DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and lingo3a

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001076323.1	Gene:	lingo3a / 567293	ZFINID:	ZDB-GENE-060503-54	Length:	605	Species:	Danio rerio

Alignment Length:	437	Identity:	123/437 - (28%)
Similarity:	194/437 - (44%)	Gaps:	36/437 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 LATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFR 202
            |.|.|......|... |.|.|..::..|.|..|.|:|  ..||.:...:|||.|.|..:..:...
Zfish    16 LITASITHGQSCPQR-CDCIPHQRAVMCQNKRLGSIP--GGIPADTRLLDLSCNSLRWVEYNDLS 77

  Fly   203 GLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGM 267
            .|..|:|||:|.|::..|..:.|..|.:|.|||::.|||:.:....|.:|.||..||||.|::.:
Zfish    78 TLLRLEELDLSENLISVLEPNAFSSLLNLRVLRLRANQLKLVPMGAFSRLTNLTTLDLSGNKLVI 142

  Fly   268 LPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDF 332
            |.:..|...:.|..:.:.||.:...........:.|.||.:.|..::.:|..|:.||..|.||..
Zfish   143 LLDFTFQDLRNLRNLEVGDNDLVYISNKAFLGLVGLRELTIERCNLTSISGQSLSYLRGLVTLRL 207

  Fly   333 GWNQIAKIDDDFFAGLRSLRTLSL-HNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVEL 396
            .:..||.:::..|..|..||.|.: |...:..:|...|..| ||..|.:|...||.:...|...|
Zfish   208 RYLSIASLEEQNFRKLGGLRGLEIDHWPFLEYISPHSFQGL-NLSWLSITNTNISTVPTGALRNL 271

  Fly   397 NNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFD 461
            .:|..|.|..|.:|.:.:....::..|..|.|...||.:::.....||..:::|.|:|
Zfish   272 IHLASLNLSYNPISVLESWALRDLVRLKELHLVGTNLISVQPYGLGGLQQIRLLNLSN------- 329

  Fly   462 ARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLW 526
                             |.|:.|..|:.|.:..|..:::|.||..||||.|::.:  |...|. :
Zfish   330 -----------------NGLVTLEEGSFHSVNTLETLRVDGNPLSCDCRLLWILQ--RRKTLN-F 374

  Fly   527 DGQQPMCRGPGDLGGHEVGLLRYDDLCDGQWASMLSLSPRLPVRKHQ 573
            ||:.|:|..|.::.|..:.......|.|    ......|::..||.|
Zfish   375 DGKSPVCTAPVEVRGKSLSTFTDSALFD----HFTCQRPKIRNRKLQ 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	20/58 (34%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	57/185 (31%)
		leucine-rich repeat	207..230	CDD:275380	9/22 (41%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR_8	253..313	CDD:290566	16/59 (27%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		LRR_8	303..361	CDD:290566	19/58 (33%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR_8	349..407	CDD:290566	18/58 (31%)
		LRR_4	350..390	CDD:289563	13/40 (33%)
		leucine-rich repeat	351..374	CDD:275380	7/23 (30%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	10/44 (23%)
		leucine-rich repeat	399..422	CDD:275380	5/22 (23%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	5/22 (23%)
		LRRCT	503..554	CDD:214507	16/50 (32%)
lingo3a	NP_001076323.1	LRRNT	27..60	CDD:214470	11/35 (31%)
		LRR	<49..357	CDD:227223	94/334 (28%)
		leucine-rich repeat	58..81	CDD:275380	6/22 (27%)
		leucine-rich repeat	82..105	CDD:275380	9/22 (41%)
		leucine-rich repeat	130..153	CDD:275380	8/22 (36%)
		leucine-rich repeat	154..177	CDD:275380	3/22 (14%)
		leucine-rich repeat	178..201	CDD:275380	8/22 (36%)
		leucine-rich repeat	202..225	CDD:275380	7/22 (32%)
		leucine-rich repeat	226..249	CDD:275380	7/23 (30%)
		leucine-rich repeat	250..273	CDD:275380	7/22 (32%)
		leucine-rich repeat	274..297	CDD:275380	5/22 (23%)
		leucine-rich repeat	298..321	CDD:275380	7/22 (32%)
		leucine-rich repeat	322..342	CDD:275380	7/43 (16%)
		PCC	326..>392	CDD:188093	24/92 (26%)
		Ig	424..492	CDD:325142
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4201
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1378
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.960