Protein Alignment Dhc64C and DNAH2

DIOPT Version :9

• Sequence 1: NP_001261432.1
• Gene: Dhc64C / 38580
• FlyBaseID: FBgn0261797
• Length: 4661
• Species: Drosophila melanogaster
• Sequence 2: XP_024306372.1
• Gene: DNAH2 / 146754
• HGNCID: 2948
• Length: 4531
• Species: Homo sapiens
• Alignment Length: 4846
• Identity: 1225/4846 - (25%)
• Similarity: 2185/4846 - (45%)
• Gaps: 808/4846 - (16%)

  Fly    65 LSDPQVQALYVQRNCIKEDDSEQPAEGEDEKEQVTYQISNDV----------------------- 106
            :|:|::||.      :.:::.|...||...:.:.:.:...||
Human    41 VSEPELQAE------LPKEEPEPRLEGPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHD 99

  Fly   107 ----HFTNSRMASL------ACIKRGLVVEADKSIHSQLRLINFSDGSP----YETLHAFISKSL 157
                ||......|:      .|.  ||.:|....:.:|.:|:.|...:|    :|...|.:....
Human   100 AILEHFAQDPTESILTIFIDPCF--GLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGT 162

  Fly   158 --APYFKSYVKESGRADRDGDKMAPSVEKKLAELEMGLLHLQQNID--IPEITLTAHQTVNNVIR 218
              .||..:.::..|..      .||.:.......|....|...::.  :..:|.|.::...:.:.
Human   163 VRGPYIPALLRLLGGV------FAPQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVL 221

  Fly   219 KCAEE--NRKAKVADFGDKVEDSSFLNLLQNGVNRWIAEIKKVTKLNRDPGSGT---ALQEISFW 278
            ....|  |.|.::.     ::|...:..|:..:..|..:||::........:|.   .|:||.||
Human   222 YIPAEAMNMKPEMV-----IKDKELVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFW 281

  Fly   279 LN-------------------LERALYRIQEKRESPEVALTLDILKHGKRFHATVSFDTDTGLKQ 324
            .|                   :|..|:..:....:|.:.|...|....::..:.::|.:.  ||:
Human   282 RNRCMDLSGISKQLVKKGVKHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSI--LKE 344

  Fly   325 ALATVADYNPLMKDFPINDLLSATELEKIRPAVQQIFAH-------------LRKVRN------- 369
            ....:|...|  ||.       :::|.|:...::.|:.:             .||:.|
Human   345 PYQELAFMKP--KDI-------SSKLPKLISLIRIIWVNSPHYNTRERLTSLFRKMSNEIIRLCC 400

  Fly   370 ---------------TKYPIQRCLKLIEAISRDLSQQLLKVLGTRRLMHIPFDEFERVMNQ---- 415
                           :|..:|.|:....| .:|...|.::       |||.|.....|::|
Human   401 HAISLDRIFEGYVSSSKEDLQGCILCCHA-WKDHYVQAVQ-------MHIQFSSRGWVLDQTSIF 457

  Fly   416 ---------CFEIFSCWDDEY------DKLQGLLRDIVKKKRDEHLKMVWRVSPA-HKKLQTRME 464
                     |.::....|.:|      |..||.|......:..:..:.:..:... ||.|.|
Human   458 AQVDAFVQRCKDLIEVCDCQYHFARWEDGKQGPLPCFFGAQGPQITRNLLEIEDIFHKNLHT--- 519

  Fly   465 HMRKFRRQHEQLRTVILRVLRPTKPAVGDDGNVVETK-----QPYSLDAADANAIEEV--NL--- 519
                            ||.:|         |.:::.|     :.|:...|....:|.:  ||
Human   520 ----------------LRAVR---------GGILDVKNTCWHEDYNKFRAGIKDLEVMTQNLITS 559

  Fly   520 AYENVKEVD----CLDITKEGSEAWEAAVKRYEEKIDRVETRITAHLRDQLGTAKNANEMFRIFS 580
            |:|.|::|.    .|| |.....:.||..:.|::|                     |.:::.:|:
Human   560 AFELVRDVPHGVLLLD-TFHRLASREAIKRTYDKK---------------------AVDLYMLFN 602

  Fly   581 RFNALFVRPHIRGAIREYQTQLIQRVKDDIEALHEKFKVQYPQSKSCRLSSVRDLPPVAGSIIWA 645
            .                 :..|:.|.::......|.:..||                 :|...|.
Human   603 S-----------------ELALVNRERNKKWPDLEPYVAQY-----------------SGKARWV 633

  Fly   646 ----RQIDNQLTM-----YLKRVEDVLGKGWET-HIEGQKLKADGDSFRAKLSISDVFHEWARKV 700
                |:||..:|.     :|.|:    |.|.|: |...|.::|..:..|      ..|.||...:
Human   634 HILRRRIDRVMTCLAGAHFLPRI----GTGKESVHTYQQMVQAIDELVR------KTFQEWTSSL 688

  Fly   701 QERNFGSTGRIFTIESTRSRIGRGNVLRLRVNFLPEIITLAKEVRNIKNLGFRVPLTIVNKAHQA 765
            .:      ..|..:::...||.:.....|.|||...::.|..|:...:.|.|..|..:||.|.:|
Human   689 DK------DCIRRLDTPLLRISQEKAGMLDVNFDKSLLILFAEIDYWERLLFETPHYVVNVAERA 747

  Fly   766 NQIYPYAISLIESVRTYERTLEKLNNRSLAQNSVFKIEDRASIVPLVAGLRKDVLNLVSEGIGLI 830
            ..:.....:|:...|.|.|.:..|   |..:.::||...|.....:..||:|  |:...:|....
Human   748 EDLRILRENLLLVARDYNRIIAML---SPDEQALFKERIRLLDKKIHPGLKK--LHWALKGASAF 807

  Fly   831 WESYKLDPYVIRLSEC----------VTQF-----------QEKVDDLLV------VEEQLDVDV 868
            :           ::||          |.:|           ||..:.|||      |...|:.:.
Human   808 F-----------ITECRIHASKVQMIVNEFKASTLTIGWRAQEMSEKLLVRISGKRVYRDLEFEE 861

  Fly   869 RSLETCPYSAATFVEILSKIQHAV------------DDLSLRQYSNLSVWVTRLDEEVEKKLALR 921
            ...|   :.||...::::..|..|            |...::|  ...:::.|||..:|..|.|.
Human   862 DQRE---HRAAVQQKLMNLHQDVVTIMTNSYEVFKNDGPEIQQ--QWMLYMIRLDRMMEDALRLN 921

  Fly   922 LQAGIQAWTEALTGNKKEVDTSMDTDAPAQPTHKLGGDPQIQNAV---HEIRITNQQMYLYPSIE 983
            ::..:...::|:.|           |....|      :|..|..|   ::::.:..|:...|:::
Human   922 VKWSLLELSKAING-----------DGKTSP------NPLFQVLVILKNDLQGSVAQVEFSPTLQ 969

  Fly   984 EAR----------FQIMQQFFAWQAIVTSQVRLQSTRYQVGLEKHVSQTYRNLLTKLPEGKILEN 1038
            ...          |..:..|.....|:|.: :|.....|..:|:  .:..:.:.|::..| :..|
Human   970 TLAGVVNDIGNHLFSTISVFCHLPDILTKR-KLHREPIQTVVEQ--DEDIKKIQTQISSG-MTNN 1030

  Fly  1039 AYGAIEQKVSEVRNYVDEWLRYQSLWDLQADML---YGRLG-------EDVNLWIKCLNDIKQSR 1093
            |        |.::||:..|..|:.:|::..|..   |.||.       .|:..:.:..|::::..
Human  1031 A--------SLLQNYLKTWDMYREIWEINKDSFIHRYQRLNPPVSSFVADIARYTEVANNVQKEE 1087

  Fly  1094 TTFDTSDTRRAYGPIIIDYAKVQAKVTLKYDSWHKEALGKFGTLLGTEMTS-----FHS--KVSK 1151
            |..:...       :::|.:.::..:....:.|.    .||.||| .||.:     .|:  |.:.
Human  1088 TVTNIQF-------VLLDCSHLKFSLVQHCNEWQ----NKFATLL-REMAAGRLLELHTYLKENA 1140

  Fly  1152 SRTDLEMQSIEAASTSDAVSFITYVQSLKKDMIAWDKQVEVFREAQRILERQRFQFPNTWLH-VD 1215
            .:.....|::|....|     :..|.:||.|:...:.|:....|...|||:......::.|. :|
Human  1141 EKISRPPQTLEELGVS-----LQLVDALKHDLANVETQIPPIHEQFAILEKYEVPVEDSVLEMLD 1200

  Fly  1216 NIEGEWSAFNEIIKRKDTAIQTQVASLQAKIV--AEDKAVETRTVDFLNDWEKTKPTGGKIRPDD 1278
            ::.|||..|.:.:......::......:..::  |:|...:..|:  |.|:|........:....
Human  1201 SLNGEWVVFQQTLLDSKQMLKKHKEKFKTGLIHSADDFKKKAHTL--LEDFEFKGHFTSNVGYMS 1263

  Fly  1279 ALQQLQIFESKYSRLKEERDNVVKAKEALELQESAVPNNSAERMNVALEELQDLRGVWSELSKVW 1343
            ||.|:....:....::|| :|.::|...:...|.. |:...:.:.   :||..|:.:| |:::.|
Human  1264 ALDQITQVRAMLMAMREE-ENSLRANLGIFKIEQP-PSKDLQNLE---KELDALQQIW-EIARDW 1322

  Fly  1344 TQ-IDETREKPWLSVQPRKLRQQLEAMMAQLKELPARL--RMYESYEYVKKLIQSYIKVNMLIVE 1405
            .: .:|.:...:|.:|...:......:..:|.:|....  |.:|..|..:..|:.:.:...||.:
Human  1323 EENWNEWKTGRFLILQTETMETTAHGLFRRLTKLAKEYKDRNWEIIETTRSKIEQFKRTMPLISD 1387

  Fly  1406 LKSDALKERHWKQLTKQLR--VNWVLSDLSLGQVWDVNLQKNEGIVKDIILVAQGEMALEEFLKQ 1468
            |::.||:||||.|:..:::  .:......:|.|:.::.:.::...:.:|...|..|:|:|..|:.
Human  1388 LRNPALRERHWDQVRDEIQREFDQESESFTLEQIVELGMDQHVEKIGEISASATKELAIEVALQN 1452

  Fly  1469 VRESWQNYELDLINYQNK-CRIIRGWDDLFNKVKEHINSVAAMKLSPYYKVFEEEALTWEEKLNR 1532
            :.::|...:||::.|::| ...:||.:::|..::::..:::.||.|.:.|.||::...||..|:.
Human  1453 IAKTWDVTQLDIVPYKDKGHHRLRGTEEVFQALEDNQVALSTMKASRFVKAFEKDVDHWERCLSL 1517

  Fly  1533 INALFDVWIDVQRRWVYLEGIFSGSADIKTLLPVETSRFQSISSEFLGLMKKVTKSPKVMDVLNI 1597
            |..:.::.:.|||:|:|||.||.|. ||:..||.|::.|..::|.:..:|.::.|....:...:.
Human  1518 ILEVIEMILTVQRQWMYLENIFLGE-DIRKQLPNESTLFDQVNSNWKAIMDRMNKDNNALRSTHH 1581

  Fly  1598 PAVQRSLERLADLLGKIQKALGEYLERERTSFPRFYFVGDEDLLEIIGNSKNIARLQKHFKKMFA 1662
            |.:..:|..:..:|..|||:|..|||.:|..||||||:.::|||||:|.|:|...:|.|.||.|.
Human  1582 PGLLDTLIEMNTILEDIQKSLDMYLETKRHIFPRFYFLSNDDLLEILGQSRNPEAVQPHLKKCFD 1646

  Fly  1663 GVAAILLNEENN-----VILGISSREGEEVHFMNPVSTVEHPKINEWLSLVEKQMRFTLASLLAQ 1722
            .:..:.:.:...     ..:|:.|.:||.:.|::.| .:|.| :..||..||:.||.||..||..
Human  1647 NIKLLRIQKVGGPSSKWEAVGMFSGDGEYIDFLHSV-FLEGP-VESWLGDVEQTMRVTLRDLLRN 1709

  Fly  1723 AVQDIKQF---RDGKIDPQAYMEWCDKYQAQIVVLAAQILWSEDVESALQQASENNQSKPMQRVL 1784
            ....:::|   ||         :|..::..|:|:.|:||.|:.||...|..|.|....|.::.:.
Human  1710 CHLALRKFLNKRD---------KWVKEWAGQVVITASQIQWTADVTKCLLTAKERADKKILKVMK 1765

  Fly  1785 GNVESTLNVLADSVLQEQPPLRRRKLEHLINEFVHKRTVTRRLLNNGVTSPKSFQWLCEMRFYFD 1849
            .|..|.||..::::......:.|.|:..|:...:|.|.|..:|..:|:....||.||.::|||::
Human  1766 KNQVSILNKYSEAIRGNLTKIMRLKIVALVTIEIHARDVLEKLYKSGLMDVNSFDWLSQLRFYWE 1830

  Fly  1850 PRQTEVLQQLTIHMANARFFYGFEYLGVQDRLVQTPLTDRCYLTMTQALESRLGGSPFGPAGTGK 1914
                :.|....|...|.:|.|.:||||...|||.||||||||:|:|.||....||||.|||||||
Human  1831 ----KDLDDCVIRQTNTQFQYNYEYLGNSGRLVITPLTDRCYMTLTTALHLHRGGSPKGPAGTGK 1891

  Fly  1915 TESVKALGNQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSACSQQIQT 1979
            ||:||.||..||.:|:|.||.|..|:::|||::.||.|.|||||||||||:...:||..:.||..
Human  1892 TETVKDLGKALGIYVIVVNCSEGLDYKSMGRMYSGLAQTGAWGCFDEFNRINIEVLSVVAHQILC 1956

  Fly  1980 IQEAL-----KYEMDSNKESITVELVGKQVRVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLAM 2039
            |..||     .:..|           |.::.:.....||||||||||||:.||:|||.:||.:||
Human  1957 ILSALAAGLTHFHFD-----------GFEINLVWSCGIFITMNPGYAGRTELPENLKSMFRPIAM 2010

  Fly  2040 TTPDRQLIAEVMLFSQGFRSAEKLACKIVPFFKLCDEQLSNQSHYDFGLRALKSVLISAGNVKRD 2104
            ..||..||||::||.:||.:.:.||.|:...:.|..:|||.|.|||||||||.|:|..||..:|
Human  2011 VVPDSTLIAEIILFGEGFGNCKILAKKVYTLYSLAVQQLSRQDHYDFGLRALTSLLRYAGKKRR- 2074

  Fly  2105 RIMKIKEQMKQRGDENIDEASVAENLPEQEILIQSVCETMVPKLVAEDIPLLFSLLSDVFPNVGY 2169
                                 :..:|.::|:|:.|:.:..:.||.:.|.||..:::.|:|||:..
Human  2075 ---------------------LQPDLTDEEVLLLSMRDMNIAKLTSVDAPLFNAIVQDLFPNIEL 2118

  Fly  2170 TRAEMKGLKEEIRKVCQEDYLVCGEGDEQGAAWMEKGLGST--WVDKVLQLYQISNLNHGLMMVG 2232
            ...:...|:|.:.:..:                 :.||.||  .:.||.|||:..|..|..|:||
Human  2119 PVIDYGKLRETVEQEIR-----------------DMGLQSTPFTLTKVFQLYETKNSRHSTMIVG 2166

  Fly  2233 PSGSGKSTAWKTLLKALE--------RFEGVEGVAHVIDPKAISKEALYGVLDPNTREWTDGLFT 2289
            .:||||:.:|:.|..:|.        .|..|.  ...::|||:|...|||..|.:|.|||||:.:
Human  2167 CTGSGKTASWRILQASLSSLCRAGDPNFNIVR--EFPLNPKALSLGELYGEYDLSTNEWTDGILS 2229

  Fly  2290 HILRKIIDNVRGEINKRQWIIFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVRVMFEVQ 2354
            .::|....:.:.:   .:||:|||.||..|:||:|||:||||:|||.||||:::|..|.::|||:
Human  2230 SVMRTACADEKPD---EKWILFDGPVDTLWIENMNSVMDDNKVLTLINGERIAMPEQVSLLFEVE 2291

  Fly  2355 DLKFATLATVSRCGMVWFSEDVLSTEMIFENYLSRLRSIPLEDGDEDFVGVIKPAKDKEEEVSPS 2419
            ||..|:.|||||||||:.....|..:...:::|.:.....:|.....|          |:.::..
Human  2292 DLAMASPATVSRCGMVYTDYADLGWKPYVQSWLEKRPKAEVEPLQRMF----------EKLINKM 2346

  Fly  2420 LQVQRDIALLLLPFFSADGIVVRTLEYAMDQEHIMDFTRLRALSSLFSMLNQAARNVLTFNAQHP 2484
            |..::|....|:|                    :.:::.:.:|..|:|.|......|
Human  2347 LAFKKDNCKELVP--------------------LPEYSGITSLCKLYSALATPENGV-------- 2383

  Fly  2485 DFPCSADQLEHYIPKALVYSVLWSFAG--DAKLKVRIDLGDFVRSVT-TVPLPGAAGAPIIDYEV 2546
             .|...:.....:....|:|::||...  |.:.:.|||  .::|.:. :.|.........:|.::
Human  2384 -NPADGENYVTMVEMTFVFSMIWSVCASVDEEGRKRID--SYLREIEGSFPNKDTVYEYFVDPKI 2445

  Fly  2547 NMSGDWVPWSNKVPVIEVETHKVASPDIVVPTLDTVRHESLLYTWLAEHKPLVLCGPPGSGKTMT 2611
            .   .|..:.:|:|.............|:|||:||||:..|:.:.:|...|::|.||.|:|||..
Human  2446 R---SWTSFEDKLPKSWRYPPNAPFYKIMVPTVDTVRYNYLVSSLVANQNPILLVGPVGTGKTSI 2507

  Fly  2612 LFSALRALPDME--VVGLNFSSATTPELLLKTFDHYCEYRK----TPNGVVLSPVQIGKWLVLFC 2670
            ..|.|::||..:  |:.:|.|:.||...:....:...|.|.    .|.|        ||.::.|.
Human  2508 AQSVLQSLPSSQWSVLVVNMSAQTTSNNVQSIIESRVEKRTKGVYVPFG--------GKSMITFM 2564

  Fly  2671 DEINLPDMDSYGTQRVISFLRQLVEHKGFYRASDQAWVSLERIQFVGACNPPTDPGRKPLSHRFL 2735
            |::|:|..|.:|:|..:..:|..::: ||:....:..:...|..|:.|...|...||..:|.|..
Human  2565 DDLNMPAKDMFGSQPPLELIRLWIDY-GFWYDRTKQTIKYIREMFLMAAMGPPGGGRTVISPRLR 2628

  Fly  2736 RHVPIIYVDYPGETSLKQIYGTFSRAMLRLMPALRGYAE---PLTNAMVEFYLASQDRFTQDMQP 2797
            ....||.:.:|.::.:.:|:||.      :...|:.:.|   |:.|.:.|..|...:...|...|
Human  2629 SRFNIINMTFPTKSQIIRIFGTM------INQKLQDFEEEVKPIGNVVTEATLDMYNTVVQRFLP 2687

  Fly  2798 -----HYVYSPREMTRWVRGICEAIRPLDSLPVEGLVRLWAHEALRLFQDRLVD--DSERRWTNE 2855
                 ||:::.|::::..:|:..|.:...... ..:.|||.||..|:|.|||||  |:|.
Human  2688 TPTKMHYLFNLRDISKVFQGMLRANKDFHDTK-SSITRLWIHECFRVFSDRLVDAADTEA----- 2746

  Fly  2856 NIDLVGQKHFPGINQEE-------------ALQRPILYSNWLSKDYMPVNREELREYVHARLKVF 2907
                     |.||..::             ..:||.::.::|.:   |...|:|.:.  ..||..
Human  2747 ---------FMGIISDKLGSFFDLTFHHLCPSKRPPIFGDFLKE---PKVYEDLTDL--TVLKTV 2797

  Fly  2908 YEEELD--------VP--LVLFDEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNG 2962
            .|..|:        ||  ||||.|.::|:.||.|:..||:|::||:|:.|:|:.:|:|..:.:..
Human  2798 METALNEYNLSPSVVPMQLVLFREAIEHITRIVRVIGQPRGNMLLVGIGGSGRQSLARLASSICD 2862

  Fly  2963 LSIFQIKVHNKYTSEDFDEDLRCVLRRSGCKDEKIAFILDESNVLDSGFLERMNTLLANGEVPGL 3027
            .:.|||:|...|..::|.:|::.:.|::|.:.:..:||..::.:.|..|||.:|.:|::||||.|
Human  2863 YTTFQIEVTKHYRKQEFRDDIKRLYRQAGVELKTTSFIFVDTQIADESFLEDINNILSSGEVPNL 2927

  Fly  3028 FEGDEYTTLMTQCKEGAQREGLMLDSSDELYKWFTQQVMRNLHVVFTMNPSTDGLKDRAATSPAL 3092
            ::.||:..:.:...:.|:.|.:. :|||.|:.:..::|..|||:|..::|..|..::.....|||
Human  2928 YKPDEFEEIQSHIIDQARVEQVP-ESSDSLFAYLIERVQNNLHIVLCLSPMGDPFRNWIRQYPAL 2991

  Fly  3093 FNRCVLNWFGDWSDSALFQVGKEFTTRVDL-EKPNWHAPDFFPSVCPLVPANPTHRDAVINSCVY 3156
            .|...:|||.:|...||.:|.::....||| .:.|.|.                   .|....|.
Human  2992 VNCTTINWFSEWPQEALLEVAEKCLIGVDLGTQENIHR-------------------KVAQIFVT 3037

  Fly  3157 VHQTLHQANARLAKRGGRTMAVTPRHYLDFIHHFVKLYNEKRSDLEEQQLHLNVGLNKIAETVEQ 3221
            :|.::.|.:.::.....|...|||..||:.:..:.||..|||.:|..|...|..||.||.||.|:
Human  3038 MHWSVAQYSQKMLLELRRHNYVTPTKYLELLSGYKKLLGEKRQELLAQANKLRTGLFKIDETREK 3102

  Fly  3222 VEEMQKSLAVKKQELQAKNEAANAKLKQMFQDQQEAEKKKIQSQEIQIRLADQTVKIEEKRKYVM 3286
            |:.|...|...|:::....:.....|..:.|.::||::     |:..:....:.:.:||.:...:
Human  3103 VQVMSLELEDAKKKVAEFQKQCEEYLVIIVQQKREADE-----QQKAVTANSEKIAVEEIKCQAL 3162

  Fly  3287 ADLAQVE-----PAVIDAQAAVKSIRKQQLVEVRTMANPPSVVKLALESICLLLGENATDWKSIR 3346
            ||.||.:     ||:.:|..|::|:.|:.:.|:::...||:.|::.::::.:|.|...| |...:
Human  3163 ADNAQKDLEEALPALEEAMRALESLNKKDIGEIKSYGRPPAQVEIVMQAVMILRGNEPT-WAEAK 3226

  Fly  3347 AVIMRENFINSIVSNFGTENITDDVREKMKSKYLSNPDYNFEKVNRASMACGPMVKWAIAQIEYA 3411
            ..:..:|||.|:: ||..:||:|.|.:|: ..|.:.||:..:.:.|.|:|...:..|..|...|.
Human  3227 RQLGEQNFIKSLI-NFDKDNISDKVLKKI-GAYCAQPDFQPDIIGRVSLAAKSLCMWVRAMELYG 3289

  Fly  3412 DMLKRVEPLREELRSLEEQADVNLASAKETKDLVEQLERSIAAYKEEYAQLISQAQAIKTDLENV 3476
            .:.:.|||.|..:.:...|.....|:..|.::.:.::...:...|::|.:.::|.:.::...|.:
Human  3290 RLYRVVEPKRIRMNAALAQLREKQAALAEAQEKLREVAEKLEMLKKQYDEKLAQKEELRKKSEEM 3354

  Fly  3477 QAKVDRSIALLKSLNIERERWESTSETFKSQMSTIIGDVLLSAAFIAYGGYFDQHYRLNLFT-TW 3540
            :.|::|:..|:..|..|:.|||.|.:..:..:..::||.||:|||::|.|.|..:||..:.. .|
Human  3355 ELKLERAGMLVSGLAGEKARWEETVQGLEEDLGYLVGDCLLAAAFLSYMGPFLTNYRDEIVNQIW 3419

  Fly  3541 SQHLQAASIQYRADIARTEYLSNPDERLRWQANALPTDDLCTENAIMLKRFNRYPLIIDPSGQAT 3605
            ...:....:......|...:|.||.:...|....||:|...|||.|::.|.||:.|:|||..||.
Human  3420 IGKIWELQVPCSPSFAIDNFLCNPTKVRDWNIQGLPSDAFSTENGIIVTRGNRWALMIDPQAQAL 3484

  Fly  3606 TFLLNEYAGKKITKTSFLDDSFRKNLESALRFGNPLLVQDVENY-DPILNPVLNRELRRTGGRVL 3669
            .::.|...|:.:.........:.:.||.|:.||.|:|:|:|:.| ||.|||:||:.:.|.|||:|
Human  3485 KWIKNMEGGQGLKIIDLQMSDYLRILEHAIHFGYPVLLQNVQEYLDPTLNPMLNKSVARIGGRLL 3549

  Fly  3670 ITLGDQDIDLSPSFVIFLSTRDPTVEFPPDICSRVTFVNFTVTRSSLQSQCLNQVLKAERPDIDE 3734
            :.:||::::.:.:|..:::|:.....:.|:..::.|.|||.|....|::|.|..|::.|||:::|
Human  3550 MRIGDKEVEYNTNFRFYITTKLSNPHYSPETSAKTTIVNFAVKEQGLEAQLLGIVVRKERPELEE 3614

  Fly  3735 KRSDLLKLQGEFRLRLRQLEKSLLQALNDAKGKILDDDSVITTLETLKKEAYDINQKVDETDKVI 3799
            ::..|:......:.:|::||..:|:.||:|.|.:|||..::.||.|.|..|.::.::::.::...
Human  3615 QKDSLVINIAAGKRKLKELEDEILRLLNEATGSLLDDVQLVNTLHTSKITATEVTEQLETSETTE 3679

  Fly  3800 AEIETVSQQYLPLSVACSNIYFTMDSLNQVHFLYQYSLKMFLDIFSTVL---YNNPKLEGRTD-- 3859
            ...:...:.|.|.:...|.::|.::.:..:..:||:||..::.:|...:   :.:.|||.|.|
Human  3680 INTDLAREAYRPCAQRASILFFVLNDMGCIDPMYQFSLDAYISLFILSIDKSHRSNKLEDRIDYL 3744

  Fly  3860 ---HSERLGIVTRDLFQVCYERVARGMIHIDRLTFALLMCKIHLKGTSESNLDAEFNFFLR---- 3917
               |:           ...|....|.:....:|.|:..||...|:.:.:.|:| |:|||||
Human  3745 NDYHT-----------YAVYRYTCRTLFERHKLLFSFHMCAKILETSGKLNMD-EYNFFLRGGVV 3797

  Fly  3918 -SREGLLANPTPVEGLSAEQIESVNRLALRLPIFRKLLEKVRSIP-ELGAWLQQSSPEQ-VVPQL 3979
             .|||.:.||.. ..|:....:::..|. :|..|..|:......| :...|...::||: ::|..
Human  3798 LDREGQMDNPCS-SWLADAYWDNITELD-KLTNFHGLMNSFEQYPRDWHLWYTNAAPEKAMLPGE 3860

  Fly  3980 WDESKALSPIASSVHQLLLIQAFRPDRVIAAAHNVVNTVLGEDFMPNAEQELDFTSVVDKQLNCN 4044
            |:.:      .:.:.::|::::.|.|||.....:.:.|.||..|:  ....|:..||::.. ...
Human  3861 WENA------CNEMQRMLIVRSLRQDRVAFCVTSFIITNLGSRFI--EPPVLNMKSVLEDS-TPR 3916

  Fly  4045 TPALLCSVPGFDASGRVDDLAAEQN--KQISSIAIGSAEGFNQAERAINMACKTGRWVLLKNVHL 4107
            :|.:....||.|.:..:..||....  ::..::::|..:. ..|.|.:......|.||.|.|.||
Human  3917 SPLVFILSPGVDPTSALLQLAEHMGMAQRFHALSLGQGQA-PIAARLLREGVTQGHWVFLANCHL 3980

  Fly  4108 APQWLVQLEKKMHSLQ---PHSGFRLFLTMEINPKVPVNLLRAGRIFVFEPPPGIRANLLRTFST 4169
            :..|:..|:|.:..||   ||..|||:|:...:|..|:::|:.......|||.|::||:.|.:..
Human  3981 SLSWMPNLDKLVEQLQVEDPHPSFRLWLSSIPHPDFPISILQVSIKMTTEPPKGLKANMTRLYQL 4045

  Fly  4170 V--PAARMMKTPSERARLYFLLAWFHAIVQERLRYVPLGWAKKYEFNESDLRVACDTLDTWIDTT 4232
            :  |.......|::..:|.|.|.:||:::.||.:::.|||...|.||:||..|:.:.|..::|..
Human  4046 MSEPQFSRCSKPAKYKKLLFSLCFFHSVLLERKKFLQLGWNIIYGFNDSDFEVSENLLSLYLDEY 4110

  Fly  4233 AMGRTNLPPEKVPWDALVTLLSQSIYGGKIDNDFDQRLLTSFLKKLFTARSFEADFALVANVDGA 4297
                     |:.|||||..|::...|||.:.:|:|:||||:::...|..:|....|..::.::
Human  4111 ---------EETPWDALKYLIAGINYGGHVTDDWDRRLLTTYINDYFCDQSLSTPFHRLSALE-- 4164

  Fly  4298 SGGLRHITMPDGTRRDHFLKWIENLTDRQTPSWLGLPNNAEKVLLTTRGTDLVSKLLKMQ----- 4357
                .:....||:... :.::|..|.....|...|...||:.....|....|...||.:|
Human  4165 ----TYFIPKDGSLAS-YKEYISLLPGMDPPEAFGQHPNADVASQITEAQTLFDTLLSLQPQITP 4224

  Fly  4358 -----QLEDDD--ELAYSVEDQSEQSAVGRGEDGRPSWMKTLHNSATAWLELLPKNLQVLKRTVE 4415
                 |..::.  |||..|:.:..:.....|.      .|.|.      |:..|.|:.:|:.
Human  4225 TRAGGQTREEKVLELAADVKQKIPEMIDYEGT------QKLLA------LDPSPLNVVLLQE--- 4274

  Fly  4416 NIKDPLYRYFEREVTSGSRLLQTVILDLQDVVLICQGEKKQTNHHRSMLSELVRGIIPKGW-KRY 4479
                 :.||        :.|:||::..|.|:....||....:.....:.:.:....:|..| |.|
Human  4275 -----IQRY--------NTLMQTILFSLTDLEKGIQGLIVMSTSLEEIFNCIFDAHVPPLWGKAY 4326

  Fly  4480 TVPAGCTVIQWITDFSNRVQQLQKVSQLVSQAGAKELQGFPV--WLGGLLNPEAYITATRQCVAQ 4542
              |:...:..|..|.:.||:|.:   ...|:|..      ||  ||.|...|..::||..|..|:
Human  4327 --PSQKPLAAWTRDLAMRVEQFE---LWASRARP------PVIFWLSGFTFPTGFLTAVLQSSAR 4380

  Fly  4543 ANSWSLEELALDV---TITDAGLKNDQK---DCCFG 4572
            .|:.|::.|:.:.   |:.|:.|....|   .|.:|
Human  4381 QNNVSVDSLSWEFIVSTVDDSNLVYPPKVGASCAWG 4416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dhc64C	NP_001261432.1	DHC_N1	240..839	CDD:285571	128/699 (18%)
		DYN1	1022..4338	CDD:227570	964/3436 (28%)
		DHC_N2	1326..1724	CDD:285579	118/408 (29%)
		P-loop_NTPase	1870..2103	CDD:304359	123/237 (52%)
		P-loop_NTPase	2227..2367	CDD:304359	63/147 (43%)
		P-loop_NTPase	2572..2835	CDD:304359	73/276 (26%)
		Cas4_I-A_I-B_I-C_I-D_II-B	2834..>2943	CDD:294426	39/133 (29%)
		P-loop_NTPase	2916..3194	CDD:304359	83/278 (30%)
		MT	3208..3544	CDD:289543	90/341 (26%)
		AAA_9	3569..3784	CDD:289547	75/215 (35%)
		Dynein_heavy	3925..4636	CDD:281078	166/678 (24%)
DNAH2	XP_024306372.1	DHC_N1	242..799	CDD:312031	127/680 (19%)
		SMC_N	<1005..>1537	CDD:330553	120/567 (21%)
		DHC_N2	1309..1710	CDD:312039	117/404 (29%)
		MT	1374..4190	CDD:330758	886/3033 (29%)
		Dynein_heavy	3810..4411	CDD:308587	162/666 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710