Protein Alignment CG7509 and TLR10

DIOPT Version :9

• Sequence 1: NP_647931.1
• Gene: CG7509 / 38579
• FlyBaseID: FBgn0035575
• Length: 615
• Species: Drosophila melanogaster
• Sequence 2: NP_001017388.1
• Gene: TLR10 / 81793
• HGNCID: 15634
• Length: 811
• Species: Homo sapiens
• Alignment Length: 654
• Identity: 118/654 - (18%)
• Similarity: 202/654 - (30%)
• Gaps: 265/654 - (40%)

  Fly   165 CWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLD 229
            |.|.:|:.|| ..:.|.. ..:|||.|:|..|....|..::.|:.|.:.||.:..|....|:...
Human    34 CSNMSLRKVP-ADLTPAT-TTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNK 96

  Fly   230 SLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLP------------------------- 269
            .|..|.:.||:|:.:   |::.|..|..||||.|:...:|
Human    97 ELRYLDLSNNRLKSV---TWYLLAGLRYLDLSFNDFDTMPICEEAGNMSHLEILGLSGAKIQKSD 158

  Fly   270 ---------ESIF--------YHAQRLTVINMCDNQI-----QNFPPNLLRDQLMLEEL------ 306
                     .::|        |....|.::|.....|     .||.. ||||.:...::
Human   159 FQKIAHLHLNTVFLGFRTLPHYEEGSLPILNTTKLHIVLPMDTNFWV-LLRDGIKTSKILEMTNI 222

  Fly   307 ---------DMSRNKISELSSGSIRYLTKLK--------TLDFGWNQ------------------ 336
                     :|.||...|.:..|:..|.|:.        .|.|.|:.
Human   223 DGKSQFVSYEMQRNLSLENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYL 287

  Fly   337 -----------------------------------IAKID------------------------- 341
                                               :.|:|
Human   288 DHNSFDYSNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQY 352

  Fly   342 ---------DDFF---AGLRSLRTLSLHNNRISSLS-GTIFNNLANLVTLDLTTNRISHIDG--- 390
                     |:.|   ..|..|:||.|:.|::.:|| .:.|.|...|..|||:.|.:.|.:.
Human   353 LNFANNILTDELFKRTIQLPHLKTLILNGNKLETLSLVSCFANNTPLEHLDLSQNLLQHKNDENC 417

  Fly   391 -------NAFVELNNLNE------------LFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTL 436
                   |..:..|.|::            |.|..|.:.::|.:. :::.||..|.:..|.||
Human   418 SWPETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKET-IHLMALRELNIAFNFLT-- 479

  Fly   437 EADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLD 501
               |..|.::                     .|:|..|.|:.|.::......:...:.:..:...
Human   480 ---DLPGCSH---------------------FSRLSVLNIEMNFILSPSLDFVQSCQEVKTLNAG 520

  Fly   502 KNPWHCDCRALYLARWIR-----EFVLKLWDGQQPMCRGPGDLGG--------HE---------- 543
            :||:.|.|.   |..:|:     |.::..|.... .|..|.:|.|        ||
Human   521 RNPFRCTCE---LKNFIQLETYSEVMMVGWSDSY-TCEYPLNLRGTRLKDVHLHELSCNTALLIV 581

  Fly   544 --------VGL--------------LRYDDLCDGQWASMLSLSPRLPVRKHQISTPMNYTDYFNL 586
                    :||              ||....|...|..:...:.....|..:....::|:::.:|
Human   582 TIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSL 646

  Fly   587 YLKH 590
            ::|:
Human   647 WVKN 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	17/58 (29%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	61/345 (18%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	21/121 (17%)
		leucine-rich repeat	255..278	CDD:275380	9/64 (14%)
		leucine-rich repeat	279..302	CDD:275380	9/27 (33%)
		LRR_8	303..361	CDD:290566	20/170 (12%)
		leucine-rich repeat	303..326	CDD:275380	6/37 (16%)
		leucine-rich repeat	327..350	CDD:275380	8/120 (7%)
		LRR_8	349..407	CDD:290566	20/80 (25%)
		LRR_4	350..390	CDD:289563	15/40 (38%)
		leucine-rich repeat	351..374	CDD:275380	9/23 (39%)
		leucine-rich repeat	375..398	CDD:275380	7/32 (22%)
		LRR_8	398..>443	CDD:290566	12/56 (21%)
		leucine-rich repeat	399..422	CDD:275380	5/34 (15%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	4/22 (18%)
		LRRCT	503..554	CDD:214507	18/95 (19%)
TLR10	NP_001017388.1	LRR 1	24..46		5/12 (42%)
		LRR 2	49..70		7/21 (33%)
		leucine-rich repeat	50..73	CDD:275378	7/23 (30%)
		LRR_8	72..129	CDD:316378	19/59 (32%)
		LRR 3	73..94		6/20 (30%)
		leucine-rich repeat	74..97	CDD:275378	6/22 (27%)
		LRR 4	97..118		7/23 (30%)
		leucine-rich repeat	98..112	CDD:275378	5/16 (31%)
		leucine-rich repeat	119..143	CDD:275378	7/23 (30%)
		LRR 5	119..139		7/19 (37%)
		LRR 6	143..166		0/22 (0%)
		leucine-rich repeat	144..155	CDD:275378	0/10 (0%)
		LRR	289..>522	CDD:227223	40/259 (15%)
		LRR 7	296..321		0/24 (0%)
		LRR 8	325..348		2/22 (9%)
		LRR 9	349..368		2/18 (11%)
		leucine-rich repeat	350..373	CDD:275380	3/22 (14%)
		LRR 10	373..394		7/20 (35%)
		leucine-rich repeat	374..398	CDD:275380	9/23 (39%)
		LRR 11	398..419		6/20 (30%)
		leucine-rich repeat	399..422	CDD:275380	6/22 (27%)
		LRR 12	422..442		3/19 (16%)
		leucine-rich repeat	423..444	CDD:275380	3/20 (15%)
		LRR 13	444..465		4/21 (19%)
		leucine-rich repeat	445..467	CDD:275380	4/22 (18%)
		LRR 14	467..488		8/46 (17%)
		leucine-rich repeat	468..490	CDD:275380	8/47 (17%)
		LRR 15	489..509		4/19 (21%)
		leucine-rich repeat	491..513	CDD:275380	3/21 (14%)
		LRRCT	522..574	CDD:214507	14/55 (25%)
		TIR	633..775	CDD:214587	3/18 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910