DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and LINGO3

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001094861.1	Gene:	LINGO3 / 645191	HGNCID:	21206	Length:	592	Species:	Homo sapiens

Alignment Length:	394	Identity:	115/394 - (29%)
Similarity:	176/394 - (44%)	Gaps:	41/394 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 CRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLD 218
            |.|...|::..|....|.:||  ..||.....::||||.:..|:......|..|:|||:|.|.:.
Human    29 CECTVQTRAVACTRRRLTAVP--DGIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIA 91

  Fly   219 FLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVIN 283
            .:....|.:|..|.|||::.|||:.|....|.:|.||.:||||:|::.:|.:..|.....|..:.
Human    92 HVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLE 156

  Fly   284 MCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGL 348
            :.||.:...........|.||||.:.|..::.||..|:.:|..|..|......||.::|..|..|
Human   157 VGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRL 221

  Fly   349 RSLRTLSLHNNRI------SSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQN 407
            ..|..|.:.|..:      .||.|      .||.:|.:|...|:.:...|.....:|..|.|..|
Human   222 PGLLHLEIDNWPLLEEVAAGSLRG------LNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHN 280

  Fly   408 SMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLE 472
            .:|::|...|.::..|..|.|....|..:|...|.||..:::|.|:||:|...:...|..::.||
Human   281 PISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLE 345

  Fly   473 KLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPG 537
            .||:|.                        ||..||||.|::.:  |...|. :||:.|.|..|.
Human   346 TLRVDG------------------------NPLACDCRLLWIVQ--RRKTLN-FDGRLPACATPA 383

  Fly   538 DLGG 541
            ::.|
Human   384 EVRG 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	19/58 (33%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	58/190 (31%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	10/22 (45%)
		LRR_8	253..313	CDD:290566	18/59 (31%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		LRR_8	303..361	CDD:290566	19/57 (33%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR_8	349..407	CDD:290566	15/63 (24%)
		LRR_4	350..390	CDD:289563	11/45 (24%)
		leucine-rich repeat	351..374	CDD:275380	6/28 (21%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	13/44 (30%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	5/22 (23%)
		LRRCT	503..554	CDD:214507	15/39 (38%)
LINGO3	NP_001094861.1	LRRNT	24..58	CDD:214470	9/30 (30%)
		LRR 1	55..76		5/20 (25%)
		LRR_8	57..138	CDD:290566	31/80 (39%)
		LRR_4	59..95	CDD:289563	12/35 (34%)
		leucine-rich repeat	59..79	CDD:275380	6/19 (32%)
		LRR 2	79..100		7/20 (35%)
		leucine-rich repeat	80..103	CDD:275380	8/22 (36%)
		LRR 3	103..124		9/20 (45%)
		leucine-rich repeat	104..127	CDD:275380	10/22 (45%)
		LRR_RI	111..>286	CDD:238064	52/180 (29%)
		LRR_8	127..>172	CDD:290566	12/44 (27%)
		LRR 4	127..148		9/20 (45%)
		leucine-rich repeat	128..151	CDD:275380	8/22 (36%)
		LRR 5	151..172		3/20 (15%)
		leucine-rich repeat	152..199	CDD:275380	13/46 (28%)
		LRR 6	175..196		8/20 (40%)
		LRR_8	198..258	CDD:290566	17/65 (26%)
		leucine-rich repeat	200..223	CDD:275380	7/22 (32%)
		LRR 7	207..228		6/20 (30%)
		leucine-rich repeat	224..247	CDD:275380	6/28 (21%)
		LRR_8	247..303	CDD:290566	16/55 (29%)
		LRR 8	247..268		6/20 (30%)
		leucine-rich repeat	248..271	CDD:275380	5/22 (23%)
		LRR 9	271..292		7/20 (35%)
		leucine-rich repeat	272..293	CDD:275380	7/20 (35%)
		LRR 10	295..316		6/20 (30%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR 11	319..340		6/20 (30%)
		leucine-rich repeat	322..343	CDD:275380	6/20 (30%)
		I-set	407..497	CDD:254352
		Ig	422..490	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6410
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940