DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and igfals

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_003198203.1	Gene:	igfals / 570758	ZFINID:	ZDB-GENE-061009-25	Length:	614	Species:	Danio rerio

Alignment Length:	601	Identity:	154/601 - (25%)
Similarity:	245/601 - (40%)	Gaps:	113/601 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PAEVITGPSQAKEPPIQSLDEFRQRYLLPL-ISSDTRNCS------------------------- 55
            |:|..||  |..||..:.....:..|.|.| :...|||.:
Zfish    37 PSEEPTG--QKSEPCAKGCTCLQDDYSLELNVYCSTRNFTQVPSDIPLSTRSLWLDGNLFSNLPA 99

  Fly    56 -----LNACESLGIVSQLLMLINSMP-NGTQSAANDKKPPKSKANGHNDGDVNGGEINAMSHLAN 114
                 |...|.|.:.|.||:.:::.. .|..|.|:      .....:|...::|......|:||.
Zfish   100 GAFEKLTNLEFLNLQSSLLVSLDAHAFRGLNSLAH------LHLERNNLRSLSGLVFQGTSNLAT 158

  Fly   115 FDL-VKRVRQIESRLRSVEQPVWHLATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQV 178
            ..| ..::.:|:.||.:....:|.|..|                        ||. |..:|.|..
Zfish   159 LSLNNNQMFRIDDRLFAGMSHMWLLNLG------------------------WNL-LSVLPETGF 198

  Fly   179 IPMN-MVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLE 242
            ..:: :..:.|:.|.|:.|....|:||..|||||::.|.|..:..::|..|..|..|.:..||:.
Zfish   199 QDLHGLRELILAGNRLAYLQPQLFQGLNELKELDLTGNYLKVIKANVFLKLPKLQKLYLGQNQIV 263

  Fly   243 DIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELD 307
            .:..|.|..:::|..||||:|.:.:|.:..|...|.|.|:.:.:|.|.:..|...||...||||.
Zfish   264 TVAPRAFVGMKSLRWLDLSRNRLTVLHDETFIGLQSLHVLRLSNNSINSLRPGTFRDLQYLEELC 328

  Fly   308 MSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNL 372
            :..|:|..|.......|..|:.|:...|::.:.....|.||..|..:.|..:...||...:|..|
Zfish   329 LYHNQIRALGVRVFEGLGHLEVLNLENNRLQEARMGTFMGLNHLAVMKLTGSCFHSLPDQVFKGL 393

  Fly   373 ANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLE 437
            :.|.::.|..:.::.:...:|..|..|..|||..|::|.:....|:.:..|.:|.|..|.|||:.
Zfish   394 SKLHSIHLDRSCLTKVSSQSFSGLTGLRRLFLQHNNISLVERQSFVELQRLQQLDLRFNKLTTIT 458

  Fly   438 ADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALH--------GLKN 494
            ::.|.||.||..|||:.|:|.|..|.|..||..|..|.:..|||..:.:..::        .||:
Zfish   459 SNTFYGLKNLDYLLLSGNLLHNLPAEALLPLQHLSWLDLSGNKLELILNATIYMLPRLRYLNLKD 523

  Fly   495 LVAVK-------------LDKNPWHCDCRALYLARWIREFVLK-----------LWDGQQP---- 531
            .:.|.             |..|.|.|||.    |:..|:|:|:           |.:|::|
Zfish   524 NILVNLPVSIPESLDQLWLSGNNWKCDCS----AKPFRDFILQKPQVVPLQVEMLGEGEEPHTLI 584

  Fly   532 ------MCRGPGDLGG 541
                  .|..|....|
Zfish   585 TVYNNVTCASPSSASG 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	19/59 (32%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	56/184 (30%)
		leucine-rich repeat	207..230	CDD:275380	9/22 (41%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	21/59 (36%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	7/22 (32%)
		LRR_8	303..361	CDD:290566	16/57 (28%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		LRR_8	349..407	CDD:290566	14/57 (25%)
		LRR_4	350..390	CDD:289563	8/39 (21%)
		leucine-rich repeat	351..374	CDD:275380	6/22 (27%)
		leucine-rich repeat	375..398	CDD:275380	4/22 (18%)
		LRR_8	398..>443	CDD:290566	15/44 (34%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	8/19 (42%)
		leucine-rich repeat	471..494	CDD:275380	6/30 (20%)
		LRRCT	503..554	CDD:214507	15/60 (25%)
igfals	XP_003198203.1	LRRNT	48..81	CDD:279764	7/32 (22%)
		leucine-rich repeat	65..83	CDD:275380	3/17 (18%)
		leucine-rich repeat	84..107	CDD:275380	1/22 (5%)
		LRR_8	85..142	CDD:290566	9/62 (15%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		LRR_8	131..214	CDD:290566	21/113 (19%)
		leucine-rich repeat	132..155	CDD:275380	3/28 (11%)
		leucine-rich repeat	156..203	CDD:275380	14/71 (20%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		LRR_RI	<219..456	CDD:238064	70/236 (30%)
		LRR_8	227..286	CDD:290566	21/58 (36%)
		leucine-rich repeat	228..251	CDD:275380	9/22 (41%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		LRR_8	274..334	CDD:290566	21/59 (36%)
		leucine-rich repeat	276..299	CDD:275380	8/22 (36%)
		leucine-rich repeat	300..323	CDD:275380	7/22 (32%)
		leucine-rich repeat	324..347	CDD:275380	8/22 (36%)
		leucine-rich repeat	348..369	CDD:275380	4/20 (20%)
		LRR_8	371..430	CDD:290566	15/58 (26%)
		leucine-rich repeat	396..419	CDD:275380	4/22 (18%)
		LRR_8	418..478	CDD:290566	23/59 (39%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..467	CDD:275380	10/22 (45%)
		LRR_8	466..524	CDD:290566	19/57 (33%)
		leucine-rich repeat	468..486	CDD:275380	8/17 (47%)
		leucine-rich repeat	492..515	CDD:275380	5/22 (23%)
		leucine-rich repeat	516..540	CDD:275380	3/23 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910