DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Lgr4

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster

Alignment Length:	481	Identity:	120/481 - (24%)
Similarity:	189/481 - (39%)	Gaps:	108/481 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 NACESLGIVSQLLMLINSMPNGTQS-----AANDK--------------KPPKSKANGHNDGDVN 102
            :|.|:...|.:::.|:..: :|.:|     .|:||              .|.::..:|..|.|..
  Fly    55 DATEAEAPVREVISLLGII-DGAESDILVPDADDKCPGGYFHCNTTAQCVPQRANCDGSVDCDDA 118

  Fly   103 GGEINAMSHL--ANFDLVKRVRQIESRLRSVEQPVW---HLATGSQIEWNHCTSGVCRCNPDTKS 162
            ..|:|.::.:  ..:|.:.|           :||..   :|..|..:..|...|  |.|..|  .
  Fly   119 SDEVNCVNEVDAKYWDHLYR-----------KQPFGRHDNLRIGECLWPNENFS--CPCRGD--E 168

  Fly   163 FTCWNTNLKSVPVTQVIPM-NMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQ 226
            ..|....|..:|  :.:|. ::..:||:.|...|:| :||                    |....
  Fly   169 ILCRFQQLTDIP--ERLPQHDLATLDLTGNNFETIH-ETF--------------------FSELP 210

  Fly   227 DLDSLLVLRIQNNQLEDIDHRTFWKLRN--LNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQI 289
            |:|| |||:..:  :.:|....|.:|.:  |..|.:..|::..|||..|....:|::
  Fly   211 DVDS-LVLKFCS--IREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSI-------- 264

  Fly   290 QNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTL 354
                            |.::||.:..|.......|.||:.||...|:|...:.:.||.|.:|..|
  Fly   265 ----------------LILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVL 313

  Fly   355 SLHNNRISSLSGTIF-NNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFL 418
            .|:.|.:..|....| ..|.||.||.|..|:|..|..|.| ....|..|||..|.:|.|..:.|.
  Fly   314 YLNENHLKRLDPDRFPRTLLNLHTLSLAYNQIEDIAANTF-PFPRLRYLFLAGNRLSHIRDETFC 377

  Fly   419 NVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRID------ 477
            |:|.|..|.|..|.:...:.:.|..|.||..|||..|..:..|:|..:.|:.|:.:...
  Fly   378 NLSNLQGLHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCS 442

  Fly   478 --SNKLMFLPHG-----ALHGLKNLV 496
              .|..:..|||     .||.|.|.:
  Fly   443 AAMNVRVCDPHGDGISSKLHLLDNQI 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	14/58 (24%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	46/187 (25%)
		leucine-rich repeat	207..230	CDD:275380	2/22 (9%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	11/61 (18%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	1/22 (5%)
		LRR_8	303..361	CDD:290566	18/57 (32%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		LRR_8	349..407	CDD:290566	21/58 (36%)
		LRR_4	350..390	CDD:289563	15/40 (38%)
		leucine-rich repeat	351..374	CDD:275380	7/23 (30%)
		leucine-rich repeat	375..398	CDD:275380	9/22 (41%)
		LRR_8	398..>443	CDD:290566	15/44 (34%)
		leucine-rich repeat	399..422	CDD:275380	9/22 (41%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	8/35 (23%)
		LRRCT	503..554	CDD:214507
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486	7/36 (19%)
		LRR_RI	<184..397	CDD:238064	71/261 (27%)
		LRR_8	188..248	CDD:290566	20/83 (24%)
		leucine-rich repeat	188..211	CDD:275380	8/43 (19%)
		leucine-rich repeat	212..235	CDD:275380	8/25 (32%)
		leucine-rich repeat	238..261	CDD:275380	7/22 (32%)
		LRR_8	261..320	CDD:290566	19/82 (23%)
		leucine-rich repeat	262..285	CDD:275380	6/46 (13%)
		LRR_4	284..325	CDD:289563	14/40 (35%)
		leucine-rich repeat	286..309	CDD:275380	8/22 (36%)
		LRR_4	308..348	CDD:289563	14/39 (36%)
		leucine-rich repeat	310..334	CDD:275380	7/23 (30%)
		leucine-rich repeat	335..357	CDD:275380	9/22 (41%)
		LRR_8	356..416	CDD:290566	22/59 (37%)
		leucine-rich repeat	358..381	CDD:275380	9/22 (41%)
		LRR_4	381..421	CDD:289563	12/39 (31%)
		leucine-rich repeat	382..405	CDD:275380	6/22 (27%)
		leucine-rich repeat	406..427	CDD:275380	7/20 (35%)
		7tm_1	483..741	CDD:278431
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910