DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Lrg1

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_084072.1	Gene:	Lrg1 / 76905	MGIID:	1924155	Length:	342	Species:	Mus musculus

Alignment Length:	386	Identity:	89/386 - (23%)
Similarity:	143/386 - (37%)	Gaps:	80/386 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 TNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLL 232
            ::||...:.|....:.|:........|:|..||.       .|.:..:.|..||....|....|.
Mouse    31 SSLKECLILQSAEGSTVSCHGPTEFPSSLPADTV-------HLSVEFSNLTQLPAAALQGCPGLR 88

  Fly   233 VLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLL 297
            .|.:.:|:|:.:.......:..|..|||::|.:..||..:|..:..|:.:.:.:||::......|
Mouse    89 ELHLSSNRLQALSPELLAPVPRLRALDLTRNALRSLPPGLFSTSANLSTLVLRENQLREVSAQWL 153

  Fly   298 RDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRIS 362
            :....|..||::.|::|.|.||.:..|..|.|||.|:|.:..:.:....|.|.|:.|.|..||:.
Mouse   154 QGLDALGHLDLAENQLSSLPSGLLASLGALHTLDLGYNLLESLPEGLLRGPRRLQRLHLEGNRLQ 218

  Fly   363 SLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLT 427
            .|..::......|..|.|..|::..:...:|..|.:|:.|.|..||:||.|..|:..:...||
Mouse   219 RLEDSLLAPQPFLRVLFLNDNQLVGVATGSFQGLQHLDMLDLSNNSLSSTPPGLWAFLGRPTR-- 281

  Fly   428 LFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGL 492
                        |.|               ..||
Mouse   282 ------------DMQ---------------DGFD------------------------------- 288

  Fly   493 KNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLGGH------EVGLL 547
                   :..|||.||.....|.||:.....|::......|.||..:.|.      |:|.|
Mouse   289 -------ISHNPWICDKNLADLCRWLVANRNKMFSQNDTRCAGPEAMKGQRLLDVAELGSL 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	13/58 (22%)
		leucine-rich repeat	187..206	CDD:275380	4/18 (22%)
		LRR_RI	<201..386	CDD:238064	48/184 (26%)
		leucine-rich repeat	207..230	CDD:275380	5/22 (23%)
		leucine-rich repeat	231..254	CDD:275380	4/22 (18%)
		LRR_8	253..313	CDD:290566	16/59 (27%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		LRR_8	303..361	CDD:290566	21/57 (37%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR_8	349..407	CDD:290566	16/57 (28%)
		LRR_4	350..390	CDD:289563	10/39 (26%)
		leucine-rich repeat	351..374	CDD:275380	6/22 (27%)
		leucine-rich repeat	375..398	CDD:275380	6/22 (27%)
		LRR_8	398..>443	CDD:290566	12/44 (27%)
		leucine-rich repeat	399..422	CDD:275380	9/22 (41%)
		leucine-rich repeat	423..443	CDD:275380	3/19 (16%)
		leucine-rich repeat	471..494	CDD:275380	0/22 (0%)
		LRRCT	503..554	CDD:214507	16/51 (31%)
Lrg1	NP_084072.1	leucine-rich repeat	65..86	CDD:275380	5/20 (25%)
		LRR_8	66..121	CDD:290566	14/54 (26%)
		LRR_RI	<74..294	CDD:238064	64/286 (22%)
		leucine-rich repeat	87..110	CDD:275380	4/22 (18%)
		LRR_8	109..169	CDD:290566	16/59 (27%)
		leucine-rich repeat	111..134	CDD:275380	8/22 (36%)
		leucine-rich repeat	135..158	CDD:275380	4/22 (18%)
		leucine-rich repeat	159..182	CDD:275380	9/22 (41%)
		LRR_8	162..217	CDD:290566	20/54 (37%)
		leucine-rich repeat	183..206	CDD:275380	7/22 (32%)
		LRR_8	205..265	CDD:290566	17/59 (29%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		leucine-rich repeat	255..278	CDD:275380	9/22 (41%)
		LRRCT	292..338	CDD:214507	13/45 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831229
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840