DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhc64C and DNAH10

DIOPT Version :9

Sequence 1:	NP_001261432.1	Gene:	Dhc64C / 38580	FlyBaseID:	FBgn0261797	Length:	4661	Species:	Drosophila melanogaster
Sequence 2:	NP_001359035.1	Gene:	DNAH10 / 196385	HGNCID:	2941	Length:	4589	Species:	Homo sapiens

Alignment Length:	4987	Identity:	1280/4987 - (25%)
Similarity:	2261/4987 - (45%)	Gaps:	835/4987 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PASLNDAL--DDPVNQDTIRKFLSDPQVQ----ALYVQRNCIKE----DDSEQPA---EGEDEKE 96
            |....|.|  ||...:|.|..||:....:    ||::.|..:.|    :..|.|.   |||:|:|
Human    22 PQLFEDLLNRDDGQGEDLILHFLNQASEEEGPSALFIYRTMVPEEVEVEIDEIPVLSEEGEEEEE 86

  Fly    97 QVTYQISNDVHFTNSRMASLACIKRGLVV-----EADKSIHSQLRLINFSDGSP--------YET 148
            ..:.::.: |....::..||.....|..:     |.||.|..:|         |        .|.
Human    87 TYSQKVES-VDKVRAKRVSLRTESLGQPLNREDEEMDKEISEKL---------PSKRTAKHIMEK 141

  Fly   149 LH----------AFISKSLAPYFKSYVKESGRADRDGDKMAPSVEKKLAELEMGL-----LHLQQ 198
            :|          .|:.:::. :|....||   |..:...|..::|.....||.|:     ||..:
Human   142 MHLHMLCTPLPEEFLDQNVV-FFLRNTKE---AISEATDMKEAMEIMPETLEYGIINANVLHFLK 202

  Fly   199 NI----DIPEITLTAHQT----------------------------------------------- 212
            ||    .:|.::...|:|
Human   203 NIICQVFLPALSFNQHRTSTTVGVTSGEVSNSSEHESDLPPMPGEAVEYHSIQLIRDEFLMNVQK 267

  Fly   213 -VNNVIRKCAEENRKAKV--------ADFGDKVEDSSFLNLLQNGVNRWIAEIKKV--TKLNRDP 266
             .:|:.|...:...:.|:        .:..|...|...:::|:..|..|:.:|...  .:|.:.|
Human   268 FASNIQRTMQQLEGEIKLEMPIISVEGEVSDLAADPETVDILEQCVINWLNQISTAVEAQLKKTP 332

  Fly   267 GSGTALQEISFWLNLERALYRIQEKRESPEVALTLDILKHGK---------------RFHATVSF 316
            .....|.||.||......|..:.|:.:.|.|...||::|...               :||...|.
Human   333 QGKGPLAEIEFWRERNATLSALHEQTKLPIVRKVLDVIKESDSMLVANLQPVFTELFKFHTEASD 397

  Fly   317 DTDTGLKQALATVADY----------NPLMKDFPINDLLSATELEKIRPAVQQIFAHLRKVRNTK 371
            :.     :.|:||..|          :.::...|.  ::||..:      |..|..|..|
Human   398 NV-----RFLSTVERYFKNITHGSGFHVVLDTIPA--MMSALRM------VWIISRHYNK----- 444

  Fly   372 YPIQRCLKLIEAISRDLSQQLLKVLGTRRLMHIPFDEFERVMNQCFEI-----FSCWDDEYDKLQ 431
              .:|.:.|:|.|:.::::::.:|:..|.|    |.| .|...|...:     ...|...|...:
Human   445 --DERMIPLMERIAWEIAERVCRVVNLRTL----FKE-NRASAQSKTLEARNTLRLWKKAYFDTR 502

  Fly   432 GLLRDIVKKKRDEHLKMVWRVSPAHKKLQTRMEHMRKFRRQHEQLRTVILRVLRPTKPAVGDDGN 496
            ..:....::.|       |...  .|:|..|.::|....:....    :|::|.......|.:..
Human   503 AKIEASGREDR-------WEFD--RKRLFERTDYMATICQDLSD----VLQILEEFYNIFGPELK 554

  Fly   497 VVETKQPYSLD----AADANAIEEVNLAYENVKEVDCLDITKEGSEAWEAAVKRYEEKIDRVETR 557
            .| |..|..:|    ..|.......||.::        ..:.:.|:.|:..:..::.::..:|..
Human   555 AV-TGDPKRIDDVLCRVDGLVTPMENLTFD--------PFSIKSSQFWKYVMDEFKIEVLVIEKE 610

  Fly   558 ITAHLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIRE-YQTQLIQRVKD-------DIEALH 614
            ....:.:...|.::|...|.:..:|.      |||.  || ...|::.:..|       :|:.::
Human   611 AKHFIDESFKTLRSAEAAFDMLLKFK------HIRS--REAVNRQMMMKFNDILAQYCKEIDIIN 667

  Fly   615 EKFKVQYPQSKSCRLSSVRDLPPVAGSIIWARQIDNQL---TMYLKRVEDVL--GKGWET---HI 671
            :.| ||..::...    .::.|||||:|.|.|.:..::   .:..:.|:::|  .:|.|.   ::
Human   668 KIF-VQNLENPPL----YKNHPPVAGAIYWERSLFFRIKHTILRFQEVQEILDSDRGQEVKQKYL 727

  Fly   672 E-GQKLKADGDSFRAKLSISDVFHEWARKVQE-------RNFGSTGRIFTIESTRSRIGRGNVLR 728
            | |:.:|...|.         .:.:|....::       ::..:...|.|.|.  |.:.||.|
Human   728 EVGRTMKEYEDR---------KYEQWMEVTEQVLPALMKKSLLTKSSIATEEP--STLERGAV-- 779

  Fly   729 LRVNFLPEIITLAKEVRNIKNLGFRVPLTIVNKAHQANQIYPYAISLIESVRTYERTLEKLNNRS 793
            ..:||.|.:..:..|.:.::.|||.||....|.|.|.::...|...:...:..|...:..||:
Human   780 FAINFSPALREIINETKYLEQLGFTVPELARNVALQEDKFLRYTAGIQRMLDHYHMLIGTLND-- 842

  Fly   794 LAQNSVFKIEDRASIVPLVAGLRKDVLNLVSEGIGLIWESYKLDPYVIRLSECVTQFQEKV---- 854
             |::.:.|...:..:....:|.::           |.|.|..:..|:....:.:.:|:..|
Human   843 -AESVLLKDHSQELLRVFRSGYKR-----------LNWNSLGIGDYITGCKQAIGKFESLVHQIH 895

  Fly   855 ---DDL---LVVEEQLDV----DVRSLETCPYSAATFVEILSKIQHAVDDLSLRQYSNLSVWVTR 909
               ||:   |.:.|.:::    ..:|.|..| ....|.|.:.:.:.:..|..:|.|..:...:|:
Human   896 KNADDISSRLTLIEAINLFKYPAAKSEEELP-GVKEFFEHIERERASDVDHMVRWYLAIGPLLTK 959

  Fly   910 LD-------------------------EEVEKKLALRLQAGIQAWTEALTGNKKEVDTSMDTDAP 949
            ::                         .||..||.|:   .:|::...:.||.....|
Human   960 VEGLVVHTNTGKAPKLASYYKYWEKKIYEVLTKLILK---NLQSFNSLILGNVPLFHT------- 1014

  Fly   950 AQPTHKLGGDPQIQNAVHEIRITNQQMYLYPSIEEARFQIMQQFFAWQAIVTSQVRLQSTRYQVG 1014
                              |..:|..::.|:|:..|                ..::.....|..|.
Human  1015 ------------------ETILTAPEIILHPNTNE----------------IDKMCFHCVRNCVE 1045

  Fly  1015 LEKHVSQTYRNLLTKLPEGK------ILENAYG-------AIEQKVSEVRN----------YVDE 1056
            :.||..:.......:.|..|      ::.|.|.       .|||.|...:|          |:.:
Human  1046 ITKHFVRWMNGSCIECPPQKGEEEEVVIINFYNDISLNPQIIEQAVMIPQNVHRILINLMKYLQK 1110

  Fly  1057 WLRYQSLWDLQADMLYGRLG----------EDVNLWIKCLNDIKQSRTTFDTSDTRRAYGPIIID 1111
            |.||:.||.|...::..:..          |.:..:.|...::.:.              |:|.|
Human  1111 WKRYRPLWKLDKAIVMEKFAAKKPPCVAYDEKLQFYSKIAYEVMRH--------------PLIKD 1161

  Fly  1112 YAKVQAKV-----TLKYD--SWHKEALGKFGTLLG----TEMTSFHSKVSKSRTDLEMQSIEAAS 1165
            ...::.::     |::.:  ||    :...|.||.    .|:.:.|.::.....:|.    :..:
Human  1162 EHCIRLQLRHLANTVQENAKSW----VISLGKLLNESAKEELYNLHEEMEHLAKNLR----KIPN 1218

  Fly  1166 TSDAVSFI--TYVQSLKKDMIAWDKQVEV-FREAQRILERQRFQ-----FPNTWLH--VDNIEGE 1220
            |.:.:.|:  |..:...|.::     :|: :|:.|   ||.|..     ||.....  ||.||..
Human  1219 TLEDLKFVLATIAEIRSKSLV-----MELRYRDVQ---ERYRTMAMYNLFPPDAEKELVDKIESI 1275

  Fly  1221 WS-AFNEI---------IKRKDTAIQTQVASLQAKIVAEDKAVETRTVDFLNDWEKTKPTGGKIR 1275
            || .||:.         |||..|.: |:...:..::..|:.|....:       |.....|..:
Human  1276 WSNLFNDSVNVEHALGDIKRTFTEL-TRGEIMNYRVQIEEFAKRFYS-------EGPGSVGDDL- 1331

  Fly  1276 PDDALQQLQIFESKYSRLKEERDNVVKAKEALELQESAVPNNSAERMNVALEELQDLRGVWSELS 1340
             |..::.|.::|.:.:|.::.|..:..|::..:|..:..|    |.:.|. :|:..||.::....
Human  1332 -DKGVELLGVYERELARHEKSRQELANAEKLFDLPITMYP----ELLKVQ-KEMSGLRMIYELYE 1390

  Fly  1341 KVWTQIDETREKPWLSVQPRKLRQQLEAMMAQLKELPARLRMYESYEYVKKLIQSYIKVNMLIVE 1405
            .:....:|..:..|:::..:.|::.:|..:..|::||..:|......|::..::::.....|:::
Human  1391 GLKVAKEEWSQTLWINLNVQILQEGIEGFLRALRKLPRPVRGLSVTYYLEAKMKAFKDSIPLLLD 1455

  Fly  1406 LKSDALKERHWKQLTKQLRVNWVLSD-LSLGQVWDVNLQKNEGIVKDIILVAQGEMALEEFLKQV 1469
            ||::||::||||:|.::..|.:.::: .:|..::.:.|.|:..::.:|:..|..|:|:|:.:|::
Human  1456 LKNEALRDRHWKELMEKTSVFFEMTETFTLENMFAMELHKHTDVLNEIVTAAIKEVAIEKAVKEI 1520

  Fly  1470 RESWQNYELDLINY----QNKCRIIRGWDDLFNKVKEHINSVAAMKLSPYYKVFEEEALTWEEKL 1530
            .::|:|.:..::.|    |.:..|:...|::...:.::..::.::..|.:...|.:....||:.|
Human  1521 LDTWENMKFTVVKYCKGTQERGYILGSVDEIIQSLDDNTFNLQSISGSRFVGPFLQTVHKWEKTL 1585

  Fly  1531 NRINALFDVWIDVQRRWVYLEGIFSGSADIKTLLPVETSRFQSISSEFLGLMKKVTKSPKVMDVL 1595
            :.|..:.::|:.|||:|:|||.||.| .||::.||.|..:|.:|...|..:|.:..|.|.:....
Human  1586 SLIGEVIEIWMLVQRKWMYLESIFIG-GDIRSQLPEEAKKFDNIDKVFKRIMGETLKDPVIKRCC 1649

  Fly  1596 NIPAVQRSLERLADLLGKIQKALGEYLERERTSFPRFYFVGDEDLLEIIGNSKNIARLQKHFKKM 1660
            ..|.....|:.:::.|.|.||:|.:||:.:|.:||||:|:.|::||.|:|:|..:. :|:|..||
Human  1650 EAPNRLSDLQNVSEGLEKCQKSLNDYLDSKRNAFPRFFFISDDELLSILGSSDPLC-VQEHMIKM 1713

  Fly  1661 FAGVAAILLNEENN---VILGISSREGEEVHFMNPVSTVEHPKINEWLSLVEKQMRFTLASLLAQ 1722
            :..:|::..|:.::   ::..:.|.|||.:.|...:..  ..::.:|::.|..:||.|...:..:
Human  1714 YDNIASLRFNDGDSGEKLVSAMISAEGEVMEFRKILRA--EGRVEDWMTAVLNEMRRTNRLITKE 1776

  Fly  1723 AVQDIKQFRDGKIDPQAYMEWCDKYQAQIVVLAAQILWSEDVESALQQASE------NNQSKPMQ 1781
            |:     ||  ..:.::.::|...||..:|:.|:|:.|:.:||....:|.:      .|..:.|.
Human  1777 AI-----FR--YCEDRSRVDWMLLYQGMVVLAASQVWWTWEVEDVFHKAQKGEKQAMKNYGRKMH 1834

  Fly  1782 RVLGNVESTLNVLADSVLQEQPPLR---RRKLEHLINEFVHKRTVTRRLLNNGVTSPKSFQWLCE 1843
            |.:..:.:.:.:          ||.   |:|...::...||.|.:....:...:...:.|.|..:
Human  1835 RQIDELVTRITM----------PLSKNDRKKYNTVLIIDVHARDIVDSFIRGSILEAREFDWESQ 1889

  Fly  1844 MRFYFDPRQTEVLQQLTIHMANARFFYGFEYLGVQDRLVQTPLTDRCYLTMTQALESRLGGSPFG 1908
            :|||:|....|    |.|......|.||:||:|:..|||.||||||.|||:||||...|||:|.|
Human  1890 LRFYWDREPDE----LNIRQCTGTFGYGYEYMGLNGRLVITPLTDRIYLTLTQALSMYLGGAPAG 1950

  Fly  1909 PAGTGKTESVKALGNQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAC 1973
            ||||||||:.|.|...||...:|.||.|..|::|:|:||.||.|.|||||||||||::..:||..
Human  1951 PAGTGKTETTKDLAKALGLLCVVTNCGEGMDYRAVGKIFSGLAQCGAWGCFDEFNRIDASVLSVI 2015

  Fly  1974 SQQIQTIQEALKYEMDSNKESITVELVGKQVRVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLA 2038
            |.|||||:.||.:::      .|.:..|:::.:...|.||||||||||||:.||:::|.|||.:.
Human  2016 SSQIQTIRNALIHQL------TTFQFEGQEISLDSRMGIFITMNPGYAGRTELPESVKALFRPVV 2074

  Fly  2039 MTTPDRQLIAEVMLFSQGFRSAEKLACKIVPFFKLCDEQLSNQSHYDFGLRALKSVLISAGNVKR 2103
            :..||.|.|.|:||||:||..|:.||.|:...:||..||||.|.|||||||||||||:.||.:||
Human  2075 VIVPDLQQICEIMLFSEGFLEAKTLAKKMTVLYKLAREQLSKQYHYDFGLRALKSVLVMAGELKR 2139

  Fly  2104 DRIMKIKEQMKQRGDENIDEASVAENLPEQEILIQSVCETMVPKLVAEDIPLLFSLLSDVFPNVG 2168
            .                      :.:|.|..:|::::.:..:||.|.||:||...|:||:||.:.
Human  2140 G----------------------SSDLREDVVLMRALRDMNLPKFVFEDVPLFLGLISDLFPGLD 2182

  Fly  2169 YTRAEMKGLKEEIRKVCQED-YLVCGEGDEQGAAWMEKGLGSTWVDKVLQLYQISNLNHGLMMVG 2232
            ..|.......:.:.:|.:|: |.|.                ...||||:|:::.....|..|:||
Human  2183 CPRVRYPDFNDAVEQVLEENGYAVL----------------PIQVDKVVQMFETMLTRHTTMVVG 2231

  Fly  2233 PSGSGKSTAWKTLLKALERFEGVEGVAHVIDPKAISKEALYGVLDPNTREWTDGLFTHILRKIID 2297
            |:..|||....||.:|..:. |:....::::|||:|...|||:|||.||:||||:.::|.|:|
Human  2232 PTRGGKSVVINTLCQAQTKL-GLTTKLYILNPKAVSVIELYGILDPTTRDWTDGVLSNIFREI-- 2293

  Fly  2298 NVRGEINKRQWIIFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVRVMFEVQDLKFATLA 2362
            |...:..:|::|:||||||..||||:|||:|||:||||.||||:.|..:..::|||.||::|:.|
Human  2294 NKPTDKKERKYILFDGDVDALWVENMNSVMDDNRLLTLANGERIRLQAHCALLFEVGDLQYASPA 2358

  Fly  2363 TVSRCGMVWFSEDVLSTEMIFENYLSRLRSIPLEDGDEDFVGVIKPAKDKEEEVSPSLQVQRDIA 2427
            ||||||||:.....|.....::.::::   ||                :|.|:
Human  2359 TVSRCGMVYVDPKNLKYRPYWKKWVNQ---IP----------------NKVEQ------------ 2392

  Fly  2428 LLLLPFFSADGIVVRTLEYAMD--QEHIMDFTRLRALSSLFSMLNQAARNVLTFNAQHPDFPCSA 2490
                  ::.:.:..:.:.|.||  .|.|:|.   |....|.:::.|...|::|..|:..|.....
Human  2393 ------YNLNSLFEKYVPYLMDVIVEGIVDG---RQAEKLKTIVPQTDLNMVTQLAKMLDALLEG 2448

  Fly  2491 -----DQLEHYIPKALVYSVLWSFAGDAKLKVRIDLGDFVR---SVTTVPLPGAAGAP------- 2540
                 |.||.|..:||..|:..|...|.::|    ..::::   |::||...|....|
Human  2449 EIEDLDLLECYFLEALYCSLGASLLEDGRMK----FDEYIKRLASLSTVDTEGVWANPGELPGQL 2509

  Fly  2541 --IIDYEV-NMSGDWVPWSNKVP-VIEVETHKVASPDIVVPTLDTVRHESLLYTWLAEH-----K 2596
              :.|:.. |....|||||..|| .|.....|..  :|:|.|:||.|     .||:.|.     :
Human  2510 PTLYDFHFDNKRNQWVPWSKLVPEYIHAPERKFI--NILVHTVDTTR-----TTWILEQMVKIKQ 2567

  Fly  2597 PLVLCGPPGSGKTMTLFSALRALPDME--VVGLNFSSATTPELLLKTFDHYCEYR-KTPNGVVLS 2658
            |::..|..|:.||.|..:.|:.|.:..  |:.:||||.||...:.:..:...|.| |...|
Human  2568 PVIFVGESGTSKTATTQNFLKNLSEETNIVLMVNFSSRTTSMDIQRNLEANVEKRTKDTYG---- 2628

  Fly  2659 PVQIGKWLVLFCDEINLPDMDSYGTQRVISFLRQLVEHKGFY--RASDQAWVSLERIQFVGACNP 2721
             ..:||.|::|.|::|:|.:|.||||:.|:.|:.|:| ||:.  |..:....|:..:.|:.|..
Human  2629 -PPMGKRLLVFMDDMNMPRVDEYGTQQPIALLKLLLE-KGYLYDRGKELNCKSIRDLGFIAAMG- 2690

  Fly  2722 PTDPGRKPLSHRFLRHVPIIYVDYPGETSLKQIYGTFSRAMLRLMPALRGYAEPLTNAMVEF--- 2783
            ....||..:..||:....:..|.:|.|.||..||.:.          |:|:......::|..
Human  2691 KAGGGRNEVDPRFISLFSVFNVPFPSEESLHLIYSSI----------LKGHTSTFHESIVAVSGK 2745

  Fly  2784 ----YLASQDRFTQDMQP-----HYVYSPREMTRWVRGICEAIRPLDSLPVEGLVRLWAHEALRL 2839
                .||......||:.|     ||:::.|:::|...|:. ...|.....|..:||:|.:|.||:
Human  2746 LTFCTLALYKNIVQDLPPTPSKFHYIFNLRDLSRVFNGLV-LTNPERFQTVAQMVRVWRNECLRV 2809

  Fly  2840 FQDRLVDDSERRWTNENIDLVGQKHFPGINQEEALQRPILYSNW--LSKDYMPVNREELREYVHA 2902
            |.|||:.:::::...::|..:..:||.. :.|..::.|||:.::  ...:..|...|::::|..|
Human  2810 FHDRLISETDKQLVQQHIGSLVVEHFKD-DVEVVMRDPILFGDFQMALHEGEPRIYEDIQDYEAA 2873

  Fly  2903 R------LKVFYEEELDVPLVLFDEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMN 2961
            :      |:.:.|....:.|||||:.|:|:.|:.||.|..:||.||:||.|:||.:|||..|:..
Human  2874 KALFQEILEEYNESNTKMNLVLFDDALEHLTRVHRIIRMDRGHALLVGVGGSGKQSLSRLAAFTA 2938

  Fly  2962 GLSIFQIKVHNKYTSEDFDEDLRCVLRRSGCKDEKIAFILDESNVLDSGFLERMNTLLANGEVPG 3026
            ...:|:|.:...|:...|.|||:.:..:.|.:::.:.|:..:::|.:.||||.:|.:|.:|.||.
Human  2939 SCEVFEILLSRGYSENSFREDLKSLYLKLGIENKAMIFLFTDAHVAEEGFLELINNMLTSGIVPA 3003

  Fly  3027 LFEGDEYTTLMTQCKEGAQREGLMLDSSDELYKWFTQQVMRNLHVVFTMNPSTDGLKDRAATSPA 3091
            ||..:|..::::|..:.|.::| |..:.:.::::|..:...|||:|..|:|..|.|:......|.
Human  3004 LFSEEEKESILSQIGQEALKQG-MGPAKESVWQYFVNKSANNLHIVLGMSPVGDTLRTWCRNFPG 3067

  Fly  3092 LFNRCVLNWFGDWSDSALFQVGKEFTTRVDLEKPNWHAPDFFPSVCPLVPANPTHRDAVINSCVY 3156
            :.|...::||..|...||..|.|.|.                 ...|::||.  :.:.|:...|.
Human  3068 MVNNTGIDWFMPWPPQALHAVAKSFL-----------------GYNPMIPAE--NIENVVKHVVL 3113

  Fly  3157 VHQTLHQANARLAKRGGRTMAVTPRHYLDFIHHFVKLYNEKRSDLEEQQLHLNVGLNKIAETVEQ 3221
            |||::...:.:..::..|:..|||::|||||:.:.||.:||......|...|:.||:|:.|...|
Human  3114 VHQSVDHYSQQFLQKLRRSNYVTPKNYLDFINTYSKLLDEKTQCNIAQCKRLDGGLDKLKEATIQ 3178

  Fly  3222 VEEMQKSLAVKKQELQAKNEAANAKLKQMFQDQQEAEKKKIQSQEIQIRLADQTVKIEEKRKYVM 3286
            ::|:.:.||.:|..|..|:.|..|.|:::..:...||:||..::|..:.:.:|...|..::....
Human  3179 LDELNQKLAEQKIVLAEKSAACEALLEEIAVNTAVAEEKKKLAEEKAMEIEEQNKVIAMEKAEAE 3243

  Fly  3287 ADLAQVEPAVIDAQAAVKSIRKQQLVEVRTMANPPSVVKLALESICLLLGENATDWKSIRAVIMR 3351
            ..||:|.|.:..|:..::.:.|..:.|:|:.|.||..|:...|.|.::.|....:||:.:.|:..
Human  3244 TTLAEVMPILEAAKLELQKLDKSDVTEIRSFAKPPKQVQTVCECILIMKGYKELNWKTAKGVMSD 3308

  Fly  3352 ENFINSIVSNFGTENITDDVREKMKS--KYLSNPDYNFEKVNRASMACGPMVKWAIAQIEYADML 3414
            .||:.|:: ....::||....:.:|.  |.|:......|.|::|.:.   |:|:..|.:.|.|:.
Human  3309 PNFLRSLM-EIDFDSITQSQVKNIKGLLKTLNTTTEEMEAVSKAGLG---MLKFVEAVMGYCDVF 3369

  Fly  3415 KRVEPLREELRSLEEQADVNLASAKETKDLVEQLERSIAAYKEE-------YAQLISQAQAIKTD 3472
            :.::|.||::..||....:       ||..:|:::..:||.::|       |...|.:.|.::.:
Human  3370 REIKPKREKVARLERNFYL-------TKRELERIQNELAAIQKELETLGAKYEAAILEKQKLQEE 3427

  Fly  3473 LENVQAKVDRSIALLKSLNIERERWESTSETFKSQMSTIIGDVLLSAAFIAYGGYFDQHYRLNLF 3537
            .|.::.::..:..|:..|..|..||.:..:....:...::||.||.|||::|.|.|...:|..:.
Human  3428 AEIMERRLIAADKLISGLGSENIRWLNDLDELMHRRVKLLGDCLLCAAFLSYEGAFTWEFRDEMV 3492

  Fly  3538 T-TWSQHLQAASIQYRADIARTEYLSNPDERLRWQANALPTDDLCTENAIMLKRFNRYPLIIDPS 3601
            . .|...:....|...........|::..|..||.:..||.|:|..:|.|:..|.:|:||.|||.
Human  3493 NRIWQNDILEREIPLSQPFRLESLLTDDVEISRWGSQGLPPDELSVQNGILTTRASRFPLCIDPQ 3557

  Fly  3602 GQATTFLLNEYAGKKITKTSFLDDSFRKNLESALRFGNPLLVQDVENY-DPILNPVLNRELRRTG 3665
            .||..::..:.....:...||.|..|.|.||.::::|.|.|.:||:.| ||:::.||.:.::.:.
Human  3558 QQALNWIKRKEEKNNLRVASFNDPDFLKQLEMSIKYGTPFLFRDVDEYIDPVIDNVLEKNIKVSQ 3622

  Fly  3666 GRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDICSRVTFVNFTVTRSSLQSQCLNQVLKAERP 3730
            ||..|.|||:::|...:|.::|:|:.....:.|.:..:...:|:|||...|:.|.|:.::..||.
Human  3623 GRQFIILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQLLSVLVAYERR 3687

  Fly  3731 DIDEKRSDLLKLQGEFRLRLRQLEKSLLQALNDAKGKILDDDSVITTLETLKKEAYDINQKVDET 3795
            :::|:|..|::...|.:..|:.||.|||:.|..:.|.:||:..::.|||..|.:|.::::|:...
Human  3688 ELEEQREHLIQETSENKNLLKDLEDSLLRELATSTGNMLDNVDLVHTLEETKSKATEVSEKLKLA 3752

  Fly  3796 DKVIAEIETVSQQYLPLSVACSNIYFTMDSLNQVHFLYQYSLKMFLDIFSTVLYNNPKLEGRTDH 3860
            :|...:|:.:...|.|.:...:.::|.:..:..|:.:|||||..||::|...|   .|....:..
Human  3753 EKTALDIDRLRDGYRPAARRGAILFFVLSEMALVNSMYQYSLIAFLEVFRLSL---KKSLPDSIL 3814

  Fly  3861 SERLGIVTRDLFQVCYERVARGMIHIDRLTFALLMCKIHLKGTSESNLDAEFNFFLRSREGL--L 3923
            .:||..:...|....|.....|:....:|.|:..| .|.::.........|.:|||:....|  .
Human  3815 MKRLRNIMDTLTFSIYNHGCTGLFERHKLLFSFNM-TIKIEQAEGRVPQEELDFFLKGNISLEKS 3878

  Fly  3924 ANPTPVEGLSAEQIESVNRLA-LRLPIFRKLLEKVRSIPEL-GAWLQQSSPEQV-VPQLWDESKA 3985
            ....|...||.:..|.:..|: :....|.:|.:.|.:...: ..|....|.||. ||..:|.:
Human  3879 KRKKPCAWLSDQGWEDIILLSEMFSDNFGQLPDDVENNQTVWQEWYDLDSLEQFPVPLGYDNN-- 3941

  Fly  3986 LSPIASSVHQLLLIQAFRPDRVIAAAHNVVNTVLGEDFM--PNAEQELDFTSVVDKQLNCNTPAL 4048
            ::|.    .:||:::.||.|||..|..:.|...:||.::  |....|..|     :|...::|.:
Human  3942 ITPF----QKLLILRCFRVDRVYRAVTDYVTVTMGEKYVQPPMISFEAIF-----EQSTPHSPIV 3997

  Fly  4049 LCSVPGFDASGRVDDLAAEQ---NKQISSIAIGSAEGFNQAERAINMACKTGRWVLLKNVHLAPQ 4110
            ....||.|.:..:..||...   ..::..:|:|..:. ..|.:.:..|...|:|::|:|.||..:
Human  3998 FILSPGSDPATDLMKLAERSGFGGNRLKFLAMGQGQE-KVALQLLETAVARGQWLMLQNCHLLVK 4061

  Fly  4111 WLVQLEKKMHSL-QPHSGFRLFLTMEINPKVPVNLLRAGRIFVFEPPPGIRANLLRTFSTVPAAR 4174
            ||..|||.:..: :||..|||:||.:.....|:.:|:.....|.|||.|::.|:..|:..:....
Human  4062 WLKDLEKSLERITKPHPDFRLWLTTDPTKGFPIGILQKSLKVVTEPPNGLKLNMRATYFKISHEM 4126

  Fly  4175 MMKTPSERAR-LYFLLAWFHAIVQERLRYVPLGWAKKYEFNESDLRVACDTLDTWIDTTAMGRTN 4238
            :.:.|....: |.::||:|||:||||.::..:||...|:|||||.:|..:.|:|::......|
Human  4127 LDQCPHPAFKPLVYVLAFFHAVVQERRKFGKIGWNVYYDFNESDFQVCMEILNTYLTKAFQQR-- 4189

  Fly  4239 LPPEKVPWDALVTLLSQSIYGGKIDNDFDQRLLTSFLKK-----LFTA-------RSFEADFALV 4291
              ..::||.:|..|:.:.:|||:..:.||:|:||.::.:     :|..       |:.|.|:.:
Human  4190 --DPRIPWGSLKYLIGEVMYGGRAIDSFDRRILTIYMDEYLGDFIFDTFQPFHFFRNKEVDYKI- 4251

  Fly  4292 ANVDGASGGLRHITMPDGTRRDHFLKWIENLTDRQTPSWLGLPNNAEKVLLTTRGTDLVSKLLKM 4356
                           |.|..::.|::.||.|....||...||..|||....|....|:.:.||::
Human  4252 ---------------PVGDEKEKFVEAIEALPLANTPEVFGLHPNAEIGYYTQAARDMWAHLLEL 4301

  Fly  4357 QQLEDDDELAYSVEDQSEQSAVGRGEDGRPSWMKTLHNSATAWLELLPKNL---QVLKRTVENIK 4418
            |....:.....|.:|...|.|            |.:.|.       :||..   ||.||....:
Human  4302 QPQTGESSSGISRDDYIGQVA------------KEIENK-------MPKVFDLDQVRKRLGTGL- 4346

  Fly  4419 DPLYRYFEREVTSGSRLLQTVILDLQDVVLICQGEKKQTNHHRSMLSELVRGIIPKGWKRYTVPA 4483
            .|......:|:...::|:..:...|.::.....||...:|....:...|..|.||..|:|.....
Human  4347 SPTSVVLLQELERFNKLVVRMTKSLAELQRALAGEVGMSNELDDVARSLFIGHIPNIWRRLAPDT 4411

  Fly  4484 GCTVIQWITDFSNRVQQLQKVSQLVSQAGAKELQGFPVWLGGLLNPEAYITATRQCVAQANSWSL 4548
            ..::..|:..|..|..|.        .....|.:...:||.||..||:|:||..|...:.|.|.|
Human  4412 LKSLGNWMVYFLRRFSQY--------MLWVTESEPSVMWLSGLHIPESYLTALVQATCRKNGWPL 4468

  Fly  4549 EELALDVTIT---DAGLKNDQK-DCCFGVTGLKLQGAQ------CKNNELLLAS---TIMMDLPV 4600
            :...|...:|   ||...|::. ..|| |:||.|:||.      |     |:.|   .:::|||
Human  4469 DRSTLFTQVTKFQDADEVNERAGQGCF-VSGLYLEGADWDIEKGC-----LIKSKPKVLVVDLP- 4526

  Fly  4601 TILKWIKISSEPRISKLTL------PVYLNSTRTE-----LLFTVDL 4636
             |||.|.|.:.    :|.|      |||..|.|..     |:|..||
Human  4527 -ILKIIPIEAH----RLKLQNTFRTPVYTTSMRRNAMGVGLVFEADL 4568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhc64C	NP_001261432.1	DHC_N1	240..839	CDD:285571	125/658 (19%)
		DYN1	1022..4338	CDD:227570	982/3483 (28%)
		DHC_N2	1326..1724	CDD:285579	103/405 (25%)
		P-loop_NTPase	1870..2103	CDD:304359	129/232 (56%)
		P-loop_NTPase	2227..2367	CDD:304359	68/139 (49%)
		P-loop_NTPase	2572..2835	CDD:304359	79/284 (28%)
		Cas4_I-A_I-B_I-C_I-D_II-B	2834..>2943	CDD:294426	34/116 (29%)
		P-loop_NTPase	2916..3194	CDD:304359	87/277 (31%)
		MT	3208..3544	CDD:289543	88/345 (26%)
		AAA_9	3569..3784	CDD:289547	72/215 (33%)
		Dynein_heavy	3925..4636	CDD:281078	201/759 (26%)
DNAH10	NP_001359035.1	DHC_N1	306..876	CDD:369845	125/656 (19%)
		DYN1	1274..4265	CDD:227570	928/3214 (29%)
		DHC_N2	1372..1777	CDD:369852	104/409 (25%)
		AAA_6	1912..2238	CDD:372306	162/369 (44%)
		AAA_8	2891..3150	CDD:372310	86/278 (31%)
		Dynein_C	4288..4586	CDD:375627	83/321 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810