DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LeuRS-m and lars-2

DIOPT Version :9

Sequence 1:	NP_647932.1	Gene:	LeuRS-m / 38581	FlyBaseID:	FBgn0027085	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_001021875.1	Gene:	lars-2 / 172499	WormBaseID:	WBGene00003074	Length:	859	Species:	Caenorhabditis elegans

Alignment Length:	857	Identity:	295/857 - (34%)
Similarity:	453/857 - (52%)	Gaps:	105/857 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IEAHWREQL----SGGQFNPKDSQDKYYVLSMFPYPSGNLHMGHVRVYTIADSVARFQRMCGKNV 102
            :|.||.:.|    ...:..|.:...|.|:|||||||||.||:||:|||||:|:.||:.|:.|..|
Worm    33 LEKHWSKSLVDSFESSKNKPSNLNGKKYILSMFPYPSGRLHIGHMRVYTISDATARYYRLNGYEV 97

  Fly   103 FQPMGWDSFGLPAENAANQRGVEPASWTEQNIAQMKEQLKRLGCSFDWNHELSTCSPKYYKWTQH 167
            ..|:|||||||||||||..:||:|..||..||..||:||.:....|||..|:|||.|::::|||.
Worm    98 IHPIGWDSFGLPAENAARDKGVDPREWTINNIESMKQQLLKTKILFDWEKEISTCEPEFFRWTQW 162

  Fly   168 LFLMLHRHGLAYQNEALVNWDPVDKTVLADEQVDANGCSWRSGAKVEKKLLRQWFIRTSAYAKQL 232
            :|..|..:||..:..:.|||||:||||||.||:|.:|.|||||||.|||.|.||.|.|..|||:|
Worm   163 IFCKLFEYGLVKRTSSEVNWDPIDKTVLAAEQIDNDGKSWRSGAKAEKKKLSQWMIETPKYAKRL 227

  Fly   233 LDGLEDPTLRDWRDIINLQRHWIGECDGYAFNLLTSASGLLRVWTTHPE----HLKD-----PHA 288
            .:||...: ..|.::.::|.:|||:||.|.|.|.....|      ::.|    .:||     ...
Worm   228 QEGLRKMS-EQWGEVADIQANWIGKCDVYRFMLPVMKDG------SNDEIIDLRIKDIFEISNAE 285

  Fly   289 FLVLRSNHHLSKLKGADSLSAANPF------AGTTMPVVFSDEVTFPPKSDVYLAA--PSFRGED 345
            ||||:.:|.|:. |.|.......||      .|..:||:..:: |:.|....:|.:  .:|: :|
Worm   286 FLVLKQSHSLAD-KDATQFPYKLPFQVLNGVTGRQIPVIVVED-TYQPDVTSFLNSRIGNFQ-KD 347

  Fly   346 KDLWDSYGLAFTSNGKDEESLSPANWEMLRKEVLQAATRLNVGGYRVSSKLKDWLISRQRYWGTP 410
            |.|.:.:.:|...:.:          ::.:.::.:.|:....|||..|..|.||::||||.||||
Worm   348 KILVEKFAIAEPKHKR----------KLTKNDIQEMASFGGYGGYETSRTLTDWVVSRQRGWGTP 402

  Fly   411 IPIVHCQKCGAVPVPEEQLPV--SLPPKDSPKEAFLCDCPKCGEKDARRETDTMDTFVDSSWYYL 473
            ||::..:....|.|...:|||  |...::..||.|       ||... .:|||:|||.||:||||
Worm   403 IPMIQTKDGKRVAVQLNKLPVLGSDRGQEVDKERF-------GESGV-FDTDTLDTFFDSAWYYL 459

  Fly   474 RYLDAQNSERIFDTALTKKFMPVDLYIGGKEHAVLHLYYARFINHFLHSCGLSPTSEPFSRLLVQ 538
            ||||.:|...:......|. ||||:|:||.|||.:|:::|||:.:||....:..|:|||:.|:.|
Worm   460 RYLDNKNKSELISKGAMKN-MPVDVYVGGIEHAAVHMFFARFVAYFLKDINVIQTAEPFTDLIPQ 523

  Fly   539 GMVMGRSFRVKGSGRYVPETEVEIVNAK---KNQAVLKETKEPVVMTWEKMSKSKLNGVEPSDMF 600
            |:|.|::|..|.:|:|:...:|:....|   ||.:.::     |...:|||||||.|||:.:.:.
Worm   524 GIVRGKTFIEKETGKYLGSEDVQQSGDKLTLKNDSSVE-----VDAVYEKMSKSKNNGVDLAAIL 583

  Fly   601 NEYGTDTTRLIILADVAPTSHRNWSSATFPGILNWQKRLWLTLQDFQQAREDQTASDVVPTSEEF 665
            :..|.|.|||.:|...||.:..||......||.....|:.........||::   ...:...:|.
Worm   584 DSEGVDMTRLRLLEAAAPRAPINWGETDLKGIKKLLDRIAAINSQIVDARDN---GKPIELKKEI 645

  Fly   666 LAEDAKLFDARNFYVK--GATFNYRHAQQLSVAISKMQGLTNSLRRTPKHVLRHGKQFERALAAQ 728
               |..:.:..||:|:  |......|..  :.|:.::||.||:|::.....|.|..:.:||:.:.
Worm   646 ---DGSIKETYNFFVRNVGMCLEVLHLH--NTALMRIQGFTNALKKVDPIYLAHSPEGQRAVKSL 705

  Fly   729 IIMLAPMAPHFASELWSKFVAIPGRLNPASQELQWSEDVLAQRWPDIDPAYNLDLSIKVNGFENC 793
            ||||....||.|||:||. :|..|.|            |..|:||::|...:::..:.::|....
Worm   706 IIMLQVFCPHVASEMWSA-LANDGSL------------VSDQKWPEVDKDADIEFLLMIDGVSGG 757

  Fly   794 VIKVQRTHLDKVT------------HSDALDIAFNTESVTSYLIDKKIRTTNFVLYPGIEAILNI 846
            ...:.|..:::::            |:|.|.:....        ..|::.::::...|....|:.
Worm   758 RPSLDRRIIEEMSMDQLWERATFYEHADILRMMKED--------GMKLKNSSYISRKGFHVTLSC 814

  Fly   847 YV--DKAKMKQK 856
            .:  ||.:.::|
Worm   815 SLEGDKEENRKK 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS-m	NP_647932.1	leuS	40..848	CDD:234743	292/845 (35%)
		LeuRS_core	63..624	CDD:173906	236/582 (41%)
		Anticodon_Ia_like	624..747	CDD:299868	34/124 (27%)
		Anticodon_Ia_like	<723..799	CDD:299868	22/75 (29%)
lars-2	NP_001021875.1	leuS_bact	29..747	CDD:273057	284/768 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167055
Domainoid	1	1.000	183	1.000	Domainoid score	I2051
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6526
Inparanoid	1	1.050	468	1.000	Inparanoid score	I843
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55246
OrthoDB	1	1.010	-	-		D142174at33208
OrthoFinder	1	1.000	-	-		FOG0003811
OrthoInspector	1	1.000	-	-		oto18583
orthoMCL	1	0.900	-	-		OOG6_101393
Panther	1	1.100	-	-	LDO	PTHR43740
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1448
SonicParanoid	1	1.000	-	-		X2655
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940