DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Lingo4

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001102659.1	Gene:	Lingo4 / 499668	RGDID:	1562025	Length:	618	Species:	Rattus norvegicus

Alignment Length:	445	Identity:	120/445 - (26%)
Similarity:	176/445 - (39%)	Gaps:	94/445 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 LATGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFR 202
            |..|..|  :.|.: :|.|...|::..|.:..|.:||  ..:|::...:|||.|.|..|.:....
  Rat    47 LLPGGSI--SSCPT-LCDCTSQTRAVLCAHRRLDTVP--GGLPLDTEVLDLSGNRLWGLQRGMLS 106

  Fly   203 GLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGM 267
            .|..|:|||:|:|.|..|....|..|.|||.||:|.|:|..:....|..|..|.:|||..|:|.:
  Rat   107 RLGQLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIVGPGIFSGLSALTLLDLRLNQIVL 171

  Fly   268 LPESIFYHAQRLTVINMCDNQI-----------------------QNFPPNLLRDQ------LML 303
            ..:..|.....|..:.:.||.:                       .:..|.|...|      |.|
  Rat   172 FLDGAFGELGSLQQLEVGDNHLVFVAPGAFSGLAKLSTITLERCNLSTVPGLALAQLPALVALRL 236

  Fly   304 EELDMSRNKISELSSGSIRYLTKLKTLDF-GWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGT 367
            .|||:.|     |.||::|.|.:||.|:. .|..:..:|.....||
  Rat   237 RELDIER-----LPSGALRGLGQLKELEIHHWPSLEALDPGSLVGL------------------- 277

  Fly   368 IFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNN 432
                  ||.:|.:|...:|.:...|...|:.|..|.|.||.:|:|||.....:..|..|.|....
  Rat   278 ------NLSSLAITHCNLSSVPFQALHHLSFLQVLDLSQNPISAIPARRLSPLVRLQELRLSGAC 336

  Fly   433 LTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVA 497
            ||::.|..|.||....:|.:.:|.|:..:..||....:                        ||.
  Rat   337 LTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDK------------------------LVT 377

  Fly   498 VKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLGGHEVGLLRYDDL 552
            ::|..||..||||.|:|.|..|...   :....|.|.||..:.|.  .|..:.|:
  Rat   378 LRLSGNPLTCDCRLLWLLRLRRRLD---FGTSPPACAGPQHVQGK--NLREFSDI 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	24/58 (41%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	56/214 (26%)
		leucine-rich repeat	207..230	CDD:275380	10/22 (45%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR_8	253..313	CDD:290566	19/88 (22%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	6/51 (12%)
		LRR_8	303..361	CDD:290566	17/58 (29%)
		leucine-rich repeat	303..326	CDD:275380	10/22 (45%)
		leucine-rich repeat	327..350	CDD:275380	7/23 (30%)
		LRR_8	349..407	CDD:290566	10/57 (18%)
		LRR_4	350..390	CDD:289563	5/39 (13%)
		leucine-rich repeat	351..374	CDD:275380	0/22 (0%)
		leucine-rich repeat	375..398	CDD:275380	6/22 (27%)
		LRR_8	398..>443	CDD:290566	16/44 (36%)
		leucine-rich repeat	399..422	CDD:275380	9/22 (41%)
		leucine-rich repeat	423..443	CDD:275380	7/19 (37%)
		leucine-rich repeat	471..494	CDD:275380	0/22 (0%)
		LRRCT	503..554	CDD:214507	17/50 (34%)
Lingo4	NP_001102659.1	leucine-rich repeat	87..110	CDD:275380	7/22 (32%)
		LRR_8	88..145	CDD:290566	24/56 (43%)
		LRR_4	88..126	CDD:289563	15/37 (41%)
		LRR_RI	110..345	CDD:238064	73/264 (28%)
		leucine-rich repeat	111..134	CDD:275380	10/22 (45%)
		LRR_8	134..193	CDD:290566	20/58 (34%)
		leucine-rich repeat	135..158	CDD:275380	9/22 (41%)
		leucine-rich repeat	159..182	CDD:275380	7/22 (32%)
		LRR_8	182..237	CDD:290566	7/54 (13%)
		leucine-rich repeat	183..206	CDD:275380	3/22 (14%)
		leucine-rich repeat	207..230	CDD:275380	3/22 (14%)
		leucine-rich repeat	231..254	CDD:275380	11/27 (41%)
		leucine-rich repeat	255..302	CDD:275380	14/71 (20%)
		LRR_8	278..334	CDD:290566	19/55 (35%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		LRR_8	326..385	CDD:290566	18/82 (22%)
		leucine-rich repeat	327..348	CDD:275380	7/20 (35%)
		leucine-rich repeat	351..374	CDD:275380	5/22 (23%)
		IG_like	445..526	CDD:214653
		Ig	456..526	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910