Protein Alignment LeuRS-m and LARS2

DIOPT Version :10

• Sequence 1: NP_647932.1
• Gene: LeuRS-m / 38581
• FlyBaseID: FBgn0027085
• Length: 869
• Species: Drosophila melanogaster
• Sequence 2: NP_056155.1
• Gene: LARS2 / 23395
• HGNCID: 17095
• Length: 903
• Species: Homo sapiens
• Alignment Length: 816
• Identity: 362/816 - (44%)
• Similarity: 479/816 - (58%)
• Gaps: 65/816 - (7%)

  Fly    18 WRRLLTQSCTRND-------NPELTSDVKHRIEAHWREQL--SGGQFNPKD-SQDKYYVLSMFPY 72
            |.|.:...|||:.       ..|.|...:..:|..|.:::  ...:.:..| |:.|:||||||||
Human    28 WERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPY 92

  Fly    73 PSGNLHMGHVRVYTIADSVARFQRMCGKNVFQPMGWDSFGLPAENAANQRGVEPASWTEQNIAQM 137
            |||.|||||||||||:|::||||:|.|..|..|||||:|||||||||.:|.:.|.|||:.||..|
Human    93 PSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHM 157

  Fly   138 KEQLKRLGCSFDWNHELSTCSPKYYKWTQHLFLMLHRHGLAYQNEALVNWDPVDKTVLADEQVDA 202
            ::||.|||..|.|:.|::||.|.||||||:||:.|:..|||||.||||||||||:||||:||||.
Human   158 RKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDE 222

  Fly   203 NGCSWRSGAKVEKKLLRQWFIRTSAYAKQLLDGLEDPTLRDWRDIINLQRHWIGECDG----YAF 263
            :|||||||||||:|.||||||:|:||||.:.|.|.|  |.:|..|..:|.||||:|.|    :..
Human   223 HGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALAD--LPEWYGIKGMQAHWIGDCVGCHLDFTL 285

  Fly   264 NLLTSASG-LLRVWTTHPEHLKDPHAFLVLRSNHHL----SKLK---------GADSLS---AAN 311
            .:...|:| .|..:|..||.:... :.:.:..:|.|    |.||         |.|.|:   |.|
Human   286 KVHGQATGEKLTAYTATPEAIYGT-SHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVN 349

  Fly   312 PFAGTTMPVVFSDEVTFPPKSDVYLAAPSFRGEDKDLWDSYGLAFTS------NGKDEESLSPAN 370
            ......:|||...:.......|..:..||...||..|..:.|||::.      :|.:..|.|...
Human   350 MLTQQEVPVVILAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEF 414

  Fly   371 WEMLRKEVLQAATR----LNVGGYRVSSKLKDWLISRQRYWGTPIPIVHCQKCGAVPVPEEQLPV 431
            ..|.|::...|.|:    ..|||...|.||||||||||||||||||||||..||..|||.|.|||
Human   415 TGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPV 479

  Fly   432 SL-----------PPKDSPKEAFLCDCPKCGEKDARRETDTMDTFVDSSWYYLRYLDAQNSERIF 485
            :|           ||.....|...|.||:| :..|:||||||||||||:|||.||.|..|....|
Human   480 TLPNIASFTGKGGPPLAMASEWVNCSCPRC-KGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPF 543

  Fly   486 DTALTKKFMPVDLYIGGKEHAVLHLYYARFINHFLHSCGLSPTSEPFSRLLVQGMVMGRSFRVKG 550
            :||:...:||||||||||||||:||:||||.:||.|...:....|||.:||.||::.|::||:.
Human   544 NTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLP- 607

  Fly   551 SGRYVPETEVEIVNAKKNQAVLKETKEPVVMTWEKMSKSKLNGVEPSDMFNEYGTDTTRLIILAD 615
            ||:|:...||::..:....|   :|||.:.:|||||||||.|||:|.::..:||.||.||.||..
Human   608 SGQYLQREEVDLTGSVPVHA---KTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGIDTIRLYILFA 669

  Fly   616 VAPTSHRNWSSAT--FPGILNWQKRLWLTLQDFQQAREDQTASDVVPTSEEFLAEDAKLFDARNF 678
            ..|.....|...|  .||:|.||:|||.....|.:||....:......|.:..||..||::.:|.
Human   670 APPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNKEKAEARKLWEYKNS 734

  Fly   679 YVKGATFNYRHAQQLSVAISKMQGLTNSLRRTPKHVLRHGKQFERALAAQIIMLAPMAPHFASEL 743
            .:...|.::.....|:.|||::.||:|:|.:..:.|:.|..:||.||.|.::|.||:|||..||:
Human   735 VISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDALCALMVMAAPLAPHVTSEI 799

  Fly   744 WSKFVAIPGRLNPASQELQWSEDVLAQRWPDIDPAY 779
            |:....:|.:|   .....|...||.|.||.:||.:
Human   800 WAGLALVPRKL---CAHYTWDASVLLQAWPAVDPEF 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS-m	NP_647932.1	LeuS	40..848	CDD:440261	355/787 (45%)
LARS2	NP_056155.1	LeuS	57..887	CDD:440261	355/787 (45%)
		'HIGH' region	92..102		8/9 (89%)
		'KMSKS' region	639..643		3/3 (100%)