DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and AgaP_AGAP008171

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_001689016.1	Gene:	AgaP_AGAP008171 / 5668341	VectorBaseID:	AGAP008171	Length:	680	Species:	Anopheles gambiae

Alignment Length:	669	Identity:	149/669 - (22%)
Similarity:	237/669 - (35%)	Gaps:	249/669 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 SH-LANFDLVKR-VRQIESRLRSVEQPVWHLATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKS 172
            || .|:|:..:| ::|:::.|..:..|:                         :||
Mosquito    63 SHFFADFETQRRNIQQMQTALTVIRSPL-------------------------RSF--------- 93

  Fly   173 VPVTQVIPMN--MVNIDLSRNILSTLHKDTFRGLT-----VLKELDISHNVLDFLPFDLFQDLDS 230
                 |:..|  ...||||:|.|.||: |:..|..     :|.:|.:..|.|..:..|:|:.::|
Mosquito    94 -----VLEDNATFYTIDLSKNRLHTLY-DSSAGTATLSYPLLADLYLRENKLKHINLDVFRPMES 152

  Fly   231 LLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEI--------------GM---------LPE-- 270
            |..:.:.:||:..:.....  ..:||:||||.|.|              ||         ||:
Mosquito   153 LTRIDLSHNQISVVSGSLV--SASLNLLDLSNNRIVEMDCCGWAVPMLYGMDANDNRLRALPKCL 215

  Fly   271 -------------------SIFYHAQRLT---VINMCDNQIQNFPPNLLRDQLMLEELDMSRNKI 313
                               .:.:...|||   .:.:.||::.....|:......|..|::|.||:
Mosquito   216 EQAFLNVVRLAFDRNQLQPDVMFQFGRLTSLKFLTLTDNKLPYVTLNMSTIPKQLRHLNLSHNKL 280

  Fly   314 SEL--------------SSGSI---------RYLTKL----KTLDFGWNQI---AKIDDDFFAGL 348
            ..|              ||..|         ..||||    ..||..::.|   |.|........
Mosquito   281 KHLDVPYAPSKDFHIDVSSNCISSVDWDRVSANLTKLGMGENPLDCSFHSISTRADIRSKLHIHF 345

  Fly   349 RSLRTLSLHNNRI--------SSLSGTI---------FNNLANLVTLDLTTNRISHIDGNAFVEL 396
            |.|....||::.:        .:|..||         .::..|:.:|.|....:|.|:    :|.
Mosquito   346 RYLNVTKLHSDLLDRVKLSNDETLQATIQHSPIQQAYLSSRTNITSLLLLDTNLSDIE----IEP 406

  Fly   397 NN--LNELFLGQNSMSSIPADL---------------FLNVS--------ALTRLTLFSNNLTTL 436
            :|  |..|.:.::.:..:|..:               |||.|        :|..:.|..|.|||:
Mosquito   407 HNPKLEILTIMKSRLRCVPDSIKQLAVVLNLMQNKISFLNYSCSSGVEFPSLRVIYLAHNLLTTI 471

  Fly   437 EADDFQGLNNLKILLLNNNILKNFDARA--------------FEP-------LSQLEKLRIDSNK 480
            ..:||.|:..|.||.|:||.|.:.:.:.              |..       ||.|..|.|::|.
Mosquito   472 GMNDFNGMKLLNILDLSNNSLHSLEGQLRLSSLTDLKLSHNHFTELSCCGWNLSSLTNLDINNNT 536

  Fly   481 LMFLPHGALHGLK-----NLVAVKL--DKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGD 538
            |..||......|.     |||:..|  |.|.|.   |...|::      |.|.|
Mosquito   537 LQRLPTCMEDALPIVSYLNLVSNVLSNDDNIWD---RLASLSQ------LTLLD----------- 581

  Fly   539 LGGHEVGLLRYDDLCDGQWASMLSLSPR-LPVRKHQISTPMNY------TDYFNLYLKHIYNGTT 596
                    |.|:.|....|.: ::||.| :.:|    :.||.|      .|.||:.:    ..||
Mosquito   582 --------LSYNRLTSMVWDN-VTLSTRYINLR----NNPMKYLNIPMAIDGFNVDM----GCTT 629

  Fly   597 DEELKEADITSVSIKKVHN 615
            .::|   :|:|.|.....|
Mosquito   630 FDQL---EISSRSFNNTLN 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	20/65 (31%)
		leucine-rich repeat	187..206	CDD:275380	9/23 (39%)
		LRR_RI	<201..386	CDD:238064	57/283 (20%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	3/22 (14%)
		LRR_8	253..313	CDD:290566	22/106 (21%)
		leucine-rich repeat	255..278	CDD:275380	12/66 (18%)
		leucine-rich repeat	279..302	CDD:275380	5/25 (20%)
		LRR_8	303..361	CDD:290566	22/87 (25%)
		leucine-rich repeat	303..326	CDD:275380	10/45 (22%)
		leucine-rich repeat	327..350	CDD:275380	6/29 (21%)
		LRR_8	349..407	CDD:290566	16/76 (21%)
		LRR_4	350..390	CDD:289563	11/56 (20%)
		leucine-rich repeat	351..374	CDD:275380	6/39 (15%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	16/69 (23%)
		leucine-rich repeat	399..422	CDD:275380	7/45 (16%)
		leucine-rich repeat	423..443	CDD:275380	8/19 (42%)
		leucine-rich repeat	471..494	CDD:275380	8/27 (30%)
		LRRCT	503..554	CDD:214507	10/50 (20%)
AgaP_AGAP008171	XP_001689016.1	leucine-rich repeat	103..128	CDD:275380	10/25 (40%)
		LRR_8	127..185	CDD:290566	17/59 (29%)
		leucine-rich repeat	129..152	CDD:275380	6/22 (27%)
		leucine-rich repeat	153..174	CDD:275380	3/22 (14%)
		leucine-rich repeat	175..197	CDD:275380	8/21 (38%)
		leucine-rich repeat	198..224	CDD:275380	4/25 (16%)
		leucine-rich repeat	225..245	CDD:275380	2/19 (11%)
		leucine-rich repeat	246..269	CDD:275380	3/22 (14%)
		leucine-rich repeat	270..294	CDD:275380	6/23 (26%)
		leucine-rich repeat	411..430	CDD:275380	3/18 (17%)
		leucine-rich repeat	434..457	CDD:275378	4/22 (18%)
		LRR_RI	<456..588	CDD:238064	41/159 (26%)
		LRR_8	456..514	CDD:290566	16/57 (28%)
		leucine-rich repeat	458..481	CDD:275380	9/22 (41%)
		LRR	<482..>614	CDD:227223	41/164 (25%)
		leucine-rich repeat	482..503	CDD:275380	7/20 (35%)
		leucine-rich repeat	504..526	CDD:275380	2/21 (10%)
		leucine-rich repeat	527..550	CDD:275380	8/22 (36%)
		leucine-rich repeat	551..576	CDD:275380	9/27 (33%)
		leucine-rich repeat	577..599	CDD:275380	8/41 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910