DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and LGR5

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_003658.1	Gene:	LGR5 / 8549	HGNCID:	4504	Length:	907	Species:	Homo sapiens

Alignment Length:	448	Identity:	124/448 - (27%)
Similarity:	179/448 - (39%)	Gaps:	94/448 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 LATGSQIEWNHCTSGV--------CRCNPDTKSF---TCWNTNLKSVPVTQVIPMNMVNIDLSRN 191
            ||||.    :...|||        |.|.||.:..   .|.:..|..:|..  :.:....:|||.|
Human    18 LATGG----SSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSN--LSVFTSYLDLSMN 76

  Fly   192 ILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLN 256
            .:|.|..:....|..|:||.::.|.|.::|...|..|.||.||.:|||||..:.......||:|.
Human    77 NISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQ 141

  Fly   257 ILDLSKNEIGMLPESIF--YHAQR----------------------------------------- 278
            .|.|..|.|..:|.|.|  .|:.|
Human   142 SLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAF 206

  Fly   279 -----LTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIA 338
                 |.|:::.:|:|.:...........||.||::.|.:.|..: :||.|:.||.|.|..|.|.
Human   207 GNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPT-AIRTLSNLKELGFHSNNIR 270

  Fly   339 KIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNL-----------------------ANLVTLDL 380
            .|.:..|.|..||.|:..::|.|..:..:.|.:|                       |||.:|.|
Human   271 SIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTL 335

  Fly   381 TTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLN 445
            |..:||.:......:|.||..|.|..|.:..:|:  |.....|.::.|..|.:..::.|.||.|.
Human   336 TGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLL 398

  Fly   446 NLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKN 503
            :|:.|.|..|.:......||..|..|.||.:.||.|...|...||||.:|   ||..|
Human   399 SLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHL---KLTGN 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	22/58 (38%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	65/255 (25%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR_8	253..313	CDD:290566	20/107 (19%)
		leucine-rich repeat	255..278	CDD:275380	9/24 (38%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		LRR_8	303..361	CDD:290566	22/57 (39%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR_8	349..407	CDD:290566	20/80 (25%)
		LRR_4	350..390	CDD:289563	15/62 (24%)
		leucine-rich repeat	351..374	CDD:275380	6/45 (13%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	12/44 (27%)
		leucine-rich repeat	399..422	CDD:275380	6/22 (27%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	11/22 (50%)
		LRRCT	503..554	CDD:214507	1/1 (100%)
LGR5	NP_003658.1	LRRNT	33..70	CDD:214470	7/38 (18%)
		leucine-rich repeat	68..91	CDD:275380	7/22 (32%)
		PLN00113	71..>426	CDD:215061	96/357 (27%)
		leucine-rich repeat	92..115	CDD:275380	8/22 (36%)
		leucine-rich repeat	116..139	CDD:275380	9/22 (41%)
		leucine-rich repeat	140..163	CDD:275380	8/22 (36%)
		leucine-rich repeat	164..187	CDD:275380	1/22 (5%)
		leucine-rich repeat	188..211	CDD:275380	0/22 (0%)
		leucine-rich repeat	212..235	CDD:275380	4/22 (18%)
		leucine-rich repeat	236..258	CDD:275380	9/22 (41%)
		leucine-rich repeat	259..282	CDD:275380	9/22 (41%)
		leucine-rich repeat	283..304	CDD:275380	5/20 (25%)
		leucine-rich repeat	307..353	CDD:275378	9/45 (20%)
		leucine-rich repeat	354..375	CDD:275378	6/22 (27%)
		leucine-rich repeat	376..389	CDD:275378	3/12 (25%)
		leucine-rich repeat	400..423	CDD:275378	7/22 (32%)
		leucine-rich repeat	445..459	CDD:275378	5/12 (42%)
		7tmA_LGR5	558..831	CDD:320485
		TM helix 1	559..585	CDD:320485
		TM helix 2	592..617	CDD:320485
		TM helix 3	637..667	CDD:320485
		TM helix 4	679..701	CDD:320485
		TM helix 5	721..750	CDD:320485
		TM helix 6	759..789	CDD:320485
		TM helix 7	799..824	CDD:320485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910