DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and lrrc47

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001103842.1	Gene:	lrrc47 / 553404	ZFINID:	ZDB-GENE-060503-289	Length:	565	Species:	Danio rerio

Alignment Length:	426	Identity:	98/426 - (23%)
Similarity:	172/426 - (40%)	Gaps:	77/426 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 MVNIDLSRNILSTLHKD--------TFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRI--- 236
            |...:.|:|:...:.|.        ..:|..|.|::..|..        |...|.||.:|..
Zfish     1 MAEENSSQNVWPEIEKAEKENRRELVLQGSAVDKKIQSSGG--------LHAGLYSLSLLNYLEV 57

  Fly   237 -QNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNL--LR 298
             |...|.:| |.....|.:|..|.|.:|::..:|:|| .|.:.:.|:::..||:|..|..:  |.
Zfish    58 SQCPSLHEI-HENIRNLSHLQSLILCRNKLTSVPKSI-GHLKAVKVLDLSVNQLQALPEEICALT 120

  Fly   299 DQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFF-AGLRSLRTLSLHNNRIS 362
            :   |..|::|.|.::.|..| :....||.:::...|:::::.:|.: :||..|.::....|.|.
Zfish   121 E---LNTLNVSCNSLTALPDG-LSKCVKLASINVSKNELSRLPEDLWCSGLELLSSIIASENAIE 181

  Fly   363 SLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLT 427
            .||..| .||.:|..|||:.|::..:... ..:...|.|.....|.:..            .||.
Zfish   182 ELSSEI-QNLPSLKVLDLSNNKLQELPAE-LADCPKLKETNFKGNKLKD------------KRLE 232

  Fly   428 LFSNNLTTLEADDF---QGLNNLKILLLNNNILKNFDA--------RAFEPLSQLEKLRIDSNKL 481
            ...|...|....|:   .|....|....:..:.:..|:        .|.:..|:.|:..:|....
Zfish   233 KMVNGCPTKSVLDYLRAGGRGKGKGKQQDGEVSEKVDSGRNASKKKSAAKQKSKKEEEDVDELNQ 297

  Fly   482 MFLPHGALH--------GLKNLVAVKLDKNPW--HCDCRALYLARW--IREFVL---KLWDGQQP 531
            |.:  ..||        .:|...||| |..|:  .|..:.:.|.:.  ::.|::   ||.|   .
Zfish   298 MVV--RILHISESPTAVTVKVSAAVK-DVRPYIVCCIVKGMNLRQGNSLKRFLVAQTKLHD---E 356

  Fly   532 MC--RGPGDLGGHEVGLLRYDDLCDGQWASMLSLSP 565
            :|  |....:..|::|||:|..|.|.:....|.:.|
Zfish   357 ICAKRTTATIATHDLGLLKYPLLYDARPPDTLKIIP 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	14/69 (20%)
		leucine-rich repeat	187..206	CDD:275380	4/26 (15%)
		LRR_RI	<201..386	CDD:238064	53/191 (28%)
		leucine-rich repeat	207..230	CDD:275380	4/22 (18%)
		leucine-rich repeat	231..254	CDD:275380	7/26 (27%)
		LRR_8	253..313	CDD:290566	18/61 (30%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	6/24 (25%)
		LRR_8	303..361	CDD:290566	14/58 (24%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	5/23 (22%)
		LRR_8	349..407	CDD:290566	15/57 (26%)
		LRR_4	350..390	CDD:289563	13/39 (33%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	8/47 (17%)
		leucine-rich repeat	399..422	CDD:275380	3/22 (14%)
		leucine-rich repeat	423..443	CDD:275380	5/22 (23%)
		leucine-rich repeat	471..494	CDD:275380	5/30 (17%)
		LRRCT	503..554	CDD:214507	15/59 (25%)
lrrc47	NP_001103842.1	LRR_RI	<74..212	CDD:238064	39/144 (27%)
		LRR_8	74..132	CDD:290566	18/61 (30%)
		leucine-rich repeat	76..98	CDD:275380	8/22 (36%)
		leucine-rich repeat	99..121	CDD:275380	6/21 (29%)
		leucine-rich repeat	122..144	CDD:275380	6/22 (27%)
		leucine-rich repeat	145..169	CDD:275380	5/23 (22%)
		LRR_8	170..226	CDD:290566	16/57 (28%)
		leucine-rich repeat	170..192	CDD:275380	8/22 (36%)
		leucine-rich repeat	193..215	CDD:275380	5/22 (23%)
		B3_4	324..497	CDD:214876	18/72 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910