DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and lrrc15

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001074151.1	Gene:	lrrc15 / 791200	ZFINID:	ZDB-GENE-031113-8	Length:	564	Species:	Danio rerio

Alignment Length:	503	Identity:	116/503 - (23%)
Similarity:	212/503 - (42%)	Gaps:	103/503 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 CRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLD 218
            |:|  ......|...::|.:|    :||.                      ..:..|.||:..:.
Zfish    25 CQC--QVTKIVCQGFSVKEIP----LPMP----------------------PTINALVISNTSIQ 61

  Fly   219 FL-PFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVI 282
            .| |.|.....::|.:...:|:.:.:::..||.:..|||.|..|...:..||:::|.:...||.:
Zfish    62 SLKPSDFQTFAETLTLFVAKNSNITEVEPHTFDQAFNLNALGFSGTMLTSLPDNLFQNLTALTTL 126

  Fly   283 NMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAG 347
            .:..|:::..|.:||.....:.:||:|:|.:|.||..:.|.|.:|:.|....|.|.::....|.|
Zfish   127 TLSGNKLEVLPSSLLTPLANVNKLDLSKNLLSSLSEDAFRGLDQLEMLMLQRNSIKQLHSSTFQG 191

  Fly   348 LRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSI 412
            |..||:|.|..|:::.:...:|::|.||..|.|..|:|..:..|.|.::.||.:|:|..|.:|.:
Zfish   192 LSHLRSLFLQQNQLTDIPAGLFDDLVNLEVLHLQDNKIEQLPANLFAKVQNLKKLYLSSNRLSLL 256

  Fly   413 PADLFLNVSALTRLTLFSNN-----------------------LTTLEADDFQGLNNLKILLLNN 454
            |:.:||::..||.::|:.|.                       ||.||.:.|..|.|:::|:::.
Zfish   257 PSGIFLSLPNLTHISLYDNRLSRLMPETFGTMALQELWLYDNLLTHLEENVFSNLTNIRLLVISR 321

  Fly   455 NILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLD------------------ 501
            |.::.....||..|.:|:::.:.:|:|..:..|...||.||..:.::
Zfish   322 NRIQYISPGAFNGLKELKEVSLHTNRLTNIEPGIFRGLPNLANISIENNQIKQIPIQLLDGVSRL 386

  Fly   502 ------------------------------KNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGP 536
                                          :|||.||...:....|:.:...|:.:....||..|
Zfish   387 SLLEMQNNSLQNLPKDFLNTLSIVENVILHENPWRCDQDIIPFWGWLSQHSEKVKNLSLVMCSSP 451

  Fly   537 GDLGGHEVGLLRYDDLCDGQWASMLSL---SPRLPVRKHQISTPMNYT 581
            ..|.|..|..|..||:...:..:|.::   |...|..:.:.....|:|
Zfish   452 PPLNGRNVRELIEDDIMVQEMTTMTTVDTSSHNTPASETKRPPDSNFT 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	8/59 (14%)
		leucine-rich repeat	187..206	CDD:275380	0/18 (0%)
		LRR_RI	<201..386	CDD:238064	52/185 (28%)
		leucine-rich repeat	207..230	CDD:275380	6/23 (26%)
		leucine-rich repeat	231..254	CDD:275380	4/22 (18%)
		LRR_8	253..313	CDD:290566	18/59 (31%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	303..361	CDD:290566	21/57 (37%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR_8	349..407	CDD:290566	19/57 (33%)
		LRR_4	350..390	CDD:289563	13/39 (33%)
		leucine-rich repeat	351..374	CDD:275380	7/22 (32%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	18/67 (27%)
		leucine-rich repeat	399..422	CDD:275380	8/22 (36%)
		leucine-rich repeat	423..443	CDD:275380	9/42 (21%)
		leucine-rich repeat	471..494	CDD:275380	6/22 (27%)
		LRRCT	503..554	CDD:214507	16/50 (32%)
lrrc15	NP_001074151.1	LRRNT	21..48	CDD:214470	7/50 (14%)
		leucine-rich repeat	53..73	CDD:275380	6/19 (32%)
		LRR_RI	<163..253	CDD:238064	29/89 (33%)
		LRR_8	170..229	CDD:290566	19/58 (33%)
		leucine-rich repeat	171..194	CDD:275380	7/22 (32%)
		leucine-rich repeat	195..218	CDD:275380	7/22 (32%)
		LRR_8	218..277	CDD:290566	21/58 (36%)
		leucine-rich repeat	219..242	CDD:275380	7/22 (32%)
		LRR_4	241..280	CDD:289563	13/38 (34%)
		leucine-rich repeat	243..266	CDD:275380	8/22 (36%)
		leucine-rich repeat	267..289	CDD:275380	4/21 (19%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	312..372	CDD:290566	14/59 (24%)
		leucine-rich repeat	314..337	CDD:275380	5/22 (23%)
		leucine-rich repeat	338..361	CDD:275380	6/22 (27%)
		leucine-rich repeat	362..385	CDD:275380	1/22 (5%)
		TPKR_C2	418..467	CDD:301599	15/48 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4201
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D595054at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.930