DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and LGR6

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001017403.1	Gene:	LGR6 / 59352	HGNCID:	19719	Length:	967	Species:	Homo sapiens

Alignment Length:	441	Identity:	121/441 - (27%)
Similarity:	177/441 - (40%)	Gaps:	61/441 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 CRCNPD--TKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNV 216
            |.|..|  ..|..|....|.:|| ..:.|:. ..:|||.|.|:.|....|..|..|:||.:|.|.
Human    39 CHCQEDGIMLSADCSELGLSAVP-GDLDPLT-AYLDLSMNNLTELQPGLFHHLRFLEELRLSGNH 101

  Fly   217 LDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTV 281
            |..:|...|..|.||.:|.:|||||..|.....|:|.:|..|.|..|.|.::||..|.....|..
Human   102 LSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRH 166

  Fly   282 INMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFA 346
            :.:.||.:...|...|.:                        |..|:.:....|:|:.|.|..|.
Human   167 LWLDDNALTEIPVRALNN------------------------LPALQAMTLALNRISHIPDYAFQ 207

  Fly   347 GLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSS 411
            .|.||..|.||||||..|....|..|.||.||||..|::.... .|...|..|.||....|::.:
Human   208 NLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP-VAIRTLGRLQELGFHNNNIKA 271

  Fly   412 IPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPL---SQLEK 473
            ||...|:....|..:..:.|.:..:....||.|..|..|.||..:    |.:.|..|   :.||.
Human   272 IPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAM----DIQEFPDLKGTTSLEI 332

  Fly   474 LRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVL---KLWDGQQPMCRG 535
            |.:....:..||.|....|..|..::|..|... :..:|:..:.:.|..|   ::|
Human   333 LTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIE-ELPSLHRCQKLEEIGLQHNRIW--------- 387

  Fly   536 PGDLGGHEVGLLRYDDLCDGQWASMLSLSP----------RLPVRKHQIST 576
              ::|......|......|..|.::.|:.|          :|.:..:|::|
Human   388 --EIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTT 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	23/58 (40%)
		leucine-rich repeat	187..206	CDD:275380	8/18 (44%)
		LRR_RI	<201..386	CDD:238064	62/184 (34%)
		leucine-rich repeat	207..230	CDD:275380	9/22 (41%)
		leucine-rich repeat	231..254	CDD:275380	10/22 (45%)
		LRR_8	253..313	CDD:290566	13/59 (22%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	15/57 (26%)
		leucine-rich repeat	303..326	CDD:275380	1/22 (5%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR_8	349..407	CDD:290566	24/57 (42%)
		LRR_4	350..390	CDD:289563	19/39 (49%)
		leucine-rich repeat	351..374	CDD:275380	11/22 (50%)
		leucine-rich repeat	375..398	CDD:275380	8/22 (36%)
		LRR_8	398..>443	CDD:290566	10/44 (23%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	3/19 (16%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		LRRCT	503..554	CDD:214507	7/53 (13%)
LGR6	NP_001017403.1	LRRNT	34..68	CDD:214470	9/29 (31%)
		LRR_RI	<57..199	CDD:238064	48/167 (29%)
		leucine-rich repeat	70..91	CDD:275380	8/20 (40%)
		LRR 1	91..112		8/20 (40%)
		LRR_8	92..150	CDD:290566	24/57 (42%)
		leucine-rich repeat	92..115	CDD:275380	9/22 (41%)
		LRR 2	115..136		9/20 (45%)
		leucine-rich repeat	116..139	CDD:275380	10/22 (45%)
		LRR_RI	131..392	CDD:238064	78/301 (26%)
		LRR 3	139..160		8/20 (40%)
		leucine-rich repeat	140..163	CDD:275380	8/22 (36%)
		LRR 4	163..186		5/46 (11%)
		leucine-rich repeat	164..187	CDD:275380	6/46 (13%)
		LRR_8	186..246	CDD:290566	26/59 (44%)
		LRR 5	187..208		6/20 (30%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		LRR 6	211..232		11/20 (55%)
		leucine-rich repeat	212..235	CDD:275380	11/22 (50%)
		LRR 7	235..256		8/21 (38%)
		leucine-rich repeat	236..258	CDD:275380	8/22 (36%)
		LRR_8	258..314	CDD:290566	15/55 (27%)
		LRR 8	258..279		7/20 (35%)
		leucine-rich repeat	259..282	CDD:275380	7/22 (32%)
		LRR 9	282..303		3/20 (15%)
		leucine-rich repeat	283..304	CDD:275380	4/20 (20%)
		LRR 10	306..328		7/25 (28%)
		LRR 11	329..350		6/20 (30%)
		leucine-rich repeat	330..344	CDD:275378	3/13 (23%)
		LRR 12	353..374		4/21 (19%)
		leucine-rich repeat	354..399	CDD:275380	9/56 (16%)
		LRR_8	375..434	CDD:290566	10/69 (14%)
		LRR 13	375..396		4/31 (13%)
		leucine-rich repeat	376..390	CDD:275378	3/24 (13%)
		LRR 14	399..420		4/20 (20%)
		leucine-rich repeat	400..423	CDD:275380	4/22 (18%)
		LRR 15	423..443		3/14 (21%)
		leucine-rich repeat	424..444	CDD:275380	3/13 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910