DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Cpn2

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_082180.2	Gene:	Cpn2 / 71756	MGIID:	1919006	Length:	547	Species:	Mus musculus

Alignment Length:	432	Identity:	120/432 - (27%)
Similarity:	188/432 - (43%)	Gaps:	38/432 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 CTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDIS 213
            |..|   |:...:...|.:..|..:|..  ||.::.:|.......:|:....|.|...|.::...
Mouse    22 CPVG---CDCFGREVFCSDEQLADIPPD--IPPHITDIVFVETAFTTVRTRAFSGSPNLTKVVFL 81

  Fly   214 HNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQR 278
            :..:..|..|.|..|..|..|.|..:.:.::....|..|.:|..|.|..:.:..|||.:|.|...
Mouse    82 NTQVRHLEPDAFGGLPRLQDLEITGSPVSNLSAHIFSNLSSLEKLTLDFDRLAGLPEDLFCHMDI 146

  Fly   279 LTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDD 343
            |..:.:..||::..|..|.:....|..|::::|.:::|..|:.:.||.|:.|....|.:|::.:.
Mouse   147 LESLQLQGNQLRTLPGRLFQSLRDLRTLNLAQNLLTQLPKGAFQSLTGLQMLKLSNNMLARLPEG 211

  Fly   344 FFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNS 408
            ....|.||:.|.|..|.|:.||..:|:.|.:|..|.|..|.|.|:..:.|..|:||..|.|..|:
Mouse   212 ALGSLSSLQELFLDGNAITELSPHLFSQLFSLEMLWLQHNAICHLPVSLFSSLHNLTFLSLKDNA 276

  Fly   409 MSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEK 473
            :.::|..||.:...|..|:|..|.|.|:....|..|:.|..|.|::|.:.:.....|..|.||.|
Mouse   277 LRTLPEGLFAHNQGLLHLSLSYNQLETIPEGAFTNLSRLVSLTLSHNAITDLPEHVFRNLEQLVK 341

  Fly   474 LRIDSNKLMFLPHGALHGLKNLVAVKLDK------------------------NPWHCDCRALYL 514
            |.:|||.|..|.....|.|..|..:.|.:                        |||.|||...||
Mouse   342 LSLDSNNLTALHPALFHNLSRLQLLNLSRNQLTTLPGGIFDTNYDLFNLALLGNPWQCDCHLSYL 406

  Fly   515 ARWIREFVLKLWDGQ----QPMCRGPGDLGGHEVGLLRYDDL 552
            ..|:|     |::.|    ...|.||..|.|..|..|:.:.|
Mouse   407 TSWLR-----LYNNQISNTHTFCAGPAYLKGQLVPNLKQEQL 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	12/58 (21%)
		leucine-rich repeat	187..206	CDD:275380	3/18 (17%)
		LRR_RI	<201..386	CDD:238064	51/184 (28%)
		leucine-rich repeat	207..230	CDD:275380	5/22 (23%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	16/59 (27%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	17/57 (30%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		LRR_8	349..407	CDD:290566	22/57 (39%)
		LRR_4	350..390	CDD:289563	16/39 (41%)
		leucine-rich repeat	351..374	CDD:275380	9/22 (41%)
		leucine-rich repeat	375..398	CDD:275380	8/22 (36%)
		LRR_8	398..>443	CDD:290566	15/44 (34%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	7/19 (37%)
		leucine-rich repeat	471..494	CDD:275380	10/22 (45%)
		LRRCT	503..554	CDD:214507	20/54 (37%)
Cpn2	NP_082180.2	LRRNT	21..52	CDD:214470	8/34 (24%)
		LRR_8	73..133	CDD:290566	13/59 (22%)
		leucine-rich repeat	75..98	CDD:275380	5/22 (23%)
		LRR 1	98..119		4/20 (20%)
		leucine-rich repeat	99..122	CDD:275380	5/22 (23%)
		LRR_8	121..181	CDD:290566	16/59 (27%)
		LRR 2	122..143		7/20 (35%)
		leucine-rich repeat	123..146	CDD:275380	8/22 (36%)
		LRR 3	146..167		5/20 (25%)
		leucine-rich repeat	147..170	CDD:275380	5/22 (23%)
		LRR_RI	149..374	CDD:238064	69/224 (31%)
		LRR 4	170..191		5/20 (25%)
		LRR_8	171..229	CDD:290566	17/57 (30%)
		leucine-rich repeat	171..194	CDD:275380	6/22 (27%)
		LRR 5	194..215		4/20 (20%)
		leucine-rich repeat	195..218	CDD:275380	5/22 (23%)
		LRR_8	217..277	CDD:290566	23/59 (39%)
		LRR 6	218..239		9/20 (45%)
		leucine-rich repeat	219..242	CDD:275380	9/22 (41%)
		LRR 7	242..263		7/20 (35%)
		leucine-rich repeat	243..266	CDD:275380	8/22 (36%)
		LRR_8	266..325	CDD:290566	20/58 (34%)
		LRR 8	266..287		8/20 (40%)
		leucine-rich repeat	267..290	CDD:275380	7/22 (32%)
		LRR 9	290..311		7/20 (35%)
		leucine-rich repeat	291..314	CDD:275380	8/22 (36%)
		LRR_8	313..373	CDD:290566	19/59 (32%)
		LRR 10	314..335		5/20 (25%)
		leucine-rich repeat	315..338	CDD:275380	6/22 (27%)
		LRR 11	338..359		9/20 (45%)
		leucine-rich repeat	339..360	CDD:275380	9/20 (45%)
		LRR 12	362..383		2/20 (10%)
		leucine-rich repeat	363..382	CDD:275380	2/18 (11%)
		LRRCT	395..436	CDD:214507	17/45 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831223
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BET7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_112811
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6410
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.630