DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7509 and SLIT1

DIOPT Version :9

Sequence 1:NP_647931.1 Gene:CG7509 / 38579 FlyBaseID:FBgn0035575 Length:615 Species:Drosophila melanogaster
Sequence 2:NP_003052.2 Gene:SLIT1 / 6585 HGNCID:11085 Length:1534 Species:Homo sapiens


Alignment Length:493 Identity:120/493 - (24%)
Similarity:193/493 - (39%) Gaps:118/493 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   136 WHLATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDT 200
            |.|...:      |.: :|.|...|  ..|..|.|:::|  :.||.|...::|:.|.::.:||:.
Human    27 WRLGASA------CPA-LCTCTGTT--VDCHGTGLQAIP--KNIPRNTERLELNGNNITRIHKND 80

  Fly   201 FRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEI 265
            |.||..|:                        ||::..||:..::...|..::.|..|.|::|::
Human    81 FAGLKQLR------------------------VLQLMENQIGAVERGAFDDMKELERLRLNRNQL 121

  Fly   266 GMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTL 330
            .||||.:|.:.|.|:.:::.:|.||..|....|....|:.|.:.:|:||.:..|:.|.|..|:.|
Human   122 HMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVL 186

  Fly   331 DFGWNQIAKIDDDFFAGLRSLRTLSLHNNRI----------------------------SSLSG- 366
            ....|.|..|....|..:..|||..||:|.:                            :||.| 
Human   187 TLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGL 251

  Fly   367 -----------------------------------TIFNNL------------ANL----VTLDL 380
                                               |..|.:            |||    ..:.|
Human   252 NVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRL 316

  Fly   381 TTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLN 445
            ..|.|..|...||.....|..:.|..|.::.|..|.|..:.:|..|.|:.|.:|.|....|.||.
Human   317 ELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLY 381

  Fly   446 NLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCR 510
            .|::||||.|.:......||:.|..|..|.:..||:..|..|....|:.:..:.|.:||:.|||.
Human   382 TLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCN 446

  Fly   511 ALYLARWIREFVLKLWDGQQPMCRGPGDLGGHEVGLLR 548
            ..:||.::|...::....:   |..|..|....:|.::
Human   447 LKWLADFLRTNPIETSGAR---CASPRRLANKRIGQIK 481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7509NP_647931.1 LRR_8 182..241 CDD:290566 12/58 (21%)
leucine-rich repeat 187..206 CDD:275380 7/18 (39%)
LRR_RI <201..386 CDD:238064 55/264 (21%)
leucine-rich repeat 207..230 CDD:275380 1/22 (5%)
leucine-rich repeat 231..254 CDD:275380 5/22 (23%)
LRR_8 253..313 CDD:290566 19/59 (32%)
leucine-rich repeat 255..278 CDD:275380 9/22 (41%)
leucine-rich repeat 279..302 CDD:275380 6/22 (27%)
LRR_8 303..361 CDD:290566 20/57 (35%)
leucine-rich repeat 303..326 CDD:275380 8/22 (36%)
leucine-rich repeat 327..350 CDD:275380 6/22 (27%)
LRR_8 349..407 CDD:290566 22/137 (16%)
LRR_4 350..390 CDD:289563 18/119 (15%)
leucine-rich repeat 351..374 CDD:275380 11/98 (11%)
leucine-rich repeat 375..398 CDD:275380 7/26 (27%)
LRR_8 398..>443 CDD:290566 13/44 (30%)
leucine-rich repeat 399..422 CDD:275380 6/22 (27%)
leucine-rich repeat 423..443 CDD:275380 7/19 (37%)
leucine-rich repeat 471..494 CDD:275380 7/22 (32%)
LRRCT 503..554 CDD:214507 12/46 (26%)
SLIT1NP_003052.2 LRRNT 33..64 CDD:214470 11/41 (27%)
leucine-rich repeat 43..62 CDD:275380 7/22 (32%)
LRR_8 61..121 CDD:290566 18/83 (22%)
LRR 1 62..83 6/20 (30%)
leucine-rich repeat 63..86 CDD:275380 7/22 (32%)
LRR_4 64..101 CDD:289563 12/60 (20%)
LRR 2 86..107 6/44 (14%)
LRR_RI <87..220 CDD:238064 42/156 (27%)
leucine-rich repeat 87..110 CDD:275380 6/46 (13%)
LRR_8 109..169 CDD:290566 19/59 (32%)
LRR 3 110..131 9/20 (45%)
leucine-rich repeat 111..134 CDD:275380 9/22 (41%)
LRR 4 134..155 5/20 (25%)
leucine-rich repeat 135..158 CDD:275380 6/22 (27%)
LRR 5 158..179 6/20 (30%)
LRR_8 159..217 CDD:290566 20/57 (35%)
leucine-rich repeat 159..182 CDD:275380 8/22 (36%)
LRR 6 182..203 6/20 (30%)
leucine-rich repeat 183..206 CDD:275380 6/22 (27%)
leucine-rich repeat 207..334 CDD:275380 20/126 (16%)
TPKR_C2 219..264 CDD:301599 3/44 (7%)
LRRNT 282..313 CDD:214470 5/30 (17%)
LRR 7 310..331 6/20 (30%)
LRR_8 312..369 CDD:290566 16/56 (29%)
LRR_4 334..373 CDD:289563 11/38 (29%)
LRR 8 334..355 6/20 (30%)
leucine-rich repeat 335..358 CDD:275380 6/22 (27%)
LRR 9 358..379 7/20 (35%)
leucine-rich repeat 359..379 CDD:275380 7/19 (37%)
LRR 10 382..403 8/20 (40%)
leucine-rich repeat 383..406 CDD:275380 9/22 (41%)
LRR_8 389..441 CDD:290566 14/51 (27%)
LRR 11 406..427 6/20 (30%)
leucine-rich repeat 407..428 CDD:275380 6/20 (30%)
leucine-rich repeat 431..528 CDD:275380 13/54 (24%)
TPKR_C2 439..>469 CDD:301599 9/32 (28%)
LRRNT 513..542 CDD:214470
leucine-rich repeat 529..566 CDD:275380
LRR 12 541..562
LRR_RI <544..627 CDD:238064
LRR_8 544..601 CDD:290566
LRR 13 566..587
leucine-rich repeat 567..590 CDD:275380
LRR_8 590..649 CDD:290566
LRR 14 590..611
leucine-rich repeat 591..614 CDD:275380
LRR 15 614..635
LRR_4 615..654 CDD:289563
leucine-rich repeat 615..638 CDD:275380
LRR 16 638..659
leucine-rich repeat 639..660 CDD:275380
leucine-rich repeat 663..762 CDD:275380
LRRCT 671..719 CDD:214507
LRRNT 733..765 CDD:214470
LRR_8 761..820 CDD:290566
LRR 17 762..783
leucine-rich repeat 763..785 CDD:275380
LRR 18 785..806
LRR_4 786..827 CDD:289563
leucine-rich repeat 786..809 CDD:275380
LRR 19 809..830
leucine-rich repeat 810..830 CDD:275380
LRR 20 833..854
leucine-rich repeat 834..857 CDD:275380
LRRCT 866..915 CDD:214507
EGF_CA 927..962 CDD:238011
EGF_CA 966..1002 CDD:238011
EGF_CA 1005..1041 CDD:238011
EGF_CA 1044..1080 CDD:238011
EGF_CA 1085..1119 CDD:238011
EGF_CA <1136..1163 CDD:238011
LamG 1189..1322 CDD:214598
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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