DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and Lrrc15

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_083249.1	Gene:	Lrrc15 / 74488	MGIID:	1921738	Length:	579	Species:	Mus musculus

Alignment Length:	507	Identity:	139/507 - (27%)
Similarity:	221/507 - (43%)	Gaps:	73/507 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 SRLRSVEQPVWHLATGSQI-------EWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMN- 182
            ||...||      .||:||       .||            ..|....||::..:|..:.:.::
Mouse    32 SRASQVE------CTGAQIVAMPSPLPWN------------AMSLQILNTHITELPEDKFLNISA 78

  Fly   183 MVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHR 247
            ::.:.:.:|.|:.:....||.|..|:.|.:::|.|..||..||||:::|..|.:.||||..|...
Mouse    79 LIALKMEKNELANIMPGAFRNLGSLRHLSLANNKLKNLPVRLFQDVNNLETLLLSNNQLVQIQPA 143

  Fly   248 TFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNK 312
            .|.:..||..|.|..|.:..:||.:|.|...||.:|:.:|...:..|.:.:....|:.|.:..|:
Mouse   144 QFSQFSNLKELQLYGNNLEYIPEGVFDHLVGLTKLNLGNNGFTHLSPRVFQHLGNLQVLRLYENR 208

  Fly   313 ISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVT 377
            :|::..|:...|..|:.|....|||..:....|...|:|:.|.|.||.||.|...||..|.:|..
Mouse   209 LSDIPMGTFDALGNLQELALQENQIGTLSPGLFHNNRNLQRLYLSNNHISHLPPGIFMQLPHLNK 273

  Fly   378 LDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQ 442
            |.|..|.:..:....|..:.||.||:|..|.::|:|.:.|.:::.|..|.|..|.|:.:....|.
Mouse   274 LTLFGNSLKELSPGVFGPMPNLRELWLYNNHITSLPDNAFSHLNQLQVLILSHNQLSYISPGAFN 338

  Fly   443 GLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKL------MF------------------ 483
            ||.||:.|.|:.|.|::.|...|..|:.|..:.:.:|:|      :|
Mouse   339 GLTNLRELSLHTNALQDLDGNVFRSLANLRNVSLQNNRLRQLPGSIFANVNGLMTIQLQNNNLEN 403

  Fly   484 LPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLGGHEVGLLR 548
            ||.|....|.||..::|..|||.||...|.|..|:.....:|.....|:|..|..:.|..:.::.
Mouse   404 LPLGIFDHLGNLCELRLYDNPWRCDSNILPLHDWLILNRARLGTDTLPVCSSPASVRGQSLVIIN 468

  Fly   549 ------------------YDDLCDGQWASMLSLSPRLPVRKHQISTPMNYTD 582
                              |.|  ...:....|:|....:.:   ||..:|||
Mouse   469 VNFPGPSVQGPETPEVSSYPD--TSSYPDSTSISSTTEITR---STDDDYTD 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	19/59 (32%)
		leucine-rich repeat	187..206	CDD:275380	5/18 (28%)
		LRR_RI	<201..386	CDD:238064	63/184 (34%)
		leucine-rich repeat	207..230	CDD:275380	10/22 (45%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		LRR_8	253..313	CDD:290566	17/59 (29%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	18/57 (32%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		LRR_8	349..407	CDD:290566	22/57 (39%)
		LRR_4	350..390	CDD:289563	15/39 (38%)
		leucine-rich repeat	351..374	CDD:275380	11/22 (50%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	15/44 (34%)
		leucine-rich repeat	399..422	CDD:275380	8/22 (36%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	8/46 (17%)
		LRRCT	503..554	CDD:214507	15/68 (22%)
Lrrc15	NP_083249.1	LRR 1	54..75		5/32 (16%)
		leucine-rich repeat	58..78	CDD:275380	3/19 (16%)
		LRR 2	78..99		3/20 (15%)
		PLN00113	82..>401	CDD:215061	96/318 (30%)
		LRR 3	102..123		8/20 (40%)
		leucine-rich repeat	103..126	CDD:275380	10/22 (45%)
		LRR 4	126..147		8/20 (40%)
		leucine-rich repeat	127..150	CDD:275380	8/22 (36%)
		LRR 5	150..171		8/20 (40%)
		leucine-rich repeat	151..174	CDD:275380	8/22 (36%)
		LRR 6	174..195		5/20 (25%)
		leucine-rich repeat	175..198	CDD:275380	5/22 (23%)
		LRR 7	198..219		5/20 (25%)
		leucine-rich repeat	199..222	CDD:275380	6/22 (27%)
		LRR 8	222..243		6/20 (30%)
		leucine-rich repeat	223..246	CDD:275380	6/22 (27%)
		LRR 9	246..267		10/20 (50%)
		leucine-rich repeat	247..270	CDD:275380	11/22 (50%)
		LRR 10	270..291		5/20 (25%)
		leucine-rich repeat	271..294	CDD:275380	5/22 (23%)
		LRR 11	294..315		9/20 (45%)
		leucine-rich repeat	295..318	CDD:275380	8/22 (36%)
		LRR 12	318..339		6/20 (30%)
		leucine-rich repeat	319..342	CDD:275380	8/22 (36%)
		LRR 13	342..363		8/20 (40%)
		leucine-rich repeat	343..364	CDD:275380	7/20 (35%)
		LRR 14	366..387		4/20 (20%)
		leucine-rich repeat	367..387	CDD:275380	4/19 (21%)
		LRR 15	390..411		3/20 (15%)
		leucine-rich repeat	391..412	CDD:275380	3/20 (15%)
		LRRCT	423..>462	CDD:214507	12/38 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..509		4/37 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BET7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	179	1.000	Inparanoid score	I4001
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D595054at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42484
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.830