Protein Alignment Dhc64C and DNHD1

DIOPT Version :9

• Sequence 1: NP_001261432.1
• Gene: Dhc64C / 38580
• FlyBaseID: FBgn0261797
• Length: 4661
• Species: Drosophila melanogaster
• Sequence 2: NP_653267.2
• Gene: DNHD1 / 144132
• HGNCID: 26532
• Length: 4753
• Species: Homo sapiens
• Alignment Length: 5321
• Identity: 1066/5321 - (20%)
• Similarity: 1847/5321 - (34%)
• Gaps: 1627/5321 - (30%)

  Fly   308 KRFHATVSFDTDTGLKQALATVADYNPLMKDFPINDLLSATELEKIRPAVQQIFAHLRKVRNTKY 372
            |.:|:....|:.   :|.||........:|  |:.:....|.||       .:.|.||
Human    21 KSWHSICVLDSK---EQPLACQQKQRQFVK--PVTESEQPTVLE-------LLLAELR------- 66

  Fly   373 PIQRCLKLIEAISRDLS----QQLLKVLGT----RRLM--H---IPFDEFERVMNQCFEIFSCWD 424
                  .|..|:.:|.|    :.|..|||.    |.|:  |   :||          .|...||.
Human    67 ------TLFSAVLQDSSPAAWRYLHAVLGLLPPYRELLVGHLDLLPF----------LEQLYCWA 115

  Fly   425 D------EYDKLQGLLR---------------DIVKKKRDEHLKMVWRVSPAHKKLQTRMEHMRK 468
            .      ..|.|..:::               |...:||..|.:   ...||...:|.:.
Human   116 PWVQTHLHLDLLGAIVQAFPPDSSLLDSASHADCCPQKRRLHHR---PPCPACPFVQAQW----- 172

  Fly   469 FRRQHEQLRTVILRVLRP-TKP----AVGDDGNVVETKQPYSLD---------AADANAIEEVNL 519
               ..:|::..:...||| |.|    .:|..|..|..::...||         |||      :.:
Human   173 ---SRQQVKEELATWLRPLTLPELQRCLGIVGAQVALEEAVWLDGLSLLPLALAAD------IPV 228

  Fly   520 AYENVKEVDCLDI----TKEGSEAWEAAVKRYEEKIDRVETRI---TAHLRDQLGTAKNANEMFR 577
            .||: .:.|..::    .||.....:..|.| |:...:..|..   |:.|..|:.||.   :|.|
Human   229 RYES-SDTDNAEVEPVGRKETRSQLDYEVPR-EKAFQKSSTGFSPETSFLDSQVMTAL---KMER 288

  Fly   578 IFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIEALHEKFKVQYPQSKSCRLSSVRDLPPVAGS- 641
            ...:.:.|::........|.|...::.  .|.:...|..|..          ..:..:.||.||
Human   289 YLKKIHFLYLNVAPSRYFRPYSLMVVP--PDKVNPEHYIFSP----------FGILHVHPVEGSE 341

  Fly   642 -----------IIWARQIDNQLTMYLKRVEDVLGKG---WETHIEGQKLKADGDSFRAKLSISDV 692
                       ::| :|:  |...:.|..  :|.|.   |:.::..|.|
Human   342 TMTLGTWHHHCVLW-QQL--QFIPFFKYC--LLRKSFTCWKKNVRLQGL---------------- 385

  Fly   693 FHEWARKVQER------NFGSTGRIFTIESTRSRIGRGNVLRL-----RVNFLPEIITLAKEVRN 746
             |...:.::..      :||:              |..::.||     .|::||:.:....|:.:
Human   386 -HRLQKFLENHLLLAVPHFGA--------------GLLHISRLLQELHSVSWLPQELDRCYELLD 435

  Fly   747 IKNLGFRVPLTIVNKAHQANQIYPYAISLIESV------RTYE---------------RT----- 785
            ::.       .:..:.|:|.::....::|..|:      .||.               ||
Human   436 LQT-------ALAEEKHKALRLLHRCLNLCTSILRLVHEDTYHMQQCLQERVQNCDRIRTGQGSI 493

  Fly   786 -LEKLNNRSLAQ------------NSVFKIEDRASIVPLVAGLRKDVLNLVSEGIGLIWESYKLD 837
             |:::.::.|.|            ....::.|......|::.|.:.:.:.|:.    |.::.:..
Human   494 YLQRVQHKQLEQKLKQAEAWWLQLGKFARLVDYMICQSLISVLEEQITSFVAN----ILQAPRQK 554

  Fly   838 PYVIRLSECVTQFQEKVDDLLVVEEQLDVDVRSLETCPYSAATFVEILSKIQHAVDDLSLRQYSN 902
            |::  .|:.|.....::..:..||..:......|::...||      |..:|.|  ||   :.|:
Human   555 PFL--SSQLVFDDHGQLSHVPCVENMIQTLTGGLQSVKTSA------LQVVQSA--DL---KTSS 606

  Fly   903 LSVWVTRLDEEVEKKLALRLQAGIQAWTEALTGNKKEVDTSMDTDAPAQP--------------- 952
            .|::....|||.:.|                       |..:......||
Human   607 DSLYSEEEDEEEDSK-----------------------DEFLMPKFQGQPSDAVSIFCGPNVGLV 648

  Fly   953 ----THKLGGDPQIQNAVHEIRITNQQM-YLYPSIEE-----ARFQIMQQFFAWQAIVTSQVRLQ 1007
                :|.:.|..:::..    |:..|.. :.|..:||     .:.|        ||:...||.|:
Human   649 WPWKSHPIAGILEVRGC----RLRGQYFPHNYKQLEEDLDNNPKIQ--------QALNIQQVLLE 701

  Fly  1008 STRYQVG---LEKH-VSQTYRNLLTKLPEGKILENAYGAIEQKVSEVRNYVDEWLRYQSLWDLQA 1068
            ....:|.   .|.| ::..|..|.:..|:.  ||:..|      ..::|||
Human   702 GVLCKVQEFCREHHWITGIYEFLQSWGPQK--LEDMRG------GPIKNYV-------------- 744

  Fly  1069 DMLYGRLGEDVNLWIKCLNDIKQSRTTFDTSDTRRAYGPIIIDYAKVQAKVTLKYDSWHKEALG- 1132
             .|..||    |:|        |:|.:....:.....|.:::....|||::..|.:|..|:.|.
Human   745 -TLVSRL----NVW--------QARVSSMPIELLTKGGLLLLSCHDVQAEMESKLNSIRKDILAH 796

  Fly  1133 ------KFGTLLGTEMTSFHSKVSKSRTDLE-----MQSIEAASTS--DAVSFITYVQSLKKDMI 1184
                  .....|.||:|.|........:|:.     .|.:..|:..  :....:.||::|.:.:.
Human   797 VQNECWNLSQQLMTELTDFMHIFRTINSDIHAIAQCTQKLNEANEQYVELEERMEYVRALHELIR 861

  Fly  1185 AWDKQVEVFREAQRILERQRF------------------------QFPNTWLHVDNIEGEWSAFN 1225
            ..........||..|..|::|                        |..:.|   :..:.|.|..:
Human   862 NHFSLFSAENEALDISVRRQFGESPIPPCPPPPQPHLLHCPLLAPQLLDMW---EAFQFEKSQAS 923

  Fly  1226 EIIKRKDTAIQTQVASLQAKIVAE-----DKAVETRTVDFLNDWEKTKPTGGKIRPDDALQQLQI 1285
            |.:..|..||..::..|.|..:||     .||:....:|...|...|:            .||..
Human   924 EFLLSKRHAIMPKLQQLMAAALAELEGLLAKALSGPFMDPTQDQRSTE------------HQLVS 976

  Fly  1286 FESKYSRLKEERDNVVKAKEALELQESAVPNNSAERMNVALEELQDLRGVWSELSKVWTQIDETR 1350
            .|.::.....:...:..|.......|:.||........:..::     .:|.....:...|.|.:
Human   977 LERQFQNTVSDLSELHHAYAIFTEDETPVPLPICGTRPIVQQQ-----RIWHLYRVISENISEWK 1036

  Fly  1351 EKPWLSVQPRKLRQQLEAMMAQLKELPARLRMYES-YEYVKKLIQSYIKVNMLIVELKSDALKER 1414
            ...:....|...:::.|..:.:...:...|.::.. .::..:::..:.....|:.:|.|     .
Human  1037 CMAFAKFSPAMAQEKTEGWLTEAARMSTTLELHSPVLQHCMRILGEFRSYLPLLTKLGS-----L 1096

  Fly  1415 HWKQLTKQLRVNWVLSDLSLGQVWDVNLQKNEGIVKDIILVAQGEM---ALEEFLKQVRESWQN- 1475
            |.:.|..|.    :|..|.||.            ::.|.|:..|::   .|.||..::.:.|||
Human  1097 HPQSLNCQC----LLRALGLGS------------LQTIELLTLGQLLTYPLLEFADRINQVWQNE 1145

  Fly  1476 -------------------YELDLINY------------QNKCRIIRG--WD------------- 1494
                               .:|.|:|:            ::|.:::|.  |:
Human  1146 NERIHAQETIRRLQRYWEARQLRLLNFILHVPYEPPASERSKRQVLRSPQWEVVDKDSGTFILSD 1210

  Fly  1495 --DLFNKVKEHI----NSVAAMKLSPYYKVFEEEALTWEEKLNRINALFDVWIDVQRRWVYLEGI 1553
              :|.:.::|.:    ..:|..|.....|:    ||.|...::.:.||.:||:..|::|::|..:
Human  1211 YSNLQDSIQESLQVLSKILAIEKSGDLNKI----ALEWVAIMHGLGALLEVWLTFQQKWIFLNKV 1271

  Fly  1554 FSGSADIKTLLPVE--TSRFQSISSEFLGLMKKVTKSPKVMDVLNIPAVQRSL----ERLADLL- 1611
            ..   ::|...|..  .|||:.:..::..||:.....|.|:.:: :|:.:||.    ::|..||
Human  1272 LH---EMKIQFPNADLNSRFKVMDDQYRTLMRISVADPMVLSLV-VPSAERSPYFQGQQLQQLLQ 1332

  Fly  1612 -GKIQ-----KALGEYLERERTSFPRFYFVGDEDLLEIIGNSKNIARLQKHFKKMFAGVAAILL- 1669
             |.::     .:|...|......|||.:|:.|.:|:.::.........|...::.|..|.|:..
Human  1333 AGSVELEGIIMSLESVLYGVCAHFPRLFFLSDSELVALLAARLESCEAQLWVRRCFPHVHAVSFR 1397

  Fly  1670 ----------------NEENNV-ILGISSREGEEVHFMNPVSTVEHPKINEWLSLVEKQMRFTLA 1717
                            |.:..| .|.:....||||....|:..  ||.:.:||:.:||.:|..|.
Human  1398 SCPTGEKNTDDWESSPNTQTQVEALAVLGAGGEEVKLQGPLPL--HPDLPKWLASLEKCLRLALV 1460

  Fly  1718 SLLAQAV-----------QDIKQF-RDGKIDPQAYME-WCDKYQA---QIVVLAAQILWSEDVES 1766
            .:|...|           :.:||. :..|:..|.|:: |.|..||   |.|::|.:::|..::|.
Human  1461 HMLQGCVAARLARGPSLGEALKQLPKQNKLYLQLYVQHWIDLVQAFPWQCVLVAEEVVWRAEMEE 1525

  Fly  1767 AL-------------------------QQASENNQSKPMQRVLGNVESTLNVLADSVLQEQPPLR 1806
            ||                         |:||:..||.|..|.. ::.|.|.|:|
Human  1526 ALLEWGTLAMVSMHMRKLEVLVNFMRAQRASQGGQSLPSVRQT-SLLSALLVMA----------- 1578

  Fly  1807 RRKLEHLINEFVHKRTVTRRLLNNGVTSPKSFQWLCEMRFYFD-----PRQTEVLQQLT------ 1860
                       |..|.:.:.|..:.|:....|.|:.:::::..     |:..  ||.|.
Human  1579 -----------VTHRDIAQLLEQHQVSDLTDFHWVRQLKYHLGSPHIIPKSP--LQSLKTIASSE 1630

  Fly  1861 ---------IHMANARFFYGFEYLGVQDRLVQTP--LTDRCYLTMTQALESRLGGSPFGPAGTGK 1914
                     |.:....|.|.:||||  .||...|  |.:|..|.:..|||....|:..||.|.||
Human  1631 PSLSPAACWIDVLGRSFLYNYEYLG--PRLGPLPSLLPERPALVLLLALEEVACGTVLGPNGVGK 1693

  Fly  1915 TESVKALGNQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSACSQQIQT 1979
            ...|.:|...|||.:::..|....:.|.:.....|..|.|||...::.::|...:|||..|::..
Human  1694 RAIVNSLAQALGRQLVMLPCSPQIEAQCLSNYLNGALQGGAWLLLEKVHQLPPGLLSALGQRLGE 1758

  Fly  1980 IQE--ALKYEMDSNKESITVELVGKQVRVSPDMAIF----ITMNPGY-------AGRSNLPDNLK 2031
            :..  |..|: ::::.:.|::....|:..|   :.|    :::..||       |..|.:|.||.
Human  1759 LHHLYAPLYQ-EASRNTSTIDPTQPQLLGS---SFFEKHHVSVRLGYGCLLVLRALSSAVPANLH 1819

  Fly  2032 KLFRSLAMTTPDRQLIAEVMLFSQGFRSAEKLACKIVPFFKLCDEQLSNQSHYDFGLRALKSVL- 2095
            .|.|.:|:..||.:.:||:.|...|.|.|.::|.::..||.|..|.:|..  ....|..||.:|
Human  1820 LLLRPVALALPDLRQVAELTLLGAGMRDAFQMATRLSKFFSLERELVSGP--LPCRLPLLKQILE 1882

  Fly  2096 --ISAGNVKRDRIMKIKEQMKQRGDENIDEASVAENLPEQEILIQSVCETMVPKLVAEDIPLLFS 2158
              |...||.::.    .:..|.|....|:||:          |::|...:::..|...:   |..
Human  1883 DTIRTLNVTKEE----PKCQKPRSLAAIEEAA----------LLRSPLFSILNGLHLHN---LRG 1930

  Fly  2159 LLSDVFPNVGYTRAE------MKGL-KEEIRKVCQEDYLVCGEGDEQGAAWMEKGLGSTWVDKVL 2216
            ||..:||:.....||      ||.| .||:::|              |.......|||     :.
Human  1931 LLCALFPSASQVLAEPMTYKLMKPLVVEELQQV--------------GLDPSPDILGS-----LE 1976

  Fly  2217 QLYQISNLNHGLMMVGPSGSGKSTAWKTLLKALERFEGVEG----------VAHVIDPKAISKEA 2271
            ||.|..:...|::::||:||||:|.|.:|.|...|...:|.          :.|:. |..:|.:.
Human  1977 QLSQALSRASGILLLGPAGSGKTTCWHSLFKIQNRLAAMEDTSTQGCQPVEITHLY-PSGLSPQE 2040

  Fly  2272 LYGVLDPNTREWTDGLFTHILRKIIDNVRGEIN----KRQ---------WIIFDGDVDPEWVENL 2323
            ..|.|:.:.  |..|:|..:||     ..|:.|    |||         |||.||..:..|::::
Human  2041 FLGWLEGSC--WHHGIFPKVLR-----AAGQCNNMGQKRQTEESIGIQHWIICDGASNGAWLDSI 2098

  Fly  2324 NSVLDDNKLLTLPNGERLSLPPNVRVMFEVQDLKFATLATVSRCGMVWFSED-----VLSTEMIF 2383
            ..:|.:...|:||:|::::.||...::.||.|....:...|..|.:||...:     :||..|..
Human  2099 TCLLSELPQLSLPSGQQIARPPGTFLLMEVADTTGISPTVVGCCALVWCGGEQTWQCILSALMAS 2163

  Fly  2384 ENYLSRLRSIPLEDGDEDFVGVIKPAKDKE---EEVSPSLQVQRDIALLLLPFFSADGI-----V 2440
            ..|..||:...:.:.:. ...|:.||..:.   :.||..|||....|:       ..|:     :
Human  2164 LPYEYRLQHRTVAELNH-MAEVLVPATLRFLTCQGVSSLLQVHGQQAV-------CAGVAEVTSM 2220

  Fly  2441 VRTLEYAMDQEHIMDFTRLRA-------------------LSSLFSMLNQAARNVLTFNAQHPDF 2486
            .|.|...:|. |:    ||:.                   .||..|.||::       .....|.
Human  2221 ARILHSLLDL-HL----RLKEEKAPGPEDLSYSDPVAQSFRSSKSSFLNRS-------QVDSDDV 2273

  Fly  2487 P--CSADQLEHYIP-KALVYSVLWSFAGDAKLKVRI------DLGDFVRSVTTVPLPGAAGAPII 2542
            |  |.    ||.:. .:.:::::|.|.  |.|..|.      .:.|.:..::..|.| ...|.:.
Human  2274 PDKCR----EHLLAVSSFLFALIWGFG--AHLPSRFWPIFDTFIRDSISRLSNYPEP-PPSALVF 2331

  Fly  2543 DYEVN-MSGDWVPWSNKVPVIEVETHKVASPDIVVPTLDTVRHESLLYT---WLAEHKPLVLCGP 2603
            |..|: ..|..||::.:.    :.:|...:.....|::.|   |.|||.   .|:..:|::|.|.
Human  2332 DLHVSPEDGTLVPFTGQY----LSSHIKGTLGTFHPSIQT---ERLLYVVDLLLSGGQPVLLAGE 2389

  Fly  2604 PGSGKTM-----------TLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRKTPNGVVL 2657
            ..:||:.           .::|.:...         |||:....||.:......:....|
Human  2390 AATGKSAFVEVLVEPHHPYIYSPIHPA---------FSSSHLRLLLSRGIQGQTQASPQP----- 2440

  Fly  2658 SPVQIGKWLVLF-CDEINLPDMD-SYGTQRVISFLRQLVEHKGFYRASDQAWVSLERIQFVGACN 2720
            ...|..|..:|| .::::|...| ....|.|:..|||.::...:..::.:.......:.|:...
Human  2441 GHHQDSKPSLLFLLEDLHLATSDPEKSCQPVLETLRQAMDGTVYAHSTLELQTLQPTVNFLATV- 2504

  Fly  2721 PPTDPG--RKPLSHRFLRHVPIIYVDYPGETSLKQIYGTFSRAMLRLMPAL---RGYAEPLTNAM 2780
              |.||  .:||..|..|...::.::...:.:|.:.:....:|.|...|::   |..|..|..|.
Human  2505 --TVPGYCERPLCPRLFRLFTVLALESMTQATLLERHVPIIQAWLERFPSVERERALARGLVRAS 2567

  Fly  2781 VEFYLASQDRF-TQDMQPHYVYSPREMTR-------------------------------WVRGI 2813
            ||.:.|..:.| ...:.|||.:|...::.                               .:||.
Human  2568 VEAWEAVCNCFMPSPLHPHYHFSLHSVSHLLSSLQLLPNRTGSRGFVDYPNHQEHLRRVSGLRGT 2632

  Fly  2814 CEAIRPLDSLPVEGLVRLWAHEALRLFQDRLVDDSERRWTNENIDLVGQKHF---PG-------- 2867
            |..:    .:....:||||.|||.|.|.|||....||.:..:.:.:|.|..|   ||
Human  2633 CLTV----MMATRNVVRLWLHEAQRTFCDRLDSPRERSYCAKLLLVVAQSVFCCGPGPQHLGKDH 2693

  Fly  2868 --INQEEALQR-PILYS-----NW-------------------------------LSKDYMPVNR 2893
              ..:||..:| |.:.|     .|                               |:....||:|
Human  2694 QESEEEEEEERVPEVESEGELAQWEDFSNSNSETEEEEEPYGLQVARVSNSRDPSLTPSIGPVSR 2758

  Fly  2894 ------------------EELREYVHARLKVFYEE--ELDV--PLVL---------------FDE 2921
                              ...|..|....|.::::  ::|:  ||:|               |.:
Human  2759 GMKESISHKIRQEKGTRASNYRLQVRRSFKTWWQKKPQMDLISPLLLPVLLLHPQEKPSDLVFSQ 2823

  Fly  2922 VL--------------------------------------------DHVLRIDRIFRQPQGH-LL 2941
            .|                                            .||.|:.|:..:|:.| ||
Human  2824 ELILGPNSETPNLYLERQWEKLEEQLATSAAQLKLSPHLARCHSMAQHVARLVRVLARPRQHGLL 2888

  Fly  2942 LIGVSGAGKTTLSRFVAWMNGLSIFQIKVHNKYTSEDFDEDLRCVLR----RSGCKDEKIAFILD 3002
            |.|..|.|:.|.....:     ||.|  .|..:.....:|.:...||    .:|...:.:|.::.
Human  2889 LSGALGTGRHTAITLAS-----SICQ--AHFFHLPSGSEEAILQCLRDASWHAGMLSQPVALLVP 2946

  Fly  3003 ESNVLDSGFLERMNTLLANGEVPGLFEGDEYTTL-MTQCKEGAQREGLMLDSS---DELYKWFTQ 3063
            ..  :|...|.|:..|..:|..||     :||.. :.:..|...||.|.:..:   :.:.:.|.|
Human  2947 SG--VDLTTLHRLLALATSGSFPG-----QYTEADLDRIGEHLPRENLGVKQNIKKEMVLQRFHQ 3004

  Fly  3064 QVMRNLHVVFTMN--------PSTDGLKDRAATSPALFNRCV------LNWFGDWSDSALFQVGK 3114
            ||..:||:.|.:.        |||            ||.|.:      ::.:..|..:||.:|.:
Human  3005 QVCSHLHLFFLIGDKQAHKQLPST------------LFLRLLQLATASIDRYEPWDQAALAKVAQ 3057

  Fly  3115 ---EFTTRVDLEKPNWHAPDF---FPSVCPLVPANPTHRDAVIN-SCVYVHQTLHQANARLAKRG 3172
               |....|.|:..:|..||.   .|||...:        |:|: |..:.|:.|..|
Human  3058 HHLEGAQSVPLDDGSWKYPDLQASIPSVAKAM--------ALIHLSATHYHEHLCPA-------- 3106

  Fly  3173 GRTMAVTPRHYLDFIHHFVKLYNEK------------------RSDLEEQQLHLNVGLNKIAETV 3219
              ...|||:.:|||:..|:.|..:.                  |..::|...|.|:    |.:..
Human  3107 --LPLVTPKTFLDFLDTFLMLQQQTILKIKNKAQRVQNALENLRMLIKEHGTHANL----IFDLE 3165

  Fly  3220 EQVEEMQKSLAVKKQELQAKNEAANAKLKQMFQDQQEAEKKKIQSQEIQIRLADQTVKIEEKRKY 3284
            :|:::..|||::.:|:|:........:|::....:...|....|...:|   |.:...:|:..|.
Human  3166 QQLKDSGKSLSMFQQQLEQSKLLYKQQLEECRHQENLIENLARQRDALQ---AQREAFLEQMSKA 3227

  Fly  3285 VMADLAQVEPAVIDAQAAVKSIRKQQLVEVRTMANPPSVVKLALESICLLLGENATDWKSIRAVI 3349
            .:..|:|::.|..:              |:|:...||..|....:::|.|. .:.|.|.|.:.::
Human  3228 FLEPLSQLQVADFE--------------EIRSYRAPPESVVRVTDAMCDLF-HHETGWASAKQLL 3277

  Fly  3350 MRENFINSIVSNFGTENITDDVREKMKSKYLSNPDYNFEKVNRASMACGPMVKWAIAQIEY---- 3410
            ..|:|...:|. |..|.|||....|: ...|..|..:...:...|.....:..|..|.:.|
Human  3278 CTEDFYQELVF-FPKEKITDSELIKL-HLILKAPGMDDAALRAVSRPAASLAAWLWAVLHYGLAH 3340

  Fly  3411 -----AD-MLKRVEP--LREELR------SLEEQADVNLASAKETKDLVEQLERSIAAYKEEYAQ 3461
                 .| :|::||.  .||:.|      ..:|..:.|||.||    :||..:.|    ....|:
Human  3341 CRGLPTDLLLQQVEATLTREQARLGYYQFQAQETLEHNLALAK----MVEDAQAS----HNCVAK 3397

  Fly  3462 LISQAQAIKTDLENVQAKVDRSIALLKSLNIERERWESTSETFKSQMSTIIGDVLLSAAFIAYGG 3526
            .:||||.      ....|.....|||..:    ..|.:..:..|.:..|:.||.||.:|.|.|.|
Human  3398 TLSQAQC------GQYHKWPMKAALLTPM----RAWTTQLQKLKGRCMTVFGDTLLCSAAIIYLG 3452

  Fly  3527 YFDQHYRLNLFTTW----------------SQHL----QAASIQYRADIART-------EYLSNP 3564
            .|....|..|...|                :|.|    ::.||..:..:..|       ..||:.
Human  3453 PFPPLRRQELLDEWLALCRGFQEALGPDDVAQALKRKQKSVSIPPKNPLLATHSPFSILSLLSSE 3517

  Fly  3565 DERLRWQANALPTDDLCTENAIMLKRFN-----RYPLIIDPSGQATTFL--------------LN 3610
            .|:.:|..|..|.........::|:...     |:||::|||.:|..:|              |.
Human  3518 SEQYQWDGNLKPQAKSAHLAGLLLRSPTHYSSCRWPLLLDPSNEALIWLDPLPLEENRSFAPALT 3582

  Fly  3611 EYAGKKI-------TKTSFL--DDSFRKNLES--------ALRFGNPLLVQDVENYD-------- 3650
            |..||.:       :||...  ||...::.|:        |....|....:..||.:
Human  3583 EGRGKGLMRNQKRESKTDMKEEDDESEESNEAEDQTKEQKAEERKNEQEKEQEENEEKEEEKTES 3647

  Fly  3651 --------------PIL------NPVLNRELRRT---GGRVLIT-----LGDQDI---------- 3677
                          |.|      :|.|..:|:..   |..||:|     ||.:::
Human  3648 QGSKPAYETQLPSLPYLSVLSGADPELGSQLQEAAACGLPVLLTNVELGLGCEELQWLLQREQLS 3712

  Fly  3678 --DLSPSFVIFLSTRDPTVEFPPDICSR-----------VTFVNFTVTRSSLQSQCLNQVLKAER 3729
              .:.|.|.::|||   |:    .:|:.           :..::..:....|:.|.|:::|..|.
Human  3713 PPQVQPGFCLYLST---TL----SLCAMEKVLGCELLKGLNVLDLGLNMEILEEQMLHEILCREY 3770

  Fly  3730 PDIDEKRSDLLKLQ----------GEFRLRL--------RQLEKSLLQALNDAKGKILDDDSVIT 3776
            |:::.:..| ||::          .|.||..        ||.....|:.:..|:||:....:...
Human  3771 PELETRWQD-LKIRALDTCKAVEAAEERLLTMLLFQNPKRQKPAKFLRNIVRAQGKLCQLRAHCE 3834

  Fly  3777 TLETLKKEAYDINQKVDET------DKVI----AEIETVS--QQYLPLSVACSNIYFTMDSLNQV 3829
            .||         .||:.|.      ..|:    |.::.:|  |..|||        |.|...|
Human  3835 ELE---------GQKLQEMVLWAPYRPVVWHGMAMVKALSQLQNLLPL--------FCMSPEN-- 3880

  Fly  3830 HFLYQYSLKMFLDIFSTVLYNNPKLEGRTDHSERLGI--------VTRDLFQVCYERVARGMIHI 3886
               :....|..||..      .|:   ..:|.|.|..        :||.|.......:....:.:
Human  3881 ---WLAVTKQALDSM------KPR---EINHGEDLASHLLQLRAHLTRQLLGSTVTALGLTQVPL 3933

  Fly  3887 DRLTFALLMCKIHLKGTSE-SNLDAEFNFFLRSREGLLANPTPVEGLSAEQIESVNRLALRLPIF 3950
            .....||.:    |:.|.: |.|:.     |....||.|:|:.|.   ::.:..|.|.|...|..
Human  3934 VGALGALAL----LQATGKASELER-----LALWPGLAASPSTVH---SKPVSDVARPAWLGPKA 3986

  Fly  3951 RKLLEKVRSIPEL----GAWLQQSSPEQVVPQLWDESKALSPI-------ASSVHQLLLIQAFRP 4004
            ....|.:..:|..    .:....||..|....|  .|..|.|.       .|.:.:|:|.:..||
Human  3987 WHECEMLELLPPFVGLCASLAGHSSAWQAYLSL--SSTVLGPAPGPGPEPLSLLQKLILWRVLRP 4049

  Fly  4005 DRVIAAAHNVVNTVLGEDFMPNA-EQELDFTSVVDKQLNCNTPALLCSVPGFDASGRVDDLAAEQ 4068
            :.:..|..:...::||.....|. ...:.|     |......|.|:...|....|..:..|...|
Human  4050 ECLAGALADFTTSLLGRPLDENTYAPTMPF-----KHSQATQPMLILLPPPGHPSATLHPLTVIQ 4109

  Fly  4069 ---------NKQISSIAIGSAEGFNQAE---RAINMACKTGRWVLLKNVHLAPQW---------- 4111
                     .||:..||:|| |.::...   ..::.|...|.|::|.|.||.|.|
Human  4110 KLAAKYQQGQKQLQVIALGS-EAWDPVSVVVSTLSQAMYEGHWLVLDNCHLMPHWPKELLQLLLE 4173

  Fly  4112 -------LVQLEKKMHSLQP--------HSGFRLFLTM--EINPKVPVNL------------LRA 4147
                   :..||.:....||        |..|||:|.:  |.:..:|..|            |..
Human  4174 LLGRAKVVADLESEQLLDQPESRNVSTVHRDFRLWLIVPAESSASLPAVLTQHSMPVFWNQSLEL 4238

  Fly  4148 GRIFVFEPPPGIRANLLRTFSTVPAARM---MKTPSERARLYFLLAWFHAIVQERLRYVPLGWAK 4209
            |.:.:               .:|..|:.   |:.|::...|..|    |.::..|..|.....|.
Human  4239 GHVLI---------------DSVELAQQVLYMQPPTQALPLLLL----HGLLLHRQLYGTRLQAH 4284

  Fly  4210 KYEFNESDLRVACDTLD-TWIDTTAMGRTNLPPEKVPWDALVTLLSQSIYGGKIDNDFDQRLLTS 4273
            :..:::..|.....|.| .|...:.           |..|:..|.:...|||.:.:..|:..|.|
Human  4285 RGRWSQVTLTQVLQTQDQLWASLSN-----------PRAAMQELAASVFYGGPLGDTEDREALIS 4338

  Fly  4274 FLKKLFTARSFEADFALVANVDGASGGLRHITMPDGTRRDHFLKWIENLTDRQTPSWLGLPNNAE 4338
            ..:               |.:..:||                 .|::             |:..:
Human  4339 LTQ---------------ACLSPSSG-----------------SWVQ-------------PHTPQ 4358

  Fly  4339 KVLLTTRGTDLVSKLLKMQQLEDDDELA------YSVEDQSEQSAVGRGEDGRPSW--------- 4388
            .:|.|         |:.:.:|.:.|.:|      :.:....|....|..| |..:|
Human  4359 SLLAT---------LMPLPELRELDAMAECKAQMHLLPSPPEPRLCGLSE-GPQAWLLRRQSRAL 4413

  Fly  4389 MKTLHNSATAWL-----------ELLPKNLQVLKRTVENIKD----------------------- 4419
            :..|..|:..|:           ..|.:.|..:.|.:|:::|
Human  4414 LSALQRSSPVWVPESRRGAQLAERRLRQRLVQVNRRLESLQDLLTHVIRQDESDAPWSVLGPNAR 4478

  Fly  4420 -PLYRYFEREVTSGSRLLQTVILDLQDVVLICQGEKKQTNHHRSMLSE-LVRGIIPKGWKRYTVP 4482
             ||....|.|....|:|:.|:..||..::...:|.....:...:.::. |..|.:|..|:.: .|
Human  4479 RPLEGVLETEALELSQLVGTLQRDLDCLLQQLKGAPPCPSRRCAAVAHALWTGRLPLPWRPH-AP 4542

  Fly  4483 AG-CTVIQWITDFSNRVQQLQKVSQLVSQAGAKELQGFP---VWLGGLLNPEAYITATRQCVAQA 4543
            || .....|:...|.|.|.|.:...:    ||......|   ..|....:|...:.|.|
Human  4543 AGPQPPWHWLRQLSRRGQLLVRYLGV----GADASSDVPERVFHLSAFRHPRRLLLALR------ 4597

  Fly  4544 NSWSLEELALDVTITDAGLKNDQKDCCFGVTGLKLQGAQCKNNELLL--------------ASTI 4594
                 .|.|||..:..:.....:     |....:||..:.:.|...|              ...:
Human  4598 -----GEAALDQNVPSSNFPGSR-----GSVSSQLQYKRLEMNSNPLHFRVENGPNPTVPERGLL 4652

  Fly  4595 MMDLPVTILKWIKI--------SSEPRISKLTLPVYLNSTR----TELLFTVDLAV 4638
            ::.|.|...:|..|        ||:|.    .||....||:    ::|....||.|
Human  4653 LIGLQVLHAEWDPIAGALQDSPSSQPS----PLPPVSISTQAPGTSDLPAPADLTV 4704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dhc64C	NP_001261432.1	DHC_N1	240..839	CDD:285571	114/650 (18%)
		DYN1	1022..4338	CDD:227570	842/4075 (21%)
		DHC_N2	1326..1724	CDD:285579	91/485 (19%)
		P-loop_NTPase	1870..2103	CDD:304359	74/250 (30%)
		P-loop_NTPase	2227..2367	CDD:304359	45/162 (28%)
		P-loop_NTPase	2572..2835	CDD:304359	61/315 (19%)
		Cas4_I-A_I-B_I-C_I-D_II-B	2834..>2943	CDD:294426	42/240 (18%)
		P-loop_NTPase	2916..3194	CDD:304359	78/366 (21%)
		MT	3208..3544	CDD:289543	84/369 (23%)
		AAA_9	3569..3784	CDD:289547	63/327 (19%)
		Dynein_heavy	3925..4636	CDD:281078	159/858 (19%)
DNHD1	NP_653267.2	DHC_N2	1019..1467	CDD:285579	91/483 (19%)
		P-loop_NTPase	1649..1867	CDD:304359	66/223 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2688..2766		10/77 (13%)
		P-loop_NTPase	2870..3119	CDD:304359	72/292 (25%)
		MT	<3193..3467	CDD:289543	74/311 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3580..3657		13/76 (17%)
		AAA_9	<3664..3802	CDD:289547	29/145 (20%)
		Dynein_heavy	3979..4741	CDD:281078	158/844 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4669..4697		7/31 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810