DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7509 and LRRC4

DIOPT Version :9

Sequence 1:NP_647931.1 Gene:CG7509 / 38579 FlyBaseID:FBgn0035575 Length:615 Species:Drosophila melanogaster
Sequence 2:NP_071426.1 Gene:LRRC4 / 64101 HGNCID:15586 Length:653 Species:Homo sapiens


Alignment Length:396 Identity:104/396 - (26%)
Similarity:156/396 - (39%) Gaps:112/396 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   135 VWHL----ATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILST 195
            ||.|    |..:.....:|.| ||.|:.......|....|..||  |.||.|...::|..|.:..
Human    28 VWILCAAIAAAASAGPQNCPS-VCSCSNQFSKVVCTRRGLSEVP--QGIPSNTRYLNLMENNIQM 89

  Fly   196 LHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDL 260
            :..||||.|         |:               |.||::..|.:..|:...|..|.:||.|:|
Human    90 IQADTFRHL---------HH---------------LEVLQLGRNSIRQIEVGAFNGLASLNTLEL 130

  Fly   261 SKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLT 325
            ..|.:.::|                                                ||:..||:
Human   131 FDNWLTVIP------------------------------------------------SGAFEYLS 147

  Fly   326 KLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDL-TTNRISHID 389
            ||:.|   |                     |.||.|.|:....||.:.:|:.||| ...::.:|.
Human   148 KLREL---W---------------------LRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYIS 188

  Fly   390 GNAFVELNNLNELFLGQNSMSSIPADLFLNVS---ALTRLTLFSNNLTTLEADDFQGLNNLKILL 451
            ..||..|.||..|.||..::..:|     |::   .|..|.:..|:...:....|.||::||.|.
Human   189 EGAFEGLFNLKYLNLGMCNIKDMP-----NLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLW 248

  Fly   452 LNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLAR 516
            :.|:.:...:..||:.|:.|.:|.:..|.|..|||.....|:.||.:.|..|||:|||..|:||.
Human   249 VMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAW 313

  Fly   517 WIREFV 522
            |:||::
Human   314 WLREYI 319

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7509NP_647931.1 LRR_8 182..241 CDD:290566 13/58 (22%)
leucine-rich repeat 187..206 CDD:275380 7/18 (39%)
LRR_RI <201..386 CDD:238064 36/185 (19%)
leucine-rich repeat 207..230 CDD:275380 1/22 (5%)
leucine-rich repeat 231..254 CDD:275380 7/22 (32%)
LRR_8 253..313 CDD:290566 6/59 (10%)
leucine-rich repeat 255..278 CDD:275380 6/22 (27%)
leucine-rich repeat 279..302 CDD:275380 0/22 (0%)
LRR_8 303..361 CDD:290566 11/57 (19%)
leucine-rich repeat 303..326 CDD:275380 4/22 (18%)
leucine-rich repeat 327..350 CDD:275380 3/22 (14%)
LRR_8 349..407 CDD:290566 20/58 (34%)
LRR_4 350..390 CDD:289563 12/40 (30%)
leucine-rich repeat 351..374 CDD:275380 7/22 (32%)
leucine-rich repeat 375..398 CDD:275380 8/23 (35%)
LRR_8 398..>443 CDD:290566 11/47 (23%)
leucine-rich repeat 399..422 CDD:275380 6/25 (24%)
leucine-rich repeat 423..443 CDD:275380 4/19 (21%)
leucine-rich repeat 471..494 CDD:275380 8/22 (36%)
LRRCT 503..554 CDD:214507 12/20 (60%)
LRRC4NP_071426.1 LRRNT 46..79 CDD:214470 13/35 (37%)
LRR <74..291 CDD:227223 74/317 (23%)
LRR 1 76..97 6/20 (30%)
leucine-rich repeat 77..100 CDD:275380 7/31 (23%)
LRR 2 100..121 6/35 (17%)
leucine-rich repeat 101..124 CDD:275380 7/22 (32%)
LRR 3 124..145 8/68 (12%)
leucine-rich repeat 125..148 CDD:275380 10/70 (14%)
LRR 4 148..169 10/44 (23%)
leucine-rich repeat 149..172 CDD:275380 10/46 (22%)
LRR 5 172..194 7/21 (33%)
leucine-rich repeat 173..197 CDD:275380 8/23 (35%)
LRR 6 197..218 7/25 (28%)
leucine-rich repeat 198..219 CDD:275380 6/25 (24%)
LRR 7 219..240 4/20 (20%)
leucine-rich repeat 220..243 CDD:275380 6/22 (27%)
LRR 8 243..264 6/20 (30%)
leucine-rich repeat 244..267 CDD:275380 7/22 (32%)
LRR 9 267..288 7/20 (35%)
leucine-rich repeat 268..289 CDD:275380 7/20 (35%)
LRRCT 300..351 CDD:214507 12/20 (60%)
IG 359..441 CDD:214652
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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