DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and SLIT3

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001258875.2	Gene:	SLIT3 / 6586	HGNCID:	11087	Length:	1530	Species:	Homo sapiens

Alignment Length:	480	Identity:	119/480 - (24%)
Similarity:	194/480 - (40%)	Gaps:	108/480 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 RCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDF 219
            :|.....|..|....|::||  :.||.|...:||.||.::.:.|..|.|
Human    37 KCTCSAASVDCHGLGLRAVP--RGIPRNAERLDLDRNNITRITKMDFAG---------------- 83

  Fly   220 LPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINM 284
                    |.:|.||.:::||:..|:...|..|:.|..|.|:||::.:|||.:|....:||.:::
Human    84 --------LKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDL 140

  Fly   285 CDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLR 349
            .:||||..|....|....::.|.:..|.||.:..|:.|.|..|:.|....|.|::|....|..:.
Human   141 SENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMP 205

  Fly   350 SLRTLSLHNNRI----------------------------------------------------- 361
            .:|||.||:|.:
Human   206 KIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEP 270

  Fly   362 -----SSLS----GTIFNNL------------ANL----VTLDLTTNRISHIDGNAFVELNNLNE 401
                 :|:|    .|..||:            |||    |.:.|..|.|..|...||.:...|..
Human   271 PSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKR 335

  Fly   402 LFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFE 466
            :.:.:|.:|.|..|.|..:.:||.|.|:.|.:|.:....|.||.:|::||||.|.:.......|:
Human   336 IDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIVKGLFDGLVSLQLLLLNANKINCLRVNTFQ 400

  Fly   467 PLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQP 531
            .|..|..|.:..|||..:..|....|:::..:.|.:||:.|||...:||.::::..::....:
Human   401 DLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGAR-- 463

  Fly   532 MCRGPGDLGGHEVGLLRYDDL-CDG 555
             |..|..|....:..::.... |.|
Human   464 -CSSPRRLANKRISQIKSKKFRCSG 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	13/58 (22%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	58/262 (22%)
		leucine-rich repeat	207..230	CDD:275380	1/22 (5%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		LRR_8	253..313	CDD:290566	19/59 (32%)
		leucine-rich repeat	255..278	CDD:275380	9/22 (41%)
		leucine-rich repeat	279..302	CDD:275380	8/22 (36%)
		LRR_8	303..361	CDD:290566	19/57 (33%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		LRR_8	349..407	CDD:290566	22/135 (16%)
		LRR_4	350..390	CDD:289563	19/117 (16%)
		leucine-rich repeat	351..374	CDD:275380	11/96 (11%)
		leucine-rich repeat	375..398	CDD:275380	8/26 (31%)
		LRR_8	398..>443	CDD:290566	13/44 (30%)
		leucine-rich repeat	399..422	CDD:275380	6/22 (27%)
		leucine-rich repeat	423..443	CDD:275380	7/19 (37%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		LRRCT	503..554	CDD:214507	10/51 (20%)
SLIT3	NP_001258875.2	LRRNT	33..64	CDD:214470	9/28 (32%)
		LRR	<62..>220	CDD:227223	53/181 (29%)
		LRR 1	62..83		7/20 (35%)
		leucine-rich repeat	64..86	CDD:275380	8/45 (18%)
		LRR 2	86..107		7/20 (35%)
		leucine-rich repeat	87..110	CDD:275380	8/22 (36%)
		internalin_A	107..>478	CDD:380193	93/373 (25%)
		LRR 3	110..131		9/20 (45%)
		leucine-rich repeat	111..134	CDD:275380	9/22 (41%)
		LRR 4	134..155		7/20 (35%)
		leucine-rich repeat	135..158	CDD:275380	8/22 (36%)
		LRR 5	158..179		5/20 (25%)
		leucine-rich repeat	159..182	CDD:275380	7/22 (32%)
		LRR 6	182..203		6/20 (30%)
		leucine-rich repeat	183..206	CDD:275380	6/22 (27%)
		leucine-rich repeat	207..308	CDD:275380	14/100 (14%)
		LRR 7	308..329		7/20 (35%)
		leucine-rich repeat	309..332	CDD:275380	7/22 (32%)
		LRR_8	311..367	CDD:338972	17/55 (31%)
		LRR 8	332..353		6/20 (30%)
		leucine-rich repeat	333..356	CDD:275380	6/22 (27%)
		LRR 9	356..377		7/20 (35%)
		leucine-rich repeat	357..377	CDD:275380	7/19 (37%)
		LRR 10	380..401		7/20 (35%)
		leucine-rich repeat	381..404	CDD:275380	8/22 (36%)
		LRR 11	404..425		6/20 (30%)
		leucine-rich repeat	405..428	CDD:275380	7/22 (32%)
		LRRNT	505..535	CDD:214470
		LRR 12	533..554
		LRR_8	534..593	CDD:338972
		leucine-rich repeat	534..558	CDD:275380
		LRR 13	558..579
		leucine-rich repeat	559..582	CDD:275380
		LRR_8	582..641	CDD:338972
		LRR 14	582..603
		leucine-rich repeat	583..606	CDD:275380
		LRR 15	606..627
		leucine-rich repeat	607..630	CDD:275380
		LRR 16	630..651
		leucine-rich repeat	631..654	CDD:275380
		PCC	636..>714	CDD:188093
		leucine-rich repeat	655..745	CDD:275380
		LRRNT	725..756	CDD:214470
		LRR	<743..>869	CDD:227223
		leucine-rich repeat	746..776	CDD:275380
		LRR 17	753..775
		LRR_8	776..835	CDD:338972
		LRR 18	776..797
		leucine-rich repeat	777..800	CDD:275380
		LRR 19	800..821
		leucine-rich repeat	801..824	CDD:275380
		LRR 20	824..845
		leucine-rich repeat	825..846	CDD:275380
		PCC	830..>912	CDD:188093
		EGF_CA	963..1001	CDD:238011
		EGF_CA	1005..1038	CDD:238011
		EGF_CA	1042..1079	CDD:238011
		EGF_CA	1081..1117	CDD:238011
		EGF	1130..1160	CDD:333761
		LamG	1188..1321	CDD:214598
		EGF	1379..1407	CDD:333761
		GHB_like	<1473..1528	CDD:389804
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910