DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and TRIL

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_055632.2	Gene:	TRIL / 9865	HGNCID:	22200	Length:	811	Species:	Homo sapiens

Alignment Length:	417	Identity:	119/417 - (28%)
Similarity:	169/417 - (40%)	Gaps:	48/417 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 VC--RCN-PDTKSFTCWNTNLKSVPVTQVIPM--NMVNIDLSRNILSTLHKDTFRGLTVLKELDI 212
            ||  ||: ...:...|.|..|:.||.|..:|.  :::...|..|.::.:....|..|..|:.||:
Human    26 VCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDL 90

  Fly   213 SHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQ 277
            .:|.:..|....|:.|..|..|.:.||.|:.:...|...||.|.||..:.|||..|....|...:
Human    91 QYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLE 155

  Fly   278 RLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQI--AKI 340
            .|..:.:..|.:...|..:......|..|.:..|:|..|...:...|.||:.|:...|::  :..
Human   156 SLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLR 220

  Fly   341 DDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLG 405
            ....||.||||.:|.|..|.:..|...||.:|..|..|.|..|:::|:...||..|..|.||.|.
Human   221 HAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLE 285

  Fly   406 QNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQ 470
            .|.:|.:|..|...:.:|..|.|..|.|:.|....|..|..|:.|.|.||.|.......|.....
Human   286 GNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPA 350

  Fly   471 LEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPM--- 532
            |.:|                        .||.|.|.||||...|.||:.:     |..|..:
Human   351 LYRL------------------------DLDGNGWTCDCRLRGLKRWMGD-----WHSQGRLLTV 386

  Fly   533 ---CRGPGDLGGHEVGLLRYDDLCDGQ 556
               ||.|..|.|      :|.|..|.|
Human   387 FVQCRHPPALRG------KYLDYLDDQ 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	15/58 (26%)
		leucine-rich repeat	187..206	CDD:275380	4/18 (22%)
		LRR_RI	<201..386	CDD:238064	55/186 (30%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	15/59 (25%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		LRR_8	303..361	CDD:290566	19/59 (32%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	6/24 (25%)
		LRR_8	349..407	CDD:290566	22/57 (39%)
		LRR_4	350..390	CDD:289563	14/39 (36%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	8/22 (36%)
		LRR_8	398..>443	CDD:290566	15/44 (34%)
		leucine-rich repeat	399..422	CDD:275380	8/22 (36%)
		leucine-rich repeat	423..443	CDD:275380	7/19 (37%)
		leucine-rich repeat	471..494	CDD:275380	2/22 (9%)
		LRRCT	503..554	CDD:214507	18/56 (32%)
TRIL	NP_055632.2	LRR_RI	<2..194	CDD:238064	45/167 (27%)
		leucine-rich repeat	37..61	CDD:275380	7/23 (30%)
		LRR 1	61..81		3/19 (16%)
		leucine-rich repeat	62..84	CDD:275380	4/21 (19%)
		LRR_8	84..143	CDD:290566	19/58 (33%)
		LRR 2	84..105		6/20 (30%)
		leucine-rich repeat	85..108	CDD:275380	7/22 (32%)
		LRR 3	108..129		6/20 (30%)
		leucine-rich repeat	109..132	CDD:275380	7/22 (32%)
		LRR 4	132..153		8/20 (40%)
		leucine-rich repeat	133..156	CDD:275380	8/22 (36%)
		LRR_8	156..215	CDD:290566	13/58 (22%)
		LRR 5	156..177		3/20 (15%)
		leucine-rich repeat	157..180	CDD:275380	3/22 (14%)
		LRR 6	180..201		5/20 (25%)
		leucine-rich repeat	181..204	CDD:275380	6/22 (27%)
		LRR 7	204..223		4/18 (22%)
		leucine-rich repeat	205..254	CDD:275380	16/48 (33%)
		LRR 8	230..251		8/20 (40%)
		LRR_8	239..289	CDD:290566	18/49 (37%)
		LRR_RI	<249..>364	CDD:238064	39/138 (28%)
		LRR 9	254..275		7/20 (35%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		LRR 10	278..299		8/20 (40%)
		LRR_8	279..337	CDD:290566	21/57 (37%)
		leucine-rich repeat	279..302	CDD:275380	8/22 (36%)
		LRR 11	302..323		7/20 (35%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		LRR 12	326..347		7/20 (35%)
		leucine-rich repeat	327..346	CDD:275380	6/18 (33%)
		leucine-rich repeat	351..363	CDD:275378	6/35 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..549
		fn3	589..667	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141286
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840