DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dhc64C and dhc-4

DIOPT Version :9

Sequence 1:NP_001261432.1 Gene:Dhc64C / 38580 FlyBaseID:FBgn0261797 Length:4661 Species:Drosophila melanogaster
Sequence 2:NP_001338793.1 Gene:dhc-4 / 189209 WormBaseID:WBGene00012272 Length:2727 Species:Caenorhabditis elegans


Alignment Length:3405 Identity:603/3405 - (17%)
Similarity:1162/3405 - (34%) Gaps:1051/3405 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   667 WETHIEGQKLKADGDSFRAK-----LSISDVFHEWARK--VQERNFGSTGRIFTIESTRSRIGRG 724
            |  |:|.|:.|......|.|     :.::.:::...:|  ::.|...|..|:..:.....||.:.
 Worm    57 W--HVEQQEAKKKFRRLREKNRDESIYVAKLWYYVLKKHPLKPRVEWSFQRVHKLSPKNERIAQE 119

  Fly   725 NVLRLRVNFLPEIITLAKEVRNIKNLGFRVPLTIVNKAHQANQIYPYAISLIESVRTYERTLEKL 789
                     |.|::..|:....|:|:.......:.::..:.|:|..|.    ..|:.....|  |
 Worm   120 ---------LEELMDCAERYALIENVADGYQKRVKDELARLNKIEKYH----HHVKNNREIL--L 169

  Fly   790 NNRSLAQNSV-FKIEDRASIVPLVAGLRKDVLNLVSEGIGLIWESYKL-DPYV----------IR 842
            .::|||...: ...|:|.                     |||:|..:| ||.|          :.
 Worm   170 RSQSLAAMKIRIFFENRK---------------------GLIFEVNELIDPEVGNIPIKKFREVT 213

  Fly   843 LSECVTQFQEKVDDLLVVEEQLDVDVRSL-------ETCPYSAATFVEILSKIQHAVDDLSLR-Q 899
            |:: |.:|.::::..|:.:...|...|::       ||...:..|....|..:::....||:. .
 Worm   214 LTK-VLEFSQEINMKLLKKNWRDEKKRNIVQNCIVQETTNAAFGTIQAYLKTLRNKPAFLSIDCM 277

  Fly   900 YSNLSVWVTRLDEEVEKKLALRLQAGIQAWTEALTGNKKEVDTSMDTDAPAQPTHKLGGDPQIQN 964
            ..:..:||.  .|::  :|.|:....:....|.:..:.::.:|..                  :.
 Worm   278 IVDRKLWVN--SEQI--RLLLKEPISVMCALENVRMSTEDCETWQ------------------EE 320

  Fly   965 AVHEIRITNQQMYL-YPSIEEARFQIMQQFFAWQAIVTSQVRL--QSTRYQVGLEKHVS-QTYRN 1025
            |:..:.:.:.::.: :|.|:...|.|.....:.:......:::  .||..|:.|.|.|. .|.|.
 Worm   321 AMICVEVLSHELIVHHPFIQPYAFLIDDYKVSPKLTEEELIKMYDDSTHLQIRLTKAVKLLTIRC 385

  Fly  1026 LLTKLPEGKILENAYGAIEQKVSEVRNYVDEWLRYQSLWDLQADMLYGRLGEDVNLWIKCLNDIK 1090
            .:.:      ||:.:..:::::...||.:...:|.:.                ..|..|.|:|.:
 Worm   386 FVLR------LESVWSEVDRRIRSFRNQLKMAIRRKF----------------TTLLNKLLHDFR 428

  Fly  1091 QSRTTFDTSDTRRAYGPIIIDYAKVQAKVTLKYDSWHKEALGKFGTLLGTEMTSFHSKVSKSRTD 1155
            :    :|.:...|:..|.::...|.|..:.|:.:             :|..:..|          
 Worm   429 K----YDRALQYRSIDPSMMLSNKAQVDLMLQNE-------------IGDSVRQF---------- 466

  Fly  1156 LEMQSIEAASTSDAVSFITYVQSLKKDMIAWDKQVEVFREAQRILERQRFQFP---NTWLHVDNI 1217
                    ....|.|..||  |.:..|....|..::        |...|...|   |.  |....
 Worm   467 --------VEVYDKVFEIT--QHISLDTSQLDTLLQ--------LASLRLSLPQCIND--HAHFF 511

  Fly  1218 EGEWSAFNEIIKRKDTAIQTQVASLQAKIVAEDKAVETRTVDFLNDWEKTKPTGGKIRPDDALQQ 1282
            :...|.|...:.:|.:.:.:.|.....|:    |.|:|              .|.....|:.|.|
 Worm   512 QKRISTFLHFVTKKQSKVMSNVQKAMEKL----KIVQT--------------MGNPQEVDNYLTQ 558

  Fly  1283 LQIFESKYSRLKEERDNVVKAKEALELQESAVPNNSAE--RMNVALEELQDLRGVWSELSKVWTQ 1345
            :       ::|:...||::...|.|...|:||....::  :|...:.|:..|:.::...|..:..
 Worm   559 M-------AKLRPMLDNLITEIEDLNKFETAVDIQVSDVTKMRHFVGEIGSLQSLFEATSGYYKH 616

  Fly  1346 IDETREKPWLSVQPRKLRQQLEAMMAQLKELPARLRMYES-----------YEYVKKLIQSYIKV 1399
            ::...|.       |:....::|....:.:...:|.::||           ..|.:..:.:: |.
 Worm   617 VNAFFES-------RRTLVNIDASRNFIDQFTIQLSIFESSLTTHRAAKHFIAYARNEVDAF-KK 673

  Fly  1400 NMLIVELKS-DALKERHWKQLTKQLRVNWVLS-DL------SLGQVWDVNLQKNEGIVKDIILVA 1456
            |..:.|:.| ..|.:.||      ||::.::. ||      |:.|:.::.|:.:...:|.|...|
 Worm   674 NFAVAEVMSCRRLLDAHW------LRMSEIVGFDLTPYANSSIAQICELGLEAHLQQLKPIAFSA 732

  Fly  1457 QGEMALEEFLKQVRESWQNYELDLINY-QNKCRIIRGWDDLFNKVKEHINSVAAMKLSPYYKVFE 1520
            :.|....:.|..:...|....|::..| |.|..:.....:|.::|:..||::..|  :...::.:
 Worm   733 EREATAADQLHAIVTFWSQEPLEMRCYVQWKLSLALKLSELHHRVQNDINTLKHM--TNVEQITD 795

  Fly  1521 EEALTWEEKLNRINALFDVWIDVQRRWVYLEGIFSGSADIKTLLPVETSRFQSISSEFLGLMKKV 1585
            :....|.|...|...:...|.:.|::|:.:..||....|   .|..|....::.:..|:.:.:.|
 Worm   796 DSLPQWIEWTARAEKILKAWCETQQKWMRVANIFVTCRD---TLQKEYELLRTCAKYFIKIERNV 857

  Fly  1586 TKSPKVMDVLNIPAVQRSLERLADLLGKIQKALGEYLERERTSFPRFYFVGDEDLLEIIGNSKNI 1650
            .|...:..|:.:|.:...::::..::..|.:.:...|:..|.:..|.....:..||.:...:...
 Worm   858 LKDETIYRVMQLPHLPCWIQKINSMVSIIIQGVRGLLDGMRMNNARLCLSSEVHLLNLFSTTSIE 922

  Fly  1651 ARLQKHFKKMFAGVAAILLNEENNVILGISSREGEEVHFMNPVSTVEHPKINEWLSLVEKQMRFT 1715
            .||:...|..|..:..:..|..|.:         |.|..:....||:..|     |.:|.|..  
 Worm   923 TRLKLLLKDCFPSLRRLCFNRRNQL---------EMVDLLEEKVTVDLTK-----SEIESQEP-- 971

  Fly  1716 LASLLAQAVQDIKQFRDGKIDPQAYMEWCDKYQAQIVVLAAQILWSEDVESALQQASENNQSKPM 1780
                 .:.::.|:|....|:             ..|:....|                 ::||..
 Worm   972 -----CELIRSIEQAFASKL-------------TDIITYERQ-----------------DRSKAA 1001

  Fly  1781 QRVLGNV------ESTLNVLADSVLQEQPPLRRRKLEH---LINEFVHKRTVTRRLLNNGVTSPK 1836
            .||..||      ..||:.|..|.:::...::.|.::.   |..:||:...:.|.:       |:
 Worm  1002 SRVGANVAELIETRQTLDPLFLSRVEKTYYIQHRSVQRQSLLTVDFVYSTEINRFI-------PR 1059

  Fly  1837 SF--QW-----------LCEMRFYFDPRQTEVLQQLTIHMANARFFYGFEYLGVQDRLVQTPLTD 1888
            |.  .|           :|..|.:       ||:......:|.|.....:       |::....:
 Worm  1060 SLADSWSSGHIVLLIGEMCSTRSF-------VLRLANCMCSNLRIVNSHQ-------LLEPAFLE 1110

  Fly  1889 RCYLTMTQALESRLGGSPFGPAGTGKTESVKALGNQLGRFVLVFNCDETFDFQAMGRIFVGLC-Q 1952
            |  :|...|:.|                          .|||:.|.| ..|.|.:.::|..|. |
 Worm  1111 R--VTKGIAMSS--------------------------WFVLLENVD-LLDSQLIFKLFKILASQ 1146

  Fly  1953 VGAWGCFDEFNRLEERMLSACSQQIQTIQEALKYEMDSNKESITVELVG---KQVRVSPDMAIFI 2014
            |      ..|.||   .||:..:        :|.::.:|   |.||.:|   :.|.|||  |...
 Worm  1147 V------TSFPRL---FLSSTDE--------IKNQLPTN---IAVEHLGVFHEFVEVSP--AFKF 1189

  Fly  2015 TMNPGYAGRSNLPDNLKKLFRSLAMTTPDRQLIAEVMLFSQGFRSAEKLACKIVPFFKLCDEQLS 2079
            ..:|..:.|::   ::.||...|..|.........|:|        ||:..||      .:.::|
 Worm  1190 ETSPLSSVRTS---SIPKLPAQLVSTGQPPSSPHSVLL--------EKIGAKI------RNREIS 1237

  Fly  2080 NQSHYDFGLRALKSVLISAGNVKRDRIMKIKEQMKQRGDENIDEASVAENLPEQ------EILIQ 2138
            .                ..|::       .||.:|:          ..:|.||:      ::.::
 Worm  1238 G----------------CVGSL-------AKETLKE----------TLQNFPEKIIWVYTDVFVR 1269

  Fly  2139 SVCETMVPKLVAEDIPLLFSLLSDVFPNVGYTRAEMKGLKEEIRKVCQEDYLVCGEG--DEQGAA 2201
            ....|...:..|....:||.:||..                           ..|.|  |.:.:.
 Worm  1270 DQMVTRSDEFAATQSGILFEVLSPA---------------------------TTGNGGSDSERSY 1307

  Fly  2202 WMEKGLGSTWVDKVLQLYQISNLNHGLMMVGPSGSGKSTAWKTLLKALERFEGVEGVAHVIDPKA 2266
            .......|..::.::..|                 |.|..|              .:...|.|..
 Worm  1308 HSTISTSSVTINTIVVFY-----------------GFSEFW--------------NIFPFISPLF 1341

  Fly  2267 ISKEAL------YGVLDPNTREW-------------TDGLFTHILRK-------IIDNVRGEINK 2305
            :.|:..      :..||..:..|             .:|...:.::|       :.:|::.:: .
 Worm  1342 LKKDGYSAQTPPFLTLDDGSTYWPQENVQFLMCIPDEEGFHLNTVKKFDIPFHVVNENLKMDV-A 1405

  Fly  2306 RQWIIFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVRVMFEVQDLKFATLATVSRCGMV 2370
            |.|       ...|.:....:.:           ::||   |.:|.|:.|...:.:|:..:...:
 Worm  1406 RSW-------RKVWHKKYTELFN-----------KISL---VEIMDELVDRILSPMASHFKSTFL 1449

  Fly  2371 WFS-------EDVLSTEMIFENYLSRLRSIPLEDGDEDFVGVIKPAKDKEEEVSPSLQVQRDIAL 2428
            |.|       .|:  ||:|   ..||:.|                       |:.:|::  .:.|
 Worm  1450 WPSTLFQVIYHDL--TEVI---PTSRITS-----------------------VNDTLRI--TVVL 1484

  Fly  2429 LLLPFFSADGIVVRTLEYAMDQEHIMDFTRLRALSSLFSMLNQAARNVLTFNAQHPDFPCSADQL 2493
            ....|.|.         :|.||..:..:.. |||.::...|          :.|.||..|:    
 Worm  1485 ATANFISI---------FADDQGKVEKYMG-RALGAIREKL----------SIQMPDDICN---- 1525

  Fly  2494 EHYIPKALVYSVLWSFA-GDAKLKVRIDLGDFVRSVTTVPLPGAAGAPIIDYEVNMSGDWVPWSN 2557
                         |..: .||...||.:...|.:|  ::....|.|        |:.        
 Worm  1526 -------------WKISYQDATKLVRWEDEPFCQS--SIDKDSAIG--------NIM-------- 1559

  Fly  2558 KVPVIEVETHKVASPDIVVPTLDTVRHESLLYT--WLAEHKPLVLCGPPGSGKTMTLFSALRALP 2620
                            ||.|.:|.:    |.|:  .||....:::.|||.|.|||.:....:.|.
 Worm  1560 ----------------IVTPNMDRL----LFYSIRLLASGHNILVHGPPYSRKTMFVKMISKFLS 1604

  Fly  2621 D------MEVVGLNFSSATTPELLLKTFDHY---CEYRKTPNGVVLSPVQIGKWLVLFCDEINLP 2676
            .      :|.:.|:..|....::..|.|...   ||           .....|.|.:..|..:. 
 Worm  1605 STVGDLTVEFLWLDGKSRVGNDVAQKKFADVVGTCE-----------RAHQSKQLYIVIDRFSF- 1657

  Fly  2677 DMDSYGTQRVISFLRQLVEHKGFYR------------------ASDQAWVSLERI---QFVGACN 2720
                  |:.::..:...|:||.:::                  ..|.||:...:.   .|||...
 Worm  1658 ------TEPLLPIIEFFVDHKTYWKDGKLCNSDAQIRMIIITDEEDYAWLHKTKALASTFVGIAM 1716

  Fly  2721 PPTD--PGRKPLSHRFLRHVPIIYVDYPGE---TSLKQIYGTFSRAMLRLMPALRGYAEPLTNAM 2780
            |.:.  ..:|||..      .:|..::..:   :....|..:||..::.::  .:.|.|.|::..
 Worm  1717 PASTKFKDQKPLVQ------SLIAANFTAKSFSSEYHHILESFSSCIVEIV--RKPYVENLSSMA 1773

  Fly  2781 VEFYLASQDRFTQDMQPHYVYSPREMTRWVRGICEAIRPLDSLP-VEGLVRLWAHEALRLFQDRL 2844
            :...||....|...                          |:.| .:.|:||:.||:.|:..|.:
 Worm  1774 LATRLAKSFFFAFP--------------------------DNCPDPDALLRLFIHESARVIGDAI 1812

  Fly  2845 VDDSERRWT---------NENIDLVGQ---KHFPGINQEEALQR-------------PILYSNWL 2884
              |...|.|         :||.:...|   ||...|::||..:.             .::||...
 Worm  1813 --DPIHRATFAQQFETLIDENFNTAFQAILKHIAQISEEEEEEEGVEKRMTASLDMFDLIYSEVD 1875

  Fly  2885 SKD------YMP-VNR------------EELREYVHARLKVFYEEELDVPLVLFDEVLDHVLRID 2930
            :.|      |.| |:|            |..|.:...|:::|.:.|..          ..|.|:.
 Worm  1876 AHDVVDGLAYEPVVDRVQFQRSIENFLFEHHRNHTKDRVRLFVDWETS----------GWVQRVM 1930

  Fly  2931 RIFRQPQGHLLLIGVSGAGKTTLSR----------------------FVA-WMNGLS-------- 2964
            |:.||...|::|.....:|:|.:.:                      |:: |...||        
 Worm  1931 RVIRQASEHMVLTAPPNSGRTQVVKAACVACNATMMHMQVDATCYDTFISRWEYALSRAINIIAN 1995

  Fly  2965 ---IFQIKVHNKYTSEDFD----EDLR----CVLRRSGCKDEKIAFILDESNVLDSGFLERMNTL 3018
               ...|.||..:..|..:    |.::    |...:....||::..:.::....:.....:|.|:
 Worm  1996 TNQHVVILVHLDFCYEKVEPRWMEQIKLWIECPNTQHLVSDEQLHTMGEQLIECEKNLATQMQTI 2060

  Fly  3019 LANGEVPGLFEGDEYTTLMTQCKEGAQREGLMLDSSDE---LYKWFTQQVMRNLHVVFTMNP--S 3078
              ...:||          ...||.      |.:::..|   |.|....::...|||:|.::|  .
 Worm  2061 --GLRLPG----------QRMCKY------LPVETLKEPQALRKVLEARIFDALHVMFLVDPQFK 2107

  Fly  3079 TDGLKDRAATSPALFNRCVLNWFGDWSDSALFQVGKEFTTRVDLEKPNWHAPDFFPSVCPLVPAN 3143
            ||            |:.|           .:|.|            |.....:....|..::...
 Worm  2108 TD------------FSWC-----------TIFHV------------PTIEKSELLSKVSKIISDC 2137

  Fly  3144 PTHRDAVINSCVYVHQTLHQANARLAKRGGRTMAVTPRHYLDFIHHFVKLYNEKRSDLEEQQLHL 3208
            .....|.|     :..|.......|...|............:....|..::.|::.:|..:...|
 Worm  2138 KVDEAAQI-----IVSTFFIVKKYLQSIGIALYGTVFSQLFEVADCFQIVFREQKKELVAEGTRL 2197

  Fly  3209 NVGLN------KIAETVEQV--EEMQKSLAVKKQELQAKNEAANAKLKQMFQDQQEAEKKKIQSQ 3265
            |..|:      |:||..::|  |.:|:.:..|:..|...|...|.|..:|          ::.|:
 Worm  2198 NEALHTCEQIEKLAEMGKEVDIEAVQRRIVEKETMLSKMNRERNTKGARM----------EVLSE 2252

  Fly  3266 EIQIRLAD-QTVKIEEKRKYVMADLAQVEPAVIDA-----QAAVKSIRKQQLVEVRTMA--NPPS 3322
            .:.::..: :|::.||      |.|.....|::.|     :..|:.:.|....:::|::  ..||
 Worm  2253 LVAVKATNLETMRAEE------AALKTTVEAMVSAPQEEFRKCVEELLKFSNTDIKTLSKITKPS 2311

  Fly  3323 V-VKLALESICLLLGEN-------ATDW-KSIRAVIMRENFINSIVSNFGTENITDDVREKMKSK 3378
            | ::|..|.:..:...|       |..| :|::.|..:..||.  ::....:.:|.| :.|:..|
 Worm  2312 VGIRLCCEMLRTIFEPNFKPKRHAAEAWTESLKFVSDKAFFIK--LATCDADILTVD-QMKVLKK 2373

  Fly  3379 YLSNPDYNFEKVNRASMACGPMVKWAIAQIEYADMLKRVEPLREELRSLEEQADVNLASAKETKD 3443
            |:...::|..|:...|:.|..:.:|..|.:|.|.          .||.:|||.:       |:|:
 Worm  2374 YVDRAEFNANKIEHESVVCACLCRWIGAFLELAC----------TLRVMEEQVE-------ESKE 2421

  Fly  3444 LVEQLERSIAAYKEEYAQLISQAQAIKTDLENVQAKV---------DRSIA--------LLKSLN 3491
            |.|.:.::...::.|    .|:.|.:|:|:|.:...:         ||.:.        ||.:|.
 Worm  2422 LREHIRQTEVRFENE----SSEMQQLKSDVEKLTVLIRENEQVLANDRRLCDYRLRSGDLLAALE 2482

  Fly  3492 IERERWESTSETFKSQMSTIIGDVLLSAAFIAYGGYFDQHYRLNLFTTWSQHLQAASIQYRADIA 3556
            ..|:||:|..:..:.:...::|:.||.|...|:....::...|...:..:.||.:.::|:.:.:|
 Worm  2483 PHRKRWKSQLKQNEKKQKELVGNTLLFAIHRAHLLCQEKAVTLICVSMCTSHLTSQNVQFDSSMA 2547

  Fly  3557 RTEYLSNPDERLRWQANALPTDDLCTENAIMLKRFNRYPLIIDPSGQATTFLLNEYAGKKITKTS 3621
            .:   ||...|:      |.|          ||...|:.|.:     :||..|.:.....:...:
 Worm  2548 SS---SNVINRI------LRT----------LKSSRRFCLFL-----STTDSLLQNVRSVLPGAT 2588

  Fly  3622 FLDDSFRKNLESALRFGNPLLVQDVENYDPILNPVLNRELRRTGGRVLITLGDQDIDLSPSFVIF 3686
            :||      :...|.:..|.:...::.:...:.|.:...|             .::.....:.|.
 Worm  2589 YLD------ISPPLTWKEPQMAVSLQKHVYSIVPTVFYNL-------------TEVPPPEMYEIL 2634

  Fly  3687 LSTRDPTV-------EFPPDICSRVTFVNFTVTRSSLQSQCLNQVLKAERP--DIDEK----RSD 3738
            :.:.:..|       |.|.||.  ..||...:.....|.:.|.:|:....|  .|:::    |::
 Worm  2635 MKSEEKEVCYHNKPLELPDDIL--FVFVAKNLGHIPDQIRKLMEVIVVSIPLEPIEDREKIERNE 2697

  Fly  3739 LLKLQGEFR----LRLRQLEKSLLQ 3759
            |..|.|||.    |..|.|.:..:|
 Worm  2698 LSSLLGEFTAADILESRDLTRKAMQ 2722

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dhc64CNP_001261432.1 DHC_N1 240..839 CDD:285571 35/180 (19%)
DYN1 1022..4338 CDD:227570 536/3019 (18%)
DHC_N2 1326..1724 CDD:285579 75/417 (18%)
P-loop_NTPase 1870..2103 CDD:304359 46/236 (19%)
P-loop_NTPase 2227..2367 CDD:304359 22/165 (13%)
P-loop_NTPase 2572..2835 CDD:304359 55/300 (18%)
Cas4_I-A_I-B_I-C_I-D_II-B 2834..>2943 CDD:294426 33/152 (22%)
P-loop_NTPase 2916..3194 CDD:304359 50/324 (15%)
MT 3208..3544 CDD:289543 81/377 (21%)
AAA_9 3569..3784 CDD:289547 38/208 (18%)
Dynein_heavy 3925..4636 CDD:281078
dhc-4NP_001338793.1 DHC_N2 599..990 CDD:369852 78/443 (18%)
SMC_prok_A <2413..>2502 CDD:274009 22/99 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5245
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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