DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and LRRC7

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001357714.1	Gene:	LRRC7 / 57554	HGNCID:	18531	Length:	1575	Species:	Homo sapiens

Alignment Length:	422	Identity:	107/422 - (25%)
Similarity:	175/422 - (41%)	Gaps:	72/422 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 IESRLRSVEQPVWHLATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVN--- 185
            :|:.:|....|.:..:...::.      ...|..|: :...|.....|...:.:::|.....
Human     2 MENLIRGRNPPQYQRSPCKEVR------AALRKRPE-EELQCLEMTTKRKIIGRLVPCRCFRGEE 59

  Fly   186 -----IDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDID 245
                 :|.|...|..:.|:.|.....|:||.:..|.::.||..|| :..:|..|.|.:|.|.::.
Human    60 EIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLSNLP 123

  Fly   246 HRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLR----DQLMLEE- 305
             .|...|.||..||:|||.:...||:| ...:.||:|....|.|...|....:    .||.|.:
Human   124 -TTIASLVNLKELDISKNGVQEFPENI-KCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDA 186

  Fly   306 -----------------LDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRT 353
                             |::..|.:..|.. |:..|.:|:.||.|.|:..:: .:....:::||.
Human   187 FLEFLPANFGRLVKLRILELRENHLKTLPK-SMHKLAQLERLDLGNNEFGEL-PEVLDQIQNLRE 249

  Fly   354 LSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNN---LNELFLGQNSMSSIPAD 415
            |.:.||.:..|.|:| ..|..||.||::.|||..:|    ::::.   |.:|.|..|.:..:|..
Human   250 LWMDNNALQVLPGSI-GKLKMLVYLDMSKNRIETVD----MDISGCEALEDLLLSSNMLQQLPDS 309

  Fly   416 LFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFE----P-----LSQL 471
            :.|           ...||||:.||.| |..|...:.|.::|:.||....|    |     |..|
Human   310 IGL-----------LKKLTTLKVDDNQ-LTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSL 362

  Fly   472 EKLRIDSNKLMFLPHGALHGLKNLVAVKLDKN 503
            ..|.:|.|.|..||. .:...||:..:.|..|
Human   363 RTLAVDENFLPELPR-EIGSCKNVTVMSLRSN 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	17/66 (26%)
		leucine-rich repeat	187..206	CDD:275380	5/18 (28%)
		LRR_RI	<201..386	CDD:238064	60/206 (29%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	21/81 (26%)
		leucine-rich repeat	255..278	CDD:275380	9/22 (41%)
		leucine-rich repeat	279..302	CDD:275380	7/26 (27%)
		LRR_8	303..361	CDD:290566	16/75 (21%)
		leucine-rich repeat	303..326	CDD:275380	6/40 (15%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		LRR_8	349..407	CDD:290566	20/60 (33%)
		LRR_4	350..390	CDD:289563	16/39 (41%)
		leucine-rich repeat	351..374	CDD:275380	9/22 (41%)
		leucine-rich repeat	375..398	CDD:275380	8/22 (36%)
		LRR_8	398..>443	CDD:290566	12/47 (26%)
		leucine-rich repeat	399..422	CDD:275380	6/22 (27%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		LRRCT	503..554	CDD:214507	1/1 (100%)
LRRC7	NP_001357714.1	leucine-rich repeat	64..85	CDD:275380	5/20 (25%)
		LRR_8	85..140	CDD:338972	20/56 (36%)
		leucine-rich repeat	86..108	CDD:275380	8/22 (36%)
		leucine-rich repeat	109..131	CDD:275380	7/22 (32%)
		LRR	130..440	CDD:227223	79/285 (28%)
		leucine-rich repeat	132..177	CDD:275380	15/45 (33%)
		leucine-rich repeat	178..200	CDD:275380	3/21 (14%)
		leucine-rich repeat	201..223	CDD:275380	5/22 (23%)
		leucine-rich repeat	224..246	CDD:275380	5/22 (23%)
		leucine-rich repeat	247..269	CDD:275380	9/22 (41%)
		leucine-rich repeat	270..292	CDD:275380	8/25 (32%)
		leucine-rich repeat	316..336	CDD:275380	9/20 (45%)
		leucine-rich repeat	339..361	CDD:275380	6/21 (29%)
		leucine-rich repeat	362..384	CDD:275380	7/22 (32%)
		leucine-rich repeat	385..407	CDD:275380	2/9 (22%)
		leucine-rich repeat	408..430	CDD:275380
		PDZ_signaling	1485..1570	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910