DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Vasn

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001102852.1	Gene:	Vasn / 679921	RGDID:	1598149	Length:	673	Species:	Rattus norvegicus

Alignment Length:	412	Identity:	108/412 - (26%)
Similarity:	169/412 - (41%)	Gaps:	84/412 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 GSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLT 205
            ||.::  .|.|| |:||.....| |  |..:...|.:.:|.:.|.:.:..|.::||....|.|..
  Rat    19 GSGVQ--SCPSG-CQCNQPQTVF-C--TARQGTTVPRDVPPDTVGLYIFENGITTLDVGCFAGFP 77

  Fly   206 VLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPE 270
            .|:.||:|.|.:..||..:||.|.:|..|.:..|:|.:|.:.||..||.|..|.|.||.|..:..
  Rat    78 GLQLLDLSQNQITSLPGGIFQPLVNLSNLDLTANKLHEISNETFRGLRRLERLYLGKNRIRHIQP 142

  Fly   271 SIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWN 335
            ..|.....|..:.:.||:::..|| |...:|:|  ||:|.|.|..|.:|.:
  Rat   143 GAFDALDHLLELKLPDNELRVLPP-LHLPRLLL--LDLSHNSIPALEAGIL-------------- 190

  Fly   336 QIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLN 400
                                               :.||:..|.|....:..:|...|..|.||:
  Rat   191 -----------------------------------DTANVEALRLAGLGLRQLDEGLFGRLRNLH 220

  Fly   401 ELFLGQNSMSSIPADLFLNVSALTRLTLFSN-NLTTLEADDFQGLNNLKILLLNNNILKNFDARA 464
            :|.:..|.:..:|: :...:..||||.|..| .:..:..:|..||..|:.|.::|
  Rat   221 DLDVSDNQLGHMPS-VIQGLRGLTRLRLAGNTRIAQIRPEDLAGLTALQELDVSN---------- 274

  Fly   465 FEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQ 529
               || |:.|..|.:.|  .|.     |:.|.|.   :||::|.|...:...|:||..:.|...:
  Rat   275 ---LS-LQALPSDLSSL--FPR-----LRLLAAA---RNPFNCLCPLSWFGPWVRESHVVLASPE 325

  Fly   530 QPMCRGPGDLGGHEVGLLRYDD 551
            :..|..|....|..:..|.|.|
  Rat   326 ETRCHFPPKNAGRLLLELDYAD 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	19/58 (33%)
		leucine-rich repeat	187..206	CDD:275380	5/18 (28%)
		LRR_RI	<201..386	CDD:238064	47/184 (26%)
		leucine-rich repeat	207..230	CDD:275380	10/22 (45%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		LRR_8	253..313	CDD:290566	20/59 (34%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	303..361	CDD:290566	8/57 (14%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	0/22 (0%)
		LRR_8	349..407	CDD:290566	10/57 (18%)
		LRR_4	350..390	CDD:289563	4/39 (10%)
		leucine-rich repeat	351..374	CDD:275380	0/22 (0%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	12/45 (27%)
		leucine-rich repeat	399..422	CDD:275380	4/22 (18%)
		leucine-rich repeat	423..443	CDD:275380	7/20 (35%)
		leucine-rich repeat	471..494	CDD:275380	6/22 (27%)
		LRRCT	503..554	CDD:214507	14/49 (29%)
Vasn	NP_001102852.1	LRRNT	25..55	CDD:214470	11/33 (33%)
		leucine-rich repeat	35..57	CDD:275380	5/24 (21%)
		PPP1R42	58..257	CDD:411060	64/251 (25%)
		leucine-rich repeat	58..78	CDD:275380	5/19 (26%)
		leucine-rich repeat	79..102	CDD:275380	10/22 (45%)
		leucine-rich repeat	103..126	CDD:275380	8/22 (36%)
		leucine-rich repeat	127..150	CDD:275380	7/22 (32%)
		leucine-rich repeat	151..194	CDD:275380	15/94 (16%)
		leucine-rich repeat	195..218	CDD:275380	5/22 (23%)
		leucine-rich repeat	219..241	CDD:275380	4/22 (18%)
		leucine-rich repeat	242..266	CDD:275380	9/23 (39%)
		leucine-rich repeat	267..290	CDD:275380	9/38 (24%)
		PCC	271..>350	CDD:188093	25/101 (25%)
		EGF	410..441	CDD:394967
		fn3	469..546	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910