DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and Tril

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_080093.1	Gene:	Tril / 66873	MGIID:	1914123	Length:	809	Species:	Mus musculus

Alignment Length:	474	Identity:	129/474 - (27%)
Similarity:	176/474 - (37%)	Gaps:	108/474 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 VC--RCN-PDTKSFTCWNTNLKSVPVTQVI--PMNMVNIDLSRNILSTLHKDTFRGLTVLKELDI 212
            ||  ||: ...:...|.|..|::||.|..:  |.:::...|..|.::.:....|..|..|:.||:
Mouse    26 VCPERCDCQHPQHLLCTNRGLRAVPKTSSLPSPQDVLTYSLGGNFITNITAFDFHRLGQLRRLDL 90

  Fly   213 SHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQ 277
            .:|.:..|....|:.|..|..|.:.||.|:.:...|...||.|.||..:.||||
Mouse    91 QYNQIRSLHPKTFEKLSRLEELYLGNNLLQALVPGTLAPLRKLRILYANGNEIG----------- 144

  Fly   278 RLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDD 342
                                                 .||.||...|..|..|....|.:..:.|
Mouse   145 -------------------------------------RLSRGSFEGLESLVKLRLDGNVLGALPD 172

  Fly   343 DFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRI--SHIDGNAFVELNNLNELFLG 405
            ..||.|.:|..|.|.:|||..|....|:.|..|..|:|:.|.:  |......||.|.:|:.|.|.
Mouse   173 AVFAPLGNLLYLHLESNRIRFLGKNAFSQLGKLRFLNLSANELQPSLRHAATFVPLRSLSTLILS 237

  Fly   406 QNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQ 470
            .||:..:...:|.::..|..|:|..|.||.|..:.|.||..|:.|.|..|.|........|||..
Mouse   238 ANSLQHLGPRVFQHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRLNQLPLTLLEPLHS 302

  Fly   471 LEKLRIDSNKL----------------MFLPHGALHGLKN--------LVAVKLDKNPWHCDCRA 511
            ||.|.:..|:|                :.|...||..|..        |..:.||.|.|.||||.
Mouse   303 LEALDLSGNELSALHPATFGHQGRLRELSLRDNALSALSGDIFAASPALYRLDLDGNGWTCDCRL 367

  Fly   512 LYLARWIREFVLKLWDGQQPM------CRGPGDLGGHEVGLLRYDDLCDGQW---ASMLSLSPR- 566
            ..|.||:..     |..|..:      ||.|..|.|      :|.|..|.|.   .|.:..||.
Mouse   368 RGLKRWMGN-----WHSQGRLLTVFVQCRHPPALRG------KYLDYLDDQLLQNGSCVDPSPSP 421

  Fly   567 --------LPVRKHQISTP 577
                    ||....:..||
Mouse   422 TAGSRQWPLPTSSEEGMTP 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	15/58 (26%)
		leucine-rich repeat	187..206	CDD:275380	4/18 (22%)
		LRR_RI	<201..386	CDD:238064	49/186 (26%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	8/59 (14%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	0/22 (0%)
		LRR_8	303..361	CDD:290566	16/57 (28%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR_8	349..407	CDD:290566	20/59 (34%)
		LRR_4	350..390	CDD:289563	14/41 (34%)
		leucine-rich repeat	351..374	CDD:275380	9/22 (41%)
		leucine-rich repeat	375..398	CDD:275380	8/24 (33%)
		LRR_8	398..>443	CDD:290566	14/44 (32%)
		leucine-rich repeat	399..422	CDD:275380	6/22 (27%)
		leucine-rich repeat	423..443	CDD:275380	8/19 (42%)
		leucine-rich repeat	471..494	CDD:275380	9/38 (24%)
		LRRCT	503..554	CDD:214507	18/56 (32%)
Tril	NP_080093.1	LRR_RI	<11..194	CDD:238064	55/215 (26%)
		leucine-rich repeat	37..57	CDD:275378	6/19 (32%)
		LRR 1	61..81		3/19 (16%)
		LRR_8	84..143	CDD:290566	19/58 (33%)
		LRR 2	84..105		6/20 (30%)
		leucine-rich repeat	85..108	CDD:275380	7/22 (32%)
		LRR 3	108..129		6/20 (30%)
		leucine-rich repeat	109..132	CDD:275380	7/22 (32%)
		LRR 4	132..153		11/68 (16%)
		leucine-rich repeat	133..156	CDD:275380	12/70 (17%)
		LRR_8	156..215	CDD:290566	20/58 (34%)
		LRR 5	156..177		5/20 (25%)
		leucine-rich repeat	157..180	CDD:275380	7/22 (32%)
		LRR 6	180..201		8/20 (40%)
		leucine-rich repeat	181..204	CDD:275380	9/22 (41%)
		LRR 7	204..223		5/18 (28%)
		leucine-rich repeat	205..230	CDD:275380	8/24 (33%)
		LRR_RI	229..>364	CDD:238064	38/134 (28%)
		LRR_8	229..289	CDD:290566	20/59 (34%)
		LRR 8	230..251		6/20 (30%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR 9	254..275		8/20 (40%)
		leucine-rich repeat	255..278	CDD:275380	10/22 (45%)
		LRR 10	278..298		5/19 (26%)
		leucine-rich repeat	279..302	CDD:275380	8/22 (36%)
		LRR_8	302..359	CDD:290566	12/56 (21%)
		LRR 11	302..323		5/20 (25%)
		leucine-rich repeat	303..323	CDD:275380	5/19 (26%)
		LRR 12	326..347		4/20 (20%)
		leucine-rich repeat	327..350	CDD:275380	4/22 (18%)
		TPKR_C2	359..406	CDD:301599	18/57 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..462		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..563
		FN3	587..659	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831227
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840