DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Lrrtm2

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001102939.1	Gene:	Lrrtm2 / 685472	RGDID:	1593785	Length:	515	Species:	Rattus norvegicus

Alignment Length:	464	Identity:	121/464 - (26%)
Similarity:	184/464 - (39%)	Gaps:	100/464 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 CRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLD 218
            |||  :...|.|.:....|||  .......:.:.|..|.::.|.:|.|...:.|..|.:.||.:.
  Rat    38 CRC--EKLLFYCDSQGFHSVP--NATDKGSLGLSLRHNHITALERDQFASFSQLTWLHLDHNQIS 98

  Fly   219 FLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVIN 283
            .:..|.||.|..|..|.:.:|::..:.:.||.:|.||..||||.|::..|...:||..::|..::
  Rat    99 TVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLH 163

  Fly   284 MCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGL 348
            :..|.::..|..|..|...||.||:|.|::..|:......|.||:.|....||:.||:...|..|
  Rat   164 LRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRL 228

  Fly   349 RSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIP 413
            .||.||.|..|:||:|:..:....:.|..||||.|.|..||
  Rat   229 SSLHTLFLQWNKISNLTCGMEWTWSTLEKLDLTGNEIKAID------------------------ 269

  Fly   414 ADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDS 478
                        ||:            |:.:.||||||::||.|.:.|::
  Rat   270 ------------LTV------------FETMPNLKILLMDNNKLNSLDSK--------------- 295

  Fly   479 NKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLGGHE 543
                     .|..|::|..|.|..|.|.|..|...||.|:..|..: |: ...:|..|....|.:
  Rat   296 ---------ILSSLRSLTTVGLSGNLWECSPRVCALASWLGSFQGR-WE-HSILCHSPDHTQGED 349

  Fly   544 V-GLLRYDDLCDGQWASMLSLSPRLPVRKHQISTPMNYTDYFNLYLKHIYNG------------T 595
            : ..:....||   |    :||..:.........|.  |:|..:.....:.|            |
  Rat   350 ILDAVHGFQLC---W----NLSTTVTAMATTYRDPT--TEYTKISSSSYHVGDKEIPTTAGIAVT 405

  Fly   596 TDEELKEAD 604
            |:|...|.|
  Rat   406 TEEHFPEPD 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	16/58 (28%)
		leucine-rich repeat	187..206	CDD:275380	5/18 (28%)
		LRR_RI	<201..386	CDD:238064	62/184 (34%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	21/59 (36%)
		leucine-rich repeat	255..278	CDD:275380	9/22 (41%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	23/57 (40%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		LRR_8	349..407	CDD:290566	18/57 (32%)
		LRR_4	350..390	CDD:289563	17/39 (44%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	9/22 (41%)
		LRR_8	398..>443	CDD:290566	3/44 (7%)
		leucine-rich repeat	399..422	CDD:275380	0/22 (0%)
		leucine-rich repeat	423..443	CDD:275380	3/19 (16%)
		leucine-rich repeat	471..494	CDD:275380	2/22 (9%)
		LRRCT	503..554	CDD:214507	13/51 (25%)
Lrrtm2	NP_001102939.1	LRR 1	61..83		5/21 (24%)
		leucine-rich repeat	66..86	CDD:275380	5/19 (26%)
		LRR_RI	73..311	CDD:238064	85/309 (28%)
		LRR 2	84..107		6/22 (27%)
		LRR_8	85..145	CDD:290566	21/59 (36%)
		leucine-rich repeat	87..110	CDD:275380	8/22 (36%)
		LRR 3	109..131		5/21 (24%)
		leucine-rich repeat	111..134	CDD:275380	6/22 (27%)
		LRR 4	132..155		10/22 (45%)
		LRR_8	134..193	CDD:290566	21/58 (36%)
		leucine-rich repeat	135..158	CDD:275380	9/22 (41%)
		LRR 5	156..179		4/22 (18%)
		leucine-rich repeat	159..182	CDD:275380	5/22 (23%)
		LRR_8	181..241	CDD:290566	23/59 (39%)
		LRR 6	181..203		7/21 (33%)
		leucine-rich repeat	183..206	CDD:275380	8/22 (36%)
		LRR 7	205..227		8/21 (38%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		LRR 8	229..251		9/21 (43%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		LRR 9	252..275		12/70 (17%)
		LRR_8	253..312	CDD:290566	27/130 (21%)
		leucine-rich repeat	255..278	CDD:275380	12/70 (17%)
		LRR 10	276..299		11/46 (24%)
		leucine-rich repeat	279..300	CDD:275380	10/44 (23%)
		Involved in DLG4-binding	512..515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910