Protein Alignment CG7509 and LINGO3

DIOPT Version :10

• Sequence 1: NP_647931.1
• Gene: CG7509 / 38579
• FlyBaseID: FBgn0035575
• Length: 615
• Species: Drosophila melanogaster
• Sequence 2: NP_001094861.1
• Gene: LINGO3 / 645191
• HGNCID: 21206
• Length: 592
• Species: Homo sapiens
• Alignment Length: 394
• Identity: 115/394 - (29%)
• Similarity: 176/394 - (44%)
• Gaps: 41/394 - (10%)

  Fly   154 CRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLD 218
            |.|...|::..|....|.:||  ..||.....::||||.:..|:......|..|:|||:|.|.:.
Human    29 CECTVQTRAVACTRRRLTAVP--DGIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIA 91

  Fly   219 FLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVIN 283
            .:....|.:|..|.|||::.|||:.|....|.:|.||.:||||:|::.:|.:..|.....|..:.
Human    92 HVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLE 156

  Fly   284 MCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGL 348
            :.||.:...........|.||||.:.|..::.||..|:.:|..|..|......||.::|..|..|
Human   157 VGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRL 221

  Fly   349 RSLRTLSLHNNRI------SSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQN 407
            ..|..|.:.|..:      .||.|      .||.:|.:|...|:.:...|.....:|..|.|..|
Human   222 PGLLHLEIDNWPLLEEVAAGSLRG------LNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHN 280

  Fly   408 SMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLE 472
            .:|::|...|.::..|..|.|....|..:|...|.||..:::|.|:||:|...:...|..::.||
Human   281 PISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLE 345

  Fly   473 KLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPG 537
            .||:|.                        ||..||||.|::.:  |...|. :||:.|.|..|.
Human   346 TLRVDG------------------------NPLACDCRLLWIVQ--RRKTLN-FDGRLPACATPA 383

  Fly   538 DLGG 541
            ::.|
Human   384 EVRG 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR	185..>437	CDD:443914	76/257 (30%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	10/22 (45%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		leucine-rich repeat	351..374	CDD:275380	6/28 (21%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	5/22 (23%)
		PCC	476..>561	CDD:188093	16/66 (24%)
LINGO3	NP_001094861.1	LRRNT	24..58	CDD:214470	9/30 (30%)
		LRR	54..>303	CDD:443914	75/254 (30%)
		LRR 1	55..76		5/20 (25%)
		leucine-rich repeat	59..79	CDD:275380	6/19 (32%)
		LRR 2	79..100		7/20 (35%)
		leucine-rich repeat	80..103	CDD:275380	8/22 (36%)
		LRR 3	103..124		9/20 (45%)
		leucine-rich repeat	104..127	CDD:275380	10/22 (45%)
		LRR 4	127..148		9/20 (45%)
		leucine-rich repeat	128..151	CDD:275380	8/22 (36%)
		LRR 5	151..172		3/20 (15%)
		leucine-rich repeat	152..199	CDD:275380	13/46 (28%)
		LRR 6	175..196		8/20 (40%)
		leucine-rich repeat	200..223	CDD:275380	7/22 (32%)
		LRR 7	207..228		6/20 (30%)
		leucine-rich repeat	224..247	CDD:275380	6/28 (21%)
		LRR 8	247..268		6/20 (30%)
		leucine-rich repeat	248..271	CDD:275380	5/22 (23%)
		LRR 9	271..292		7/20 (35%)
		leucine-rich repeat	272..293	CDD:275380	7/20 (35%)
		LRR 10	295..316		6/20 (30%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR 11	319..340		6/20 (30%)
		leucine-rich repeat	322..343	CDD:275380	6/20 (30%)
		PCC	334..>406	CDD:188093	21/81 (26%)
		Ig	408..497	CDD:472250
		Ig strand B	425..429	CDD:409353
		Ig strand C	438..442	CDD:409353
		Ig strand E	463..467	CDD:409353
		Ig strand F	477..482	CDD:409353
		Ig strand G	490..493	CDD:409353