DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7509 and SLITRK2

DIOPT Version :9

Sequence 1:NP_647931.1 Gene:CG7509 / 38579 FlyBaseID:FBgn0035575 Length:615 Species:Drosophila melanogaster
Sequence 2:NP_001137475.1 Gene:SLITRK2 / 84631 HGNCID:13449 Length:845 Species:Homo sapiens


Alignment Length:614 Identity:137/614 - (22%)
Similarity:210/614 - (34%) Gaps:195/614 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   135 VWHLATGS-----QIEWNHCTSGVC--RC-----------NPDTKSFTC---------------W 166
            ||.|:..:     |.|.......:|  ||           |.:.|.||.               .
Human     5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFL 69

  Fly   167 NTNLKSVPVTQVIP------MNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLF 225
            |.||    :|::.|      .|.|.:.|..|.|..:....|.||..||.|.:::|.|:.|..|.|
Human    70 NGNL----LTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTF 130

  Fly   226 QDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIF---------YHAQRLTV 281
            ..|:||..|:...|.:..|:...|.||..|.:|.|:.|.:..||.::|         ....||.|
Human   131 LGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKV 195

  Fly   282 I----------NMCDNQIQNFPPNLLRDQLMLEE-LD---------------------------- 307
            :          .:.:.|::..|.|...|.|.|:. ||                            
Human   196 MPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQLTRQ 260

  Fly   308 -----MSRNKISELSSGSIRYLTKLK-TLDFGWN---------------------QIAKIDDDFF 345
                 .|.:..|:..|.:..::.:|. |::...|                     .::| |...|
Human   261 DLCPRKSASDSSQRGSHADTHVQRLSPTMNPALNPTRAPKASRPPKMRNRPTPRVTVSK-DRQSF 324

  Fly   346 AGLRSLRT----------------LSLHNNRISSLSGTIFNNLANL-------VTLDLTTNRISH 387
            ..:...:|                .|..|....:.....|.|:::|       ..|.||.|.:..
Human   325 GPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQT 389

  Fly   388 IDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLL 452
            :..|..:|.::|:.|.||.|.::.|....|.|:::|.||.|..|.|..|....|.||.:|:.|.|
Human   390 VYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYL 454

  Fly   453 NNNILKNFDARAFEPLSQLEKLRIDSNKLMFLP------------------------HGALHGLK 493
            ..|::|......|:.|..|:.|.:::|.|..||                        .|.|..|.
Human   455 EYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLP 519

  Fly   494 NLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPM------CRGPGDLGGHEVGLLRYDDL 552
            ..:.:.|.:|||.|.|..:.|..|...       ...|:      |..|....|..:..|..:.:
Human   520 AFIQIDLQENPWDCTCDIMGLKDWTEH-------ANSPVIINEVTCESPAKHAGEILKFLGREAI 577

  Fly   553 C-------DGQWASM---------LSLSP 565
            |       ||...||         ||:||
Human   578 CPDSPNLSDGTVLSMNHNTDTPRSLSVSP 606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7509NP_647931.1 LRR_8 182..241 CDD:290566 21/58 (36%)
leucine-rich repeat 187..206 CDD:275380 6/18 (33%)
LRR_RI <201..386 CDD:238064 57/282 (20%)
leucine-rich repeat 207..230 CDD:275380 9/22 (41%)
leucine-rich repeat 231..254 CDD:275380 7/22 (32%)
LRR_8 253..313 CDD:290566 19/112 (17%)
leucine-rich repeat 255..278 CDD:275380 7/31 (23%)
leucine-rich repeat 279..302 CDD:275380 6/32 (19%)
LRR_8 303..361 CDD:290566 15/129 (12%)
leucine-rich repeat 303..326 CDD:275380 6/56 (11%)
leucine-rich repeat 327..350 CDD:275380 6/44 (14%)
LRR_8 349..407 CDD:290566 16/80 (20%)
LRR_4 350..390 CDD:289563 10/62 (16%)
leucine-rich repeat 351..374 CDD:275380 5/38 (13%)
leucine-rich repeat 375..398 CDD:275380 7/29 (24%)
LRR_8 398..>443 CDD:290566 16/44 (36%)
leucine-rich repeat 399..422 CDD:275380 8/22 (36%)
leucine-rich repeat 423..443 CDD:275380 8/19 (42%)
leucine-rich repeat 471..494 CDD:275380 9/46 (20%)
LRRCT 503..554 CDD:214507 13/63 (21%)
SLITRK2NP_001137475.1 LRR 1 63..84 5/24 (21%)
leucine-rich repeat 67..87 CDD:275380 5/23 (22%)
LRR_RI <82..>217 CDD:238064 36/134 (27%)
LRR_8 86..146 CDD:290566 21/59 (36%)
LRR 2 87..108 6/20 (30%)
leucine-rich repeat 88..111 CDD:275380 7/22 (32%)
LRR 3 111..132 8/20 (40%)
leucine-rich repeat 112..135 CDD:275380 9/22 (41%)
LRR_8 135..193 CDD:290566 15/57 (26%)
LRR 4 135..156 6/20 (30%)
leucine-rich repeat 136..159 CDD:275380 7/22 (32%)
LRR 5 159..180 7/20 (35%)
leucine-rich repeat 160..181 CDD:275380 7/20 (35%)
Required for interaction with PTPRD. /evidence=ECO:0000250|UniProtKB:Q810C0 167..215 8/47 (17%)
leucine-rich repeat 208..369 CDD:275380 22/161 (14%)
TPKR_C2 216..>252 CDD:301599 7/35 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 263..321 7/58 (12%)
leucine-rich repeat 370..400 CDD:275380 7/29 (24%)
LRR 7 376..397 5/20 (25%)
LRR_8 399..459 CDD:290566 22/59 (37%)
LRR 8 400..421 7/20 (35%)
leucine-rich repeat 401..424 CDD:275380 8/22 (36%)
LRR_4 423..466 CDD:289563 15/42 (36%)
LRR 9 424..445 8/20 (40%)
leucine-rich repeat 425..448 CDD:275380 10/22 (45%)
LRR 10 448..469 6/20 (30%)
leucine-rich repeat 449..468 CDD:275380 5/18 (28%)
LRR 11 472..493 6/20 (30%)
leucine-rich repeat 473..491 CDD:275380 6/17 (35%)
LRR 12 495..516 1/20 (5%)
leucine-rich repeat 496..509 CDD:275378 0/12 (0%)
leucine-rich repeat 521..533 CDD:275378 4/11 (36%)
LRRCT 529..579 CDD:214507 12/56 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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