Protein Alignment LeuRS-m and lars-1

DIOPT Version :10

• Sequence 1: NP_647932.1
• Gene: LeuRS-m / 38581
• FlyBaseID: FBgn0027085
• Length: 869
• Species: Drosophila melanogaster
• Sequence 2: NP_497837.1
• Gene: lars-1 / 175538
• WormBaseID: WBGene00003073
• Length: 1186
• Species: Caenorhabditis elegans
• Alignment Length: 1110
• Identity: 198/1110 - (17%)
• Similarity: 325/1110 - (29%)
• Gaps: 437/1110 - (39%)

  Fly    37 DVKHRIEAHWREQLSGGQFNPKDSQDKYYVLSMFPYPSGNLHMGHVRVYTIADSVARFQRMCGKN 101
            :::..|:..|..:.:.......|.:.||.|...|||.:|.||:||....:..:..|.|||:.||.
 Worm    16 EIEKSIQELWESKKAFEADARDDGKPKYLVTFPFPYMNGRLHLGHTFSASKCEFAAGFQRLQGKE 80

  Fly   102 VFQPMGWDSFGLPAENAANQRGVE------PASWTEQNIAQMKEQ-------------------- 140
            |..|.|:...|:|.:..|::...|      |.::.|..:.::||:
 Worm    81 VLFPFGFHCTGMPIKACADKLKREMQDFGYPPNFPEDVVEEVKEEVSAVDEIIKDKSKGKKSKLV 145

  Fly   141 -------------------------------------------LKRLGCSFDWNHELST--CSPK 160
                                                       ||::|...||.....|  .:|.
 Worm   146 AKTGNAKYQWQIMKSLGLCDEEIKEFSDPNHWLYYFPPHCIADLKKMGLKADWRRSFITTDVNPY 210

  Fly   161 YYKWTQHLFLMLHRHGLAYQNEALVNWDPVDKTVLAD-EQVDANGCSWRSGAKVEKKLL------ 218
            :..:.:..|.:|.........:....:.|.|.....| ::....|...:....::.|:|
 Worm   211 FDSFVRWQFNLLRAAKKIDFGKRYTIYSPKDGQPCMDHDRASGEGVGPQEYTLIKLKVLDPKPQA 275

  Fly   219 -------------------------------------------RQWFIRTSAYAKQL-LDGL--E 237
                                                       :|.|:.|:..|:.: ..||  |
 Worm   276 LSHIKEDIYLVAATLRPETMYGQTNCYLHPDIQYSVFYATENEKQVFVATARSARIMSYQGLTKE 340

  Fly   238 DPTLRDWRDIINLQRHWIGECDG-------------YAFNLLT----SASGLLRVWTTHPEHLKD 285
            :..:   ..::.|::....:..|             ||..:||    ..:|::   |:.|....|
 Worm   341 NGKV---NYVLGLEKIAGSKILGAPLSAPLAKYERVYALPMLTIKDDKGTGVV---TSVPSDSPD 399

  Fly   286 PHAFL-------VLRSNHHLS-------------KLKGADSLSAANPFAGTTMPVVFSDEVTFPP 330
            ..|.|       .||..:.|:             |::|...|:|....:...:......:.....
 Worm   400 DFAALSDLKKKKPLREKYGLTDEMVLPFEPVPIIKIEGLGDLAAVEMCSRLKIESQNEKDKLEEA 464

  Fly   331 KSDVYLAAPSFRGEDKDLWDSYGLA------------------FTSNGKDEESLSP--------- 368
            |.:|||         |..:|...|.                  .|:.|...:.:.|
 Worm   465 KKEVYL---------KGFYDGVMLVGKYAGKKTADVKKVIQDDLTAEGLATKYVEPEKKVMSRSG 520

  Fly   369 -----------------ANWEMLRKEVLQAATRLNVGGYRVSSKLKDWL----ISRQRYWGTPIP 412
                             |.|:...|:||:.....|....|......|||    .||....||.:|
 Worm   521 DECVVALCDQWYLNYGEAEWKAAAKKVLEPLRTFNDETRRGLETTVDWLHEYACSRSYGLGTKLP 585

  Fly   413 ---------------------IVHCQKCGAVPVPEEQLPVSLPPKDSPKEAFLCDCPKCGEKDAR 456
                                 :.|..:.||.                       |....|....:
 Worm   586 WDTQYLIESLSDSTIYNAYYTVAHLLQQGAF-----------------------DGSVVGPAGIK 627

  Fly   457 RETDTMDTFVDSSWYYLRYLDAQNSERIFDT-----------ALTKKFM---PVDLYIGGKEHAV 507
                 .|...|:||.|: :|.     .|:|:           :|.|:||   |:|:...||:...
 Worm   628 -----ADQMTDASWSYV-FLG-----EIYDSKTMPVEEEKLKSLRKEFMYWYPIDMRASGKDLIG 681

  Fly   508 LHLYYARFINHFLHSCGLSPTSE---PFSRLLVQGMVMGRSFRVKGSGRYVPETEVEIVNAKKNQ 569
            .||.|..| ||    ..:.||..   |            :..|..|.
 Worm   682 NHLTYLLF-NH----AAIWPTDTSKWP------------KGIRANGH------------------ 711

  Fly   570 AVLKETKEPVVMTWEKMSKSKLNGVEPSDMFNEYGTDTTRLIILADVAPTSHRNWSSATF----- 629
                     :::..||||||..|.:...:...::..|..|| .|||...    ....|.|
 Worm   712 ---------LLLNNEKMSKSTGNFMTLEEAIEKFSADGMRL-SLADAGD----GLEDANFVYAMA 762

  Fly   630 -PGILNWQKRLWLTLQDFQQAREDQTASDVVPTSEEFLAEDAKLFDAR------NFYVKGATFNY 687
             ..||    ||:..::..::..|.:.|.        .|.:|||.|..|      |..:.....||
 Worm   763 DAAIL----RLFTMIEWIKEMIEQRDAG--------LLRKDAKKFADRVFANEMNSLIAATEQNY 815

  Fly   688 ---RHAQQLSVAISKMQGLTNSLRRTPKHV---LRHGKQFERALAAQIIMLAPMAPHFASELWSK 746
               .....|.....:.|.:.::.|.....:   :.....| |.:..|:::|:|:.||.|..:|
 Worm   816 EATNFKDALKTGFFEYQAIRDTYRELCAGIDEPMSESLVF-RFIETQMLILSPICPHIAEYIW-- 877

  Fly   747 FVAIPGRLNPASQELQWSEDVLAQR-WPDIDPAYNLDLSIKVNGFENCVIKVQRTHLDKVTHSDA 810
                         :|...:.::... ||.:||                           |....|
 Worm   878 -------------QLLGKDGLIVNAPWPTVDP---------------------------VDEKLA 902

  Fly   811 LDIAFNTESVT-------SYLIDKKIRTTNFVLYPGIEAILNIYVDKAKMKQKPP----TTDDAE 864
            :...|.|||:.       :|:..||.........| .||:  |||    .|:.||    ..|..|
 Worm   903 IGARFITESLAEFRARLKTYMTPKKKALKEIPEVP-TEAV--IYV----AKEYPPWQKTILDILE 960

  Fly   865 AQPQA 869
            .|.:|
 Worm   961 KQAKA 965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS-m	NP_647932.1	LeuS	40..848	CDD:440261	189/1080 (18%)
lars-1	NP_497837.1	PLN02959	6..1074	CDD:215518	198/1110 (18%)