DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KRT10 and LamC

DIOPT Version :9

Sequence 1:	NP_001366295.1	Gene:	KRT10 / 3858	HGNCID:	6413	Length:	624	Species:	Homo sapiens
Sequence 2:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster

Alignment Length:	421	Identity:	114/421 - (27%)
Similarity:	186/421 - (44%)	Gaps:	63/421 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   146 EKVTMQNLNDRLASYLDKVRALEESNYEL--------------EGKIKEWYEKH--------GNS 188
            ||..:|:||||||.|:|::|.||..|..|              ...:|..|||.        ..:
  Fly    46 EKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDET 110

Human   189 HQGEPR---DYSKYYKTIDDLKNQILNLTTDNANILLQIDNARLAADDF-------------RLK 237
            .:.:.:   |..:.::..||||.: |:..|..|.:  ..:||||..:.:             |.|
  Fly   111 AKEKAKLEIDIKRLWEENDDLKPR-LDKKTKEATV--AENNARLYENRYNEVNGKYNQSLADRKK 172

Human   238 YEN---EVAL-RQSVEADINGLRRVLDELTLTKADLEMQIESLTEELAYLKKNHEEEMKDLRN-- 296
            :|:   |:|| .:.:...::.||:.|:..||.:.|||.|.:||.||||:..:.|.:|:.:.|:
  Fly   173 FEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRR 237

Human   297 -VSTGDVNVEMNAAPGVDLTQLLNNMRSQYEQLAEQNRKDAEAWFNEKSKELTTEIDNNIEQISS 360
             :...:::..::......|.|.|..:|.|||.....||::.|..::.:.:.|....:...:..:.
  Fly   238 QIEISEIDGRLSRQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSAL 302

Human   361 YKSEITELRRNVQALEIELQSQLALKQSLEASLAETEGRYCVQLSQIQAQISALEEQLQQIRAET 425
            ...|:..:|..:..|..:||:.......|.|.:.|.|.....:..:....|::||.:||::|.|.
  Fly   303 ATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEM 367

Human   426 ECQNTEYQQLLDIKIRLENEIQTYRSLLEGEG---SSGGGGRGGGSFGGGYGGGSSGGGSSGGGH 487
            ..|..|||.|:|||:.|:.||..|..||.||.   :....||          ..:..|.||.|.|
  Fly   368 AHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGR----------PTTDSGISSNGSH 422

Human   488 GGGHGGSSGGGYGGGSSGGGSSGGGYGGGSS 518
            ......|..|..  ..||..|:..|..|.|:
  Fly   423 LTASASSRSGRV--TPSGRRSATPGISGSSA 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRT10	NP_001366295.1	Head	1..145
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Filament	145..454	CDD:365827	96/352 (27%)
		Coil 1A	146..181		17/48 (35%)
		Linker 1	182..202		4/30 (13%)
		Coil 1B	203..294		34/107 (32%)
		Linker 12	295..317		2/24 (8%)
		Coil 2	318..456		39/137 (28%)
LamC	NP_001260974.1	Filament	45..401	CDD:278467	99/357 (28%)
		ATP-synt_B	<67..>142	CDD:304375	15/75 (20%)
		MreC	<178..>224	CDD:302802	18/45 (40%)
		LTD	473..574	CDD:279300
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910