DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and lingo4b

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001082850.1	Gene:	lingo4b / 559074	ZFINID:	ZDB-GENE-091214-3	Length:	604	Species:	Danio rerio

Alignment Length:	382	Identity:	120/382 - (31%)
Similarity:	189/382 - (49%)	Gaps:	33/382 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 CRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLD 218
            |.|:.|.....|.:.:|.:||  :.:|.|...:|||.|.|.||.:..|..|:.|::||:|.|::.
Zfish    33 CSCSRDPLEVNCSSRHLTAVP--EGLPTNAKRLDLSGNQLKTLARRQFSSLSKLEDLDLSENIIS 95

  Fly   219 FLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVIN 283
            .:..:.||.|.:|..|||:||:|:.:....|..|.||..||:|:|||.:..:..|
Zfish    96 MIEVETFQGLKNLRYLRIKNNRLKILPVGVFSGLSNLRRLDISENEILVFLDYTF---------- 150

  Fly   284 MCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGL 348
                          ||.:.|::||...|.:..:|..:...|..||.|:...:.:..|..:..:.|
Zfish   151 --------------RDMINLQQLDAGENDLVFISQRAFVGLQALKELNVDRSNLTSIPTEALSQL 201

  Fly   349 RSLRTLSLHNNRISSLSGTIFNNLANLVTLD-LTTNRISHIDGNAFVELNNLNELFLGQNSMSSI 412
            :||..|.|....||.|....|..|..|.||. |..:.:..::.|:.|.| ||..|.|...::|:|
Zfish   202 QSLTKLRLRKLTISVLPNNAFRRLHQLRTLQILHWSSLEMLNSNSLVGL-NLTTLVLTNCNLSAI 265

  Fly   413 PADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKIL-LLNNNILKNFDARAFEPLSQLEKLRI 476
            |.....:::.|..|.|..|.:|:::.:....|..|:.| |:..|:|: .:..||..||:...|.:
Zfish   266 PYSPLRHLAYLQYLDLSYNPITSIQGNLLGDLLRLQELHLVGGNLLR-IEPGAFRGLSRFRLLNV 329

  Fly   477 DSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMC 533
            .||:|..|...|.|.:.||..::||:||..||||.|::.|..|...   :||:||.|
Zfish   330 SSNRLSTLEESAFHSVGNLQTLRLDRNPLACDCRLLWVMRRRRRLD---FDGRQPTC 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	24/58 (41%)
		leucine-rich repeat	187..206	CDD:275380	9/18 (50%)
		LRR_RI	<201..386	CDD:238064	54/185 (29%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR_8	253..313	CDD:290566	15/59 (25%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	2/22 (9%)
		LRR_8	303..361	CDD:290566	15/57 (26%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		LRR_8	349..407	CDD:290566	20/58 (34%)
		LRR_4	350..390	CDD:289563	13/40 (33%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	7/23 (30%)
		LRR_8	398..>443	CDD:290566	12/44 (27%)
		leucine-rich repeat	399..422	CDD:275380	6/22 (27%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		LRRCT	503..554	CDD:214507	14/31 (45%)
lingo4b	NP_001082850.1	LRRNT	28..61	CDD:214470	9/29 (31%)
		leucine-rich repeat	41..62	CDD:275380	6/22 (27%)
		LRR	<56..304	CDD:227223	80/272 (29%)
		leucine-rich repeat	63..83	CDD:275380	9/19 (47%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		leucine-rich repeat	132..155	CDD:275380	10/46 (22%)
		leucine-rich repeat	156..179	CDD:275380	6/22 (27%)
		leucine-rich repeat	180..203	CDD:275380	5/22 (23%)
		leucine-rich repeat	204..251	CDD:275380	15/47 (32%)
		leucine-rich repeat	228..250	CDD:275380	6/21 (29%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		leucine-rich repeat	276..297	CDD:275380	5/20 (25%)
		LRR_8	299..358	CDD:316378	21/59 (36%)
		leucine-rich repeat	300..321	CDD:275380	7/21 (33%)
		leucine-rich repeat	324..344	CDD:275380	6/19 (32%)
		I-set	415..498	CDD:254352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4201
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1378
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.960