DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and lrig1

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_688817.4	Gene:	lrig1 / 560325	ZFINID:	ZDB-GENE-031113-23	Length:	1022	Species:	Danio rerio

Alignment Length:	521	Identity:	139/521 - (26%)
Similarity:	223/521 - (42%)	Gaps:	92/521 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 CRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLD 218
            |.|..||..  |...::..||  |.:|.:.|:::||.|.|:.:..|....|..|:|:.:.||.|.
Zfish    36 CTCTLDTTD--CSRLDMTDVP--QDLPKSTVHLNLSHNKLTAVDMDILSNLPHLREVRLDHNELT 96

  Fly   219 FLPFDLFQD-LDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIF--------- 273
            .:|  .|.| ..|::.|.:.:|::..::.........|..||||.|:|..|.|..|
Zfish    97 SIP--SFGDAAASVVTLLLHHNRIRRLEGSLLQNFSALETLDLSNNDITELREHCFPLGLQIKDL 159

  Fly   274 -------YH---------AQRLTVINMCDNQIQNFP------PNLLRDQL--------------- 301
                   .|         |..|.::.:..|::.:.|      |.|.:.:|
Zfish   160 HLSSNKIVHLEFGAFKNLAGSLQILRLSRNRLTHLPVKGLELPKLTQLELSRNRLRLIEGLTFQG 224

  Fly   302 --MLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSL 364
              .||.|.:.||.||:|:.|:...|.:::.|...:|.:.:::.....||.||..|.|.||.||:.
Zfish   225 LSSLEVLKLQRNNISKLTDGAFWGLARMRVLHLDYNSLREVNSGSLYGLESLLQLYLANNSISNF 289

  Fly   365 SGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLF 429
            :...:.....|..|:|:.|.::.:...:|.:|.||..|.||.||:|.|....|..:|:|..|.|.
Zfish   290 NPEGWGFCERLRELNLSYNNLTKLSEGSFAKLVNLISLRLGHNSISHITEGAFRGLSSLRTLELD 354

  Fly   430 SNNLT-TLE--ADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHG 491
            .|::: |:|  :..|.||.||..|.|..|.:|:...:||..|..||.|.:..|.:..:...|...
Zfish   355 HNDISGTIEDTSGAFTGLENLNKLTLFGNKIKSVAKKAFSGLEALEHLNLGENAIRSIQPEAFSK 419

  Fly   492 LKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLGGHEVGLLRY------- 549
            :|||..:.:..:.:.|||:..:...|:  ....|..|.|..|..|..|.|..:    |
Zfish   420 MKNLRYLHIQSDSFLCDCQLHWFPDWL--LTRGLNPGVQATCAHPESLKGTSI----YQAPPQSF 478

  Fly   550 --DDLCDGQ-------WASMLSLSPRLP-VRKHQISTPMNYTDYFNLYLKHIYNGTTDEELKEAD 604
              |||...|       .|::|....||. ......|:||.:|     :||      ..|.|::|:
Zfish   479 VCDDLPKPQITVHPVTTAAVLGKDVRLTCTAASSSSSPMTFT-----WLK------DQETLRQAE 532

  Fly   605 I 605
            :
Zfish   533 V 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	18/59 (31%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	56/233 (24%)
		leucine-rich repeat	207..230	CDD:275380	8/23 (35%)
		leucine-rich repeat	231..254	CDD:275380	2/22 (9%)
		LRR_8	253..313	CDD:290566	23/107 (21%)
		leucine-rich repeat	255..278	CDD:275380	12/47 (26%)
		leucine-rich repeat	279..302	CDD:275380	6/45 (13%)
		LRR_8	303..361	CDD:290566	20/57 (35%)
		leucine-rich repeat	303..326	CDD:275380	10/22 (45%)
		leucine-rich repeat	327..350	CDD:275380	4/22 (18%)
		LRR_8	349..407	CDD:290566	19/57 (33%)
		LRR_4	350..390	CDD:289563	12/39 (31%)
		leucine-rich repeat	351..374	CDD:275380	7/22 (32%)
		leucine-rich repeat	375..398	CDD:275380	6/22 (27%)
		LRR_8	398..>443	CDD:290566	18/47 (38%)
		leucine-rich repeat	399..422	CDD:275380	9/22 (41%)
		leucine-rich repeat	423..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	471..494	CDD:275380	5/22 (23%)
		LRRCT	503..554	CDD:214507	15/59 (25%)
lrig1	XP_688817.4	LRRNT	31..63	CDD:214470	9/30 (30%)
		leucine-rich repeat	63..84	CDD:275380	6/20 (30%)
		LRR_RI	77..334	CDD:238064	65/258 (25%)
		LRR_8	83..142	CDD:290566	17/60 (28%)
		leucine-rich repeat	85..107	CDD:275380	8/23 (35%)
		leucine-rich repeat	108..131	CDD:275380	2/22 (9%)
		LRR_8	132..191	CDD:290566	14/58 (24%)
		leucine-rich repeat	132..155	CDD:275380	10/22 (45%)
		leucine-rich repeat	156..180	CDD:275380	2/23 (9%)
		leucine-rich repeat	181..203	CDD:275380	3/21 (14%)
		LRR_8	202..262	CDD:290566	15/59 (25%)
		leucine-rich repeat	204..227	CDD:275380	2/22 (9%)
		leucine-rich repeat	228..251	CDD:275380	10/22 (45%)
		LRR_8	251..310	CDD:290566	16/58 (28%)
		leucine-rich repeat	252..275	CDD:275380	4/22 (18%)
		leucine-rich repeat	276..299	CDD:275380	7/22 (32%)
		LRR_8	299..358	CDD:290566	21/58 (36%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	324..347	CDD:275380	9/22 (41%)
		leucine-rich repeat	348..372	CDD:275380	7/23 (30%)
		LRR_4	373..414	CDD:289563	13/40 (33%)
		LRR_8	374..433	CDD:290566	17/58 (29%)
		leucine-rich repeat	375..398	CDD:275380	8/22 (36%)
		leucine-rich repeat	399..420	CDD:275380	5/20 (25%)
		LRRCT	433..481	CDD:214507	12/53 (23%)
		Ig_3	485..572	CDD:290638	14/60 (23%)
		IG_like	492..586	CDD:214653	13/53 (25%)
		I-set	590..680	CDD:254352
		Ig_1	607..681	CDD:143240
		I-set	684..771	CDD:254352
		IGc2	698..761	CDD:197706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910