DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhc64C and Dync1h1

DIOPT Version :9

Sequence 1:	NP_001261432.1	Gene:	Dhc64C / 38580	FlyBaseID:	FBgn0261797	Length:	4661	Species:	Drosophila melanogaster
Sequence 2:	NP_062099.3	Gene:	Dync1h1 / 29489	RGDID:	2511	Length:	4644	Species:	Rattus norvegicus

Alignment Length:	4663	Identity:	3343/4663 - (71%)
Similarity:	3953/4663 - (84%)	Gaps:	68/4663 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SIANYDAFANYLRKAVTILLPEDDVVPASLNDALDDPVNQDTIRKFLSDPQVQALYVQRNCIKED 83
            ::|:......:|||.|.:||.:....||:|..||::....:.:|||||||||..:.|:|:.:|||
  Rat    21 NVADVSVLQKHLRKLVPLLLEDGGDAPAALEAALEEKSALEQMRKFLSDPQVHTVLVERSTLKED 85

  Fly    84 DSEQPAEGEDEKEQVTYQISNDVHFTNSRMASLACIKRGLVVEADKSIHSQLRLINFSDGSPYET 148
            ..:   |||:|||.::|.|:.|:|: ..:..|||.|||..|::|||.:.||||::..|:.|||||
  Rat    86 VGD---EGEEEKEFISYNINIDIHY-GVKSNSLAFIKRAPVIDADKPVSSQLRVLTLSEDSPYET 146

  Fly   149 LHAFISKSLAPYFKSYVKESGRADRDGDKMAPSVEKKLAELEMGLLHLQQNIDIPEITLTAHQTV 213
            ||:|||.::||:||||::|||:|||||||||||||||:||||||||||||||:||||:|..|..:
  Rat   147 LHSFISNAVAPFFKSYIRESGKADRDGDKMAPSVEKKIAELEMGLLHLQQNIEIPEISLPIHPII 211

  Fly   214 NNVIRKCAEENRKAKVADFGDKVEDSSFLNLLQNGVNRWIAEIKKVTKLNRDPGSGTALQEISFW 278
            .||.::|.|...|.||.||||||||.:|||.||:||||||.||:|||||:|||.|||||||||||
  Rat   212 TNVAKQCYERGEKPKVTDFGDKVEDPTFLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFW 276

  Fly   279 LNLERALYRIQEKRESPEVALTLDILKHGKRFHATVSFDTDTGLKQALATVADYNPLMKDFPIND 343
            |||||||||||||||||||.||||||||||||||||||||||||||||.||.||||||||||:||
  Rat   277 LNLERALYRIQEKRESPEVLLTLDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLND 341

  Fly   344 LLSATELEKIRPAVQQIFAHLRKVRNTKYPIQRCLKLIEAISRDLSQQLLKVLGTRRLMHIPFDE 408
            |||||||:|||.|:..||.||||:|||||||||.|:|:||||||||.|||||||||:|||:.::|
  Rat   342 LLSATELDKIRQALVAIFTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMHVAYEE 406

  Fly   409 FERVMNQCFEIFSCWDDEYDKLQGLLRDIVKKKRDEHLKMVWRVSPAHKKLQTRMEHMRKFRRQH 473
            ||:||..|||:|..|||||:|||.|||||||:||:|:||||||::|||:|||.|::.||||||||
  Rat   407 FEKVMVACFEVFQTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARLDQMRKFRRQH 471

  Fly   474 EQLRTVILRVLRPTKPAVGDDGNVVETKQPYSL-------DAADANAIEEVNLAYENVKEVDCLD 531
            ||||.||:|||||...||... |..|..:|..:       ||||||||||||||||||||||.||
  Rat   472 EQLRAVIVRVLRPQVTAVAQQ-NQGEAPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLD 535

  Fly   532 ITKEGSEAWEAAVKRYEEKIDRVETRITAHLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIR 596
            ::|||:||||||:|||:|:||||||||||.|||||||||||||||||||||||||||||||||||
  Rat   536 VSKEGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIR 600

  Fly   597 EYQTQLIQRVKDDIEALHEKFKVQYPQSKSCRLSSVRDLPPVAGSIIWARQIDNQLTMYLKRVED 661
            |||||||||||||||:||:|||||||||::|::|.|||||||:||||||:|||.|||.|:|||||
  Rat   601 EYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTAYMKRVED 665

  Fly   662 VLGKGWETHIEGQKLKADGDSFRAKLSISDVFHEWARKVQERNFGSTGRIFTIESTRSRIGRGNV 726
            |||||||.|:||||||.||||||.||:..::|.:||||||:||.|.:||||||||.|.|...|||
  Rat   666 VLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLGVSGRIFTIESARVRGRSGNV 730

  Fly   727 LRLRVNFLPEIITLAKEVRNIKNLGFRVPLTIVNKAHQANQIYPYAISLIESVRTYERTLEKLNN 791
            |:|:||||||||||:|||||:|.|||||||.||||||||||:||:||||||||||||||.|
  Rat   731 LKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAISLIESVRTYERTCE---- 791

  Fly   792 RSLAQNSVFKIEDRASIVPLVAGLRKDVLNLVSEGIGLIWESYKLDPYVIRLSECVTQFQEKVDD 856
                     |:|:|.:|..|||||:|:|..|::|||.|:||||||||||.||:|.|..|||||||
  Rat   792 ---------KVEERNTISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETVFNFQEKVDD 847

  Fly   857 LLVVEEQLDVDVRSLETCPYSAATFVEILSKIQHAVDDLSLRQYSNLSVWVTRLDEEVEKKLALR 921
            ||::||::|::|||||||.|...||.|||:::|.|||||:|..||||.:||.:||.|:|:.|.:|
  Rat   848 LLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWVNKLDMEIERILGVR 912

  Fly   922 LQAGIQAWTEALTG---NKKEVDTSMDTDAPAQPTHKLGGDPQIQNAVHEIRITNQQMYLYPSIE 983
            ||||::|||:.|.|   :|.|||  |||||| |.:||.||:|:|:|.|||:|||||.:||.|.||
  Rat   913 LQAGLRAWTQVLLGQAEDKAEVD--MDTDAP-QVSHKPGGEPKIKNVVHELRITNQVIYLNPPIE 974

  Fly   984 EARFQIMQQFFAWQAIVTSQVRLQSTRYQVGLEKHVSQT---YRNLLTKLPEGKI-LENAYGAIE 1044
            |.|:::.|:.|||:.||.|..|:||.|||||:...:::.   |||.||::|:|.: ||.:|.|:.
  Rat   975 ECRYKLYQEMFAWKMIVLSLPRIQSQRYQVGVHYELTEEEKFYRNALTRMPDGPVALEESYSAVM 1039

  Fly  1045 QKVSEVRNYVDEWLRYQSLWDLQADMLYGRLGEDVNLWIKCLNDIKQSRTTFDTSDTRRAYGPII 1109
            ..|:||..||..||:||.|||:||:.:|.|||||::.|...|..|:::|.|||.::|::.:||::
  Rat  1040 GIVTEVEQYVKVWLQYQCLWDMQAENIYNRLGEDLSKWQALLVQIRRARGTFDNAETKKEFGPVV 1104

  Fly  1110 IDYAKVQAKVTLKYDSWHKEALGKFGTLLGTEMTSFHSKVSKSRTDLEMQSIEAASTSDAVSFIT 1174
            |||.|||:||.|||||||||.|.|||.:||:.||.|||::||||.:||..|::.|||||||:|||
  Rat  1105 IDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMTEFHSQISKSRQELEQHSVDTASTSDAVTFIT 1169

  Fly  1175 YVQSLKKDMIAWDKQVEVFREAQRILERQRFQFPNTWLHVDNIEGEWSAFNEIIKRKDTAIQTQV 1239
            ||||||:.:..::||||::|..||:||:||||||.:||::|||||||.|||:|::|||:|||.||
  Rat  1170 YVQSLKRKIKQFEKQVELYRNGQRLLEKQRFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQV 1234

  Fly  1240 ASLQAKIVAEDKAVETRTVDFLNDWEKTKPTGGKIRPDDALQQLQIFESKYSRLKEERDNVVKAK 1304
            |:||.|||.||:|||:||.|.|.|||||||..|.:||::|||.|.|:|.|:.|||::|:...|||
  Rat  1235 ANLQMKIVQEDRAVESRTTDLLTDWEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAK 1299

  Fly  1305 EALELQESAVPNNSAERMNVALEELQDLRGVWSELSKVWTQIDETREKPWLSVQPRKLRQQLEAM 1369
            |||||.::.:.:.|.||:.|||||||||:||||||||||.|||:.:|:||:|||||||||.|:.:
  Rat  1300 EALELTDTGLLSGSEERVQVALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLDGL 1364

  Fly  1370 MAQLKELPARLRMYESYEYVKKLIQSYIKVNMLIVELKSDALKERHWKQLTKQLRVNWVLSDLSL 1434
            :.|||..|||||.|.|||:|::|::.|:|:|||::||||:|||:||||||.|:|.||||:|:|:|
  Rat  1365 LNQLKNFPARLRQYASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELTL 1429

  Fly  1435 GQVWDVNLQKNEGIVKDIILVAQGEMALEEFLKQVRESWQNYELDLINYQNKCRIIRGWDDLFNK 1499
            ||:|||:|||||.||||::|||||||||||||||:||.|..|||||:|||||||:||||||||||
  Rat  1430 GQIWDVDLQKNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNK 1494

  Fly  1500 VKEHINSVAAMKLSPYYKVFEEEALTWEEKLNRINALFDVWIDVQRRWVYLEGIFSGSADIKTLL 1564
            ||||||||:|||||||||||||:||:||:|||||.||||||||||||||||||||:||||||.||
  Rat  1495 VKEHINSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHLL 1559

  Fly  1565 PVETSRFQSISSEFLGLMKKVTKSPKVMDVLNIPAVQRSLERLADLLGKIQKALGEYLERERTSF 1629
            ||||.||||||:|||.|||||:|||.|||||||..|||||||||||||||||||||||||||:||
  Rat  1560 PVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGKIQKALGEYLERERSSF 1624

  Fly  1630 PRFYFVGDEDLLEIIGNSKNIARLQKHFKKMFAGVAAILLNEENNVILGISSREGEEVHFMNPVS 1694
            ||||||||||||||||||||:|:||||||||||||::|:|||:::|:|||||||||||.|..|||
  Rat  1625 PRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDSSVVLGISSREGEEVMFKTPVS 1689

  Fly  1695 TVEHPKINEWLSLVEKQMRFTLASLLAQAVQDIKQFRDGK---IDPQAYMEWCDKYQAQIVVLAA 1756
            ..|||||||||:||||:||.|||.|||::|.:::.|  ||   |||..|:.|.||||||:|||:|
  Rat  1690 ITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIF--GKATSIDPNTYITWIDKYQAQLVVLSA 1752

  Fly  1757 QILWSEDVESALQQASENNQSKPMQRVLGNVESTLNVLADSVLQEQPPLRRRKLEHLINEFVHKR 1821
            ||.|||:||:||..........|:|.||.|||.||||||||||.||||||||||||||.|.||:|
  Rat  1753 QIAWSENVENALSNVGGGGDVGPLQSVLSNVEVTLNVLADSVLMEQPPLRRRKLEHLITELVHQR 1817

  Fly  1822 TVTRRLLNNGVTSPKSFQWLCEMRFYFDPRQTEVLQQLTIHMANARFFYGFEYLGVQDRLVQTPL 1886
            .|||.|:.:.:.:.|||:||.:|||||||:||:|||||:|.||||:|.||||||||||:||||||
  Rat  1818 DVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQMANAKFNYGFEYLGVQDKLVQTPL 1882

  Fly  1887 TDRCYLTMTQALESRLGGSPFGPAGTGKTESVKALGNQLGRFVLVFNCDETFDFQAMGRIFVGLC 1951
            |||||||||||||:||||||||||||||||||||||:||||||||||||||||||||||||||||
  Rat  1883 TDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALGHQLGRFVLVFNCDETFDFQAMGRIFVGLC 1947

  Fly  1952 QVGAWGCFDEFNRLEERMLSACSQQIQTIQEALKYEMDSNKES----ITVELVGKQVRVSPDMAI 2012
            |||||||||||||||||||||.|||:|.|||||:...:.|.:.    ||.||:.|||:|||||||
  Rat  1948 QVGAWGCFDEFNRLEERMLSAVSQQVQCIQEALREHSNPNYDKTSAPITCELLNKQVKVSPDMAI 2012

  Fly  2013 FITMNPGYAGRSNLPDNLKKLFRSLAMTTPDRQLIAEVMLFSQGFRSAEKLACKIVPFFKLCDEQ 2077
            ||||||||||||||||||||||||||||.|||||||:|||:|||||:||.||.||||||||||||
  Rat  2013 FITMNPGYAGRSNLPDNLKKLFRSLAMTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQ 2077

  Fly  2078 LSNQSHYDFGLRALKSVLISAGNVKRDRIMKIKEQMKQRGDENIDEASVAENLPEQEILIQSVCE 2142
            ||:|||||||||||||||:|||||||:||.|||.:.::|| |.:||..:||||||||||||||||
  Rat  2078 LSSQSHYDFGLRALKSVLVSAGNVKRERIQKIKREKEERG-EAVDEGEIAENLPEQEILIQSVCE 2141

  Fly  2143 TMVPKLVAEDIPLLFSLLSDVFPNVGYTRAEMKGLKEEIRKVCQEDYLVCGEGDEQGAAWMEKGL 2207
            |||||||||||||||||||||||.|.|.|.||..|:||::|||||.||..|:|:|         :
  Rat  2142 TMVPKLVAEDIPLLFSLLSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEE---------V 2197

  Fly  2208 GSTWVDKVLQLYQISNLNHGLMMVGPSGSGKSTAWKTLLKALERFEGVEGVAHVIDPKAISKEAL 2272
            |..||:||||||||:.:|||||||||||||||.||:.|||||||.||||||||:||||||||:.|
  Rat  2198 GGMWVEKVLQLYQITQINHGLMMVGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDHL 2262

  Fly  2273 YGVLDPNTREWTDGLFTHILRKIIDNVRGEINKRQWIIFDGDVDPEWVENLNSVLDDNKLLTLPN 2337
            ||.|||||||||||||||:|||||||||||:.|||||:|||||||||||||||||||||||||||
  Rat  2263 YGTLDPNTREWTDGLFTHVLRKIIDNVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPN 2327

  Fly  2338 GERLSLPPNVRVMFEVQDLKFATLATVSRCGMVWFSEDVLSTEMIFENYLSRLRSIPLEDGDEDF 2402
            |||||||||||:||||||||:|||||||||||||||||||||:|||.|:|:|||||||::|:::.
  Rat  2328 GERLSLPPNVRIMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEA 2392

  Fly  2403 VGVIKPAKDK-EEEVSPSLQVQRDIALLLLPFFSADGIVVRTLEYAMDQEHIMDFTRLRALSSLF 2466
            ....|..:|: ||..||.||:|||.|.::.|:|:::|:|.:.||:|...|||||.||||.|.|||
  Rat  2393 QRRRKGKEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFKLEHIMDLTRLRCLGSLF 2457

  Fly  2467 SMLNQAARNVLTFNAQHPDFPCSADQLEHYIPKALVYSVLWSFAGDAKLKVRIDLGDFVRSVTTV 2531
            |||:||.|||..:||.|||||...:|||.||.:.|||::|||.:||::||:|.:||:::|.:|||
  Rat  2458 SMLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRRITTV 2522

  Fly  2532 PLPGAAGAPIIDYEVNMSGDWVPWSNKVPVIEVETHKVASPDIVVPTLDTVRHESLLYTWLAEHK 2596
            |||.|...|||||||::||:|.||..|||.|||||||||:||:|||||||||||:||||||||||
  Rat  2523 PLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEALLYTWLAEHK 2587

  Fly  2597 PLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRKTPNGVVLSPVQ 2661
            |||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||:|||
  Rat  2588 PLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRRTPNGVVLAPVQ 2652

  Fly  2662 IGKWLVLFCDEINLPDMDSYGTQRVISFLRQLVEHKGFYRASDQAWVSLERIQFVGACNPPTDPG 2726
            :|||||||||||||||||.|||||||||:||:|||.||||.|||.||.|||||||||||||||||
  Rat  2653 LGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTWVKLERIQFVGACNPPTDPG 2717

  Fly  2727 RKPLSHRFLRHVPIIYVDYPGETSLKQIYGTFSRAMLRLMPALRGYAEPLTNAMVEFYLASQDRF 2791
            |||||||||||||::||||||..||.||||||:||||||:|:||.||||||.||||||..||:||
  Rat  2718 RKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIPSLRTYAEPLTAAMVEFYTMSQERF 2782

  Fly  2792 TQDMQPHYVYSPREMTRWVRGICEAIRPLDSLPVEGLVRLWAHEALRLFQDRLVDDSERRWTNEN 2856
            |||.||||:|||||||||||||.||:|||::||||||:|:||||||||||||||:|.|||||:||
  Rat  2783 TQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERRWTDEN 2847

  Fly  2857 IDLVGQKHFPGINQEEALQRPILYSNWLSKDYMPVNREELREYVHARLKVFYEEELDVPLVLFDE 2921
            ||:|..||||.|::|:|:.|||||||||||||:||::||||:||.||||||||||||||||||:|
  Rat  2848 IDMVALKHFPNIDKEKAMSRPILYSNWLSKDYIPVDQEELRDYVKARLKVFYEEELDVPLVLFNE 2912

  Fly  2922 VLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSIFQIKVHNKYTSEDFDEDLRCV 2986
            |||||||||||||||||||||||||||||||||||||||||||::|||||.|||.||||||||.|
  Rat  2913 VLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTV 2977

  Fly  2987 LRRSGCKDEKIAFILDESNVLDSGFLERMNTLLANGEVPGLFEGDEYTTLMTQCKEGAQREGLML 3051
            |||||||:||||||:||||||||||||||||||||||||||||||||.|||||||||||:|||||
  Rat  2978 LRRSGCKNEKIAFIMDESNVLDSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLML 3042

  Fly  3052 DSSDELYKWFTQQVMRNLHVVFTMNPSTDGLKDRAATSPALFNRCVLNWFGDWSDSALFQVGKEF 3116
            ||.:|||||||.||:||||||||||||::|||||||||||||||||||||||||..||:||||||
  Rat  3043 DSHEELYKWFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEF 3107

  Fly  3117 TTRVDLEKPNWHAPDFFPSVCPLVPANPTHRDAVINSCVYVHQTLHQANARLAKRGGRTMAVTPR 3181
            |:::||||||:..||:.|.|...:|..||||:|::||||:|||||||||||||||||||||:|||
  Rat  3108 TSKMDLEKPNYIVPDYMPVVYDKLPQPPTHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPR 3172

  Fly  3182 HYLDFIHHFVKLYNEKRSDLEEQQLHLNVGLNKIAETVEQVEEMQKSLAVKKQELQAKNEAANAK 3246
            ||||||:|:..|::||||:|||||:||||||.||.|||:||||:::.|.:|.|||:.||.|||.|
  Rat  3173 HYLDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDK 3237

  Fly  3247 LKQMFQDQQEAEKKKIQSQEIQIRLADQTVKIEEKRKYVMADLAQVEPAVIDAQAAVKSIRKQQL 3311
            ||:|.:|||||||||:.|||||.:|..|...|.:|:..|..||.:||||||:||.|||||:||.|
  Rat  3238 LKKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIKKQHL 3302

  Fly  3312 VEVRTMANPPSVVKLALESICLLLGENATDWKSIRAVIMRENFINSIVSNFGTENITDDVREKMK 3376
            ||||:|||||:.||||||||||||||:.||||.||::|||||||.:|| ||..|.|:|.:|||||
  Rat  3303 VEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIV-NFSAEEISDAIREKMK 3366

  Fly  3377 SKYLSNPDYNFEKVNRASMACGPMVKWAIAQIEYADMLKRVEPLREELRSLEEQADVNLASAKET 3441
            ..|:|||.||:|.|||||:||||||||||||:.||||||||||||.||:.||:.|..|...|.|.
  Rat  3367 KNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLEDDAKDNQQKANEV 3431

  Fly  3442 KDLVEQLERSIAAYKEEYAQLISQAQAIKTDLENVQAKVDRSIALLKSLNIERERWESTSETFKS 3506
            :.::..||.|||.||||||.|||:|||||.||..|:|||:||.||||||:.||||||.||||||:
  Rat  3432 EQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAERERWEKTSETFKN 3496

  Fly  3507 QMSTIIGDVLLSAAFIAYGGYFDQHYRLNLFTTWSQHLQAASIQYRADIARTEYLSNPDERLRWQ 3571
            |||||.||.|||||||||.|||||..|.|||||||.|||.|:||:|.||||||||||.|||||||
  Rat  3497 QMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQANIQFRTDIARTEYLSNADERLRWQ 3561

  Fly  3572 ANALPTDDLCTENAIMLKRFNRYPLIIDPSGQATTFLLNEYAGKKITKTSFLDDSFRKNLESALR 3636
            |::||.||||||||||||||||||||||||||||.|::|||..:|||:||||||:||||||||||
  Rat  3562 ASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFIMNEYKDRKITRTSFLDDAFRKNLESALR 3626

  Fly  3637 FGNPLLVQDVENYDPILNPVLNRELRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDIC 3701
            |||||||||||:|||:||||||||:||||||||||||||||||||||||||||||||||||||:|
  Rat  3627 FGNPLLVQDVESYDPVLNPVLNREVRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLC 3691

  Fly  3702 SRVTFVNFTVTRSSLQSQCLNQVLKAERPDIDEKRSDLLKLQGEFRLRLRQLEKSLLQALNDAKG 3766
            |||||||||||||||||||||:||||||||:||||||||||||||:|||||||||||||||:.||
  Rat  3692 SRVTFVNFTVTRSSLQSQCLNEVLKAERPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKG 3756

  Fly  3767 KILDDDSVITTLETLKKEAYDINQKVDETDKVIAEIETVSQQYLPLSVACSNIYFTMDSLNQVHF 3831
            :|||||::|||||.||:||.::.:||:|||.|:.|:|||||||||||.|||:|||||:||.||||
  Rat  3757 RILDDDTIITTLENLKREAAEVTRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQVHF 3821

  Fly  3832 LYQYSLKMFLDIFSTVLYNNPKLEGRTDHSERLGIVTRDLFQVCYERVARGMIHIDRLTFALLMC 3896
            ||||||:.||||:..|||.||.|:|.|||::||.::|:|||||.:.||||||:|.|.:|||:|:.
  Rat  3822 LYQYSLQFFLDIYHNVLYENPNLKGATDHTQRLSVITKDLFQVAFNRVARGMLHQDHITFAMLLA 3886

  Fly  3897 KIHLKGT-SESNLDAEFNFFLRSREGLL-ANPTP-VEGLSAEQIESVNRLALRLPIFRKLLEKVR 3958
            :|.|||| .|...||||..|||.:|.:| |..|| |:||:.||.|:|.||:. ||.|:.|:.||:
  Rat  3887 RIKLKGTMGEPTYDAEFQHFLRGKEIVLSAGSTPKVQGLTVEQAEAVARLSC-LPAFKDLIAKVQ 3950

  Fly  3959 SIPELGAWLQQSSPEQVVPQLWDESKALSPIASSVHQLLLIQAFRPDRVIAAAHNVVNTVLGEDF 4023
            :..:.|.||:.|||||.||.||.|....:||..::|:|||||||||||::|.||..|:|.|||.|
  Rat  3951 ADEQFGIWLESSSPEQTVPYLWTEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESF 4015

  Fly  4024 MPNAEQELDFTSVVDKQLNCNTPALLCSVPGFDASGRVDDLAAEQNKQISSIAIGSAEGFNQAER 4088
            |...||.||.|.:|..::..|||.|:|||||:||||.|:|||||||.||:|||||||||||||::
  Rat  4016 MSIMEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQADK 4080

  Fly  4089 AINMACKTGRWVLLKNVHLAPQWLVQLEKKMHSLQPHSGFRLFLTMEINPKVPVNLLRAGRIFVF 4153
            |||.|.|:||||:||||||||.||:|||||:||||||:.||||||||||||||||||||||||||
  Rat  4081 AINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFRLFLTMEINPKVPVNLLRAGRIFVF 4145

  Fly  4154 EPPPGIRANLLRTFSTVPAARMMKTPSERARLYFLLAWFHAIVQERLRYVPLGWAKKYEFNESDL 4218
            |||||::||:|||||::|.:||.|:|:||||||||||||||::||||||.||||:|||||.||||
  Rat  4146 EPPPGVKANMLRTFSSIPVSRMCKSPNERARLYFLLAWFHAVIQERLRYAPLGWSKKYEFGESDL 4210

  Fly  4219 RVACDTLDTWIDTTAMGRTNLPPEKVPWDALVTLLSQSIYGGKIDNDFDQRLLTSFLKKLFTARS 4283
            |.||||:|||:|.||.||.|:.|:|:||.||.||::||||||::||:||||||.:||::|||.||
  Rat  4211 RSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEFDQRLLNTFLERLFTTRS 4275

  Fly  4284 FEADFALVANVDGASGGLRHITMPDGTRRDHFLKWIENLTDRQTPSWLGLPNNAEKVLLTTRGTD 4348
            |:::|.|...|||.    :.|.||||.||:.|::|:|.|.|.|||||||||||||:|||||:|.|
  Rat  4276 FDSEFKLACKVDGH----KDIQMPDGIRREEFVQWVELLPDAQTPSWLGLPNNAERVLLTTQGVD 4336

  Fly  4349 LVSKLLKMQQLEDDDELAYSVEDQSEQSAVGRGEDGRPSWMKTLHNSATAWLELLPKNLQVLKRT 4413
            ::||:||||.|||:|:|||:  :..:::......||||:||:|||.:|:.||.|:|:.|..||||
  Rat  4337 MISKMLKMQMLEDEDDLAYA--ETEKKTRTDSTSDGRPAWMRTLHTTASNWLHLIPQTLSPLKRT 4399

  Fly  4414 VENIKDPLYRYFEREVTSGSRLLQTVILDLQDVVLICQGEKKQTNHHRSMLSELVRGIIPKGWKR 4478
            ||||||||:|:|||||..|::|||.|..||.|||.:|:|:|||||:.|::::|||:||:|:.|..
  Rat  4400 VENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSH 4464

  Fly  4479 YTVPAGCTVIQWITDFSNRVQQLQKVSQLVSQAGAKELQGFPVWLGGLLNPEAYITATRQCVAQA 4543
            ||||||.|||||::|||.|::|||.:||..:..|||||:...|.||||..||||||||||.||||
  Rat  4465 YTVPAGMTVIQWVSDFSERIKQLQNISQAAAAGGAKELKNIHVCLGGLFVPEAYITATRQYVAQA 4529

  Fly  4544 NSWSLEELALDVTITDAGLKNDQKDCCFGVTGLKLQGAQCKNNELLLASTIMMDLPVTILKWIK- 4607
            ||||||||.|:|.:| |........|.|||||||||||.|.||:|.|::.|...||:|.|:|.|
  Rat  4530 NSWSLEELCLEVNVT-ASQSTTLDACSFGVTGLKLQGATCSNNKLSLSNAISTVLPLTQLRWGKQ 4593

  Fly  4608 ISSEPRISKLTLPVYLNSTRTELLFTVDLAVAAGQESHSFYERGVAVL 4655
            .|:|.:.|.:|||||||.||.:|:||||..:|..::..||||||||||
  Rat  4594 TSAEKKASVVTLPVYLNFTRADLIFTVDFEIATKEDPRSFYERGVAVL 4641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhc64C	NP_001261432.1	DHC_N1	240..839	CDD:285571	460/605 (76%)
		DYN1	1022..4338	CDD:227570	2467/3330 (74%)
		DHC_N2	1326..1724	CDD:285579	317/397 (80%)
		P-loop_NTPase	1870..2103	CDD:304359	205/236 (87%)
		P-loop_NTPase	2227..2367	CDD:304359	125/139 (90%)
		P-loop_NTPase	2572..2835	CDD:304359	229/262 (87%)
		Cas4_I-A_I-B_I-C_I-D_II-B	2834..>2943	CDD:294426	90/108 (83%)
		P-loop_NTPase	2916..3194	CDD:304359	234/277 (84%)
		MT	3208..3544	CDD:289543	231/335 (69%)
		AAA_9	3569..3784	CDD:289547	190/214 (89%)
		Dynein_heavy	3925..4636	CDD:281078	450/712 (63%)
Dync1h1	NP_062099.3	Stem. /evidence=ECO:0000250	2..1865		1273/1866 (68%)
		DHC_N1	238..830	CDD:285571	460/605 (76%)
		Interaction with DYNC1I2. /evidence=ECO:0000269\|PubMed:10893223	446..701		193/255 (76%)
		Interaction with DYNC1LI2. /evidence=ECO:0000269\|PubMed:10893223	649..800		113/163 (69%)
		DYN1	1044..4327	CDD:227570	2456/3300 (74%)
		DHC_N2	1321..1719	CDD:285579	317/397 (80%)
		P-loop_NTPase	1866..2103	CDD:304359	205/236 (87%)
		AAA 1. /evidence=ECO:0000250	1866..2097		200/230 (87%)
		AAA 2. /evidence=ECO:0000250	2178..2450		202/280 (72%)
		P-loop_NTPase	2217..2357	CDD:304359	125/139 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2389..2409		4/19 (21%)
		AAA 3. /evidence=ECO:0000250	2554..2803		220/248 (89%)
		P-loop_NTPase	2565..2826	CDD:304359	227/260 (87%)
		AAA 4. /evidence=ECO:0000250	2897..3166		230/268 (86%)
		P-loop_NTPase	2907..3185	CDD:304359	234/277 (84%)
		Stalk. /evidence=ECO:0000250	3187..3498		212/311 (68%)
		MT	3199..3530	CDD:289543	228/331 (69%)
		AAA 5. /evidence=ECO:0000250	3551..3780		199/228 (87%)
		AAA_9	3559..3774	CDD:289547	190/214 (89%)
		Dynein_heavy	3920..4630	CDD:281078	451/717 (63%)
		AAA 6. /evidence=ECO:0000250	4003..4219		162/215 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346518
Domainoid	1	1.000	928	1.000	Domainoid score	I38
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1053
Inparanoid	1	1.050	5405	1.000	Inparanoid score	I1
OMA	1	1.010	-	-		QHG54007
OrthoDB	1	1.010	-	-		D26380at2759
OrthoFinder	1	1.000	-	-		FOG0005527
OrthoInspector	1	1.000	-	-		oto96570
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	1	1.100	-	-	LDO	PTHR10676
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3378
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810