DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhc64C and DNAH17

DIOPT Version :9

Sequence 1:	NP_001261432.1	Gene:	Dhc64C / 38580	FlyBaseID:	FBgn0261797	Length:	4661	Species:	Drosophila melanogaster
Sequence 2:	XP_011523718.1	Gene:	DNAH17 / 8632	HGNCID:	2946	Length:	4466	Species:	Homo sapiens

Alignment Length:	4902	Identity:	1239/4902 - (25%)
Similarity:	2187/4902 - (44%)	Gaps:	769/4902 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DAFANYLRKAVTILL---PE--DDVVPASLNDALDDPVNQDTIRKFLSDPQVQALYVQRN----- 78
            |....||.:..:|:|   |:  ..::.|..|.||        ..:|...|.||.|.:..|
Human     6 DVRLEYLEEVASIVLKFKPDKWSKLIGAEENVAL--------FTEFFEKPDVQVLVLTLNAAGMI 62

  Fly    79 --CIKEDDSEQPAEGEDEKEQVTYQISNDVHFTNSRMASLACIKRGLVVEADKSIHSQLRLINFS 141
              |:....|.:               |..|:|..::..::           :|..:....|....
Human    63 IPCLGFPQSLK---------------SKGVYFIKTKSENI-----------NKDNYRARLLYGDI 101

  Fly   142 DGSPYETLHAFISKSLAPYF--------------KSYVKESGRADRDGDKMAPSVEKKLAELEMG 192
            ..:|.:.|.|.:.:.|:...              :..||:..|...:...|:..::.|.
Human   102 SPTPVDQLIAVVEEVLSSLLNQSENMAGWPQVVSEDIVKQVHRLKNEMFVMSGKIKGKT------ 160

  Fly   193 LLHLQQNIDIPEITLTAHQTVNNVIRKCAEENRKAKVADFGDKVEDSSFLNLLQNGVNRWIAEIK 257
            ||.:.:::...:.||.:.:.:.:.:                    |:..|:.::..:..|..:|:
Human   161 LLPIPEHLGSLDGTLESMERIPSSL--------------------DNLLLHAIETTIIDWSHQIR 205

  Fly   258 KVTKLNRDPGSGTAL---------QEISFW----LNLERALYRIQEKRESPEVALTLDILKHGKR 309
            .|  |::|  |..||         .|..||    |||:    .|.|:...|:|...::||:..|.
Human   206 DV--LSKD--SAQALLDGLHPLPQVEFEFWDTRLLNLK----CIHEQLNRPKVNKIVEILEKAKS 262

  Fly   310 FH----ATVSFDTDTGLKQALATVADYNPL--------MKDFPINDLLSATELEKIRPAVQQIFA 362
            .:    ..|..:...|||:|...|....||        ..||    .:..|.:.|:...:..|:|
Human   263 CYWPALQNVYTNVTEGLKEANDIVLYLKPLRILLEEMEQADF----TMLPTFIAKVLDTICFIWA 323

  Fly   363 HLRKVRNTKYPI-----QRCLKLIEAISRDLS-QQLLKVLGTRRLMHIPFDEFERVM-------N 414
             ..:..||...|     :.|.::||.....|| :::||.|.         .|.|.|:       |
Human   324 -TSEYYNTPARIIVILQEFCNQIIEMTRTFLSPEEVLKGLQ---------GEIEEVLSGISLAVN 378

  Fly   415 QCFEIFSCWDDEYDKLQGLLRDIVKKKRDEHLKMVWRVSPAHKKLQTRMEHMRKFRRQHEQLRTV 479
            ...|::..:|.....::...:|      .|.:...:..|.|..::.:..:.::..    |:|...
Human   379 VLKELYQTYDFCCVNMKLFFKD------KEPVPWEFPSSLAFSRINSFFQRIQTI----EELYKT 433

  Fly   480 ILRVLRPTKPAVGD-DGNVVETKQPYSLDAADANAIEEVNLAYENVKE-VDC-LDITKEGSEAWE 541
            .:..|:..|..:|. .||:        |.:......:||   :|.||. .|| .|....|...::
Human   434 AIEFLKLEKIELGGVRGNL--------LGSLVTRIYDEV---FELVKVFADCKYDPLDPGDSNFD 487

  Fly   542 AAVKRYEEKIDRVETRITAHLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIREYQTQLIQRV 606
            .....:|.||..::.|:..................::......|..||.|...:....:.:::..
Human   488 RDYADFEIKIQDLDRRLATIFCQGFDDCSCIKSSAKLLYMCGGLMERPLILAEVAPRYSVMLELF 552

  Fly   607 KDDIEALHEKFKVQYPQSKSCRLSSV-RDLPPVAGSIIWARQIDNQLTM---YLKRVEDVLGKGW 667
            ..:::.....:..|...|:...:..: :::|||||.:.|:.::..:|.:   :||.||..:..|.
Human   553 DAELDNAKILYDAQMAASEEGNIPLIHKNMPPVAGQLKWSLELQERLEVSMKHLKHVEHPVMSGA 617

  Fly   668 ETHIEGQKLKADGDSFRAKLSISDVFHEWARKVQERNFGSTGRIFTIESTRSRIGRGNVLRLRVN 732
            |..:..||.....:..|...  ..::.:|...|.:....:.|:...:....|.:       :.||
Human   618 EAKLTYQKYDEMMELLRCHR--EKIYQQWVAGVDQDCHFNLGQPLILRDAASNL-------IHVN 673

  Fly   733 FLPEIITLAKEVRNIKNLGFRVPLTIVNKAHQANQIYPYAISLIESVRTYERTLEKLNNRSLAQN 797
            |...::.:.:||   |.|.|:          |..:|...|.||.....|:.:.:..|.......|
Human   674 FSKALVAVLREV---KYLNFQ----------QQKEIPDSAESLFSENETFRKFVGNLELIVGWYN 725

  Fly   798 SVFKIEDRASIVPLVAGLRKDVLNLVSEGIGLIWESYKLDPYVIRLSECVTQFQ----------- 851
            .:..|......:.:.:.|....:.|:|....|.|....:..|:..:.|.:...|
Human   726 EIKTIVKAVEFLLIKSELEAIDVKLLSAETTLFWNGEGVFQYIQEVREILHNLQNRMQKAKQNIE 790

  Fly   852 ---------------EKVDDLLVVEEQLDVDVRSLE-TCPYSAATFVEILSKIQHAV-DDLSLRQ 899
                           |:.|:  ..|..||:|.|... ...|:|.....:  |||..| ::..|.:
Human   791 GISQAMKDWSANPLFERKDN--KKEALLDLDGRIANLNKRYAAVRDAGV--KIQAMVAENAELFR 851

  Fly   900 YSNLSV-W-----------VTRLDEEVEKKLALRLQAGIQAWTEALTGNKKEVDTSMDTDA-PAQ 951
            ...||: |           :...|:.:.|.|:..:...:   .:.......|:...:|.|. ...
Human   852 ADTLSLPWKDYVIYIDDMVLDEFDQFIRKSLSFLMDNMV---IDESIAPLFEIRMELDEDGLTFN 913

  Fly   952 PTHKLGGD----PQIQNAVHEIRITNQQMYLYPSIEEARFQIMQQFFAWQAIVTSQVRLQSTRYQ 1012
            ||.::|.|    ..|:..|::|....:   |.|.:.:.|.                      .|:
Human   914 PTLEVGSDRGFLALIEGLVNDIYNVAR---LIPRLAKDRM----------------------NYK 953

  Fly  1013 VGLEKHVSQTYRNLLTKLPEGKILENAYGAIEQKVSEVRNYVDEWLRYQSLW--DLQADM----L 1071
            :.||.:         |.|.|  :.|.....:...:.|...|.|.:.||..||  :||..|    :
Human   954 MDLEDN---------TDLIE--MREEVSSLVINAMKEAEEYQDSFERYSYLWTDNLQEFMKNFLI 1007

  Fly  1072 YG--RLGEDVNLWIKCLNDIKQSRTTFDTSDTRRAYGPIIIDYAKVQAKV-----TLKYDSW--- 1126
            ||  ...||::.|        ...|...|..|...:...|..|.|:..:|     |..:..|
Human  1008 YGCAVTAEDLDTW--------TDDTIPKTPPTLAQFQEQIDSYEKLYEEVSKCENTKVFHGWLQC 1064

  Fly  1127 ----HKEAL----GKFGTLLGTEMTSFHSKVSKSRTDLE----------MQSIEAASTSDAVSFI 1173
                .|:||    .::|.:....::   :.|:.|..|||          .:.::.......|..:
Human  1065 DCRPFKQALLSTIRRWGFMFKRHLS---NHVTNSLADLEAFMKVARMGLTKPLKEGDYDGLVEVM 1126

  Fly  1174 TYVQSLKKDMIAWDKQVEVFREAQRILERQRFQFP-NTWLHVDNIEGEWSAFNEIIKRKDTAIQT 1237
            .::..:|:...|.|...|..::...:|:....:.| ...|.:..:...|:      ..|..|||.
Human  1127 GHLMKVKERQAATDNMFEPLKQTIELLKTYGEEMPEEIHLKLQELPEHWA------NTKKLAIQV 1185

  Fly  1238 Q--VASLQAKIVA----EDKAVETRTVDFLNDWEKTKPTGGKIRPDDALQQLQIFE--SKYSRLK 1294
            :  ||.|||..|:    :.:..|.:..:|...:.:..|..              |.  :.|..|.
Human  1186 KLTVAPLQANEVSILRRKCQQFELKQHEFRERFRREAPFS--------------FSDPNPYKSLN 1236

  Fly  1295 EERDNVVKAKEALE-LQESA----VPNNSAERMNVALEELQDLRGVWSELSKVWTQIDETREKPW 1354
            :::.::...:..:| |.:|.    ||....:::.....|::.|:.:|..:..|.|.|::.:...|
Human  1237 KQQKSISAMEGIMEALSKSGGLFEVPVPDYKQLKACHREVRLLKELWDMVVVVNTSIEDWKTTKW 1301

  Fly  1355 LSVQPRKLRQQLEAMMAQLKELPARLRMYESYEYVKKLIQSYIKVNMLIVELKSDALKERHWKQL 1419
            ..:...::....:.....::.|...::.::::..:...:::.|.....:.||::.|::||||:||
Human  1302 KDINVEQMDIDCKKFAKDMRSLDKEMKTWDAFVGLDNTVKNVITSLRAVSELQNPAIRERHWQQL 1366

  Fly  1420 TKQLRVNWVLS-DLSLGQVWDVNLQKNEGIVKDIILVAQGEMALEEFLKQVRESWQNYELDLINY 1483
            .:..:|.:.:| :.:|..:..:||...|..|::|:..|..|..:|:.||.:..:|     .::.:
Human  1367 MQATQVKFKMSEETTLADLLQLNLHSYEDEVRNIVDKAVKESGMEKVLKALDSTW-----SMMEF 1426

  Fly  1484 QNK------CRIIRGWDDLFNKVKEHINSVAAMKLSPYYKVFEEEALTWEEKLNRINALFDVWID 1542
            |::      ..:::..:.|...::::...:..:.:|.|...|.:|..:|::||:..:::..:|.:
Human  1427 QHEPHPRTGTMMLKSSEVLVETLEDNQVQLQNLMMSKYLAHFLKEVTSWQQKLSTADSVISIWFE 1491

  Fly  1543 VQRRWVYLEGIFSGSADIKTLLPVETSRFQSISSEFLGLMKKVTKSPKVMDVLNIPAVQRSLERL 1607
            |||.|.:||.||.||.||:|.||.::.||..|:.||..||:...|:|.|::..:.|.:...||.|
Human  1492 VQRTWSHLESIFIGSEDIRTQLPGDSQRFDDINQEFKALMEDAVKTPNVVEATSKPGLYNKLEAL 1556

  Fly  1608 ADLLGKIQKALGEYLERERTSFPRFYFVGDEDLLEIIGNSKNIARLQKHFKKMFAGVAAILL--- 1669
            ...|...:|||.||||.:|.:|||||||...|||:|:.|..:...:.:|..|:|..:..:..
Human  1557 KKSLAICEKALAEYLETKRLAFPRFYFVSSADLLDILSNGNDPVEVSRHLSKLFDSLCKLKFRLD 1621

  Fly  1670 --NEENNVILGISSREGEEVHFMNPVSTVEHPKINEWLSLVEKQMRFTLASLLAQAVQDIKQFRD 1732
              ::...|.||:.|:|.|.:.|......  ..::..||:.|..:|..||...:.:||...::
Human  1622 ASDKPLKVGLGMYSKEDEYMVFDQECDL--SGQVEVWLNRVLDRMCSTLRHEIPEAVVTYEE--- 1681

  Fly  1733 GKIDPQAYMEWCDKYQAQIVVLAAQILWSEDVESA---LQQASEN-----NQSKPMQRVLGNVES 1789
               .|:.  :|...|.||:.:...||.|:.:|..|   |::..||     |:.:..|
Human  1682 ---KPRE--QWILDYPAQVALTCTQIWWTTEVGLAFARLEEGYENAIRDYNKKQISQ-------- 1733

  Fly  1790 TLNVLADSVLQEQPPLRRRKLEHLINEFVHKRTVTRRLLNNGVTSPKSFQWLCEMRFYFDPRQTE 1854
             ||||...::.......|.|:..:....||.|.|..:::...|.|.::|.|..::|..:|    |
Human  1734 -LNVLITLLMGNLNAGDRMKIMTICTIDVHARDVVAKMIVAKVESSQAFTWQAQLRHRWD----E 1793

  Fly  1855 VLQQLTIHMANARFFYGFEYLGVQDRLVQTPLTDRCYLTMTQALESRLGGSPFGPAGTGKTESVK 1919
            ..:....::.:|:..|.:||||...|||.||||||||:|:||:|...:||:|.|||||||||:.|
Human  1794 EKRHCFANICDAQIQYSYEYLGNTPRLVITPLTDRCYITLTQSLHLIMGGAPAGPAGTGKTETTK 1858

  Fly  1920 ALGNQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSACSQQIQTIQEAL 1984
            .||..||..|.||||.|..|:::.|.|:.||.|.|||||||||||:...:||..:.|::.:|:|:
Human  1859 DLGRALGTMVYVFNCSEQMDYKSCGNIYKGLAQTGAWGCFDEFNRISVEVLSVIAVQVKCVQDAI 1923

  Fly  1985 KYEMDSNKESITVELVGKQVRVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLAMTTPDRQLIAE 2049
            :    :.|::.  ..:|:.:.:.|.:.||||||||||||:.||:|||.|||..||..||.:||.|
Human  1924 R----AKKKAF--NFLGEIIGLIPTVGIFITMNPGYAGRAELPENLKALFRPCAMVVPDFELICE 1982

  Fly  2050 VMLFSQGFRSAEKLACKIVPFFKLCDEQLSNQSHYDFGLRALKSVLISAGNVKRDRIMKIKEQMK 2114
            :||.::||..|..||.|.:..:.||.|.||.|.|||:||||:||||:.||::|
Human  1983 IMLMAEGFLEARLLARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLK------------ 2035

  Fly  2115 QRGDENIDEASVAENLPEQEILIQSVCETMVPKLVAEDIPLLFSLLSDVFPNVGYTRAE----MK 2175
             |||         .:..|.::|::::.:..:||:|.:|:|:...|:.|:||.:...|..    .|
Human  2036 -RGD---------PSRAEDQVLMRALRDFNIPKIVTDDLPVFMGLIGDLFPALDVPRKRDLNFEK 2090

  Fly  2176 GLKEEI--RKVCQEDYLVCGEGDEQGAAWMEKGLGSTWVDKVLQLYQISNLNHGLMMVGPSGSGK 2238
            .:|:.|  .|:..||                     ::|.||:||.::..:.|.:.:||.:||||
Human  2091 IIKQSIVELKLQAED---------------------SFVLKVVQLEELLQVRHSVFIVGNAGSGK 2134

  Fly  2239 STAWKTLLKALERFEGVEGVAHVIDPKAISKEALYGVLDPNTREWTDGLFTHILRKIIDNVRGEI 2303
            |...|:|.|..:..:. :.||..:||||::.:.|:|:::|.||||.||||:.|:|.:. |:..:.
Human  2135 SQVLKSLNKTYQNLKR-KPVAVDLDPKAVTCDELFGIINPVTREWKDGLFSTIMRDLA-NITHDG 2197

  Fly  2304 NKRQWIIFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVRVMFEVQDLKFATLATVSRCG 2368
            .|  |||.|||:||.|:|:||:|:||||:|||.:.||:.|...:|::||:..|:.||.|||||.|
Human  2198 PK--WIILDGDIDPMWIESLNTVMDDNKVLTLASNERIPLNRTMRLVFEISHLRTATPATVSRAG 2260

  Fly  2369 MVWFSEDVLSTEMIFENYLSRLRSIPLEDGDEDFVGVIKPAKDKEEEVSPSLQVQRDIALLLLPF 2433
            :::.:...|....:..:::.|.:                              ||.:.|.|::.|
Human  2261 ILYINPADLGWNPVVSSWIERRK------------------------------VQSEKANLMILF 2295

  Fly  2434 FSADGIVVRTLEYAMDQ-EHIMDFTRLRALSSLFSMLNQAARNVLTFNAQHPDFPCSADQLEHYI 2497
            .......:..|.:...: ..:.:.|.::.:..|...|       ||.....||.|  .:..|.|
Human  2296 DKYLPTCLDKLRFGFKKITPVPEITVIQTILYLLECL-------LTEKTVPPDSP--RELYELY- 2350

  Fly  2498 PKALVYSVLWSFAG----DAKLKVRIDLGD-FVRSVTTVPLPGAAGAPIIDYEVNM-SGDWVPWS 2556
               .|::..|:|.|    |..:..|::... ::....|:..|  :...|.||.::. :..::||:
Human  2351 ---FVFTCFWAFGGAMFQDQLVDYRVEFSKWWINEFKTIKFP--SQGTIFDYYIDPDTKKFLPWT 2410

  Fly  2557 NKVPVIEVETHKVASPDI-----VVPTLDTVRHESLLYTWLAEHKPLVLCGPPGSGKTMTLFSAL 2616
            :|||..|::      ||:     :|.|.:|:|....:...:.:..|::|.|..|:||::.:...|
Human  2411 DKVPSFELD------PDVPLQASLVHTTETIRIRYFMDLLMEKSWPVMLVGNAGTGKSVLMGDKL 2469

  Fly  2617 RALPD----MEVVGLNF--SSATTPELLLKTFDHYCEYRKTPNGVVLSPVQIGKWLVLFCDEINL 2675
            .:|..    ::.|..||  :||....:|.|..:........|.|.        |.||.|.|::|:
Human  2470 ESLNTDNYLVQAVPFNFYTTSAMLQGVLEKPLEKKSGRNYGPPGT--------KKLVYFIDDMNM 2526

  Fly  2676 PDMDSYGTQRVISFLRQLVEHKGFYRASDQAWVSLERIQFVGACNPPTDPGRKPLSHRFLRHVPI 2740
            |::|.|||....:.:||.::|:.:|.........:...|:|...||.:  |...:..|..||..:
Human  2527 PEVDKYGTVAPHTLIRQHMDHRHWYDRHKLTLKDIHNCQYVACMNPTS--GSFTIDSRLQRHFCV 2589

  Fly  2741 IYVDYPGETSLKQIYGTFSRAMLRLMPALRGYA---EPLTNAMVEFYLASQDRFTQDMQP----- 2797
            ..|.:||:.:|..||.|.....|    |.|..:   :.:::.:|...||...:.|....|
Human  2590 FAVSFPGQEALTTIYNTILTQHL----AFRSVSMAIQRISSQLVAAALALHQKITATFLPTAIKF 2650

  Fly  2798 HYVYSPREMTRWVRGI----CEAIR-PLDSLPVEGLVRLWAHEALRLFQDRLVDDSERRWTNENI 2857
            |||::.|:::...:|:    .|.:: |||      |||||.||..|::.|::||:.::...:...
Human  2651 HYVFNLRDLSNIFQGLLFSTAEVLKTPLD------LVRLWLHETERVYGDKMVDEKDQETLHRVT 2709

  Fly  2858 DLVGQKHFPGINQEEALQRPILYSNWL----SKDYMPV-NREELREYVHARLKVFYEEELDVPLV 2917
            ....:|.|..:..|....:|.::.::.    ...|:|| :...|.:.:...|..:.|....:.||
Human  2710 MASTKKFFDDLGDELLFAKPNIFCHFAQGIGDPKYVPVTDMAPLNKLLVDVLDSYNEVNAVMNLV 2774

  Fly  2918 LFDEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSIFQIKVHNKYTSEDFDED 2982
            ||::.:.|:.||:||...|:|:.||:||.|:||.:|||..|:::||.:|||.:...|...|...|
Human  2775 LFEDAVAHICRINRILESPRGNALLVGVGGSGKQSLSRLAAYISGLDVFQITLKKGYGIPDLKID 2839

  Fly  2983 LRCVLRRSGCKDEKIAFILDESNVLDSGFLERMNTLLANGEVPGLFEGDEYTTLMTQCKEGAQRE 3047
            |.....::..|:....|::.:|.|.:..||..:|.|||:||:||||..||...:::..:...:..
Human  2840 LAAQYIKAAVKNVPSVFLMTDSQVAEEQFLVLINDLLASGEIPGLFMEDEVENIISSMRPQVKSL 2904

  Fly  3048 GLMLDSSDELYKWFTQQVMRNLHVVFTMNPSTDGLKDRAATSPALFNRCVLNWFGDWSDSALFQV 3112
            | |.|:.:..:|:|.::|.|.|.|:...:|....|:.||...||:.|...::||.:|.:.||..|
Human  2905 G-MNDTRETCWKFFIEKVRRQLKVILCFSPVGSVLRVRARKFPAVVNCTAIDWFHEWPEDALVSV 2968

  Fly  3113 GKEFTTRVDLEKPNWHAP---DFFPSVCPLVPANPTHRDAVINSCVYVHQTLHQANARLAKRGGR 3174
            ...|..  :.|...|...   .||.|                    |||.|:::.:........|
Human  2969 SARFLE--ETEGIPWEVKASISFFMS--------------------YVHTTVNEMSRVYLATERR 3011

  Fly  3175 TMAVTPRHYLDFIHHFVKLYNEKRSDLEEQQLHLNVGLNKIAETVEQVEEMQKSLAVKKQELQAK 3239
            ....||:.:|:.|..:..|..:||::|..:...|..||.|:..|..||::::..||:::.||:.|
Human  3012 YNYTTPKTFLEQIKLYQNLLAKKRTELVAKIERLENGLMKLQSTASQVDDLKAKLAIQEAELKQK 3076

  Fly  3240 NEAANAKLKQMFQDQQEAEKKKIQSQEIQIRLADQTVKIEEKRKYVMADLAQVEPAVIDAQAAVK 3304
            ||:|:..::.:..:.::..|:|..:.:.::::......:.||:|....|||:.|||::.||.|:.
Human  3077 NESADQLIQVVGIEAEKVSKEKAIADQEEVKVEVINKNVTEKQKACETDLAKAEPALLAAQEALD 3141

  Fly  3305 SIRKQQLVEVRTMANPPSVVKLALESICLLL---GENATD--WKSIRAVIMR-ENFINSIVSNFG 3363
            ::.|..|.|:::..:||..|.....::.:|.   |:...|  ||:.:.::.: :.|::|: ..|.
Human  3142 TLNKNNLTELKSFGSPPDAVVNVTAAVMILTAPGGKIPKDKSWKAAKIMMGKVDTFLDSL-KKFD 3205

  Fly  3364 TENITDDVREKMKSKYLSNPDYNFEKVNRASMACGPMVKWAIAQIEYADMLKRVEPLREELRSLE 3428
            .|:|.:...:..| .|..||.::.|.:...|.|...:..|.|..:.:.::...|.|.|:.|
Human  3206 KEHIPEACLKAFK-PYQGNPTFDPEFIRSKSTAAAGLCSWCINIVRFYEVYCDVAPKRQAL---- 3265

  Fly  3429 EQADVNLASAKE----TKDLVEQLERSI----AAYKEEYAQLIS-QAQAIKTDLENVQAKVDRSI 3484
            |:|:..||.|:|    .|:.:.:|..::    :|:::..|:.|. |.:|..|:  .|....:|.:
Human  3266 EEANAELAEAQEKLSRIKNKIAELNANLSNLTSAFEKATAEKIKCQQEADATN--RVILLANRLV 3328

  Fly  3485 ALLKSLNIERERWESTSETFKSQMSTIIGDVLLSAAFIAYGGYFDQHYRLNLFTT-WSQHLQ--A 3546
            ..|.|.||   ||..:.|.|:||..|:.|||||.:||::|.|||.:.||..|... |..::.  .
Human  3329 GGLASENI---RWAESVENFRSQGVTLCGDVLLISAFVSYVGYFTKKYRNELMEKFWIPYIHNLK 3390

  Fly  3547 ASIQYRADIARTEYLSNPDERLRWQANALPTDDLCTENAIMLKRFNRYPLIIDPSGQATTFLLNE 3611
            ..|.....:.....|::..:...|....||:|.:.||||.:|....|:|||:|...|...::.|:
Human  3391 VPIPITNGLDPLSLLTDDADVATWNNQGLPSDRMSTENATILGNTERWPLIVDAQLQGIKWIKNK 3455

  Fly  3612 YAGK----KITKTSFLDDSFRKNLESALRFGNPLLVQDV-ENYDPILNPVLNRELRRTGGRVLIT 3671
            |..:    ::.:.|:||     .:|.|:..|:.||:::: |..||:|:|:|.|...:.|  ..|.
Human  3456 YRSELKAIRLGQKSYLD-----VIEQAISEGDTLLIENIGETVDPVLDPLLGRNTIKKG--KYIK 3513

  Fly  3672 LGDQDIDLSPSFVIFLSTRDPTVEFPPDICSRVTFVNFTVTRSSLQSQCLNQVLKAERPDIDEKR 3736
            :||::::..|.|.:.|.|:.....:.|::.::.|.:||.|||..|:.|.|..|:..||||:::.:
Human  3514 IGDKEVEYHPKFRLILHTKYFNPHYKPEMQAQCTLINFLVTRDGLEDQLLAAVVAKERPDLEQLK 3578

  Fly  3737 SDLLKLQGEFRLRLRQLEKSLLQALNDAKGKILDDDSVITTLETLKKEAYDINQKVDETDKVIAE 3801
            ::|.|.|.||::.|::||.|||..|:.|.|..|.|.:::..|||.|..|.:|.:||.|......:
Human  3579 ANLTKSQNEFKIVLKELEDSLLARLSAASGNFLGDTALVENLETTKHTASEIEEKVVEAKITEVK 3643

  Fly  3802 IETVSQQYLPLSVACSNIYFTMDSLNQVHFLYQYSLKMFLDIFSTVLY-NNPKLEGRTDHSERLG 3865
            |....:.|.|.:...|.:||.::.||:::.:||:|||.|..:|...:. ..|..|.:    :|:.
Human  3644 INEARENYRPAAERASLLYFILNDLNKINPVYQFSLKAFNVVFEKAIQRTTPANEVK----QRVI 3704

  Fly  3866 IVTRDLFQVCYERVARGMIHIDRL------TFALLMCKIHLKGTSESNLDAEFNFFLR--SREGL 3922
            .:|.::....|...|||:...|:|      ||.:|..|..|.       ..|.:|.||  .:.|:
Human  3705 NLTDEITYSVYMYTARGLFERDKLIFLAQVTFQVLSMKKELN-------PVELDFLLRFPFKAGV 3762

  Fly  3923 LANPTPVEGLSAEQIESVNRLALRLPIFRKLLEKVRSIPELGAW---LQQSSPE-QVVPQLWDES 3983
            :   :||:.|..:....:..|: .:..|:.|...:....:  .|   ::..:|| ::.|:.|...
Human  3763 V---SPVDFLQHQGWGGIKALS-EMDEFKNLDSDIEGSAK--RWKKLVESEAPEKEIFPKEWKNK 3821

  Fly  3984 KALSPIASSVHQLLLIQAFRPDRVIAAAHNVVNTVLGEDFMPNAEQELDFTSVVDKQLNCNTPAL 4048
            .||       .:|.:::..||||:..|..|.|...:|..|:..  :.::|:...::. :.:|...
Human  3822 TAL-------QKLCMVRCLRPDRMTYAIKNFVEEKMGSKFVEG--RSVEFSKSYEES-SPSTSIF 3876

  Fly  4049 LCSVPGFDASGRVDDLAAE-----QNKQISSIAIGSAEGFNQAERAINMACKTGRWVL----LKN 4104
            ....||.|....|:.|..:     .|.::.::::|..:.. .||.|:::|.:.|.||:    |:|
Human  3877 FILSPGVDPLKDVEALGKKLGFTIDNGKLHNVSLGQGQEV-VAENALDVAAEKGHWVILQSWLQN 3940

  Fly  4105 VHLAPQWLVQLEKKM--HSLQPHSGFRLFLTMEINPK-----VPVNLLRAGRIFVFEPPPGIRAN 4162
            :||..:||..|:||:  :|...|..:|:|::.|..|.     :|..:|........|||.|:.||
Human  3941 IHLVARWLGTLDKKLEHYSTGSHEDYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHAN 4005

  Fly  4163 LLRTFS--TVPAARMMKTPSERARLYFLLAWFHAIVQERLRYVPLGWAKKYEFNESDLRVACDTL 4225
            |.:...  |.....|.....|...:.|.|.:|||:|.||.::...||.:.|.||..||.::.:.|
Human  4006 LHKALDLFTQDTLEMCTKEMEFKCMLFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTISINVL 4070

  Fly  4226 DTWIDTTAMGRTNLPPEKVPWDALVTLLSQSIYGGKIDNDFDQRLLTSFLKKLFTARSFEADFAL 4290
            ..:::..         .|||||.|..|..:.:|||.|.:|:|:||..::|.:.......|.|..|
Human  4071 YNYLEAN---------PKVPWDDLRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRTEMLEGDVLL 4126

  Fly  4291 VANVDGASGGLRHITMPDGTRRDHFLKWIENLTDRQTPSWLGLPNNAEKVLLTTRGTDLVSKLLK 4355
                  |.|    ..:|.......:.::|:.....::|...||..|||...||.....|...:|:
Human  4127 ------APG----FQIPPNLDYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLE 4181

  Fly  4356 MQQLEDDDELAYSVEDQSEQSAVGRGEDGRPSWMKTLHNSATAWLELLPKNL---QVLKRTVENI 4417
            ||..|.|......|..:.:..||                 ....||.:|:..   :::.:..|
Human  4182 MQPKETDSGAGTGVSREEKVKAV-----------------LDDILEKIPETFNMAEIMAKAAE-- 4227

  Fly  4418 KDPLYRYFEREVTSGSRLLQTVILDLQDVVLICQGEKKQTNHHRSMLSELVRGIIPKGWKRYTVP 4482
            |.|......:|....:.|...:...|:::.|..:||...|.....:.:.|....:|..|.....|
Human  4228 KTPYVVVAFQECERMNILTNEMRRSLKELNLGLKGELTITTDVEDLSTALFYDTVPDTWVARAYP 4292

  Fly  4483 AGCTVIQWITDFSNRVQQLQKVSQLVSQAGAKELQGFP--VWLGGLLNPEAYITATRQCVAQANS 4545
            :...:..|..|...|:::|        :|...:. ..|  |||.|..||::::||..|.:|:.|.
Human  4293 SMMGLAAWYADLLLRIREL--------EAWTTDF-ALPTTVWLAGFFNPQSFLTAIMQSMARKNE 4348

  Fly  4546 WSLEELALDVTITDAGLKNDQKDCCFG------VTGLKLQGAQCKNNELLLASTIMMDL----PV 4600
            |.|:::.|.|.:|    |.:::|....      |.||.::||:......::|...:.:|    ||
Human  4349 WPLDKMCLSVEVT----KKNREDMTAPPREGSYVYGLFMEGARWDTQTGVIAEARLKELTPAMPV 4409

  Fly  4601 TILKWIKISSEPRISKLTLPVYLNSTR 4627
            ..:|.|.:......:....|||....|
Human  4410 IFIKAIPVDRMETKNIYECPVYKTRIR 4436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhc64C	NP_001261432.1	DHC_N1	240..839	CDD:285571	126/643 (20%)
		DYN1	1022..4338	CDD:227570	968/3482 (28%)
		DHC_N2	1326..1724	CDD:285579	108/409 (26%)
		P-loop_NTPase	1870..2103	CDD:304359	122/232 (53%)
		P-loop_NTPase	2227..2367	CDD:304359	64/139 (46%)
		P-loop_NTPase	2572..2835	CDD:304359	75/286 (26%)
		Cas4_I-A_I-B_I-C_I-D_II-B	2834..>2943	CDD:294426	28/113 (25%)
		P-loop_NTPase	2916..3194	CDD:304359	86/280 (31%)
		MT	3208..3544	CDD:289543	100/351 (28%)
		AAA_9	3569..3784	CDD:289547	75/219 (34%)
		Dynein_heavy	3925..4636	CDD:281078	178/740 (24%)
DNAH17	XP_011523718.1	DHC_N1	189..767	CDD:285571	126/642 (20%)
		DHC_N2	1272..1676	CDD:285579	108/410 (26%)
		P-loop_NTPase	1809..2039	CDD:304359	126/257 (49%)
		P-loop_NTPase	2123..2258	CDD:304359	63/138 (46%)
		AAA_7	2416..2687	CDD:289541	76/296 (26%)
		AAA_8	2764..3031	CDD:289546	87/289 (30%)
		MT	3043..3386	CDD:289543	100/353 (28%)
		AAA_9	3413..3626	CDD:289547	75/219 (34%)
		Dynein_heavy	3766..4456	CDD:281078	177/736 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710