DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and zgc:153913

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001073448.1	Gene:	zgc:153913 / 559700	ZFINID:	ZDB-GENE-061103-397	Length:	496	Species:	Danio rerio

Alignment Length:	455	Identity:	128/455 - (28%)
Similarity:	201/455 - (44%)	Gaps:	60/455 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 HLATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPV---TQV---------IP--------- 180
            ||..|.      |....|:|...:| ..|.:..:||:||   |||         ||
Zfish    14 HLYCGV------CCPEPCQCFSGSK-LVCSDDRMKSLPVNISTQVRELIVVASGIPDLDQQSFPE 71

  Fly   181 -MNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDL--FQDLDSLLVLRIQNNQLE 242
             :.:..:.....:|.::..:.|..|..|:||:||.|:. ::..|:  |..|.:|..|.:.||:|.
Zfish    72 TLRLSKLVFLNGMLKSVSGEAFERLVELRELEISGNIC-WMSLDIQTFSSLTNLTRLLLNNNKLS 135

  Fly   243 DIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELD 307
            .:|...|..|..|.:|.|..|.:..|...:|....|                        |:|||
Zfish   136 GVDAGLFHSLHQLEMLQLRGNGLSFLSGRLFQRLHR------------------------LQELD 176

  Fly   308 MSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNL 372
            :|.|:||.||:...:..::|:.|....|:|..:.|..|..|..|:.|:|.:|.|..|:...|.
Zfish   177 LSFNQISSLSTELFQNNSELRVLSLQANKIPNLPDGIFTHLDHLQELNLRSNLIRVLTPGSFP-- 239

  Fly   373 ANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLE 437
            |:|.||.|..|.:..:....|..|:.:..|.|.|||::.:|||||.|:.:|..|.|..|.::||.
Zfish   240 ASLKTLILKKNLLEKLTNAVFHTLHYITYLDLSQNSLTEVPADLFQNLISLETLDLSENRISTLA 304

  Fly   438 ADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDK 502
            ...|:||.::|.:.|..|.|.:.||...:....|:.|.:.:|.|..:|.|....|......:|..
Zfish   305 GSVFKGLFSIKSVYLQKNSLISVDAHLLKDQHDLQLLDLSNNSLRSIPSGFFEDLDFQCVFELRG 369

  Fly   503 NPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLGGHEVGLLRYDDLCDGQWASMLSLSPRL 567
            |||.|||...|...|::.....:.|..:..|..|..:.||.:..:..:.|...:.:|  |.||.:
Zfish   370 NPWSCDCGIHYFYDWLKYNHKHVKDLSRVSCEAPELIQGHNLRSVDREQLVCSRNSS--SNSPEM 432

Fly 568 567
Zfish 433 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	16/60 (27%)
		leucine-rich repeat	187..206	CDD:275380	3/18 (17%)
		LRR_RI	<201..386	CDD:238064	56/186 (30%)
		leucine-rich repeat	207..230	CDD:275380	9/24 (38%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		LRR_8	253..313	CDD:290566	13/59 (22%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..302	CDD:275380	0/22 (0%)
		LRR_8	303..361	CDD:290566	21/57 (37%)
		leucine-rich repeat	303..326	CDD:275380	10/22 (45%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR_8	349..407	CDD:290566	17/57 (30%)
		LRR_4	350..390	CDD:289563	13/39 (33%)
		leucine-rich repeat	351..374	CDD:275380	7/22 (32%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	18/44 (41%)
		leucine-rich repeat	399..422	CDD:275380	11/22 (50%)
		leucine-rich repeat	423..443	CDD:275380	7/19 (37%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		LRRCT	503..554	CDD:214507	14/50 (28%)
zgc:153913	NP_001073448.1	leucine-rich repeat	75..98	CDD:275380	3/22 (14%)
		LRR_RI	141..>350	CDD:238064	71/234 (30%)
		LRR_8	147..206	CDD:290566	20/82 (24%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		leucine-rich repeat	172..195	CDD:275380	10/22 (45%)
		LRR_8	194..252	CDD:290566	20/59 (34%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	7/22 (32%)
		leucine-rich repeat	266..289	CDD:275380	11/22 (50%)
		LRR_8	267..324	CDD:290566	23/56 (41%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		leucine-rich repeat	314..337	CDD:275380	6/22 (27%)
		leucine-rich repeat	338..359	CDD:275380	6/20 (30%)
		TPKR_C2	370..>404	CDD:301599	10/33 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BET7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_112811
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6410
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.700