DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and NYX

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001365406.2	Gene:	NYX / 60506	HGNCID:	8082	Length:	476	Species:	Homo sapiens

Alignment Length:	454	Identity:	120/454 - (26%)
Similarity:	184/454 - (40%)	Gaps:	95/454 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 CRCNPDTK--SFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNV 216
            |.|:...:  |..|....|..||..  :|...|:|||.||.|..|.:..|..|..|:.|.:.||.
Human    30 CACSTVERGCSVRCDRAGLLRVPAE--LPCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNN 92

  Fly   217 LDFLPFDLFQDLDSLLVLRI-QNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLT 280
            |.|:....|:.|..|..||: .|..|..:..|||..|..|..|||:...:..:||.:......|.
Human    93 LSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALR 157

  Fly   281 VINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFF 345
            .:...||..:.. |..||....|....:.|.:|..::|.|::
Human   158 ELAAFDNLFRRV-PGALRGLANLTHAHLERGRIEAVASSSLQ----------------------- 198

  Fly   346 AGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMS 410
             |||.||:|||..||:.::....|.:...|..|.|..|.::.:..:||..|..|..|.||.|::.
Human   199 -GLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALD 262

  Fly   411 SIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLR 475
            .:....|.:::.|..|.|..|::..:|...||.|:.|..|.||.|.|......||:|...|.:|
Human   263 RVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRL- 326

  Fly   476 IDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPM----CRGP 536
                 .:|                  :|||.||||    ..|:|:::    :|...:    |..|
Human   327 -----FLF------------------RNPWCCDCR----LEWLRDWM----EGSGRVTDVPCASP 360

  Fly   537 GDLGGHEVGLLRYDDLCDG---------------------------QWASMLS--LSPRLPVRK 571
            |.:.|.::..:.:....||                           :::|:||  |:||:||.:
Human   361 GSVAGLDLSQVTFGRSSDGLCVDPEELNLTTSSPGPSPEPAATTVSRFSSLLSKLLAPRVPVEE 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	22/59 (37%)
		leucine-rich repeat	187..206	CDD:275380	8/18 (44%)
		LRR_RI	<201..386	CDD:238064	51/185 (28%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	9/23 (39%)
		LRR_8	253..313	CDD:290566	14/59 (24%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	303..361	CDD:290566	14/57 (25%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	2/22 (9%)
		LRR_8	349..407	CDD:290566	20/57 (35%)
		LRR_4	350..390	CDD:289563	12/39 (31%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	12/44 (27%)
		leucine-rich repeat	399..422	CDD:275380	6/22 (27%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	3/22 (14%)
		LRRCT	503..554	CDD:214507	14/54 (26%)
NYX	NP_001365406.2	LRR_8	61..115	CDD:404697	20/53 (38%)
		leucine-rich repeat	63..82	CDD:275380	8/18 (44%)
		leucine-rich repeat	83..106	CDD:275380	8/22 (36%)
		leucine-rich repeat	107..131	CDD:275380	9/23 (39%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		PPP1R42	150..310	CDD:411060	48/184 (26%)
		leucine-rich repeat	156..178	CDD:275380	6/22 (27%)
		leucine-rich repeat	179..202	CDD:275380	7/46 (15%)
		leucine-rich repeat	203..226	CDD:275380	8/22 (36%)
		LRR_8	227..285	CDD:404697	17/57 (30%)
		leucine-rich repeat	227..250	CDD:275380	7/22 (32%)
		leucine-rich repeat	251..274	CDD:275380	6/22 (27%)
		leucine-rich repeat	275..296	CDD:275380	7/20 (35%)
		leucine-rich repeat	323..335	CDD:275378	6/35 (17%)
		LRRCT	331..>365	CDD:214507	13/41 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910