DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and LINGO1

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_116197.4	Gene:	LINGO1 / 84894	HGNCID:	21205	Length:	620	Species:	Homo sapiens

Alignment Length:	526	Identity:	129/526 - (24%)
Similarity:	211/526 - (40%)	Gaps:	133/526 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 VRQIESRLRSVEQPVWHLATGSQIEWNHCTSGV---CRCNPDTKSFTCWNTNLKSVPVTQVIPMN 182
            ||.:.|.|.:..||:..|..||.:..:  .:|.   |.|:...::..|......:||  :.||..
Human    12 VRSMPSPLLACWQPILLLVLGSVLSGS--ATGCPPRCECSAQDRAVLCHRKRFVAVP--EGIPTE 72

  Fly   183 MVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHR 247
            ...:||.:|.:.||::|.|.....|:||:::.|::..:....|.:|.:|..|.:::|:|:.|...
Human    73 TRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLG 137

  Fly   248 TFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNK 312
            .|..|.||..||:|:|:|.:|.:.:|
Human   138 VFTGLSNLTKLDISENKIVILLDYMF--------------------------------------- 163

  Fly   313 ISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVT 377
                     :.|..||:|:.|.|.:..|....|:||.||..|:|....::|:.....::|..|:.
Human   164 ---------QDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIV 219

  Fly   378 LDLTTNRISHIDGNAF-------------VELN----------------NLNELFLGQNSMSSIP 413
            |     |:.|::.||.             :|::                ||..|.:...:::::|
Human   220 L-----RLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVP 279

  Fly   414 ADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDS 478
            .....::..|..|.|..|.::|:|......|..|:.:.|....|...:..||..|:.|..|.:..
Human   280 YLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSG 344

  Fly   479 NKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYL--ARWIREFVLKLWDGQQPMCRGPGDLGG 541
            |:|..|.....|.:.||..:.||.||..||||.|::  .||...|     :.|||.|..|..:.|
Human   345 NQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNF-----NRQQPTCATPEFVQG 404

  Fly   542 HE------VGLLRY------------------DD------LC--DGQ-WASMLSLSPRLPVRKHQ 573
            .|      |.|..|                  |:      :|  ||. ..::|.|||    |||.
Human   405 KEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSP----RKHL 465

  Fly   574 ISTPMN 579
            :|...|
Human   466 VSAKSN 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	16/58 (28%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	42/184 (23%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	9/59 (15%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	0/22 (0%)
		LRR_8	303..361	CDD:290566	14/57 (25%)
		leucine-rich repeat	303..326	CDD:275380	1/22 (5%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR_8	349..407	CDD:290566	16/86 (19%)
		LRR_4	350..390	CDD:289563	10/39 (26%)
		leucine-rich repeat	351..374	CDD:275380	5/22 (23%)
		leucine-rich repeat	375..398	CDD:275380	7/51 (14%)
		LRR_8	398..>443	CDD:290566	10/44 (23%)
		leucine-rich repeat	399..422	CDD:275380	3/22 (14%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	6/22 (27%)
		LRRCT	503..554	CDD:214507	22/84 (26%)
LINGO1	NP_116197.4	LRRNT	41..75	CDD:214470	8/35 (23%)
		LRR	<66..371	CDD:227223	83/359 (23%)
		LRR 1	72..93		7/20 (35%)
		leucine-rich repeat	73..96	CDD:275380	7/22 (32%)
		LRR 2	96..117		5/20 (25%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		LRR_8	120..179	CDD:338972	22/106 (21%)
		LRR 3	120..141		6/20 (30%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR 4	144..165		9/68 (13%)
		leucine-rich repeat	145..192	CDD:275380	18/94 (19%)
		LRR 5	168..189		7/20 (35%)
		LRR 6	192..213		5/20 (25%)
		leucine-rich repeat	193..216	CDD:275380	5/22 (23%)
		LRR 7	216..237		6/25 (24%)
		leucine-rich repeat	217..264	CDD:275380	7/51 (14%)
		LRR 8	264..285		4/20 (20%)
		leucine-rich repeat	265..288	CDD:275380	3/22 (14%)
		LRR 9	288..309		6/20 (30%)
		leucine-rich repeat	289..312	CDD:275380	7/22 (32%)
		LRR 10	312..333		5/20 (25%)
		leucine-rich repeat	313..336	CDD:275380	6/22 (27%)
		LRR 11	336..357		5/20 (25%)
		leucine-rich repeat	337..357	CDD:275380	5/19 (26%)
		PCC	341..>421	CDD:188093	28/84 (33%)
		Ig	439..514	CDD:386229	12/37 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910