DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and LGI1

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_005088.1	Gene:	LGI1 / 9211	HGNCID:	6572	Length:	557	Species:	Homo sapiens

Alignment Length:	648	Identity:	124/648 - (19%)
Similarity:	214/648 - (33%)	Gaps:	218/648 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 NACESLGIVSQLLMLINSMPNGTQSAANDKKPPKSKANGHNDGDVNGGEINAMSHLANFDLVKRV 121
            |||..|..::..|.|::::     .....|||.|.|
Human    11 NACIPLKRIAYFLCLLSAL-----LLTEGKKPAKPK----------------------------- 41

  Fly   122 RQIESRLRSVEQPVWHLATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNI 186
                                       |.: ||.|..|  :..|  .|.:|:|.|  :|.:::::
Human    42 ---------------------------CPA-VCTCTKD--NALC--ENARSIPRT--VPPDVISL 72

  Fly   187 DLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWK 251
            ...|:..:.:.:.:|.....|:.|..:.|..|.:..|.|..|..|..|.|:||.::.|...||..
Human    73 SFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRG 137

  Fly   252 LRNLNILDLSKNEIGMLPESIFYHAQRLTVINM------CDNQIQNFPPNLLRDQLMLEEL---- 306
            |::|..|.|:.|.:..||:.||.....||.:::      ||.:::.....|......:|::
Human   138 LKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEG 202

  Fly   307 --DMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIF 369
              :..:.||:.|||         |..|....:.||..|..:..| |:.|.|..|:....::....
Human   203 PPEYKKRKINSLSS---------KDFDCIITEFAKSQDLPYQSL-SIDTFSYLNDEYVVIAQPFT 257

  Fly   370 NNLANLV--TLDLTTNRISHIDGNAFVELNNL---NELFLGQNSMSSIPADLFLNVSALTRLTLF 429
            .....|.  .::.|.....:|.|.:.|....:   .:|::       |.|.|| ..|.:.:...|
Human   258 GKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYV-------IVAQLF-GGSHIYKRDSF 314

  Fly   430 SNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKL-----------MF 483
            :|.        |..:.:::||    .|.|..|...|:..:....:..||:|.           .|
Human   315 ANK--------FIKIQDIEIL----KIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGF 367

  Fly   484 LPHGALHGLKNLVAVKLDKNPWHCDCRALYLA-------------------------RW------ 517
            ..|.:||.             |:.|....||.                         :|
Human   368 YSHQSLHA-------------WYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQL 419

  Fly   518 ---------------IREFVLKLWDGQQPMC--RGPGDLGGHEVGLLRYDDLCDGQWASMLSLSP 565
                           ::.|.:|   |...:|  |..||....:.|...:.|:            .
Human   420 FTNQTDIPNMEDVYAVKHFSVK---GDVYICLTRFIGDSKVMKWGGSSFQDI------------Q 469

  Fly   566 RLPVRKHQISTPMNYTDYFNLYL------KHIYNGTTDE----ELKEADI------TSVSIKK 612
            |:|.|...:..|:...:|....|      ..:||...::    :.:|.::      |.|||.|
Human   470 RMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	14/58 (24%)
		leucine-rich repeat	187..206	CDD:275380	2/18 (11%)
		LRR_RI	<201..386	CDD:238064	48/198 (24%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR_8	253..313	CDD:290566	14/71 (20%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	5/28 (18%)
		LRR_8	303..361	CDD:290566	16/63 (25%)
		leucine-rich repeat	303..326	CDD:275380	6/28 (21%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		LRR_8	349..407	CDD:290566	10/62 (16%)
		LRR_4	350..390	CDD:289563	7/41 (17%)
		leucine-rich repeat	351..374	CDD:275380	3/22 (14%)
		leucine-rich repeat	375..398	CDD:275380	5/24 (21%)
		LRR_8	398..>443	CDD:290566	9/47 (19%)
		leucine-rich repeat	399..422	CDD:275380	5/25 (20%)
		leucine-rich repeat	423..443	CDD:275380	3/19 (16%)
		leucine-rich repeat	471..494	CDD:275380	7/33 (21%)
		LRRCT	503..554	CDD:214507	14/98 (14%)
LGI1	NP_005088.1	leucine-rich repeat	71..92	CDD:275378	2/20 (10%)
		LRR_8	91..151	CDD:404697	20/59 (34%)
		LRR 1	92..113		6/20 (30%)
		leucine-rich repeat	93..116	CDD:275378	7/22 (32%)
		LRR 2	116..137		8/20 (40%)
		leucine-rich repeat	117..140	CDD:275378	9/22 (41%)
		LRR 3	140..161		8/20 (40%)
		leucine-rich repeat	141..164	CDD:275378	8/22 (36%)
		PCC	146..>221	CDD:188093	18/83 (22%)
		leucine-rich repeat	165..177	CDD:275378	2/11 (18%)
		EAR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	225..267		9/42 (21%)
		EPTP	225..264	CDD:397689	8/39 (21%)
		EAR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	271..313		10/49 (20%)
		EPTP	272..310	CDD:397689	9/45 (20%)
		EAR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	317..364		10/58 (17%)
		EPTP	317..361	CDD:397689	10/55 (18%)
		EAR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	366..415		9/61 (15%)
		EAR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	419..462		7/45 (16%)
		EPTP	420..459	CDD:397689	7/41 (17%)
		EAR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	464..506		9/53 (17%)
		EPTP	464..502	CDD:397689	7/49 (14%)
		EAR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	510..552		6/23 (26%)
		EPTP	510..549	CDD:397689	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141296
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930