DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and lingo1a

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_005174327.1	Gene:	lingo1a / 564943	ZFINID:	ZDB-GENE-080327-16	Length:	615	Species:	Danio rerio

Alignment Length:	509	Identity:	131/509 - (25%)
Similarity:	209/509 - (41%)	Gaps:	120/509 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 QPVWHLATGSQIEWN--HCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILST 195
            ||:..|..|:.:..:  .|.|. |.||...:|..|....|.|||  :.||.....:|||:|.:.|
Zfish    17 QPILILMLGTVLSGSATGCPSR-CECNVQERSVLCHRKKLMSVP--EGIPSETRLLDLSKNRIKT 78

  Fly   196 LHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDL 260
            ::.|.|.....|:||:::.|.:..:....|.:|..|..|.:::|:|:.|....|..|.||..||:
Zfish    79 INPDEFSAFPQLEELELNENTISAIEPGAFNNLYGLQTLGLRSNKLKLIQLGVFTGLSNLTKLDI 143

  Fly   261 SKNEIGMLPESIFYHAQRLTVINMCDNQI-----QNFPPNLLRDQLMLEELDMS----------- 309
            |:|:|.:|.:.:|.....|..:.:.||.:     :.|......:||.||:.:::
Zfish   144 SENKIVILLDYMFQDLYNLRSLEVGDNDLVFISHRAFHGLSSLEQLTLEKCNLTSVPTEAFTHLH 208

  Fly   310 -------RN-KISELSSGSIRYLTKLKTLDF-GWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLS 365
                   || .|:.:...|.:.|.:||.|:. .|..:..:..:...|| :|.:|::.|..::|:.
Zfish   209 SLVTLRLRNLNINSIRDYSFKRLYRLKVLEIANWPYLDTMTTNCLYGL-NLTSLTITNANLTSIP 272

  Fly   366 GTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFS 430
            .....:|..|..|:::.|.|..|:||...:|..|.||:                        |..
Zfish   273 YLALRHLVYLRFLNMSYNPIQMIEGNRLHDLLRLQELY------------------------LVG 313

  Fly   431 NNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNL 495
            ..|:.:|...|:|||.||:|.:::|.|...:...|..:..||.|             |||
Zfish   314 GRLSVIEPYSFRGLNYLKVLNVSSNFLTTLEESVFHSVGNLETL-------------ALH----- 360

  Fly   496 VAVKLDKNPWHCDCRALYL--ARWIREFVLKLWDGQQPMCRGPGDLGGHEVGLLRYDDLCDGQWA 558
                  .||..||||.|::  .||...|     :.|||.|..|..:.|.|     :.|..|
Zfish   361 ------DNPLACDCRLLWVFRRRWRLNF-----NRQQPTCSSPEFVQGKE-----FKDFPD---- 405

  Fly   559 SMLSLSP--------RLPVRKHQISTPMNYTDYFNLYLKHIYNGTTDEELKEAD 604
               .|.|        |:..||.|              .|.:..|||...:.:||
Zfish   406 ---ILQPNYFTCRKSRIRDRKPQ--------------QKFVDEGTTVHFVCQAD 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	16/58 (28%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	50/209 (24%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	19/83 (23%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	5/27 (19%)
		LRR_8	303..361	CDD:290566	16/77 (21%)
		leucine-rich repeat	303..326	CDD:275380	7/41 (17%)
		leucine-rich repeat	327..350	CDD:275380	6/23 (26%)
		LRR_8	349..407	CDD:290566	16/57 (28%)
		LRR_4	350..390	CDD:289563	10/39 (26%)
		leucine-rich repeat	351..374	CDD:275380	5/22 (23%)
		leucine-rich repeat	375..398	CDD:275380	8/22 (36%)
		LRR_8	398..>443	CDD:290566	7/44 (16%)
		leucine-rich repeat	399..422	CDD:275380	3/22 (14%)
		leucine-rich repeat	423..443	CDD:275380	4/19 (21%)
		leucine-rich repeat	471..494	CDD:275380	6/22 (27%)
		LRRCT	503..554	CDD:214507	18/52 (35%)
lingo1a	XP_005174327.1	LRRNT	34..68	CDD:214470	13/36 (36%)
		LRR_RI	<55..231	CDD:238064	47/177 (27%)
		leucine-rich repeat	66..89	CDD:275380	7/22 (32%)
		LRR_8	88..148	CDD:290566	19/59 (32%)
		leucine-rich repeat	90..113	CDD:275380	6/22 (27%)
		leucine-rich repeat	114..137	CDD:275380	7/22 (32%)
		LRR_8	136..196	CDD:290566	17/59 (29%)
		leucine-rich repeat	138..185	CDD:275380	12/46 (26%)
		LRR_8	184..241	CDD:290566	12/56 (21%)
		leucine-rich repeat	186..209	CDD:275380	4/22 (18%)
		leucine-rich repeat	210..257	CDD:275380	11/47 (23%)
		leucine-rich repeat	234..256	CDD:275380	4/21 (19%)
		LRR_8	257..316	CDD:290566	17/82 (21%)
		leucine-rich repeat	258..281	CDD:275380	5/22 (23%)
		leucine-rich repeat	282..305	CDD:275380	8/22 (36%)
		LRR_8	305..364	CDD:290566	23/106 (22%)
		leucine-rich repeat	306..329	CDD:275380	9/46 (20%)
		leucine-rich repeat	330..350	CDD:275380	6/19 (32%)
		TPKR_C2	362..>398	CDD:301599	15/40 (38%)
		I-set	421..507	CDD:254352	9/36 (25%)
		Ig	432..507	CDD:299845	5/11 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4201
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1378
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.960