DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and slit2

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_021331524.1	Gene:	slit2 / 80353	ZFINID:	ZDB-GENE-010306-3	Length:	1551	Species:	Danio rerio

Alignment Length:	507	Identity:	122/507 - (24%)
Similarity:	195/507 - (38%)	Gaps:	160/507 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 CTSGV--C--RCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKE 209
            |.:|.  |  :|:....:..|...:|:|||  :.||.|:..:||:.|.|:.:.|..|.|
Zfish    14 CGAGAQSCPSQCSCSGTAVDCHGQSLRSVP--RNIPRNVERLDLNANNLTKITKADFAG------ 70

  Fly   210 LDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFY 274
                              |.:|.||::..|::..|:...|..|:.|..|.|::|.:.:|||.:|.
Zfish    71 ------------------LKNLRVLQLMENKISSIERGAFQDLQELERLRLNRNNLQVLPELLFL 117

  Fly   275 HAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAK 339
            ...:|..:::.:||||..|....|                    ||    |::|.|...:|||:.
Zfish   118 GTTKLFRLDLSENQIQGIPRKAFR--------------------GS----TEIKNLQLDYNQISC 158

  Fly   340 IDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRI------------------- 385
            |:|..|..||.|..|:|:||.||.||...||::..|.|..|.:|.:
Zfish   159 IEDGAFRALRDLEVLTLNNNNISRLSVASFNHMPKLRTFRLHSNNLLCDCNVAWLSDWLRQRPRL 223

  Fly   386 -----------------------------------SH------------------ID--GNAFVE 395
                                               ||                  :|  |....|
Zfish   224 GLYTQCMAPPSLRGHNIAEVQKKEFMCTDFSEGPQSHSSCSVLQCPELCTCSNNVVDCRGKGLTE 288

  Fly   396 L-----NNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLN---------- 445
            :     ..:.|:.|.|||:..|||..|.....|.|:.|.:|.:|.|.:|.||||.
Zfish   289 IPTNLPETITEIRLEQNSIKIIPAGAFAPYKRLRRIDLSNNQITELASDSFQGLRSLNSLVLYGN 353

  Fly   446 --------------NLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLV 496
                          :|::||||.|.:......:|:.|..|..|.:..|||..:..|....|:.:.
Zfish   354 KITELPKGLFDGLFSLQLLLLNANKINCLRVDSFQDLQNLNLLSLYDNKLQTIAKGTFSSLRAIQ 418

  Fly   497 AVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLGGHEVGLLR 548
            .:.|.:||:.|||...:||.::::..::....:   |..|..|....:|.::
Zfish   419 TLHLAQNPFMCDCHLKWLADYLQDNPIETSGAR---CTSPRRLANKRIGQIK 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	13/58 (22%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	53/238 (22%)
		leucine-rich repeat	207..230	CDD:275380	1/22 (5%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	15/59 (25%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	7/22 (32%)
		LRR_8	303..361	CDD:290566	18/57 (32%)
		leucine-rich repeat	303..326	CDD:275380	2/22 (9%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR_8	349..407	CDD:290566	23/136 (17%)
		LRR_4	350..390	CDD:289563	18/113 (16%)
		leucine-rich repeat	351..374	CDD:275380	11/22 (50%)
		leucine-rich repeat	375..398	CDD:275380	9/101 (9%)
		LRR_8	398..>443	CDD:290566	17/44 (39%)
		leucine-rich repeat	399..422	CDD:275380	9/22 (41%)
		leucine-rich repeat	423..443	CDD:275380	8/19 (42%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		LRRCT	503..554	CDD:214507	11/46 (24%)
slit2	XP_021331524.1	LRRNT	21..51	CDD:214470	10/31 (32%)
		leucine-rich repeat	32..49	CDD:275380	7/18 (39%)
		LRR_8	48..108	CDD:316378	20/83 (24%)
		leucine-rich repeat	50..73	CDD:275380	8/46 (17%)
		leucine-rich repeat	74..97	CDD:275380	7/22 (32%)
		LRR_8	97..156	CDD:316378	21/82 (26%)
		leucine-rich repeat	98..121	CDD:275380	8/22 (36%)
		leucine-rich repeat	122..145	CDD:275380	9/46 (20%)
		LRR_8	144..204	CDD:316378	26/59 (44%)
		leucine-rich repeat	146..169	CDD:275380	9/22 (41%)
		leucine-rich repeat	170..193	CDD:275380	11/22 (50%)
		PCC	175..>237	CDD:188093	13/61 (21%)
		leucine-rich repeat	194..320	CDD:275380	18/125 (14%)
		LRRNT	267..299	CDD:214470	3/31 (10%)
		LRR_8	298..355	CDD:316378	20/56 (36%)
		leucine-rich repeat	321..344	CDD:275380	11/22 (50%)
		leucine-rich repeat	345..365	CDD:275380	0/19 (0%)
		LRR_8	375..427	CDD:316378	13/51 (25%)
		leucine-rich repeat	393..416	CDD:275380	7/22 (32%)
		PCC	398..>461	CDD:188093	16/65 (25%)
		LRRNT	507..537	CDD:214470
		leucine-rich repeat	517..535	CDD:275380
		leucine-rich repeat	539..561	CDD:275380
		LRR_8	560..620	CDD:316378
		leucine-rich repeat	562..585	CDD:275380
		leucine-rich repeat	586..609	CDD:275380
		LRR_8	609..668	CDD:316378
		leucine-rich repeat	610..633	CDD:275380
		leucine-rich repeat	634..657	CDD:275380
		PCC	639..>716	CDD:188093
		leucine-rich repeat	658..780	CDD:275380
		leucine-rich repeat	677..728	CDD:275380
		NEL	<698..>863	CDD:330839
		leucine-rich repeat	736..757	CDD:275380
		LRR_8	780..839	CDD:316378
		leucine-rich repeat	781..804	CDD:275380
		leucine-rich repeat	805..828	CDD:275380
		leucine-rich repeat	829..850	CDD:275380
		PCC	834..>1026	CDD:188093
		EGF	1015..1042	CDD:306513
		EGF_CA	1060..1096	CDD:238011
		EGF_CA	1098..1134	CDD:238011
		Laminin_G_2	1210..1338	CDD:308045
		GHB_like	1489..1550	CDD:328788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910