Rat   275 DPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETANGDIFICTQRAARNMSYQ 339

  Fly   247 -------IINLQRHWIGE------------CDG--YAFNLLT----SASGLLRVWTTHPEHLKDP 286
                   ::.:.:..:||            |..  |...:||    ..:|::   |:.|.  ..|
  Rat   340 GFTKHNGVVPVVKELMGEEILGASLSAPLTCYKVIYVLPMLTIKEDKGTGVV---TSVPS--DSP 399

  Fly   287 HAFLVLRSNHHLSKLKGADSLSAAN------------------PFAGTTMPVVFSDEVTFPPKSD 333
            ..|..||.      ||...:|.|..                  |..|....|...||:....::|
  Rat   400 DDFAALRD------LKKKQALRAKYAVRDDMVLPFEPVPVLEIPGIGNLPAVTVCDELKIQSQND 458

  Fly   334 ----------VYL--------AAPSFRGE---------DKDLWDSYGLAFTSNGKDEESLSPA-- 369
                      :||        ....|:|:         .|::.|: |.|......:::.:|.:
  Rat   459 REKLAEAKEKLYLRGFYDGVMLVDGFKGQKIQHVKKTIQKNMIDA-GDALIYMEPEKQVVSRSAD 522

  Fly   370 -----------------NWEMLRKEVLQAATRLNVGGYRVSSKLK-----DWL----ISRQRYWG 408
                             ||   :|:..|...  |:..:...|:..     |||    .||....|
  Rat   523 ECVVALCDQWYLDYGDENW---KKQTFQCLK--NMETFCEESRKNFEASLDWLQEHACSRTYGLG 582

  Fly   409 TPIP---------------------IVHCQKCGAVPVPEEQLPVSLPPKDSPKE----AFLCDCP 448
            |.:|                     :.|..:.|.:....|. |:.:.|:...::    .|..|.|
  Rat   583 TRLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGDLQGQAES-PLGIRPQQMTRDVWDYVFFKDAP 646

  Fly   449 KCGEKDARRETDTMDTFVDSSWYYLRYLDAQNSERIFDTALTKKFMPVDLYIGGKEHAVLHLYYA 513
            ....:..:.:.|.:....: .||                       ||||...||:....||.|.
  Rat   647 FPKTQIPKEKLDQLKQEFE-FWY-----------------------PVDLRASGKDLIPNHLSYY 687

  Fly   514 RFINHFLHSCGLSPTSE---PFSRLLVQGMVMGRSFRVKGSGRYVPETEVEIVNAKKNQAVLKET 575
            .: ||    ..:.|...   |.|              |:.:|.
  Rat   688 IY-NH----VAMWPEQSDKWPVS--------------VRANGH---------------------- 711

  Fly   576 KEPVVMTWEKMSKSKLNGVEPSDMFNEYGTDTTRLIILADVAPT-SHRNWSSA-TFPGIL----- 633
               :::..||||||..|.:..|...:::..|..|| .|||...| ...|:..| ...|||
  Rat   712 ---LLLNSEKMSKSTGNFLTLSQAVDKFSADGMRL-ALADAGDTVEDANFVEAMADAGILRLYTW 772

  Fly   634 -NWQKRLWLTLQDFQQAREDQTASDVVPTSEEFLAEDAKLFDARNFYVKGATFNYRHAQQLSVAI 697
             .|.|.:.......:....: :.:|.|..||    .:|.:......|.|   ..::.|  |....
  Rat   773 VEWVKEMLANCSSLRSGPAN-SFNDRVFASE----MNAGIIKTDQNYEK---MMFKEA--LKTGF 827

  Fly   698 SKMQGLTNSLRRTPKHVLRHGKQFERALAAQIIMLAPMAPHFASELWSKFVAIPGRLNPASQELQ 762
            .:.|...:..|......: |.:...|.:..|.|:|.|..||....:|:    :.|:
  Rat   828 FEFQAAKDKYRELATEGM-HRELVFRFIEVQTILLTPFCPHLCEHIWT----LLGK--------- 878

  Fly   763 WSEDVLAQRWPDIDP---------------AYNLDLSIK---------------VNGFENCVIKV 797
             .:.::...||...|               |::|.|.:|               |....:|.|.|
  Rat   879 -PDSIMHASWPVAGPVDESLIRSSQYLMEVAHDLRLRLKNYMTPAKGKKTDKQPVQRPSHCTIYV 942

  Fly   798 QRT-----HLDKVTHSDALDIAFNTESVTSYLIDKKIRTTNFVLYPGIEAILN-----IYVDKAK 852
            .:.     |:...|      :..:.|:....|.|.|:........|.::..:.     :.:.|..
  Rat   943 AKNYPVWQHITLTT------LRSHFEANNGKLPDNKVIACELGSLPELKKYMKKVMPFVAMIKEN 1001

  Fly   853 MKQKPPTTDDAEAQ 866
            |::|.|...|.|.:
  Rat  1002 MEKKGPRVLDLELE 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS-m	NP_647932.1	leuS	40..848	CDD:234743	188/1092 (17%)
		LeuRS_core	63..624	CDD:173906	138/796 (17%)
		Anticodon_Ia_like	624..747	CDD:299868	26/129 (20%)
		Anticodon_Ia_like	<723..799	CDD:299868	20/105 (19%)
Lars1	NP_001009637.1	PLN02959	5..1064	CDD:215518	195/1119 (17%)
		nt_trans	47..>231	CDD:294020	36/183 (20%)
		LeuRS_core	<527..759	CDD:173906	57/306 (19%)
		Anticodon_Ia_Leu_AEc	757..876	CDD:153413	26/133 (20%)
		Anticodon_Ia_like	<858..907	CDD:299868	10/62 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0495
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900