DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and LRRTM4

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001317299.1	Gene:	LRRTM4 / 80059	HGNCID:	19411	Length:	591	Species:	Homo sapiens

Alignment Length:	436	Identity:	103/436 - (23%)
Similarity:	176/436 - (40%)	Gaps:	88/436 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 LANFDLVKRVRQIESRLRSVEQPVWHLATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVT 176
            :..|.|:.:::.:...|..:...:..:.||:|   ..|... |||  |.|...|.:.....:|
Human     1 MPGFHLITQLKGMSVVLVLLPTLLLVMLTGAQ---RACPKN-CRC--DGKIVYCESHAFADIP-- 57

  Fly   177 QVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQL 241
            :.|......:.|..|.:..|..:.|.||..|..|.:.||.:..:..|.||.:..|..|.:.:|::
Human    58 ENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKI 122

  Fly   242 EDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEEL 306
            ..:.::||..:.||..||||.|::..|....|...::|.::::..|.::..|..:.:|...|:.|
Human   123 TYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFL 187

  Fly   307 DMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNN 371
            |:..|::..||..:...|.|||.|....||.:||:...|..|.:||::.|..|||.|:|..:...
Human   188 DLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWT 252

  Fly   372 LANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTL 436
            .::|..|||:.|
Human   253 WSSLHNLDLSGN----------------------------------------------------- 264

  Fly   437 EADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLD 501
               |.||:                :...|:.|..|:||.:|||||..:....::...:|:::.|.
Human   265 ---DIQGI----------------EPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLS 310

  Fly   502 KNPWHCDCRALYLARWIREFVLKLWDGQQP---MCRGPGDLGGHEV 544
            .|.|.|......|..|::.|     .|.:.   :|.||..:.|.:|
Human   311 GNMWECSRSICPLFYWLKNF-----KGNKESTMICAGPKHIQGEKV 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	16/58 (28%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	58/184 (32%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	17/59 (29%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		LRR_8	303..361	CDD:290566	21/57 (37%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR_8	349..407	CDD:290566	13/57 (23%)
		LRR_4	350..390	CDD:289563	13/39 (33%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	1/44 (2%)
		leucine-rich repeat	399..422	CDD:275380	0/22 (0%)
		leucine-rich repeat	423..443	CDD:275380	1/19 (5%)
		leucine-rich repeat	471..494	CDD:275380	8/22 (36%)
		LRRCT	503..554	CDD:214507	12/45 (27%)
LRRTM4	NP_001317299.1	leucine-rich repeat	44..62	CDD:275380	4/19 (21%)
		leucine-rich repeat	65..87	CDD:275380	6/21 (29%)
		LRR_RI	<85..291	CDD:238064	68/277 (25%)
		LRR_8	87..146	CDD:290566	19/58 (33%)
		leucine-rich repeat	88..111	CDD:275380	7/22 (32%)
		leucine-rich repeat	112..135	CDD:275380	5/22 (23%)
		LRR_8	134..194	CDD:290566	17/59 (29%)
		leucine-rich repeat	136..159	CDD:275380	8/22 (36%)
		leucine-rich repeat	160..183	CDD:275380	4/22 (18%)
		leucine-rich repeat	184..207	CDD:275380	7/22 (32%)
		leucine-rich repeat	208..231	CDD:275380	9/22 (41%)
		LRR_8	231..290	CDD:290566	24/130 (18%)
		leucine-rich repeat	232..255	CDD:275380	8/22 (36%)
		leucine-rich repeat	256..279	CDD:275380	10/94 (11%)
		leucine-rich repeat	304..316	CDD:275378	4/11 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910